HALT-C researchers: Interferon as long-term treatment for hepatitis C not effective

DALLAS Dec. 4, 2008 Use of the drug interferon as a long-term maintenance strategy to slow the progression of liver disease associated with the hepatitis C virus is ineffective, UT Southwestern Medical Center researchers and their colleagues from nine other institutions have found in a multicent...

Only Half of MS Patients Respond to Interferon Therapy

Finding may support idea that multiple sclerosis isn't a single disease, one expert says WEDNESDAY, Nov. 12 (HealthDay News) -- New research suggests that treating multiple sclerosis with the drug interferon only works for about half of patients. Interferon works by reducing inflamm...

Study shows that high-dose, high-frequency interferon produces no additional benefit

CAMBRIDGE, MA April 15, 2008 -- Results of a phase IV, open label, head-to-head study of intramuscular AVONEX and high-dose, high-frequency subcutaneous Rebif (interferon beta-1a) provide clinical evidence that the two drugs show similar efficacy over 18 to 30 months of continued therapy in patie...

PEGINTRON(TM) and REBETOL(R) Approved in European Union for Retreating Hepatitis C Patients Who Failed Previous Pegylated or Non-Pegylated Interferon Therapy

First and Only Peginterferon Therapy Approved for Retreating Both Hepatitis C Relapsers and Nonresponders KENILWORTH, N.J., Nov. 15 /PRNewswire-FirstCall/ -- Schering-Plough Corporation (NYSE: SGP ) today announced that the European Commission on October 30 approved 48-week ...

Stem cells: Deathly awakening by interferon

After injuries with blood loss, the body quickly needs to restore the vital blood volume. This is accomplished by a special group of stem cells in the bone marrow. These hematopoietic stem cells remain dormant throughout their lives and are only awakened to activity in case of injury and loss of b...

Patients Of MS Are Not At Risk From The Interferon Treatment

Research suggests that the patients of multiple sclerosis (MS) may gain from treatment with Interferon and// not be at risk from it. Although treatment with interferon appears to reduce the formation of new areas of damage in the brains of patients with multiple sclerosis (MS), including lesions...

High expression of interferon induces lupus disease

Scientists had been able to find a biomarker that will help in medical practitioners to diagnose lupus disease in their early state only for effective treatment.// Lupus is a condition that happens when the body’s tissues are affected by the body’s own immune system. Patients affected with lup...

Researchers Identify New Method to Selectively Kill Metastatic Melanoma Cells

...igestion that leads to programmed cell death specifically in melanoma cells. Fisher said that mda-5 is a key regulator of innate immunity that induces interferon beta production limiting replication of specific pathogenic viruses. This work was supported by grants from the National Institutes of Health, th...

Researchers identify new method to selectively kill metastatic melanoma cells

...igestion that leads to programmed cell death specifically in melanoma cells. Fisher said that mda-5 is a key regulator of innate immunity that induces interferon beta production limiting replication of specific pathogenic viruses. ...

New Report Just Published: World Hepatitis C Virus And Therapeutics Market Report

... II-1 Market Overview II-2 Pegylated Alpha interferon Plus Ribavirin - The Standard Therapy II-2 App...pe (2007): Percentage of Patients Treated with interferon Drugs in Select Countries (includes correspond...rapy Treatment II-37 Comparison of Response of interferon Based Drugs in Chronic Hepatitis C Treatment I...

Interferon in Medical Technology

Helix Receives Approval to Open Sites in Germany for its Ongoing Clinical Trial With Topical Interferon Alpha-2b in Patients With Ano-Genital Warts

AURORA, Ontario, Sept. 22 /PRNewswire/ -- Helix BioPharma announced today that it has received the necessary regulatory approvals to open clinical sites in Germany to expand upon its clinical trial with Topical Interferon Alpha-2b in patients with ano-genital warts, which is presently underway...

Modigene Awarded Israeli Government Grant to Support Development of Its Longer-Acting Interferon Beta

- $25 Million Interferon-Beta-CTP Development Program Has Been Approved For First Year Funding Through a Special Grant From the Israeli Office of the Chief Scientist - NES-ZIONA, Israel, Aug. 5 /PRNewswire-FirstCall/ -- Modigene Inc. (OTC Bulletin Board: MODG) today re...

Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III Melanoma Demonstrated Significant and Sustained Impact on Relapse-Free Survival

EORTC 18991 Phase III Study Results Published in The Lancet KENILWORTH, N.J., July 11 /PRNewswire-FirstCall/ -- Today, Schering-Plough (NYSE: SGP ) and the EORTC announced that long-term treatment with pegylated interferon alfa-2b in stage III melanoma patients had a significant and sus...

