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Intraperitoneal in Medical News

Death Risk Of Ovarian Cancer Reduced By Intraperitoneal Chemotherapy

Direct injection of chemotherapeutic agents into directly into the body cavity rather than the conventional intravenous route, seems to be // associated with an improved prognosis of ovarian cancer patients, according to a latest study. // Ovarian cancer is the fourth leading cause of death...

NOSCAR(R) Increases NOTES(R) Research with Olympus Medical Systems Corporation Grant

...for the development of even less invasive methods to treat conditions in both the gut lumen and in the peritoneal cavity. It seems feasible that major intraperitoneal surgery may one day be performed without skin incisions. The natural orifices may provide the entry point for surgical interventions in the peritoneal...

NOSCAR(R) Announces NOTES(R) Multicenter Human Trials in the U.S.

...for the development of even less invasive methods to treat conditions in both the gut lumen and in the peritoneal cavity. It seems feasible that major intraperitoneal surgery may one day be performed without skin incisions. The natural orifices may provide the entry point for surgical interventions in the peritoneal...

Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells

...lines. Upon demonstrating specific in vitro targeting, in vivo targeting to subcutaneous growing human pancreatic cancer was tested by intravenous and intraperitoneal administration of the ablated adenoviral vector. They found that ablation of native cellular binding sites reduced adenoviral transduction at least...

Ethnic differences found for fatty liver disease and insulin resistance

...roughout the body. They found that there was a close association between intraperitoneal fat and liver fat regardless of ethnicity. "Controlling for intraperitoneal fat content almost entirely eliminated ethnic differences in levels of HTGC...

Proteasome inhibition affects epigenetic mechanisms

...ere fed ethanol for one moth using the Tsukamoto-French model and were compared to rats given the proteasome inhibitor PS-341 (Bortezomib, Velcade) by intraperitoneal injection. Microarray analysis and Real time PCR were performed and proteasome activity assays and Western blot analysis were performed using isolated...

Bioniche Updates re: Mycobacterial Cell Wall Technology Platform

... Mycobacterial Cell Wall-DNA Complex (MCC) towards ovarian cancer cell lines by Mario C. Filion, Catherine Morin and Nigel C. Phillips 2. intraperitoneal anticancer activity of Mycobacterial Cell Wall-DNA Complex (MCC) against murine peritoneal carcinomatosis by Catherine Morin, Melanie Lehoux...

Researchers study new drug and indications for heated chemotherapy treatment

... WINSTON-SALEM, N.C. Studies have shown that surgery combined with intraperitoneal Hyperthermic Chemotherapy (IPHC) can improve survival rates for select patients with peritoneal carcinoma (cancer of the lining of the abdominal cavit...

Combo Treatment Ups Survival When Cancer Spreads to Abdominal Lining

... of the Society of Surgical Oncology in Chicago. The first study was a phase I trial to establish the maximum tolerated dose of oxaliplatin used in intraperitoneal Hyperthermic Chemotherapy (IPHC) in treating colorectal and appendix cancers that have spread to the peritoneum. The 15-patient study found that IPHC ...

JCI table of contents: Oct. 25, 2007

...naling were detected in the CNS several days before the onset of paralysis in mice. Consistent with a central role for TGF-beta in initiating disease, intraperitoneal administration of an inhibitor of TGF-beta signaling ameliorated disease and reduced the accumulation in the CNS of immune cells able to attack the ne...
Intraperitoneal in Medical Technology

NexGenix Pharmaceuticals Presents Data on a Novel Small Molecule Inhibitor of Heat Shock Protein 90 (Hsp90) at the GTCbio Cancer Drugs Research & Development Conference

...ther cancer cell lines at low nanomolar concentrations. Pharmacokinetic studies demonstrate that NXD30001 can achieve potential therapeutic levels via intraperitoneal (i.p.) dosing and that the compound accumulates in tumors at above micromolar concentrations. Tumor pharmacodynamic analysis demonstrated depletion ...

Expression Genetics, Inc. Announces Successful Completion of Phase I Trial of Gene-Based IL-12 for Treatment of Ovarian Cancer

...ing, mild to moderate peritonitis, nausea, and mild elevation of body temperature. These data demonstrate that this IL-12 gene therapeutic is safe for intraperitoneal administration in ovarian cancer patients. Several clinical and biological parameters were evaluated as secondary endpoints of this study. Tumor ...

