Newly appreciated membrane estrogen receptor important therapeutic target for breast cancer
...activation of a latent adhesion receptor (known as integrin
Filardo says, "Activation of integrin
51 by GPR30 is a significant event...mary breast cancer. This happens because activated integrin
51 can convert soluble plasma prot...
Protein helps immune cells to divide and conquer
... protein functions in cells by helping to transmit integrin
signals, as well as transporting amino acids the ...l proliferation.
"CD98hc interacts with certain integrin
subunits to prompt signaling events that control c...ction, is aided by the CD98hc protein's support of integrin
signaling," Cantor said.
Nanoparticle Stops Cancer From Spreading
...team from the University of California, San Diego, designed a "nanoparticle" anti-cancer drug delivery system that zooms in on a protein marker called integrin
avB3, which is found on the surface of certain tumor blood vessels. The marker is tied to the development of new blood vessels and malignant tumor gro...
'Smart bomb' nanoparticle strategy impacts metastasis
...d vice chair of pathology, and members of his team report that the nanoparticle carrying a payload of chemotherapy homes in on a protein marker called integrin
ανβ3 found on the surface of certain tumor blood vessels where it is associated with development of new blood vessels and malignant tum...
Applying Parallel Pressure Improves Vascular Grafting
...s exposed human adipose-derived stem cells (ASC) differentiated toward endothelial-like cells to physiological levels of shear stress. Measurements of integrin
activity and cell attachment were taken on sample culture plates precoated with collagen I, fibronectin or gelatin -- all vascular basement membrane c...
Sticky blood protein yields clues to autism
...hat a well-known protein found in blood platelets, integrin
beta3, physically associates with and regulates th... the platelet.
Prior research had fingered the integrin
beta3 gene as a determinant of blood serotonin lev...ntrol SERT activity. One of these turned out to be integrin
Once they confirmed a physical relation...
JCI online early table of contents: March 3, 2008
...ly with the beta-3 component of a protein known as integrin
alpha-IIb/beta-3, and this led to increased SERT e...ed that the demonstration that SERT interacts with integrin
beta-3 provides a possible mechanistic basis for t...ase and depression.
TITLE: Interactions between integrin
alpha-IIb/beta-3 and the serotonin transporter reg...
NIAID scientists identify new cellular receptor for HIV
...entists identify a cell adhesion molecule known as integrin
alpha 4 beta 7 as another potentially important re...s where the virus really takes hold. We found that integrin
alpha 4 beta 7, whose natural function is to direc... gp120 protein, part of the HIV envelope, binds to integrin
alpha 4 beta 7 on CD4+ T cells, which promotes the...
Researchers find new way to block destructive rush of immune cells
...e it would be incredibly useful to precisely block integrin
activation, and thus T cell migration, said Minsoo... is that past, system-wide attempts that block all integrin
activation, like the multiple sclerosis drug Tysab...ed with the association between MyH9 and the LFA-1 integrin
were found to prevent the trailing edge of the cra...
GlaxoSmithKline Presents Innovative Neuroscience Pipeline
...cause no or a low immune response, could
result in a significant new treatment option for patients.
A phase II study with firategrast, a dual alpha4 integrin
(VLA4), in MS is ongoing in 13 countries. Comprising 350 patients, the
study aims to provide proof-of-concept data supporting the potential...
Integrin in Biological News
UCSD researchers create roadmap to integrin activation
Calling it an important technical advance in the study of the complex receptors and pathways of the body's cellular system, researchers at the University of California, San Diego (UCSD) School of Medicine have reconstructed the signaling pathways that impact activation of a receptor that is critica...
Research yields potential target for cancer, wound healing and fibrosis
...es such as cancer and fibrosis. The paper, β1 integrin
Cytoplasmic Domain Residues Selectively Modulate F...
Of the many integrins that exist, the beta-1 integrin
is of great interest because it is involved in nea...els for disease, cannot survive without the beta-1 integrin
Potential therapy for congenital muscular dystrophy
...regenerative capacity in a mouse model for alpha 7 integrin
congenital myopathy," appears in the January 2009 ...ts with mutations in the adhesion molecule alpha 7 integrin
experience delayed developmental milestones and im...here is currently no treatment or cure for alpha 7 integrin
Interactions of alpha 7...
Metastatic movements in 3-D
...ration, but exactly how has been unclear. Recent work has suggested that an integrin
called a5b1 drives random movement, while an integrin
called avb3 has been associated with unidirectional migrationthe balance of...
UC Davis researchers discover new drug target for inflammatory disease
In the current study, Takada and team evaluated the possibility of integrin
binding by sPLA2-IIA using a computer program that predicts how small molec...s in pro-inflammatory signals. We have to continue to better understand the integrin
signaling process if we are to find more potential drug targets for the tre...
Researchers coat titanium with polymer to improve integration of joint replacements
...that direct bone formation. Therefore, controlling integrin
binding to the titanium will result in targeted si...s. However, this region alone binds many different integrin
receptors and with much less affinity than the ful...tions also known to have sites that participate in integrin
To evaluate the in vivo performance of...
Integrins as receptors give insight into rotavirus and diarrhea
...ibe two receptors for the enterotoxin, both of them integrins.
The two, integrin
alpha1 beta1 and integrin
alpha2 beta1, are members of a class of molecules that are involved in atta...
Clumps of red and white blood cells may contribute to sickle cell disease
...ckle cell patients. The study also shows how the red and white blood cells adhere to one another: the interaction is mediated by a particular protein, integrin
alpha four beta one.
First author Julia E. Brittain, Ph.D., a research assistant professor in the medical schools department of biochemistry and b...
Genome of marine organism tells of humans' unicellular ancestors
... that lack a centralized nervous system.
Likewise, choanoflagellates have five immunoglobulin domains, though they have no immune system; collagen, integrin
and cadherin domains, though they have no skeleton or matrix binding cells together; and proteins called tyrosine kinases that are a key part of signa...
Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
...e that many pharmaceutical companies had tried to develop compounds against integrin
molecules (a large and important family of adhesion molecules that promote ...st the same roadblock.
While potential therapeutics bound to the cancer integrin
molecules with high affinity and specificity, the compounds were quickly cl...
Integrin in Biological Technology
Integrin in Biological Definition
...iple topogenic sequences .
Some cell adhesion proteins
Some receptor proteins
See also : membrane topology , transmembrane helix , membrane protein
Integrin in Biological Dictionary
...for contraction. To facilitate energy and calcium conductance in cardiac muscle... Key Words: intercalated discs • kindlin-2 • cardiomyopathy • integrin
... Thus, the intercalated discs ensure proper function of the heart with efficient ... ... Mechanical and Electrical Junctions at the Inter...
... glycoprotein IIb/IIIa, an integrin
found on platelets that is required for ... Structure of Glycoprotein and Carbohydrate Chain - Home Page for Learning ... P- glycoprotein is...