Side Effects of Sunitinib in Kidney Cancer Are 2 to 3 Times More Expensive to Manage Than Those of Avastin Plus Interferon

- Tolerability is an Increasingly Important Factor When Selecting Treatment Options for Patients - ABSTRACT No: 5110 (Poster 6H) BASEL, Switzerland, May 30 /PRNewswire/ -- Data presented at the largest oncology meeting in the world, the American Societ...

Helix BioPharma Corp. Announces Positive Phase II Clinical Results with its Topical Interferon Alpha-2b

Helix BioPharma Corp. AURORA, ON, March 30, 2007 /PRNewswire-FirstCall/ - Helix today announced positive results from its phase II clinical study of its Topical Interferon Alpha-2b in women with human papilloma virus (HPV) induced low-grade cervical lesions. The study showed a clinically effic...

First Pharmacoeconomic Analysis with Long-Term Data Showed Copaxone Was More Cost-Effective Than Interferon Beta Therapies for Treatment of Relapsing-Remitting Multiple Sclerosis (RRMS)

KANSAS CITY, Mo.--(BUSINESS WIRE)--Apr 11, 2007 - A comparison of the long-term economic outcomes of four immunomodulatory drug therapies combined with symptom management versus symptom management alone revealed that COPAXONE(R) (glatiramer acetate injection) was the most cost-effective treatment s...

Intarcia Therapeutics Announces Final Results From a Phase 2 Study of Injectable Omega Interferon plus Ribavirin for the Treatment of Hepatitis C Genotype-1

Potent Synergy, Activity and Patient Tolerance Support Development of Omega DUROS Continuous Delivery Therapy BARCELONA, Spain, April 12, 2007 /PRNewswire/ -- Intarcia Therapeutics, Inc., a privately held biopharmaceutical company, today announced final results from a Phase 2 study of omega interf...

Idenix Reports Results from Two Phase IIb Studies of the Combination of Valopicitabine and Pegylated Interferon in Hepatitis C Genotype-1 Patients at the 42nd Annual Meeting of the European Association for the Study of the Liver

Additional Preclinical Data Presented on Valopicitabine Combined with an Investigational Protease Inhibitor BARCELONA, Spain, April 12, 2007 /PRNewswire-FirstCall/ -- Idenix Pharmaceuticals, Inc. today announced results from two phase IIb studies of the novel combination of valopicitabine (NM283) ...

New One-Year Pharmacoeconomic Study Shows Avonex is Cost-Effective Relative to Other Interferon Therapies for Multiple Sclerosis

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Apr 13, 2007 - Biogen Idec Inc. (NASDAQ: BIIB) announced today that one-year data presented at the Academy of Managed Care Pharmacy's (AMCP) 2007 Annual Meeting show that AVONEX(R) (Interferon beta-1a) is a cost-effective therapy in multiple sclerosis (MS) when co...

Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III Melanoma Demonstrated Significant and Sustained Impact on Relapse-Free Survival

-- EORTC 18991 Phase III Study Results Presented At ASCO -- CHICAGO – June 2, 2007 – Long-term treatment with pegylated interferon alfa-2b in stage III melanoma had a significant and sustained impact on relapse-free survival (RFS), according to the results of the largest adjuvant tri...

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Interferon in Biological News

Gamma interferon could aid fight against fungal infections

Interferon, the superhero cure for viral infections, may be a strong weapon in the battle against fungal infections in immunocompromised patients, according to an article in the November issue of Microbiology Today. Fungal infections (mycoses) were once seen as exotic diseases, but this is chan...

Newfound roadblock to interferon effectiveness against malignant melanoma

Researchers have uncovered a significant contributing factor to interferon resistance of malignant melanoma cells. The finding represents a step forward in understanding the molecular events that govern the growth of this type of cancer and the changes in gene expression and cellular signaling that...

Gene Signatures Predict Interferon Response For Multiple Sclerosis Patients

Multiple sclerosis (MS) can be an unpredictable disease. It develops when the body's immune system attacks healthy nerve cells and disrupts normal nerve signaling. Patients experience a wide range of symptoms—including tingling, paralysis, pain, fatigue, and blurred vision—that can appear independe...

Genes In The Interferon System Important In Systemic Lupus Erythematosus

Two genes with very strong associations with the disease systemic lupus erythematosus (SLE) have been identified by a team of scientists headed by researchers at the Department of Medical Sciences at Uppsala University. The findings are being published today on the Web page of the highly prestigiou...

Tips from the journals of the American Society for Microbiology

... Newly Discovered interferon Response May Offer Early Control of H5N1 Influenza...m Georgia suggest that the cell-signaling protein, interferon type 1, reduced H5N1 influenza virus replication i...mune responses within the host, such as the type 1 interferon (IFN-a/B) response, contributes to the virulence o...

