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Intractable in Medical News

Plastic Surgery Technique Might Ease Migraines

...ght after the surgery and go back to work within a week." But Lipton wants to see another study, and feels surgery should be reserved for the most intractable cases. "This is obviously not for everyone. This is for people who are really suffering, who've had adequate trials of medical therapy and who hav...

Columbia leads national effort to develop early intervention for schizophrenia

...s of these projects to help transform the care for all New Yorkers with serious mental illness." Schizophrenia: Often Considered the Most Serious, intractable Mental Illness Schizophrenia affects just over one percent of the adult population. The disease often strikes in the college or early adult years,...

Minimally Invasive Surgery Not Better for Sciatica

...d rehabilitation medicine at the University of Miami Miller School of Medicine. "In general, the answer is, when you have a neurological deficit or intractable pain or a problem threatening loss in terms of neurological function," Wang said. The most common reason is to ease pain, he said. The differences ...

Clinical Studies Validate Cancer Gene Delivery Platform: Landmark Publication Confirms Rexin-G Effectively Targets Metastatic Cancers and Improves Patient Survival

...ablishing critical pharmacological thresholds of bioactivity and dose-dependent efficacy for a new class of biological anti-cancer agents in otherwise intractable cancers, and (3) By validating the potential of Rexin-G to control metastatic cancer with single-agent efficacy, whereas other targeted therapies must...

Epeius Biotechnologies' Rexin-G Receives FDA Fast Track Designation for the Treatment of Pancreatic Cancer

...r systemic or dose-limiting toxicity, but it served to establish the critical thresholds of bioactivity and the dose-response relationships in several intractable cancers, which confirms and reveals the physiological mechanisms-of-action. These quantitative aspects of applied pharmacology are of paramount import...

NxStage Announces Strategic Business Alliance with Asahi Kasei Kuraray Medical

...pheresis, transfusion therapy, and virus removal for biotherapeutic products. Asahi Kasei Kuraray Medical works to introduce innovative therapies for intractable diseases by extending the frontiers of medical devices and system, combining its core technology in functional materials for membrane filtration and s...

Brain Stimulation Therapy Eases Tough-to-Treat Depression

... April, other researchers reported that deep brain stimulation -- where electrodes are inserted into specific brain areas -- cut symptoms of otherwise intractable depression by 50 percent for about half of those treated. The technique has also been successful in treating some cases of obsessive-compulsive disord...

New Hope for Relief of Chronic Sciatica

...al Research in Los Angeles. For the past ten years he has been, and is currently, using locally administered etanercept for treatment of patients with intractable sciatica, back and neck pain(3,4,5,6). This type of off-label use is an example of a repositioned use of an existing therapeutic, a topic of increasin...

USAID Recognizes World Malaria Day

...the disease are all sharply reducing malaria deaths in several African countries. These efforts are bringing newfound hope that malaria is not an intractable problem, and giving children a fighting chance to improve their quality of life and build better futures. Progress has been dramatic thanks to ma...

New Topical Painkiller Relieves Severe Pain in Minutes

...estingly, this medication has been effective in some extremely hard to treat conditions such as TemperoMandibular Joint disease and the chronic severe intractable nerve pain that may occur in some cases of shingles. One of the most resistant pain conditions afflicting the human race, Reflex Sympathetic Dystroph...
Intractable in Medical Technology

Clinician Reports Fast Healing of Intractable Wounds Using MEDIHONEY(R)

Jason Hanft of Baptist Health South Florida Reports on 11 Patients at SAWC PRINCETON, N.J., April 29 /PRNewswire-FirstCall/ -- Derma Sciences (OTC Bulletin Board: DSCI), a provider of advanced wound care products, announced that yesterday at the annual Symposium on the Advances in W...

International Journal of Occupational and Environmental Health Features Discovery of Asbestos-Related Pain Origin from Scientists at the Karmanos Cancer Institute in Detroit

... Evidence based on the CT findings, the physical examination, pulmonary function studies, epidemiology and history of the patient's intractable pleural pain meets the criteria for diagnosis of asbestosis. Combined with the known science of taconite dust, a link between the mine where the patie...

