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Intracellular in Medical News

Protein-dependent 'switch' regulates intracellular trafficking in epithelial cells

NEW YORK (Dec. 10, 2007) -- With findings highlighted on a recent cover of Developmental Cell, researchers at Weill Cornell Medical College in New York City have shed important new light on key trafficking mechanisms within epithelial cells. Epithelial cells line the outside of nearly all organs. ...

Rigel Announces Second Quarter 2009 Financial Results

... develops novel, small-molecule drugs for the treatment of inflammatory/autoimmune diseases and metabolic diseases. Our pioneering research focuses on intracellular signaling pathways and related targets that are critical to disease mechanisms. Rigel's productivity has resulted in strategic collaborations with lar...

Human cells secrete cancer-killing protein, UK study finds

...f a tumor cell, it triggers a biological process called apoptosis or "cell suicide." Consistent with previous research by Rangnekar's laboratory with intracellular Par-4, the newly discovered secreted Par-4 acts selectively against cancer cells, leaving healthy cells unharmed. Few other molecules are known to ex...

Rigel to Host Conference Call to Discuss Results of Its Phase 2b TASKi3 Clinical Trial of R788 in Rheumatoid Arthritis

... develops novel, small molecule drugs for the treatment of inflammatory/autoimmune diseases and metabolic diseases. Our pioneering research focuses on intracellular signaling pathways and related targets that are critical to disease mechanisms. Rigel's productivity has resulted in strategic collaborations with lar...

AlphaRx Presents Positive Preclinical Data on Zysolin(TM) Inhalable Nanoparticles at Controlled Release Society Annual Meeting

... development of a drug that targets and eradicates intracellular pathogens, which to date, have proven to be very d...ally-ventilated patients. Zysolin(TM) improves the intracellular activity of Tobramycin - in layman's term, increas... thus improving its antibacterial activity against intracellular Klebsiella, Pseudomondas aeruginosa and Staphyloco...

Study aims to induce recovery from ankylosing spondylitis

...the worldwide Cochrane Collaboration in evidence-based medicine. The treatment protocol is based on a molecular understanding of the interaction of intracellular and biofilm bacteria with the operation and control of the body's nuclear receptors. Dysregulation of these receptors has been shown to promote the s...
Intracellular in Medical Technology

Pre-Clinical Data Show Intracellular Pathways Affected by ONCONASE(R)

SOMERSET, N.J., Feb. 21 /PRNewswire-FirstCall/ -- Alfacell Corporation (Nasdaq: ACEL ) today announced that in vitro and in vivo data presented at the 5th Cancer Drug Research & Development conference show the genes affected and biological pathways impacted by ONCONASE stimulated intracellula...

Paper in International Journal of Oncology Reports Alfacell's ONCONASE(R) Suppresses Intracellular Oxidative Stress

SOMERSET, N.J., Aug. 22 /PRNewswire-FirstCall/ - Alfacell Corporation (Nasdaq: ACEL ) today announced that a paper published in the International Journal of Oncology (2007; Vol. 31, Issue 3: 663-669) reports that ONCONASE(R) substantially decreases reactive oxygen intermediates (ROI) in norma...

Researchers Identify Intracellular Pathway of Alfacell's Onconase

Paper Published in Journal of Cell Science Shows ONCONASE Uptake in Cells Differs from other RNases BLOOMFIELD, N.J., April 05, 2007 /PRNewswire-FirstCall/ -- Alfacell Corporation today announced that European researchers have identified the pathway that ONCONASE (ranpirnase) follows to enter cell...

Abraxis BioScience Presents Results from Pre-Clinical Study That Demonstrates nab-Rapamycin's Robust Antitumor Properties and Ability to Target Intracellular Sites Such as the mTOR Pathway

LOS ANGELES--(BUSINESS WIRE)--Apr 19, 2007 - Abraxis BioScience, Inc. (NASDAQ:ABBI), an integrated, global biopharmaceutical company, presented first-time data from a pre-clinical study evaluating the toxicity and antitumor effect of nab-rapamycin (ABI-009), an albumin-bound mTOR kinase inhibitor, ...

Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer

...er the last twenty-five years indicate that KRAS plays an important role in cell growth regulation. In mCRC, EGFR transmits signals through a set of intracellular proteins. Upon reaching the nucleus, these signals instruct the cancer cell to reproduce and metastasize, leading to cancer progression. Anti-EGFR an...

