HIV integrase inhibitor effective for patients beginning antiretroviral treatment

A member of a new class of antiretroviral drugs is safe and effective for patients beginning treatment against HIV, according to researchers who have completed a two-year multisite phase III clinical trial comparing it with standard antiretroviral drugs. The results are online and scheduled for...

Impending FDA Approval Decision on the First HIV Integrase Inhibitor Can Have Significant Impact for Patients

ANALYST AVAILABLE TO COMMENT ON THE MARKET FORECAST FOR THE DRUG WALTHAM, Mass., Oct. 12 /PRNewswire/ -- Dr. Sylvia Eash, Ph.D., analyst at Decision Resources, is available to discuss the impact of the Food and Drug Administration's (FDA) possible approval of Merck's Isentress, the first i...

Sales of Antiretroviral Agents Will Drive Substantial Six Percent Annual Growth in the HIV Drug Market Through 2013

...he report also finds that two novel classes of antiretroviral agents -- the integrase inhibitors and CCR5 antagonists -- have been received with different levels...asm among interviewed experts and prescribers. Merck's Isentress, the first integrase inhibitor on the market, has been received with great enthusiasm by physici...

GlaxoSmithKline and Pfizer Announce Innovative Agreement to Create a New World-Leading, Specialist HIV Company

... Pipeline Product Class Product Class Phase Agenerase Protease inhibitor GSK 1349572 integrase II inhibitor Combivir NRTI UK-453061 NNRTI ...

Specialists are Highly Satisfied with the Safety and Efficacy of Atripla and Isentress in the Treatment of HIV Patients

... The new report entitled HIV: Opportunity lies for Drug Developers in integrase Inhibitors and Next Generation CCR5 Antagonists finds that a novel drug in... About the Report HIV: Opportunity lies for Drug Developers in integrase Inhibitors and Next Generation CCR5 Antagonists is a DecisionBase 2009 rep...

Monogram Announces 2008 Second Quarter Financial Results

...d California state Medicaid programs. -- Announcement of the availability August 4 of the PhenoSense Integrase assay for assessing resistance to the integrase class of HIV drugs. -- Extension of Trofile's availability outside of the U.S. to thirteen European countries, Canada, Brazil and Argentina. "Sele...

New therapy for HIV treatment

...IV medicines had the amount of virus in the blood reduced to similar levels. "This is the first drug in a new class of antiretroviral drugs called integrase inhibitors," said UNSW Professor David Cooper AO, the Director of NCHECR . "The drug has a different mechanism of action, is very potent, seems ver...

Monogram Biosciences Collaborates with Gilead Sciences for Elvitegravir Phase III Studies

...says used to study promising new integrase inhibitor SOUTH SAN FRANCISCO, Calif., June 18 /...ith Elvitegravir during the study. Both Monogram's integrase phenotype and genotype assays were used in Elviteg...ew class of drugs known as "Integrase inhibitors." integrase is a viral enzyme that helps HIV integrate its gen...

amfAR announces inaugural Mathilde Krim Fellowship Awards for AIDS research

...e nucleus of the cell and inserts itself into the DNA is incompletely understood, though researchers know that the HIV DNA must bind to the HIV enzyme integrase as well as the cell protein LEDGF. Dr. Gupta plans to use an array of technologies to generate the first atomic-level illustrations detailing the ways...

Combination Therapies Continue to Thrive Among Pharma Brands

...reatment for HIV with two existing treatments, Fuzeon and Prezista. According to a company statement, 98% of patients who received the investigational integrase inhibitor raltegravir, along with Fuzeon and the protease inhibitor Prezista, achieved undetectable levels of HIV according to new interim clinical da...

Integrase in Medical Technology

Analysis of Long-Term Vicriviroc Data Provides Evidence of Sustained Viral Suppression, Increased CD4 Cell Counts and Tolerability in Treatment-Experienced HIV-Infected Patients

...on.(8-10) This approach represents a potential opportunity to preserve nucleoside and non-nucleoside reverse transcriptase inhibitors (NRTIs, NNRTIs), integrase inhibitors, fusion inhibitors and most protease inhibitors for later lines of HIV treatment. The full study will involve approximately 200 patients an...

DHHS Guidelines Support Use of Trofile(TM) Assay Prior to CCR5 Inhibitor Use

...mance of our products; the growth in revenues; the size, timing and success or failure of any clinical trials for CCR5 inhibitors, entry inhibitors or integrase inhibitors; the risk that our Trofile Assay may not be utilized for patient use with CCR5 inhibitors; our ability to successfully conduct clinical stu...

