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Intron in Medical News

Schering-Plough Reports Financial Results for 2009 First Quarter

... 3% REBETOL 66 59 12% CAELYX 61 74 (18%) intron A 54 55 (3%) PROVENTIL / ALBUTEROL CFC 54 50 7% REMERON ...

Schering-Plough Reports Financial Results for Third Quarter of 2008

...SUBUTEX / SUBOXONE 63 55 15% 178 163 10% REMERON c/ 61 - - 190 - - intron A 61 61 - 177 176 1% CERAZETTE c/ 49 - - 142 - - LIVIAL...

RNA-associated introns guide nerve-cell channel production

...trical channel, called the BK channel, contains an intron that is present outside the nucleus. This intron plays an important role in ensuring that functiona...ucleus serves a critical cellular function. The intron acts like a guide or gatekeeper, says Eberwine. It...

PEGINTRON(TM) and REBETOL(R) Approved in European Union for Retreating Hepatitis C Patients Who Failed Previous Pegylated or Non-Pegylated Interferon Therapy

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin may caus...cirrhotic CHC patients before or during treatment. intron A (Interferon alfa- 2b, recombinant) for Injection...ntraindicated in patients with hypersensitivity to intron A or any component of the product, autoimmune hepa...

Schering-Plough Reports Financial Results for Third Quarter of 2007

... AVELOX 78 63 24% 269 201 34% CAELYX 64 52 23% 191 156 22% intron A 61 57 7% 176 180 (2%) REBETOL 60 72 (16%) 206 237 (13%) SUBUTEX...

Gene Variation Associated With Better Mobility For Older Individuals

...basis for this is unclear, but there appears to be a strong genetic component. A certain gene variation (an insertion [I]/deletion [D] polymorphism in intron 16 of the angiotensin-converting enzyme [ACE]) gene has been identified as a potential marker for differential response to exercise in younger adults....
Intron in Medical Technology

Schering-Plough Provides Update on Boceprevir Clinical Development and Introduces Potent Next-Generation Oral HCV Protease Inhibitor for Treating Patients With Chronic Hepatitis C

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin...irrhotic CHC patients before or during treatment. intron A (Interferon alfa-2b, recombinant) for Injection ...ntraindicated in patients with hypersensitivity to intron A or any component of the product, autoimmune hepa...

Boceprevir Phase II Study Showed High Rate of Sustained Response With 28- and 48-Week Regimens in Genotype 1 Treatment-Naive Hepatitis C Patients

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin may cau...cirrhotic CHC patients before or during treatment. intron A (Interferon alfa-2b, recombinant) for Injection ...ntraindicated in patients with hypersensitivity to intron A or any component of the product, autoimmune hepa...

Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin may cau...cirrhotic CHC patients before or during treatment. intron A (Interferon alfa-2b, recombinant) for Injection ...ntraindicated in patients with hypersensitivity to intron A or any component of the product, autoimmune hepa...

Schering-Plough To Initiate Phase III Studies With HCV Protease Inhibitor Boceprevir in Previously Untreated Hepatitis C Patients and Those Who Failed Prior Treatment

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin may cau...cirrhotic CHC patients before or during treatment. intron A (Interferon alfa-2b, recombinant) for Injection ...ntraindicated in patients with hypersensitivity to intron A or any component of the product, autoimmune hepa...

Schering-Plough Highlights PEGINTRON(TM) and Boceprevir Hepatitis C Data Presentations at Digestive Disease Week (DDW) Annual Meeting

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin may cau...cirrhotic CHC patients before or during treatment. intron A (Interferon alfa-2b, recombinant) for Injection ...ntraindicated in patients with hypersensitivity to intron A or any component of the product, autoimmune hepa...

Interim Results from Boceprevir Phase II Study in Genotype 1 Treatment-Naive Hepatitis C Patients Presented At EASL

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin may cau...cirrhotic CHC patients before or during treatment. intron A (Interferon alfa-2b, recombinant) for Injection ...ntraindicated in patients with hypersensitivity to intron A or any component of the product, autoimmune hepa...