R788 in TASKi3 Clinical Trial Does Not Meet Efficacy Endpoints in RA Patients Who Had Previously Failed Biologic Therapies - Results Incongruent

... develops novel, small molecule drugs for the treatment of inflammatory/autoimmune diseases and metabolic diseases. Our pioneering research focuses on intracellular signaling pathways and related targets that are critical to disease mechanisms. Rigel's productivity has resulted in strategic collaborations with lar...
Intracellular in Medical Products

Androstanediol Glucuronide RIA Test

Description:...HT) [1,2]. 3alpha-diol G has strong androgenic activity estimated at 75% of the bioactivity of testosterone [2]. Serum 3alpha-diol G is the product of intracellular reduction of DHT, and in addition, a significant proportion of serum 3alpha-diol G is derived from DHEA-Sulfate and androstenedione. Elevated l...
Company:Diagnostic Systems Laboratories, Inc.

Androstanediol Glucuronide EIA Test

Description:...HT) [1,2]. 3alpha-diol G has strong androgenic activity estimated at 75% of the bioactivity of testosterone [2]. Serum 3alpha-diol G is the product of intracellular reduction of DHT, and in addition, a significant proportion of serum 3alpha-diol G is derived from DHEA-Sulfate and androstenedione. Elevated l...
Company:Diagnostic Systems Laboratories, Inc.

Cortisol RIA Test

Description:... cortisol is bound with high affinity to corticosteroid-binding globulin (CBG), with the remainder loosely bound to albumin. Cortisol acts on specific intracellular receptors with effects in numerous physiologic systems, including immune function, glucose counter-regulation, vascular tone, substrate utilization an...
Company:Diagnostic Systems Laboratories, Inc.

DHT RIA Test

Description:...association with the nuclear membrane. DHT exerts its biological action by intracellular binding to the androgen receptor; and this complex is then transferred to t...ltant effects on DNA transcription [2]. Most of the residual DHT undergoes intracellular metabolism to 3a -androstanediol and 3a -androstanediol glucuronide. Only ...
Company:Diagnostic Systems Laboratories, Inc.

Toxoplasma IgM - Rapid Test

Description:... Toxoplasmosis is caused by the intracellular parasite Toxoplasma gondii and may be contracted by consuming contaminated meat or by contract with cat feces containing oocytes. If a pregnant woman ...
Company:Bio-Quant, Inc.

Pathfinder Chlamydia Culture Confirmation Test

Description:... The Pathfinder Chlamydia Culture Confirmation provides clear and reliable staining of intracellular inclusions (elementary bodies and reticulate bodies) in tissue culture. The monoclonal antibody used in this kit is directed against the Chlamydia li...
Company:Bio-Rad Laboratories
Intracellular in Medical Dictionary

Intracellular

Intracellular . From Wikipedia, the free encyclopedia. Jump to: navigation, search ... biology and related fields, the word intracellular means "inside the cell" ... Intracellular receptors are receptors located inside the cell rather than on its cell membrane. Examples ...

Rickettsia

...-4 μm long) or thread-like (10 μm long). Obligate intracellular parasites, the Rickettsia ... A Microbial Bi... The Rickettsia are Gram-negative, obligate intracellular bacteria that infect ... Rickettsia replicate... Species in the genus Rickettsia are obligate intracellular symbionts of plants, ... Most Rickettsia -contai...

Pathogen

...oes a developmental cycle in ... However, the role of tick genes in pathogen development is unknown. ... Salmonella enterica is a facultative intracellular pathogen of worldwide importance. ... Specific pathogen -free out-bred Rhode Island Red chickens were reared at the ... This group of nosocom...

Olfactory

...ches or clusters within glomeruli of the olfactory ... Gated currents in isolated olfactory receptor neurons of the ... Trotier D, MacLeod P. intracellular recordings from salamander olfactory receptor cells. ... The mechanism of excitatory olfactory receptor transduction has been intensely studie...

Lipid

...lets are also present in the cytoplasm of the alveolar ... The large lipid droplets, which were present at day 18 of pregnancy, are not ... The intracellular lipid droplet that forms from the coalescence of ... However, its role in lipid accumulation by adipocytes has not been investigated. ... Dis...