Roche Diagnostics' HIV Viral Load Test Used in Clinical Trials for Isentress, a New Class of HIV Drug

... INDIANAPOLIS, Oct. 29 /PRNewswire/ -- Merck's new integrase inhibitor, Isentress, approved last week by the Fo...own as Raltegravir, is an HIV integrase inhibitor. integrase inhibitors prevent replication of the virus by blo...terial into human DNA. There are several other HIV integrase inhibitor drugs under development. Isentress clin...

Abbott Receives Supplemental FDA Approval for its Best-in-Class in Sensitivity RealTime HIV-1 Viral Load Test

...dard of care in diagnostic sensitivity of 50 copies per mL. Also, unlike other assays, the Abbott RealTime HIV-1 test targets the highly conserved pol integrase region of the HIV-1 genome, giving the test its unique ability to detect and measure all known genetic variations of the virus. "Because of what we n...

Ambrilia Highlights Encouraging Data for its HIV Integrase Inhibitor Program and Recent Developments at Annual Meeting

...CENT HIGHLIGHTS - Ambrilia's novel series of HIV integrase inhibitors were presented at the prestigious XVI I... lead to a different resistance profile from known integrase inhibitors currently in clinical development by ph...companies. The Company is now accelerating its HIV integrase Inhibitor Program and aims to have a drug candidat...

Integrase in Biological News

New class of drug offers hope to treatment-resistant AIDS patients

... global public health problem. A series of HIV integrase inhibitors discovered by Vasu Nair, Georgia Resear...no fully approved drugs stop the action of the HIV integrase enzyme, the insertion of HIV DNA into human DNA. N...ments over time, explained Nair. Now, with HIV integrase inhibitors, we have a new class of drugs for peopl...

Mayo researchers discover HIV dependence on a human protein

... They Did It The researchers started by noticing that p75 "tethers" HIV integrase to human chromosomes like a molecular rope and also protects it from the ce...ot Currently Be Eradicated Each time HIV reproduces itself, it uses its integrase protein to insert a copy of its genome into a chromosome. That copy becomes...

AIDS drug from sunflowers

...ch centre. 'It is one of the few substances known today which inhibit viral integrase ?this is an enzyme which is essential if the pathogen is to reproduce.' In ...nzymes medical experts expect there to be only a few side-effects from such integrase inhibitors. In the pharmaceuticals industry they are therefore seen as the ...

Major WHO study concludes calcium supplements can reduce complications during pregnancy

...opment of potential inhibitors of the third enzyme associated with HIV, the integrase enzyme. "Other simulations by our group discovered an unknown binding site on the integrase enzyme, " McCammon explained. "Merck's new anti-integrase inhibitors includ...

Computer simulation hints at new HIV drug target

...opment of potential inhibitors of the third enzyme associated with HIV, the integrase enzyme. "Other simulations by our group discovered an unknown binding site on the integrase enzyme, " McCammon explained. "Merck's new anti-integrase inhibitors includ...

SLU researchers uncover direct evidence on how HIV invades healthy cells

...anism of this process is significant in developing integrase inhibitors." Integrase, which was discovered b...(RNA) in HIV into deoxyribonucleic acid (DNA). integrase then inserts the HIV DNA into the immune cell's DN... Transfer, Bera and his colleagues showed that the integrase holds the two ends of the viral DNA together prior...

HIV inserts into human genome using a DNA-associated protein

... Now, Penn researchers showed in this study that the way LEDGF binds to HIV integrase and to specific sites on chromosomes suggests that HIV targets integration ...iptase and then integrate that DNA copy into the DNA of the host, using the integrase enzyme. The new viral particles are made by transcription of the viral geno...

Supercomputers to focus brains on AIDS dilemma

...es of the structure of a complex between the HIV-1 integrase catalytic domain and an inhibitor pointed to the e... indicated a single format for small inhibitors of integrase to bind at the catalytic site, typically with a cy...roup began new molecular dynamics studies of HIV-1 integrase using SDSC's supercomputers. As the power of compu...

Integrase in Biological Technology

Monogram Biosciences Launches First Resistance Assay for HIV Integrase Inhibitors

PhenoSense(R) Integrase Now Enables Clinicians to Monitor Activity of New Class of Potent Antiretroviral Drugs SOUTH SAN FRANCISCO, Calif., Aug. 4 /PRNewswire-FirstCall/ -- Monogram Biosciences, Inc. (Nasdaq: MGRM ) today announced the launch of its PhenoSense(R) Integrase ass...

Merck Engages PharmaVentures to Assist in the Divestment of its Italian Research Centre IRBM

...he-art small molecule and biological discovery centre. IRBM has an outstanding record of drug discovery including Isentress(R), the first approved HIV integrase inhibitor and winner of the Prix Galien USA 2008 award for the best pharmaceutical agent. The centre has received significant investment since 2000 an...