Mutant Genes in High-Risk Childhood Leukemias Identified

...blood diseases in adults. While the cure rate in pediatric ALL has reached about 85 percent, the remaining high-risk cases have proven especially intractable because they arise from different, unidentified genetic mutations. Discovery of the mutations was led by scientists from St. Jude Children's Res...

ICON and MedAvante Sign Alliance Agreement

...ting services to the pharmaceutical, biotechnology, and medical device industries. MedAvante is a pioneer in developing a solution for one of the most intractable problems in CNS clinical trials: the high rate of uninformative or failed studies. MedAvante applies unique methods to systematically remove potential...

Advances in Science and Treatment of Pain Presented at 25th Annual American Academy of Pain Medicine Meeting January 28 - 31, 2009

...t in Pediatric Cancer Patients, Poster 153 Interventional Treatment for intractable Migraine, Poster 155 Acute Treatment of intractable Migraine, Poster 157 Chronic Pain and Depression, Poster 175 GABAer...

Algeta Completes Comprehensive Phase II Clinical Program With Alpharadin for Treating Bone Metastases in Patients With Advanced Prostate Cancer

... high incidence cancers as well as HRPC (e.g. breast, lung and thyroid). Bone metastases are a serious consequence of certain advanced cancers causing intractable and debilitating pain as well as further reducing life expectancy. In addition, the results, including data from the final trial in the program...

Algeta Reports Positive Headline Phase II Data on Pain Palliation With Alpharadin

...rom the disease each year. In 85% of these men the tumor will have spread into the bones. These metastases are a significant problem as they can cause intractable and debilitating pain as well as contributing to a further reduction in life expectancy. The BC1-03 study was a double-blind randomised pain control...

Genasense(R) Chemotherapy Program Yields High Response Rate in Patients with Stage 4 Melanoma

...program with tesetaxel, the Company's novel orally absorbed taxane, thus potentially affording patients a highly convenient treatment program for this intractable disease." About AGENDA AGENDA is a Phase 3, randomized, double-blind, placebo-controlled trial that is intended to support global registration of ...

DermaGen AB Receives Over 1 Million Euros From a New Share Issue

...of the skin, which affects about 10-20 % of children and 1-3 % of adults worldwide Moderate-to-severe AD has a profound effect on the quality of life. intractable itching, skin damage, soreness and sleep loss all compound the burden of disease. More than 90 % of all patients are colonized or infected by Staphylo...

Epeius Biotechnologies Applauds the Belated Scholarship of Their Academic Contemporaries in 2007, As Targeted Gene Therapy Comes of Age in Clinical Medicine

... only targeted injectable genetic medicine that was designed, engineered, manufactured, validated, tested, and approved for the treatment of otherwise intractable metastatic cancers; the first and so far only one of the plethora of targeted biologics that exhibits broad spectrum anti-cancer activity when adminis...
Intractable in Medical Dictionary

Zollinger-Ellison Syndrome

...ase" by the ... Zollinger - Ellison syndrome ( ′zälənjər ′eləsən ′sin′drōm ) ( medicine ) Gastric hypersecretion and hyperacidity, fulminating intractable atypical WebMD looks at symptoms and treatments of the digestive disease called Zollinger - Ellison syndrome or ZES. ... who has Zollinger ...

Portacaval shunt

...al vein and ... End-to-side portacaval shunt was much less effective. ... Side-to-side portacaval shunt is very effective treatment of intractable ascites ... ...

Hyperemesis gravidarum

...and vomiting in pregnancy. ... Some women with hyperemesis gravidarum appear to have clinical ... Hyperemesis gravidarum is a severe and intractable form of nausea and vomiting in pregnancy. ... Differential Diagnoses & Workup: Pregnancy, Hyperemesis Gravidarum ... Complications tha...