Lipofuscin

...ophages, and in Lipofuscin (LF) is a conglomerate of lipids, metals, organic molecules, and ... Lipofuscin is a name assigned to a class of intracellular compounds that ... Lipofuscin . Terman A, Brunk UT. ... intralysosomal substance, lipofuscin , ... Lipofuscin is often considered a hallmark ...
Intracellular in Biological News

MSI releases 'moleculizer' - a new approach to simulation of intracellular biochemical networks

Dr. Roger Brent, President and Director of Research at the Molecular Sciences Institute ("MSI") , announced today the release of a new approach to simulation of intracellular biochemical networks in the January 2005 edition of Nature Biotechnology. The research article, entitled "Automatic gene...

Little-known protein found to be key player

...intaining healthy cells. Even more surprising, their report in the journal Nature shows that the protein, called "atlastin," does its work by fusing intracellular membranes in a previously undocumented way. "If you'd asked me a year ago whether this was possible, I would have said, 'No,'" said study co-author...

Grant supports LSUHSC research on how like cell receptor systems determine very different functions

... targets are involved in the development of disease. Dr. Ashok Pullikuth in Catling's lab has recently identified a protein that functions in the intracellular movement and cell division activity of growth factor receptors as a novel phosphorylation target. Understanding this novel mechanism might be importan...

'Normal' cells far from cancer give nanosignals of trouble

...al fellow in Backman's research group. PWS can look inside the cell and see those critical building blocks, which include proteins, nucleosomes and intracellular membranes, and detect changes to this nanoarchitecture. Conventional microscopy cannot do this, and other techniques that can (to some degree) are exp...

Research explores interactions between nanomaterials, biological systems

...te remarkable advances in nanoscience, relatively little is known about the intracellular activity and function of engineered nanomaterials, an area of study particu...in an ecosystem or food chain. Nanoparticles can elicit a wide range of intracellular responses, depending on their properties, concentrations and interactions w...

Slicing chromosomes leads to new insights into cell division

...gainst cells' microtubules. Microtubules are long, thin tubes that form a central component of the cytoskeleton and the mitotic spindle. They serve as intracellular structural supports and as railways along which molecular motors move cargoes such as chromosomes. Hunt's group hypothesized that polar ejection fo...
Intracellular in Biological Technology

Measuring Intracellular Enhanced Green Fluorescent Protein With the VersaFluor Fluorometer

Contributed by Jeff Wilson, and Andrew Segal, M.D., Genitrix, LLC, Cambridge, MA Introduction The Green Fluorescent Protein (GFP) derived from Aqueorius victoria has recently become a popular choice as a reporter gene. GFP can be used...

Detection of antibody-stained cell surface and intracellular protein targets with the Agilent 2100 bioanalyzer

This Application Note describes how the Agilent 2100 bioanalyzer and the Cell Fluorescence LabChip kit can be used to detect cell surface and intracellular protein targets by antibody staining. CD3 staining on Jurkat cell...

Cis-Reporting System Monitors Intracellular Calcium Mobilization

New PathDetect reporting system for studying NFAT activation Li Xu Matthew Hsu Mary Buchanan Chao-Feng Zheng Stratagene Stratagenes new PathDetect cis-reporter plasmid, the pNFAT-Luc reporter plasmid, is designed for studying the activation of the nuclear fa...

Cis-Reporting System Monitors Intracellular Calcium Mobilization

New PathDetect reporting system for studying NFAT activation Li Xu Matthew Hsu Mary Buchanan Chao-Feng Zheng Stratagene Stratagenes new PathDetect cis-reporter plasmid, the pNFAT-Luc reporter plasmid, is designed for studying the activation of the nuclear factor of a...

Enzyme Immunoassay for Studying Intracellular Levels of cAMP

Sensitive, nonradioactive cyclic-AMP detection kit and adenylate cyclase (AC) toxin Danny Q. Hoang Stratagene Cloning Systems, Inc. Xinping Yang and Timothy G. Kingan, Ph.D. American Qualex Stratagenes EIA cAMP Kit is a highly sensitive and specific antibody-base...

LNA-Based HIF-1 Alpha Inhibitor Shows Early Signs of Clinical Benefit

...iogenesis, cell metabolism, cell proliferation, cell death (apoptosis) and cell invasion. HIF-1 alpha protein is low in normal cells, but reaches high intracellular concentrations in a variety of cancers and is strongly correlated with poor prognosis and resistance to therapy. Enzon is currently conducting two Pha...