Biolex presents Locteron US Phase 2a hepatitis C data at EASL

... Copenhagen, Denmark. Locteron, controlled-release interferon alpha 2b, is designed to improve patient care by p...there continues to be a need for a next-generation interferon that can improve patient compliance through a comb...ron Overview Locteron is a controlled-release interferon alpha designed to improve patient care in the trea...

Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer

...se by mobilizing and expanding a broad range of intrinsic host defence mechanisms. Unlike first generation IMRs such as Toll-like receptor agonists or interferon alpha, each of which have a limited spectrum of activity and lack the ability to treat a broad range of malignant diseases, MIS416 acts on multiple pa...

Researchers identify new anti-tumor gene

...t to chemotherapy of radiotherapy. "We have uncovered a new way by which interferon can induce anti-tumor activity. The identification of SARI also provides a ... killing of tumor cells," said Fisher. "The present study indicates that interferon can suppress cancer growth by inhibiting expression of a cancer-dependent t...

New therapeutic target identified for rheumatoid arthritis

...ry proteins or cytokines. Researchers have also known that a protein called interferon gamma can increase inflammatory response, but they didn't know the exact me...at were turned on by the activation of Toll-like receptors and inhibited by interferon gamma. This subset of genes included genes that are involved in the Notch s...

Scripps research team sheds light on immune system suppression

...monstration that a virus causes suppression of the interferon response in vivo," says the paper's senior author ...this binding triggers massive production of type I interferon that then triggers other immune responses. But...otcytic choriomeningitis virus effectively blocked interferon production, it did not kill the dendritic cells, i...

Interferon in Biological Technology

Helix BioPharma Receives Approval to Initiate Phase II Pharmacokinetic Clinical Study of Topical Interferon Alpha-2b in Patients with Low-Grade Cervical Lesions

AURORA, Ontario, March 16 /PRNewswire/ -- Helix BioPharma Corp. (TSX, FSE: "HBP") announced that it has received the necessary regulatory approvals in Germany to initiate its planned Phase II pharmacokinetic study of Topical Interferon Alpha-2b in patients with low-grade cervical lesions. The...

Phase 2 Data Show Daclizumab Significantly Reduced Multiple Sclerosis Lesions in Patients Receiving Interferon Beta Therapy

- Phase 2 monotherapy trial to be initiated by end of 2007 - PRAGUE, Czech Republic, Oct. 11 /PRNewswire-FirstCall/ -- Biogen Idec Inc. (Nasdaq: BIIB ) and PDL BioPharma, Inc. (PDL) (Nasdaq: PDLI ) announced today that Phase 2 data demonstrated a significant reduction in new or enlarge...

InterMune Reports Second Quarter 2009 Financial Results and Business Highlights

...d initial results from the novel Phase 1 INFORM-1 clinical trial evaluating ITMN-191 in combination with nucleoside polymerase inhibitor R7128, but no interferon or ribavirin, in patients with HCV infection. Data from the first four dosage cohorts of the study demonstrated that the combination resulted in sust...

Anadys Pharmaceuticals Reports Second Quarter 2009 Financial Results and Program Highlights

...l tolerated with no serious adverse events. Plasma drug levels were proportional to dose, and there was a dose-dependent induction of well-recognized interferon dependent biomarkers. Phase I Clinical Trial in Oncology. In order to focus its resources on ANA598, Anadys recently elected to stop enroll...

PROLOR Biotech Acquires License Option from Yeda for Development of Long-Acting Anti-Obesity Drug

...ROLOR is currently developing long-acting versions of human growth hormone, interferon beta and erythropoietin, which are in late preclinical development, as well...including any long-acting versions of human growth hormone, erythropoietin, interferon beta, GLP-1, and other products; that the long-acting products in developme...

PROLOR Biotech Announces $10 Million Preferred Stock Line From Members of The Frost Group

...ROLOR is currently developing long-acting versions of human growth hormone, interferon beta and erythropoietin, which are in late preclinical development, as well...including any long-acting versions of human growth hormone, erythropoietin, interferon beta or GLP-1; that the long-acting products in development may fail, may n...

GeneGo Donates Proprietary Cytokine Pathway Maps to ISICR

... the leading systems biology tools company, announced today that they have recently donated 41 canonical pathway maps to the International Society for interferon and Cytokine Research (www.isicr.org). These maps are constructed from manually curated, experimentally validated biological and chemical pathway inte...

Idenix Pharmaceuticals Reports Second Quarter and Six Month 2009 Financial Results

...irman and chief executive officer of Idenix. "As we work through the second half of the year, we plan to evaluate IDX184 in combination with pegylated interferon and ribavirin in a 14-day dose-ranging study. Additionally, we plan to file investigational new drug applications from our non-nucleoside polymerase i...