Hiccups

...and amphibian gulping are inhibited by ... What are hiccups ? Hiccups occur when a spasm contracts the diaphragm, a large ... While very rare, intractable hiccups can cause exhaustion, lack of sleep, and ... More about Hiccups : Causes and symptoms Diagnosis Treatment Prognosis Prevention Resource...

Esophageal manometry

...Esophageal manometry can be a helpful diagnostic tool in several different ... Esophageal manometry and pH testing are useful in diagnosing intractable heartburn and swallowing disorders. ... Esophageal manometry is a test that takes ... Esophageal manometry is the recording of muscle ...

Conduct disorder

...(ODD), diagnostic considerations for each disorder , and treatment options Overview: Conduct disorder (CD) is one of the most difficult and intractable ... courses of the 2 types of conduct disorder (CD) are somewhat predictable. ... Conduct disorder is a common childhood psychiatric probl...

Aspiration

...es a clinical and radiological ... antibiotics for secondary bacterial infection and infected fluid aspiration . ... Surgical Management of intractable Aspiration : Grand Rounds presentation from ... Aspiration is penetration of secretions below the level of the true vocal cords. ... Pediatrici...
Intractable in Biological News

Climate change's impact on invasive plants in Western US may create restoration opportunities

...ds, "creating opportunities for restoration in areas currently dominated by intractable invasive species," according to the study. The five species were selecte... "The restoration opportunities associated with the retreat of currently intractable invasive species are vast in the western United States," the authors wrote....

American Association for Cancer Research hosts Science of Health Care Disparities Meeting

...reatment and outcomes among cancer patients are well known, little is understood about the underlying causes and what can be done to solve a seemingly intractable problem. The American Association for Cancer Research is hosting a collaboration of scientists who are working to understand what can be done to addre...

Human embryonic stem cell secretions minimized tissue injury after heart attack

...f reperfusion injury in the most clinically relevant experimental setting. "Using secretion instead of cells allows us to circumvent many highly intractable problems such as tumour formation, immune compatibility, cell viability, delivery, costs and timeliness," said IMB'S Dr Lim Sai Kiang, who leads the S...

Pre-eclampsia may be autoimmune disease

...igh blood pressure or pre-eclampsia may be an autoimmune disease. Their research could provide novel diagnostic and therapeutic possibilities for this intractable disease. Findings appear online in Nature Medicine on July 27. Scientists in the laboratory of Yang Xia, M.D., Ph.D., an assistant professor of b...

Climate change

...espect to the balancing of adaptation and mitigation in the societal response to climate change. Opening session Global Warming: How to Solve an intractable Problem? Theme 1 Exploring the Risks: Understanding Climate Change Theme 2 Sharing the Burdens and Opportunities: Equity Issues Theme ...

Michigan Tech researchers link 11 genetic variations to type 2 diabetes

...Mich.--Mathematicians at Michigan Technological University have developed powerful new tools for winnowing out the genes behind some of humanitys most intractable diseases. With one, they can cast back through generations to pinpoint the genes behind inherited illness. With another, they have isolated 11 vari...

New approach builds better proteins inside a computer

...-based drug design and in improved models for crystallographic calculations. And in the future, this method might provide structural information about intractable molecules that are difficult to study experimentally, wrote Dodson, who is at the University of York in the United Kingdom. Baker and his colleagues ...

New research on structure of bones raises questions for treatment of osteoporosis

...e a problem which will only intensify as our population ages. Among the young, especially sportsmen and women, bone and joint injuries prove the most intractable and are also the ones most likely to develop into afflictions (such as osteoarthritis) later in life. Dr David Reid, from the Duer Group, Departmen...

Dealing deadly cancers a knockout punch

...in animal models, and in human clinical trials. Oncolytics' proprietary reovirus formulation, Reolysin®, is active against numerous cancers, including intractable sarcomas and melanomas. Recent studies also indicate that Reolysin works synergistically with standard anti-cancer drugs, providing significantl...