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Intracellular in Biological Products

Label IT Tracker Fluorescien Intracellular Nucleic Acid Localization Kit from Mirus Bio Corporation

Description: ...
Company:Mirus Bio Corporation

ApoStat Intracellular Caspase Detection (FITC-VD-FMK) from R&D Systems

Description: Designed for flow cytometric applications intended to identify...
Company:R&D Systems

Label IT siRNA Tracker Biotin Intracellular Localization Kit with TransIT-TKO siRNA Transfection Reagent from Mirus Bio Corporation

Description: The Label IT siRNA Tracker Intracellular Localization Kit provides a straight forward approach to directly label and deliver siRNA, of your design, in an efficient yet non-destructive manner, for in vitro tracking experiments. Subcellular localization and functional inhibition of target gene expres...
Company:Mirus Bio Corporation

Label IT siRNA Tracker Fluorescein Intracellular Localization Kit with TransIT-TKO siRNA Transfection Reagent from Mirus Bio Corporation

Description: The Label IT siRNA Tracker Intracellular Localization Kit provides a straight forward approach to directly label and deliver siRNA, of your design, in an efficient yet non-destructive manner, for in vitro tracking experiments. Subcellular localization and functional inhibition of target gene expres...
Company:Mirus Bio Corporation

Label IT siRNA Tracker Intracellular Localization Kit with TransIT-TKO Transfection Reagent (Cy5 Labeling Kit) from Mirus Bio Corporation

Description: The Label IT siRNA Tracker Intracellular Localization Kit provides a straight forward approach to directly label and deliver siRNA, of your design, in an efficient yet non-destructive manner, for in vitro tracking experiments. Subcellular localization and functional inhibition of target gene expres...
Company:Mirus Bio Corporation

Label IT siRNA Tracker CX-Rhodamine Intracellular Localization Kit with TransIT-TKO siRNA Transfection Reagent from Mirus Bio Corporation

Description: The Label IT siRNA Tracker Intracellular Localization Kit provides a straight forward approach to directly label and deliver siRNA, of your design, in an efficient yet non-destructive manner, for in vitro tracking experiments. Subcellular localization and functional inhibition of target gene expres...
Company:Mirus Bio Corporation

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Intracellular in Biological Definition

Active transport

...ter, which allows three sodium ions into the cell to transport one calcium out. Many cells also posses a calcium ATPase, which can operate at lower intracellular concentrations of calcium and sets the normal or resting concentration of this important second messenger . But the ATPase exports calcium ions more ...

Adenosine triphosphate

...ATP, see ATP (disambiguation) Adenosine triphosphate ( ATP ) is the nucleotide known in biochemistry as the " molecular currency" of intracellular energy transfer; that is, ATP is able to store and transport chemical energy within cells . ATP also plays an important role in the synthesis of n...

Antibiotic

...ortunities for compounds to attack a fungal cell which will not harm a human cell. Similarly, we know now that viruses represent an incredibly minimal intracellular parasite, being stripped down to a few genes worth of DNA or RNA and the minimal molecular equipment needed to enter a cell and actually take over...

Antigen

...tigens Endogenous antigens are antigens that have been generated within the cell, as a result of normal cell metabolism , or because of viral or intracellular bacterial infection . The fragments are then presented on the cell surface in the complex with class I histocompatibility molecules . If cytotoxic C...

Axon

...form axon collaterals , along which the bifurcated impulse travels simultaneously to signal more than one other cell. History Some of the first intracellular recordings in a nervous system were made in the late 1930's by K. Cole and H. Curtis. Alan Hodgkin and Andrew Huxley also employed the squid axon (193...

Biology

...acteria) -- Eukaryota These domains reflect whether cells have nuclei or not as well as differences in cell exteriors. There is also a series of intracellular " parasites " that are progressively less alive in terms of being metabolically active: Viruses -- Viroids -- Prions Continuity: the...
Intracellular in Biological Dictionary

Transmembrane receptor

...R), comprise a large protein family of... receptor protein n. An intracellular protein or protein fraction having a ... Membrane or Transmembrane r...,biology terminology,biology terms, ... 2 The transmembrane domain. 3 The intracellular domain. 4 Regulation of receptor activity ... exact: transmembrane ...