Global Rabies Treatment May be Possible with NanoViricides Drugs

...-specific receptor peptide ligand class, as well as rabies-antibody-derived ligand class were tested in both direct intracerebral treatment as well as intraperitoneal treatment modalities. Human anti-Rabies Immunoglobulin (RIG), a commercial standard rabies treatment, was used as positive control. A 30% surviva...
Intraperitoneal in Medical Dictionary

Paracentesis

...abdomen is ... Ultrasound-assisted paracentesis performed by emergency physicians vs the ... Emergency diagnostic paracentesis to determine intraperitoneal fluid identity ... Palliative Medicine ... an ill patient, small volume paracentesis repeated as needed may be ... After a large volume paracen...

Ileus

...ide the abdomen, ... Ileus is a temporary arrest of intestinal peristalsis. ... In addition to postoperative causes, ileus also results from intraperitoneal or ... More about Ileus : Causes and symptoms Diagnosis Treatment Alternative treatment Prognosis Prevention Resources Ileus Definition Ileu...
Intraperitoneal in Biological Technology

Altogen Biosystems Launches New Nanoparticle-based In Vivo Transfection Reagent

... nanoparticles biotechnology that allows highly efficient delivery of various biomolecules into animal tissues via systemic administration, as well as intraperitoneal and direct intratumoral injections. Altogen Biosystems is focusing on commercializing pharma- and bio-technologies, as well as providing custom labo...

Oncolytics Biotech Inc. Announces 2008 Second Quarter Results

....S. National Cancer Institute started patient enrolment in a Phase I/II ovarian, peritoneal and fallopian tube cancer trial using systemic and intraperitoneal administration of REOLYSIN(R). - Started patient enrolment in a U.K. combination REOLYSIN(R) and cyclophosphamide trial. - Subsequent to the q...

Oncolytics Biotech Inc. Announces Start of Enrolment in Phase 1/2 Ovarian Cancer Clinical Trial with REOLYSIN(R)

...tube cancers using concurrent intravenous (IV) and intraperitoneal (IP) administration of REOLYSIN(R), Oncolytics' pr...ine the safety and tolerability of intravenous and intraperitoneal administration of REOLYSIN(R), and the MTD of IP R...ns related to the U.S. NCI Phase I/II systemic and intraperitoneal administration clinical trial for patients with me...

Oncolytics Biotech Inc. Announces 2008 First Quarter Results

...dministration for a Phase I/II clinical trial for patients with metastatic ovarian, peritoneal or fallopian tube cancers using concurrent systemic and intraperitoneal administration of REOLYSIN(R). The trial, which is being carried out at The Ohio State University Comprehensive Cancer Center, is expected to enroll u...

NexGenix Pharmaceuticals Presents Data on a Novel Small Molecule Inhibitor of Heat Shock Protein 90 (Hsp90) at the Annual Meeting of the American Association for Cancer Research (AACR); Scientific Advisory Board Chairman Tyler Jacks Named President-elect

...ther cancer cell lines at low nanomolar concentrations. Pharmacokinetic studies demonstrate that NXD30001 can achieve potential therapeutic levels via intraperitoneal (i.p.) dosing and that the compound accumulates in tumors at above micromolar concentrations. Tumor pharmacodynamic analysis demonstrated depletion ...

Oncolytics Biotech Inc. Announces Filing of Phase 1/2 Clinical Trial with REOLYSIN(R)

...ovarian, peritoneal or fallopian tube cancers using concurrent systemic and intraperitoneal administration of REOLYSIN(R), Oncolytics' proprietary formulation of the h... the Company's expectations related to the U.S. NCI Phase I/II systemic and intraperitoneal administration clinical trial for patients with metastatic ovarian, periton...

The Pittsburgh Life Sciences Greenhouse Adds New Companies to its Investment Portfolio

...eliver both intraperitoneal chemotherapy (IPC) and intraperitoneal hyperthermic chemotherapy (IPHC) to treat metastas...advanced abdominal cancers. The ability to deliver intraperitoneal hyperthermic treatment for disseminated abdominal .... (TTS) is developing a specialized pump to enable intraperitoneal chemotherapy (IPC) and intraperitoneal hyperthermi...

Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions

...CD68 and α-actin, total RNA was prepared from thioglycol late-elicited intraperitoneal macro- phages and cultured primary aortic smooth muscle cells. intraperitoneal injection of the bacterial endotoxin lipopolysaccharide (LPS) (100 g) or ve...

Reliable Assessment of Micronuclei for Genotoxicity Testing in Mice or Rats

... BALB/c mice, were given 0.9% saline and a dose response of potassium chromate (K2CrO4) (12.5, 25, and 50 mg/kg body weight) via intraperitoneal injections. Chemicals were delivered in a volume of 25 ml/kg body weight at times 0, 24, and 48 hours. Twenty four hours after t...
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