Final Results of Ideal Study Presented at Annual Meeting of the European Association for the Study of the Liver (EASL)

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin may cau...cirrhotic CHC patients before or during treatment. intron A (Interferon alfa-2b, recombinant) for Injection ...ntraindicated in patients with hypersensitivity to intron A or any component of the product, autoimmune hepa...

Schering-Plough Highlights PEGINTRON(TM) and Boceprevir Data Presentations at European Association for the Study of the Liver (EASL) Annual Meeting

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin may cau...cirrhotic CHC patients before or during treatment. intron A (Interferon alfa-2b, recombinant) for Injection ...ntraindicated in patients with hypersensitivity to intron A or any component of the product, autoimmune hepa...

Pegintron(TM) Plus Weight-Based Rebetol(R) Resulted in Higher SVR Than Flat Dosing; Low Relapse Rates in Patients With Chronic Hepatitis C

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin may cau...cirrhotic CHC patients before or during treatment. intron A (Interferon alfa- 2b, recombinant) for Injection...ntraindicated in patients with hypersensitivity to intron A or any component of the product, autoimmune hepa...

Roche responds to announcement of 'IDEAL' hepatitis C trial results

... dose. However, physicians could only prescribe EPO after the first dose ribavirin reduction in the "IDEAL" trial. Since patients in the Peg- intron arms generally had smaller ribavirin dose reductions, this introduces another potential bias and means those Peg-Intron patients were potentia...
Intron in Biological News

CSHL scientists clarify editing error underlying genetic neurodegenerative disease

...n unedited RNA molecule, the boundaries between an intron and its two flanking exons are called splice sites...y guided to the splice site at the beginning of an intron by one of its components, a small nuclear RNA call... to recognize this splice site at the start of the intron is strongest when up to 11 bases are paired up. ...

Stowers Institute's Baumann Lab identifies key step in maturation pathway of telomerase

...ome could have such a function, as the two steps of removing an internal piece of RNA and gluing the flanking ends together are tightly coupled during intron removal. To our knowledge this is the first example where uncoupling of the first and second step of splicing generates a functional product in a sing...

Researchers develop new self-training gene prediction program for fungi

...ting the exon-intron structure of eukaryotic genes, we didn't search for branch point sites, but doing so in the new program helps to better delineate intron regions inside fungal genes," added Borodovsky, who is also a Regents' Professor in the Coulter Department of Biomedical Engineering and the Computati...

Evolution of fruit size in tomato

...tion into proteins, they are nevertheless structurally and functionally important, as demonstrated in this locus. The presence of an insertion in this intron reduces expression of the fas gene. The scientists looked at where and when the gene is expressed and found it dramatically reduced in developing flo...

Scientists find a fingerprint of evolution across the human genome

...l consequences. Other sequences must likewise be preserved in the regions to be retained. The scientists found a preference for some letters across intron regions, and the opposite preference in coding regions. Together, these regions make up at least a third of the genome, which is thus under selective ...

Yale scientists visualize the machinery of mRNA splicing

... research team into the nature of group II introns , a particular type of intron within gene transcripts that catalyzes its own removal during the maturatio...oup II introns hold promise in the future as agents of gene therapy. A free intron is an infectious element that is special because it targets DNA sites very ...

Scientists find missing evolutionary link using tiny fungus crystal

...e fungus, had adapted to take over some of the RNA molecule's chemical reaction jobs inside cells. The protein stabilizes the RNA molecule - called an intron - so that the RNA can cut out non-functional genetic material and splice together the ends of a functional gene, Paukstelis said. "The RNA molecule...

RNA splicing occurs in nerve-cell dendrites

...f proteins within the human body arises in part from the many ways that mRNAs can be spliced and reconnected. Specifically, splicing removes pieces of intron and exon regions from the RNA, with the resulting spliced RNA often being made into protein. Should the RNA have different exons spliced in and out o...

Genes linked to treatment resistance in children with leukemia

...ects the CNS. For patients in the high-risk arm, the VDR FokI genotype was found to be prognostic for CNS relapse, especially when combined with a VDR intron 8 genotype. In the low-risk group, the TYMS 3/3 genotype was a risk factor. For children with these unfavorable genotypes, a potential solution may...