Transferrin receptor

...rrin receptor (TfR) is a carrier protein for transferrin . It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. Low iron concentrations promote increased levels of transferrin receptor , to increase iron intake into the cell. Thus, transfer...

Transfection

...maries, ... Transfection is the process of delivering foreign molecules such as ... Polyplus- transfection is focused on developing reagents for intracellular ... Transfection reagents selection guide. Gene Expression. Protein, virus ... ... Transfer Vector Transient Transfection Procedure. 6 Vect...

T lymphocytes

...are well ... and arrest coefficients than naive T lymphocytes in the deep paracortex. ... T lymphocytes play a major role in defense against intracellular pathogens such ... " T " lymphocytes are so called because of the role that the thymus gland plays in ... Immunobiology is intended as an intro...

Seminiferous tubules

...is provide a specialized ... seminiferous tubules . ... Contractility of rat testicular seminiferous tubules in vitro: prostaglandin f 1 ... intracellular potentials in cells of the seminiferous tubules of rats. J Physiol. ... B. Rat Seminiferous Tubules (see online summary by Kent Christens...

Second messenger

...lecules altering gene expression. ... Second messenger . Synonym(s) intracellular second messengers . Definition(s) ... Examples of second messenger s...rs Activate Second Messenger Systems. Stephen M. Stahl, M.D., Ph.D. ... intracellular second messenger that carries the information from the ... ...
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(Date:9/1/2014)... (PRWEB) September 01, 2014 The National ... to announce that Dawn Bazarko, DNP, MPH, RN, and ... of the American Academy of Nursing. They will be ... RN-BC, CCM, FACHE, whose induction we reported last May. ... 18, 2014, during the 2014 American Academy of Nursing ...
(Date:9/1/2014)... involved in federally-filed Tylenol lawsuits ( http://www.tylenollawsuitclaims.com/ ) are ... where issues related to claims involving the pain reliever ... Bernstein Liebhard LLP reports. , According to a ... the meeting is scheduled to take place on September ... of several Tylenol conferences that have taken place this ...
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(Date:8/31/2014)... An analysis of 32 studies compiled by University ... between lower levels of Vitamin D and a higher ... 2014 issue of American Journal of Public Health, ... D found in blood. , Researchers found that ... 9 nanograms/milliliter (ng/mL) were twice as likely to die ...
Breaking Medicine News(10 mins):Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 2Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 3Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 4Health News:Tylenol Lawsuit News: Bernstein Liebhard LLP Notes Upcoming Status Conference in Pennsylvania Litigation 2Health News:Tylenol Lawsuit News: Bernstein Liebhard LLP Notes Upcoming Status Conference in Pennsylvania Litigation 3Health News:Tylenol Lawsuit News: Bernstein Liebhard LLP Notes Upcoming Status Conference in Pennsylvania Litigation 4Health News:Tattoo Me Now Review Reveals Unique Ideas for Tattoo Designs 2Health News:Pixel Film Studios Released a New Tutorial Entitled ProWorld Lesson Exclusively for Final Cut Pro X 2Health News:NutriGold Highlights New Study on the Importance of Vitamin D to Our Life Span 2Health News:NutriGold Highlights New Study on the Importance of Vitamin D to Our Life Span 3Health News:NutriGold Highlights New Study on the Importance of Vitamin D to Our Life Span 4
(Date:9/1/2014)... basic building block of DNAcould initiate fragile X syndrome, the most ... The Journal of Cell Biology . , ... on the X chromosome called fragile X mental retardation 1 ... men carry a so-called premutation, in which a series of DNA ... slightly longer than normal. These repeats are prone to even further ...
(Date:9/1/2014)... The week-long discussions and decisions of the Nomenclature Section ... Melbourne, Australia in July 2011. This meeting is held ... premier experts on the rules for naming algae, fungi ... rule book for naming the organisms they study. This ... Code of Nomenclature for algae, fungi, and plants, which ...
(Date:8/31/2014)... A fast-sensitive "electronic-nose" for sniffing the highly infectious bacteria ... stomach cramps, has been developed by a team at ... the research team has demonstrated that it is possible ... which would lead to rapid diagnosis of the ... could be possible to identify different strains of the ...
Breaking Biology News(10 mins):A nucleotide change could initiate fragile X syndrome 2Week-long meeting on naming algae, fungi, and plants recorded for posterity 2Scientists develop 'electronic nose' for rapid detection of C. diff infection 2
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