Virco Lab, Inc. Enters Into Collaboration with SmartGene, Inc. Enhancing HIV Resistance Test Services for Laboratories and Physicians

...ubmitted through the secure module to Virco for interpretation and creation of a virco(R)TYPE HIV-1 report Additional genetic targets, such as integrase and gp41, are also supported by the SmartGene, Inc. service Results are automatically delivered into the module and can be stored and viewed e...

SmartGene, Inc. Enters Collaboration with Virco Lab, Inc. to Enhance HIV Genotyping and Resistance Interpretation Services in US

...quences with updated algorithms and comparing results derived from different algorithms; they are interested in analyzing new genetic targets, such as integrase and Envelope. SmartGene HIV exquisitely meets these needs," said David Ellis, President of SmartGene, Inc. "We have made excellent progress introducin...

Monogram Announces 2008 Third Quarter Financial Results

...tance of our products; the growth in revenues; the size, timing and success or failure of any clinical trials for CCR5 inhibitors, entry inhibitors or integrase inhibitors; the risk that our VeraTag assays, including HERmark, may not predict response to particular therapeutic agents; the risk that we may not b...

Medical Policy Guideline for Trofile(TM) Established By Wellpoint, Inc.

...mance of our products; the growth in revenues; the size, timing and success or failure of any clinical trials for CCR5 inhibitors, entry inhibitors or integrase inhibitors; whether larger confirmatory clinical studies will confirm the results of initial studies; our ability to establish reliable, high-volume o...

Monogram Biosciences and Avexa Announce Exclusive Collaboration to Support New HIV Drug Discovery and Development Efforts

...search and development of drugs for the treatment of infectious diseases. Avexa has dedicated resources and funding for key projects including its HIV integrase program and an antibiotic program for antibiotic-resistant bacterial infections. The Company's lead program is apricitabine (ATC), an anti-HIV drug wh...

Data Presented on Monogram HIV Tropism Tests at Retrovirus Conference sets New Standards of Assay Sensitivity

...mance of our products; the growth in revenues; the size, timing and success or failure of any clinical trials for CCR5 inhibitors, entry inhibitors or integrase inhibitors; the risk that our Trofile Assay may not be utilized for patient use with CCR5 inhibitors; our ability to successfully conduct clinical stu...

Study Reaffirms Superiority of Trofile(TM) Assay

...mance of our products; the growth in revenues; the size, timing and success or failure of any clinical trials for CCR5 inhibitors, entry inhibitors or integrase inhibitors; the risk that our Trofile Assay may not be utilized for patient use with maraviroc and other CCR5 inhibitors; our ability to successfully ...

Integrase in Biological Products

HIV Volume 2 (Biochemistry, Molecular Biology and Drug Discovery) from Promega

Description:...detailed practical information and methods for the study of major HIV proteins including: the HIV growth cycle; reverse transcriptase, ribonuclease H, integrase and protease. Expression of HIV proteins using baculoviruses; RNA binding assays; Tat and Rev assays; HIV/CD4 interactions; transient assays for Nef-i...
Company:Promega

Integrase in Biological Definition

Gene therapy

...e cell. This process is done by another enzyme carried in the virus called integrase . Now that the genetic material of the virus is incorporated and has beco...genes. One of the problems of gene therapy using retroviruses is that the integrase enzyme can insert the genetic material of the virus in any arbitrary positi...

Retrovirus

...verse transcription of its genome from RNA into DNA for insertion by integrase into the host's genome. The virus itself is just a storage form for its nu... pol ( pol ymerase) codes for reverse transcriptase , protease and integrase ; and, env ( env elope) codes for the retroviral coat proteins. F...

Integrase in Biological Dictionary

Retrotransposon

...urnal articles, magazine articles & newspaper archives. Furthermore, retrotransposon -induced mutations are relatively stable, because ... The integrase is the retrotransposon equivalent of the transposase of DNA ... Retrotransposon . Synonym(s) retroposon. Definition(s) ... retrotransposon D...

Retrovirus

...t cell via the enzyme reverse transcriptase to produce DNA from its RNA genome. The DNA is then incorporated into the host's genome by an integrase enzyme. The virus... retrovirus n. , pl. -ruses . Any of a group of viruses, many of which produce tumors, that contain RNA and reverse transcrip...

DNA virus

...cell via the enzyme reverse transcriptase to produce DNA from its RNA genome. The DNA is then incorporated into the host's genome by an integrase enzyme. The virus ... DNA Viruses . Genome is a molecule of double-stranded DNA . Hepatitis B ... These viruses contain a reverse transcr...