Reversal of role for a viral protein associated with the development of lymphoma

...-causing mutations occur at standard signals where intron removal takes place through direct splicing. Mutat...lar tools to analyze the lariats released from any intron during splicing in vivo. In his analyses, he found...at these ratchetting points mediate the removal of intron subfragments in one direction as the gene is trans...
Intron in Biological Technology

Schering-Plough Reports Financial Results for 2009 Second Quarter

...OL 67 70 (4%) 134 130 3% CAELYX 68 78 (14%) 128 152 (16%) intron 67 61 10% 121 116 4% PROVENTIL / ALBUTEROL 56 38 46% 110 89 24% A...

Frost & Sullivan Awards Precision Biosciences for Technology Innovation and Molecular Design Process in the Genomics Market

...dered the efforts to genetically engineer complex mammalian and plant cells." The technology innovation in DNE successfully bridges the fields of intron homing, protein-DNA interactions, DNA recombination, molecular modeling, and molecular catalysis. The design and production pathway for the DNE is eff...

Schering-Plough Reports Financial Results for First Quarter of 2008

... ZEMURON c/ 63 - N/M REBETOL 59 71 (17%) intron A 55 60 (8%) SUBUTEX / SUBOXONE 54 56 (4%) PROVENTIL...

Schering-Plough Reports Financial Results for 2007 Fourth Quarter, Full Year

... 1% REBETOL 71 75 (6%) 277 311 (11%) CAELYX 66 49 33% 257 206 25% intron A 57 57 - 233 237 (2%) SUBUTEX / SUBOXONE 57 51 11% 220 203 8% ...

Drug Royalty Corporation (DRC) Announces Acquisition Regarding PEG-INTRON(R) From Enzon Pharmaceuticals, Inc. (ENZN)

...very pleased to be working with Enzon Pharmaceuticals. We believe that PEG- intron is one of the most advanced medications to treat Hepatitis C on the market ...llow for less frequent dosing and to yield greater efficacy, as compared to intron A. PEG-INTRON is marketed worldwide by Schering-Plough and its affiliates. ...

Laser Capture Microdissection of muscle fiber populations and expression analysis by RT-PCR

... are amplified. The housekeeping gene GAPDH was amplified as a reference for the amount loaded and the quality of the cDNA. All primers (Table II) are intron spanning to produce a cDNA specific PCR product. To avoid false positive results by PCR product carry-over, PCRs are setup in a flow hood. ...

Detection of Mutations in the CYP21 Gene Using the DCode System

...eroid 21-hydroxylase gene mutations in the Spanish population, Hum. Genet., 96 , 198204 (1995). 5. Lajic, S., and Wedell, A., An intron 1 splice mutation and a nonsense mutation (W23X) in CYP21 causing severe congenital adrenal hyperplasia, Hum. Genet., 98 (2):18...

Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells

... gene on plasmid YEp352 and a plasmid carrying intron 2 from the COXI gene (either pJVM161 o...train 161) containing a deletion within intron 2 of the COXI gene (Zimmerly, et al., 1995) and s... P. S. and Lambowitz, A. M., A group II intron RNA is a catalytic component of a DNA endonuclease...

Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms

... used to amplify muscle-type lactate dehydrogenase intron six. Oligonucleotides were prepared by ... (Rhode Island to Virginia) were examined. The LDH intron appeared to be virtually invariant, wit...C) amplification. 7 When the size of a homologous intron varies among species, one may analyze t...

Ambion Custom

... control is guaranteed Figure 1. Crystals of Group I intron From Bacteriophage Twort. Today's laboratory demands ...transcribe milligram quantities of RNA--3.75 mg purified group I intron from bacteriophage Twort--for crystallography (Figure 1). The su...
Intron in Biological Products

TargeTron Gene Knockout System from Sigma-Aldrich

Description:...imple PCR step to re-target the TargeTron group II intron for specific insertion into the host genome. Utili... of the output primer sets to mutate the TargeTron intron template via PCR, ligation of the fragment into th...alidated TargeTron algorithm that predicts optimal intron insertion sites and designs primers for mutating t...
Company:Sigma-Aldrich

T7 RNA polymerase from Chimerx

Description:... promoter. Transcripts can be used as hybridization probes, templates for in vitro translation, substrates in RNA processing systems, or for exon and intron mapping of genomic DNA....
Company:Chimerx
Intron in Biological Definition

Intron

Introns are sections of DNA within a gene that do not encode part of the protein that the gene produces, and are spliced out of the mRNA that is transcribed from the gene before it is exported from the cell nucleus . Introns exist mainly (but not only) in eukaryotic cells . The r...

