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Introns in Medical News

RNA-associated introns guide nerve-cell channel production

PHILADELPHIA Researchers at the University of Pennsylvania School of Medicine have discovered that introns, or junk DNA to some, associated with RNA are an important molecular guide to making nerve-cell electrical channels. Senior author James Eberwine, PhD, Elmer Bobst Professor of Pharmacology,...

Genetic Test for Type II Diabetes Moves Closer

... well as biological studies will be needed to identify the causative variant. Two further loci were found in the study; the first located in the introns of exostosin 2 (EXT2), which modulates hedgehog signaling, early pancreatic development and insulin synthesis. The second is located in chromoso...
Introns in Medical Dictionary

Gene

...age of the word " gene " reflects its meaning in molecular biology, ... ... example, the expression of mMCP-7 gene was higher in B6-tg/tg ... of introns of KitL gene ... the coding region of KitL gene was compared between B6 and ... Here, we used microarray gene expression profiling and data-...
Introns in Biological News

CSHL scientists clarify editing error underlying genetic neurodegenerative disease

...od, the raw or unedited RNA copy of DNA includes excess RNA segments called introns that need to be edited out in order for the RNA's message to be functional. Once the introns are removed, the remaining segments -- called exons -- are pasted together,...

Stowers Institute's Baumann Lab identifies key step in maturation pathway of telomerase

...show that 3' end processing for telomerase RNA uses a fundamentally different and novel pathway." "We demonstrate that the machinery that removes introns from messenger RNAs also functions in generating the mature 3' end of the telomerase RNA subunit," said Jessica Box, Research Technician I and co-equa...

Researchers develop new self-training gene prediction program for fungi

...(exons) and non-coding sequences (introns and intergenic regions). Most introns start from the dinucleotide guanine-thymine (abbreviated GT) and end with t...d significant variability in genome size, gene number and average number of introns per gene. The results showed that by including branch site information in t...

Trichoplax genome sequenced -- 'rosetta stone' for understanding evolution

...illion. Earlier sequencing work showed that the mitochondrial genome of Trichoplax is over twice the size of those found in most animals with genes, introns and spacer sequences like the most primitive organisms. However, size is not all that matters. DNA sequences that organisms share in common represe...

Evolution of fruit size in tomato

...ther the mutation consisted of an insertion in the first intron, which is a non-coding sequence embedded within the protein coding sequence. Although introns are not part of a gene's protein code and are removed from the RNA sequence before translation into proteins, they are nevertheless structurally and f...

Scientists find a fingerprint of evolution across the human genome

...f splicing Previous researchers assumed that mutations in the middle of introns do not affect the final protein, so they simply accumulate. In the new work...ations even in these regions of the genome. Although the selection is weak, introns are not neutral, in their effect on survival, says CSHL professor Michael Z...

Yale scientists visualize the machinery of mRNA splicing

...d her research team into the nature of group II introns , a particular type of intron within gene transcri... removal during the maturation of RNA. Group II introns are found throughout nature, in all forms of livin...ture applications of the work, Pyle said, Group II introns hold promise in the future as agents of gene thera...

Genome of marine organism tells of humans' unicellular ancestors

...out 25,000 genes. Interestingly, the choanoflagellate has nearly as many introns - non-coding regions once referred to as "junk" DNA - in its genes as humans do in their genes, and often in the same spots. introns have to be snipped out before a gene can be used as a blueprint for a prote...

Exploring the dark matter of the genome

...ere organized quite differently from genes in euchromatin, with much longer gaps (introns) between the coding sections of the gene (exons); unlike the introns in euchromatic genes, these long gaps consisted almost entirely of repeating sequences derived from disabled transposons. The evidence suggests that h...

Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription

...in the genus Saccharomyces. The researchers found that genes of these organisms are more stable than intergenic regions near their 3?end. In addition, introns (internal non-coding regions in genes) are significantly less stable than exons (coding sequences in genes), suggesting that stable sense duplexes are...
Introns in Biological Technology

SNPs Powerful Tools for Association Studies

...rtance. Intronic SNPs Single nucleotide polymorphisms that occur in noncoding regions of a gene that separate the exons (i.e., introns). introns are transcribed into RNA, but are not translated into protein. Linkage map See genetic map Meiosis Meiosis is the process b...

Quantitative Analysis of GFP in Plant Extracts Using the VersaFluor Fluorometer System

...itates the comparative assessment of expression levels directed and influenced by attached genetic sequences, such as promoters, introns and terminators. The ability to test gene sequences in this way is a prerequisite for the correct deployment of useful gene sequ...

Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells

...3). 10. Moran, J. V., Zimmerly, S., Eskes, R., Kennell, J. C., Lambawitz, A. M., Butow, R. A. and Perlman, P. S., Mobile group II introns of yeast mitochondrial DNA are novel sitespecific retroelements, Mol. Cell Biol., 15 , 2828-2838 (1995). 11. Russell,...

Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms

...raspecific polymorphisms are drawn to introns, which often show a greater degree of site and size variation than coding regions. introns may be amplified using conserved primers targeted to flanking exon sequence, a strategy termed exon-primed intron-crossing (EPIC...

DNA-free A NEW Method to Remove DNA

... as the expected cDNA product. (Pseudogenes arise from a processed mRNA that is reverse transcribed and then integrated into the genome; no introns are present). Figure 2 illustrates how primer design can be used to detect most DNA contamination, and why a "minus-RT" control ...