PROLOR Biotech Awarded Two U.S. Patents for Its Longer-Acting Human Growth Hormone and Longer-Acting Erythropoietin

...ROLOR is currently developing long-acting versions of human growth hormone, interferon beta and erythropoietin, which are in late preclinical development, as well...including any long-acting versions of human growth hormone, erythropoietin, interferon beta or GLP-1; that the long-acting products in development may fail, may n...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

... treat swine and other H1N1 influenzas. The TB investigators presented data that showed that blood and spleen cells from immunized mice produced gamma interferon in response to the vaccine, while the cells from mice in the various control groups did not. Other recent L.E.A.P.S. data, presented by Dr. Kenneth S...

Interferon in Biological Products

Human Interferon (IFN) and Receptor, PCR Array for expression profiling from SuperArray Bioscience

Description: ...
Company:

Human Interferon Gamma Bioassay Services from PBL InterferonSource

Description: PBL's bioassays for interferons are cytopathic effect inhibition assays, also known as CPE and antiviral assays. Sample types include; tissue culture supernatents; serum from PK studies and delivery formulations. In these assays, one unit is defined as the quantity of interferon required per mill...
Company:PBL InterferonSource

Pig Interferon Alpha Bioassay Services from PBL InterferonSource

Description: PBL's bioassays for interferons are cytopathic effect inhibition assays, also known as CPE and antiviral assays. Sample types include; tissue culture supernatents; serum from PK studies and delivery formulations. In these assays, one unit is defined as the quantity of interferon required per mill...
Company:PBL InterferonSource

Human Interferon Beta Bioassay Services from PBL InterferonSource

Description: PBL's bioassays for interferons are cytopathic effect inhibition assays, also known as CPE and antiviral assays. Sample types include; tissue culture supernatents; serum from PK studies and delivery formulations. In these assays, one unit is defined as the quantity of interferon required per mill...
Company:PBL InterferonSource

Mouse Interferon Alpha Bioassay Services from PBL InterferonSource

Description: PBL's bioassays for interferons are cytopathic effect inhibition assays, also known as CPE and antiviral assays. Sample types include; tissue culture supernatents; serum from PK studies and delivery formulations. In these assays, one unit is defined as the quantity of interferon required per mill...
Company:PBL InterferonSource

Rat Interferon Gamma Bioassay Services from PBL InterferonSource

Description: PBL's bioassays for interferons are cytopathic effect inhibition assays, also known as CPE and antiviral assays. Sample types include; tissue culture supernatents; serum from PK studies and delivery formulations. In these assays, one unit is defined as the quantity of interferon required per mill...
Company:PBL InterferonSource

Human Interferon Omega Bioassay Services from PBL InterferonSource

Description: PBL's bioassays for interferons are cytopathic effect inhibition assays, also known as CPE and antiviral assays. Sample types include; tissue culture supernatents; serum from PK studies and delivery formulations. In these assays, one unit is defined as the quantity of interferon required per mill...
Company:PBL InterferonSource

Rat Interferon Alpha Bioassay Services from PBL InterferonSource

Description: PBL's bioassays for interferons are cytopathic effect inhibition assays, also known as CPE and antiviral assays. Sample types include; tissue culture supernatents; serum from PK studies and delivery formulations. In these assays, one unit is defined as the quantity of interferon required per mill...
Company:PBL InterferonSource

Mouse Interferon Beta Bioassay Services from PBL InterferonSource

Description: PBL's bioassays for interferons are cytopathic effect inhibition assays, also known as CPE and antiviral assays. Sample types include; tissue culture supernatents; serum from PK studies and delivery formulations. In these assays, one unit is defined as the quantity of interferon required per mill...
Company:PBL InterferonSource

Rat Interferon Beta Bioassay Services from PBL InterferonSource

Description: PBL's bioassays for interferons are cytopathic effect inhibition assays, also known as CPE and antiviral assays. Sample types include; tissue culture supernatents; serum from PK studies and delivery formulations. In these assays, one unit is defined as the quantity of interferon required per mill...
Company:PBL InterferonSource

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Interferon in Biological Definition

Apoptosis

...e pathologies 3.1 Apoptosis and the role of interferon in tumor suppression 3.2 Cancer and defective a...iverse pathologies Apoptosis and the role of interferon in tumor suppression In their Nature article ...nd co-workers have described their research on how interferon alpha and beta (IFN-alpha/beta)induce transcriptio...

Hepatitis B

... clearing the infection. Treatments are available in the form of antivirals such as lamivudine and adefovir and immune system modulators such as interferon alpha . There are several other antivirals under investigation. Roughly, all of the currently available treatments, when used alone, are about equall...

T cell

...survive. These cells lose either their CD4 molecules or CD8 molecules and leave the thymus via postcapillary venules. Hormonal substances (thymosin, interferon γ, interleukins, colony stimulating factors, thymopoetin) secreted by type VI epithelioreticular cells within the thymic (Hassal's) corpuscles p...