...RGD strongly binds to an integrin, a membrane protein that is anchored to metastasizing tumor cells in much higher amounts than in healthy tissue. The integrins
with RGD-equipped nanoparticles are actively brought into the cell interior with their cargo intact (receptor-mediated endocytosis).
The magnetic p...
Protein helps immune cells to divide and conquer
...er for B lymphocytes to transition into antibody-secreting cells. It also describes how this relates to the protein's role in the signaling ability of integrins
a large family of adhesion molecules that transfer information between the inside and outside of a cell.
According to first author Joseph Cantor,...
New prognostic markers for gastric cancer patients
...n a research article to be published on April 7, 2008 in the World Journal of Gastroenterology.
The team identified that syndecan-1, E-cadherin and integrins
highly correlated with each other as intracellular adhesion molecular complexes. We suggest the results of co-examination of them can be important ind...
Researchers find new way to block destructive rush of immune cells
...r Medical Center has been studying proteins called integrins
that enable T cells, a major subset of immune cell... wall close to the site of an injury or infection. integrins
on their surfaces unfold and grab onto key protein...ward the site of injury.
In a T cell at rest, integrins
are distributed evenly over the entire surface of ...
A New Target for Cancer Therapy-Integrin Alpha7 Molecule
...ole in the attachment of a cell to the extracellular matrix (ECM), which is the material that holds cells within a particular type of tissue together. integrins
also help cells attach to one another and are involved in transmitting chemical signals between cells and the ECM.
In this study, the research...
Penn Scientists Engineer Small Molecules to Probe Proteins Deep Inside Cell Membrane
The researchers targeted two transmembrane proteins called integrins
that influence the behavior of platelets, small blood cells important in cl...de of the cell. "We wanted to see if we could differentiate between the two integrins
using two different peptides – and, in fact, we can," notes co-senior autho...
Metastasis of Neuroblastoma linked to Loss Of Caspase-8 gene
...ties of metastasizing neuroblastoma.
Integrins are molecules present on the surface of the cells including neuroblastoma. The main function of the integrins
molecule is that they anchor the cells with the extra cellular matrix.
Extra cellular matrix is the material present outside the cell, which gives...
Integrins in Medical Technology
Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, Is Well Tolerated and Demonstrates Activity in Phase I Solid Tumor Patients
...uding mTORC1/2, DNA-PK, PLK-1, CK2, ATM and PIM-1. SF1126 is designed to inhibit both angiogenesis and cell proliferation by targeting and binding to integrins
that are expressed on the surface of new tumor vasculature and within the tumor compartment.
In preclinical xenograft models SF1126 has demonst...
Clinical Data on Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, to be Presented at the 2009 ASCO Meeting
...RC1/2, DNA-PK, PLK-1, CK2, ATM and PIM-1. SF1126 is designed to inhibit both angiogenesis and cell proliferation by targeting and binding to specific integrins
that are expressed on the surface of new tumor vasculature and within the tumor compartment.
In preclinical xenograft models SF1126 has demonstra...
SF1126, Semafore's PI3 Kinase Inhibitor, Found to Block Angiogenic Signaling From Both VEGF and Bv8 in Multiple Cell Lines
.... Importantly, SF1126 is designed as a dual
inhibitor of both angiogenesis and cell proliferation. SF1126 is engineered
to target and bind to specific integrins
(alpha gamma beta 3) that are
expressed on the surface of new tumor vasculature and within the tumor
endothelial compartment. In tumor xenograph model...
Semafore Broadens Pipeline With Multi-Targeted Kinase Inhibitors
.... Importantly, SF1126 is designed as a
dual inhibitor of both angiogenesis and cell proliferation. SF1126 is
engineered to target and bind to specific integrins
(alpha gamma beta 3)
that are expressed on the surface of new tumor vasculature and within the
tumor endothelial compartment. In tumor xenograph model...
Merck at ASCO 2007: Encouraging Results in Progression-Free
Survival in Patients With Aggressive Brain Tumors (glioblastoma)
Using Cilengitide in Phase I/IIa Study
...ash; that are thought to work by targeting
the tumor and its vasculature.
are cell surface receptors that are improperly
regulated in many cancer types which enables them to enhance tumor
growth, survival and invasiveness. integrins
are fundamental in the
process of angiogenesis (blood vessel growth) &ndash...