Amplification of Epstein-Barr Virus Exon C with Difficult Primers Using Eppendorf Mastercycler gradient

...20 genes.1 LMP-1 gene consists of three exons separated by short introns (Fig. 1).2 One of our investigation efforts attempted to study t...gene. The three exons (EA, EB and EC) are separated by two short introns (I-1 and I-2). Arrows indicate the position of the forward and r...
Introns in Biological Products

TargeTron Gene Knockout System from Sigma-Aldrich

Description:...ols for the rapid and specific disruption of bacterial genes by insertion of group II introns. The method exploits the retrohoming ability of group II introns and utilizes a simple PCR step to re-target the TargeTron group II intron for specific insertion into the host genome. Utility of the technology has b...
Company:Sigma-Aldrich
Introns in Biological Definition

Alternative splicing

...When the pre-mRNA has been transcribed from the DNA , it includes several introns and exons . In nematodes , the mean is 4-5 exons and introns; in the fruit fly Drosophila there are more than 100 introns and exons in one transcribed pre-mRNA. But what is an intron and what is an...

Enhancer

... some have been found to bind several hundreds of thousands base pairs upstream or downstream of the start site. Enhancers can also be found inside introns . An enhancer's orientation may even be reversed without affecting its function. Furthermore, an enhancer may be excised and inserted elsewhere in t...

Gene

...gmented internally by non-coding sequences called introns , which can be many times longer than the genes themselves. introns are removed on the heels of transcription by sp...f a gene, by keeping the exons and removing the introns . So, the DNA strand needs to be in an exon to be...

Intron

... introns are sections of DNA within a gene that do not...ene before it is exported from the cell nucleus . introns exist mainly (but not only) in eukaryotic cells... remain in the spliced mRNA are called exons . introns sometimes allow for alternative splicing of a ge...

Spliceosome

...a complex of RNA and many protein subunits, that remove the non-coding introns from unprocessed mRNA . The mRNA of prokaryotes is simpler, and they do...native splicing Alternative splicing (the re-combination of different introns ) is a major source of genetic diversity in eukaryotes. For example alte...

Splicing (genetics)

...sequences known as exons (expressed codons) and introns (interrupting codons). In contrast to prokaryote...nscript called pre-mRNA that is composed of both introns and exons (see transcription ). Pre-mRNA has to ... be translated into protein. During splicing, the introns are removed from the mRNA using one of three metho...
Introns in Biological Dictionary

Introns

Introns are common in eukaryotic pre-mRNA, but in prokaryotes they are only ... The discovery of introns led to the Nobel Prize in Physiology or Medicine in ... Introns is an album by LCD Soundsystem released in March 2006 as a digital download. It is a compilation of b-sides and re...

Group I introns

Group II intron is a class of self-catalytic ribozymes and retroelements found in rRNA, tRNA, mRNA of organelles in fungi, plants, protists, and bacteria. Self-splicing occurs in vitro, but protein machinery is probably... Group I catalytic introns are large self-splicing ribozym...

Group II introns

Group II intron is a class of self-catalytic ribozymes and retroelements found in rRNA, tRNA, mRNA of organelles in fungi, plants, protists, and bacteria. Self-splicing occurs in vitro, but protein machinery is probably... Phylogenetic tree, secondary and ORF structure to identify and ca...

Spliceosome

...osome is a complex of specialized RNA and protein subunits that removes introns from a transcribed pre-mRNA (hnRNA) segment. This process is generally ref... which is a large RNA-protein complex ... The major spliceosome splices introns containing GU at the 5' splice site and AG ... Definition of spliceo...

Splicing

...fication of an RNA after transcription, in which introns are removed and exons are joined. This is neede...NA Splicing Mechanisms and Conservation of Minor introns in Voltage ... Wire Rope splicing , wire rope ...gulators, the most common of which ... Group 1 introns are self- splicing : they pinch themselves out of...

Self-splicing

...fication of an RNA after transcription, in which introns are removed and exons are joined. This is neede...e, the self - splicing activities of 12 group I introns from various organisms ... Since the discovery of...eport the occurrence of self - splicing group I introns in viruses that infect ... A self - splicing i...

RNA Splicing

...cation of an RNA after transcription, in which introns are removed and exons are joined. This is neede... lacking. Splicing is the stage during which introns are removed from the strand, and the ... An in-de...ure 14.10, p. 289 ... This process of removing introns is called RNA splicing . ... RNA splicing ...

Pseudogene

...y ... Pseudogene evolution and natural selection for a compact genome. ... Pseudogene . Definition(s) A copy of a gene that usually lacks introns and other essential DNA sequences ... Pseudogenes, though genetically similar to the ... pseudogene synonyms. pseudogene usage examples and p...

Pre-mRNA

...difying pre mrna before moving to translation? Why is pre - mrna transcription only an indirect measurement of ... Step-by-step removal of introns present in the pre - mRNA and splicing of the remaining exons. This step takes place as the pre - mRNA continues to emerge from RNAP II. ... ...

Non-coding strand

...- coding strand , template strand . ... Anticoding Strand - Medical Dictionary Definition ... ... is that it represents non - coding DNA: introns ("intervening sequences" ... top strand is the " non - coding " strand and the bottom one is the " coding " strand . ... ... What is the seq...
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