RNA enzyme structure offers a glimpse into the origins of life

...this process poses a challenge for theories about the origins of life. "Which came first, nucleic acids or proteins? This question once seemed an intractable paradox, but with the discovery of ribozymes, it is now possible to imagine a prebiotic 'RNA World' in which self-replicating ribozymes accomplished b...
Intractable in Biological Technology

Pepscan Achieves a Breakthrough With CLIPS Immunogen Technology: Synthetic Peptide Antigen is Able to Induce Fully Functional Antibodies Against a Formerly Intractable GPCR Target CXCR7

LELYSTAD, The Netherlands, April 6 /PRNewswire/ -- Today, Pepscan reports that it has achieved a major scientific breakthrough through the use of its CLIPS-based synthetic peptide immunogen technology. By constructing synthetic 3D mimics of the ligand binding-site on CXCR7 it has induced funct...

Genmab and Pepscan to Identify Human Antibodies Against Intractable Targets

COPENHAGEN, Denmark and LELYSTAD, Netherlands, March 3 /PRNewswire-FirstCall/ -- Genmab A/S (OTC: GNMSF) and Pepscan today announced the start of a research collaboration aimed at identifying fully human monoclonal antibodies against intractable disease targets. Intractable targets include tho...

iZumi Bio and Pierian Merge to Form iPierian to Advance Cellular Reprogramming

... therapeutics." "Disease-specific pluripotent stem cells are powerful new tools for drug screening and promise to revolutionize the treatment of intractable conditions," said Dr. George Daley. "We are excited to join forces with the iZumi team, and view this as an opportunity to translate our stem cell re...

The World's Smallest Hero! Rexin-G, Targeted Therapy for Metastatic Cancers

... far and wide. Imagine an entire army of these tiny nano-particles seeking out and accumulating to high concentrations within the flagrant, otherwise intractable tumors with one goal in mind: to destroy the metastatic cancers from the inside. Guided by nature's own disease-seeking factors (i.e., pathotropic tar...

Sangamo BioSciences Announces Publication in Nature of the Use of Zinc Finger Nucleases to Accelerate Precision Trait Stacking in Commercial Crop Species

...anisms - both plant and animal. Today, ZFPs are being used to generate improved crops, powerful research reagents and novel drugs for the treatment of intractable human diseases." In June 2008 Dow AgroSciences exercised its option to become the exclusive licensee and sublicensor of Sangamo's proprietary ZFP...

Pepscan Achieves First Milestone in Research Collaboration With Genmab

...ngoing Research Collaboration aimed at identifying human antibodies against intractable targets. Pepscan is responsible for using it CLIPS(TM) technology to genera...progress that has been made in the collaboration with Genmab." About intractable Targets "Intractable" Targets are drug targets that would be desirab...

Frost & Sullivan Lauds BioTrove for Providing Research-Enabling Life Sciences and Drug Discovery Technologies

...eated by traditional mass spectrometry throughput. RF-MS is routinely used in many applications including the high-throughput screening of previously intractable drug targets, ADME assays and directed evolution studies. About Frost & Sullivan Frost & Sullivan, the Growth Partnership Company,...

Heptares Secures GBP21 Million in Series A Fund Raising to Accelerate Development of Pipeline of Small Molecules Against High-Value GPCR Drug Targets

...rug candidates will be developed against currently intractable GPCRs that are highly validated targets for the tr...improve the chances of finding drugs to previously intractable targets and enable the development of safer and mo...gainst highly validated but currently difficult or intractable GPCR targets in several disease areas. GPCR...

Aerovance Appoints Babatunde A. Otulana, M.D., as Chief Medical Officer

...rovant and Aeroderm represent a new class of compounds which, if successful in development, will provide new tools for physicians in the management of intractable severe asthma and atopic dermatitis respectively, in millions of patients." Aerovant is a recombinant human IL-4 variant that is a potent inhibit...

Xceleron Names Michael Butler as President & CEO

...the company's clinical and chemistry operational units. "This is an exciting time to join Xceleron. Our customers are dealing with the most intractable challenges the industry has ever faced including poor compound solubility, biologics development, high potency drugs, and the need for earlier human d...
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