Integrins in Biological News
Research yields potential target for cancer, wound healing and fibrosis
The research concerns the regulation of integrins
proteins on the surface of cells that serve dual ...lls within tissues and controlling cell behavior. integrins
anchor to extracellular proteins found outside the...ifferentiation in both healthy tissues and tumors. integrins
are involved in the cellular response to injury an...
Metastatic movements in 3-D
... Caswell et al.report in the Journal of Cell Biology how the altered behavior of integrins
can prompt metastatic movement in tumor cells.
On 2D surfaces, cells may migrate randomly, or be strongly unidirectional. Integrins, which link the c...
UC Davis researchers discover new drug target for inflammatory disease
...vered that a protein called sPLA2-IIA binds to two integrins
labeled alpha-V-beta-3 and alpha-4-beta-1, causing...n binds to completely different receptors the two integrins
in human cells.
are the "networkers" of the immune system, playing...
Researchers coat titanium with polymer to improve integration of joint replacements
It is important to control the integrins
binding to the titanium implant because integrins
provide signals that direct bone formation. Theref...nce bone formation around the implant.
To bind integrins
to titanium, researchers previously coated titaniu...
Integrins as receptors give insight into rotavirus and diarrhea
...lass of molecules that are involved in attaching cells to other cells and to the extracellular matrix (a part of tissue that is not part of any cell). integrins
also are involved in transforming or translating cell signals.
In looking for the receptor, Estes and her colleagues also learned more about the en...
Researcher to study astronaut bone loss for space biology agency
... enhance or recover IGF-1 receptor function. The IGF-1 will act as a signaling device to allow Long to measure the strength of the interaction between integrins
and IGF-1 receptor.
"Understanding this interaction, and the role it plays in how bones respond to mechanical forces, will allow interventions t...
UCSD researchers create roadmap to integrin activation
...hed on line in Current Biology on September 19.
are a large family of adhesion molecules that prom...eractions between cells and their environment. The integrins
also act as cellular sensor and signaling molecule...at binds to the inside of an integrin or family of integrins
?delivers the critical activation signal. Talin i...
3-D model reveals secrets of metastasis
...s to move, as they latch onto the "branches" with claw-like proteins called integrins
and pull themselves forward. When Zaman disabled some of these claws, in a ... cells become dramatically sensitive to the stiffness of the vines when the integrins
are disabled and consequently tend to squeeze through the vines rather than...
Berkeley researchers lay groundwork for cell version of DNA chip
...egrins. A surface will be laid out in a desired pattern with chemical handles called "ligands" to which the integrin-coated cells will bind. However, integrins
are cell adhesion generalists, just about all of the different types of cells will stick to the same ligands. This makes integrin-coated cells ill-su...
Unexpected lock and key mechanism found for the assembly of tumor blood vessels
...rtant clinical significance."
In their current studies of breast cancer patients for the presence of the integrin and VCAM, "We want to know if the integrins
predict aggressive breast cancer. If so, this could become a valuable, non-invasive diagnostic tool for cancer," said Varner.
In addition, knowing ...
Integrins in Biological Technology
Stem cells stand up for themselves
...top crawling even after contacting another cell.
hook onto an extracellular matrix protein called l...em cells, which travel along with itdidn't rely on integrins
for anchoring, the researchers showed. The team co...ncluded that the interaction between laminin A and integrins
ensures that FSCs remain in place, primed to divid...
Medical College of Wisconsin ties breast cancer to inflammation
... They also examined the role of caspases enzymes in programmed cell death.
The group found an increased expression of peroxisome, chemokines and integrins
in the cancerous tissue. There were also significant increases in several types of caspases in the lymphocytes from breast cancer patients.
Integrins in Biological Products
Integrins in Biological Definition
...s ("homeless" in Greek) is chronologically an inverse process: de-adhesiveness of viable cells from their surroundings inducing programmed cell death. integrins
are essential adhesive molecules in this process but additional factors probably play a role. Beyond the physiological importance, understanding these...