Alternative splicing

... exons in one transcribed pre-mRNA. But what is an intron and what is an exon is not decided yet. This decis...on sites can be spliced with the other exons. intron retaining mode : in this case, instead of splicing out an intron, the intron is retained in the mRNA transcript. However, the...

Gene therapy

...es of transfected cells. If the gene is inserted in a bad place — for example within the sequence of an important gene, or within non-coding ( intron ) regions that the cell will never translate to produce protein — then the new gene would not be properly expressed and the cell could be made...

Splicing (genetics)

...huge molecular structures composed of small nuclear ribonuclear proteins (snRNPs (pronounced "snurps")), splice the 3' end of the first exon, form the intron into a lariat , splice the 5' end of the next exon, and fuse the exon-exon junction; Self-splicing : specialized introns serves as ribozymes , p...
Intron in Biological Dictionary

Intron

An intron is a DNA region within a gene that is not translated into protein. These non-coding sections are transcribed to precursor mRNA (pre-mRNA) and some other RNAs, and subsequently removed by a process called splicing... intron n. A segment of a gene situated between exons that ...

Spliceosome

...nal that publishes full-length research papers in all disciplines of science, as well as ... This machinery, called the spliceosome , splices out intron sequences that ... The spliceosome presents special challenges to structure determination. ... Splicing is catalyzed by the spliceosome which ...

Self-splicing

...f - splicing of the Tetrahymena thermophila rRNA intron ... We report the occurrence of self - splici...s in viruses that infect ... A self - splicing intron in the small subunit rRNA gene of Pneumocystis ...... The Tetrahymena pre-rRNA self - splicing intron is shown to function in the ... In addition, even...

RNA Splicing

... will remove the introns and join the exons to give the mature RNA . ... RNA involvement in self‐ splicing is stoichiometric, but the excised intron does ... ...

Ribosomal RNA

... The other ribosomal RNA genes are found in an "operon"-like structure that's ... In some species the 28S ribosomal RNA gene contains an intron near the 3′ end. ... Created by George Rice, Montana State University Ribosomes ... The section (or gene) that codes for ribosomal RNA in a c...

Ribosomal DNA genes

...5,713. Back to main news page ... ... and in the small- and large-subunit ribosomal DNA genes of a limited number of ... spliceosomal-type intron occurs in a ribosomal protein gene ... DNA . Scope Note: DNA sequences encoding ribosomal RNA and the segments of DNA separating the ...

Primary transcript

...Researchers found that the primary RNA transcript produced by adenovirus type 2 ... The primary transcript of this gene contains an intron with two possible ... PLoS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC ... Northern blot analysis of pri-miR-433 and pr...

Mispairing

... Slipped mispairing between repeated sequences during DNA replication is an ... Slipped mispairing mediated by direct repeats and erroneous intron splicing. J ... Human Molecular Genetics 2 conveys the feel of fast-moving research while providing a description in some depth of the ... Slipped...

Introns

...e online English dictionary and encyclopedia. ... intron - sequence of a eukaryotic gene's DNA that is n...h school ... and to be a distinguished webpage of intron education. Copyrights-By Introns .net ... Wha...rons medical term. What does Introns mean? ... intron /in·tron/ (in'tron) a noncoding sequence betwee...

Intergenic DNA

...ysical role in ... ... DNA of vast amounts of non-coding sequences called introns or intergenic DNA . ... Interestingly, a large portion of intron DNA consists of repeated segments. ... Dot Plots ... Chimpanzee hemoglobin intergenic DNA against spider monkey. ... Further more, this is...
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