Initiation

ViroPharma Announces Initiation Of Non-Toxigenic Clostridium Difficile Phase 1 Program

EXTON, Pa., Aug. 6 /PRNewswire-FirstCall/ -- ViroPharma Incorporated (Nasdaq: VPHM ) today announced that dosing has begun in the Phase 1 clinical trial for NTCD (non-toxigenic Clostridium difficile ), a novel treatment approach for preventing recurrent Clostridium difficile infections (...

Bellicum Pharmaceuticals Announces Initiation of Phase I/II Clinical Trial of Novel Vaccine for Patients With Advanced Prostate Cancer

HOUSTON, Aug. 6 /PRNewswire/ -- Bellicum Pharmaceuticals, Inc. today announced dosing of the first patient in a Phase I/II clinical trial of BP-GMAX-CD1, a novel pharmacologically regulated dendritic cell vaccine for the treatment of prostate cancer. The disease-specific trial is be...

Access Pharmaceuticals Announces Initiation of Two New Cobalamin(TM) Oral Insulin Drug Delivery Collaborations

Cobalamin oral insulin and oral human growth hormone formulations provide significant pharmacological responses DALLAS, June 17 /PRNewswire-FirstCall/ -- ACCESS PHARMACEUTICALS, INC. (OTC Bulletin Board: ACCP) announced today that the Company has signed evaluation agreements with tw...

AcelRx Announces Initiation of Phase 2 Cancer Breakthrough Pain Program

REDWOOD CITY, Calif., April 22 /PRNewswire/ -- AcelRx Pharmaceuticals, Inc. today announced that it has initiated a Phase 2 clinical trial of ARX-02, a proprietary sublingual sufentanil NanoTab(TM) product candidate for cancer breakthrough pain control. The primary objective of this multicenter, r...

Transition Therapeutics Announces Initiation of a Phase Ib Clinical Study of TT-223 in combination with a GLP-1 analogue in Patients with Type 2 Diabetes

TORONTO, March 23 /PRNewswire-FirstCall/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI , TSX:TTH) announced today that the first patient has been dosed in a clinical study of gastrin analogue TT-223 in combination with a proprietary Lilly GLP-1 analogue, in patients...

Arena Pharmaceuticals Announces Initiation by Merck of Phase 2 Clinical Trial of Niacin Receptor Agonist

SAN DIEGO, Feb. 18 /PRNewswire-FirstCall/ -- Arena Pharmaceuticals, Inc. (Nasdaq: ARNA ) announced today the initiation of a Phase 2 clinical trial of an orally administered niacin receptor agonist drug candidate being developed by Merck & Co., Inc., under its collaboration with Arena to t...

Initiation in Medical Technology

Calixa Therapeutics Announces Initiation of Phase 2 Clinical Trial of Its Antibiotic, CXA-101, in Patients with Complicated Urinary Tract Infections

SAN DIEGO, June 30 /PRNewswire/ -- Calixa Therapeutics Inc. today announced the initiation of a Phase 2 clinical trial of CXA-101 in patients with complicated urinary tract infections. CXA-101 is a new broad-spectrum, parenteral cephalosporin antibiotic with excellent in vitro and in vivo act...

Abbott Advances Its Revolutionary Fully Bioabsorbable Drug Eluting Stent With Initiation of Next Phase of Clinical Trial

ABBOTT PARK, Ill., March 24 /PRNewswire-FirstCall/ -- Abbott ( NYSE: ABT ) today announced the initiation of the next phase of the ABSORB clinical trial to evaluate the safety and performance of the company's fully bioabsorbable drug eluting coronary stent. This second phase of the ABSORB clinic...

Impact Medical Solutions Announces Initiation of Pilot Clinical Trial and Listing on Frankfurt Stock Exchange

HUNTINGTON BEACH, Calif., Feb. 25 /PRNewswire-FirstCall/ -- Impact Medical Solutions, Inc. (OTC Bulletin Board: IMSU), a medical technology company, announced today that it has commenced a pilot clinical study of the Company's proprietary information technology platform, Muscle Pattern Recognition...

Arena Pharmaceuticals Announces Initiation of Phase 1 Clinical Trial of Type 2 Diabetes Drug Candidate in Partnership with Ortho-McNeil-Janssen Pharmaceuticals

SAN DIEGO, Dec. 15 /PRNewswire-FirstCall/ -- Arena Pharmaceuticals, Inc. (Nasdaq: ARNA ) announced today that Ortho-McNeil-Janssen Pharmaceuticals, Inc. (Ortho-McNeil) initiated under their partnership a first-in-human Phase 1 clinical trial of APD597, a novel oral drug candidate discovered by A...

RHEI Pharmaceuticals Announces the Initiation of the Final Clinical Study for Approval of Tibozole in China

New Product will Fill Void in the Local Treatment of Oral Candidiasis in Immunosuppressed Patients in China PLAINSBORO, N.J., Dec. 5 /PRNewswire/ -- RHEI Pharmaceuticals, Inc. today announced that the final clinical trial for Tibozole, a locally active antifungal with low dose miconazole ...

Vical Receives Milestone Payment from Merck & Co., Inc. Triggered by Planned Initiation of Investigational Cancer DNA Vaccine Trial

SAN DIEGO, Dec. 1 /PRNewswire-FirstCall/ -- Vical Incorporated (Nasdaq: VICL ) announced today the receipt of a $1.0 million milestone payment from Merck & Co., Inc. based on Merck's planned initiation of a Phase I clinical trial of an investigational plasmid DNA (pDNA) cancer vaccine. The c...

Initiation in Medical Products

Centricity Ultra Laboratory Information Management System

Description:...ntricity Ultra Laboratory has been uniquely designed to fit the needs of a single facility to integrated networks spanning multi-facilities. From test initiation and processing to management reporting and accounts receivable, Centricity Ultra facilitates quick, efficient and precise laboratory management. All s...
Company:GE Healthcare

Prolactin ELISA Test

Description:... significant amounts by the anterior pituitary gland and the placenta. Prolactin, in synergy with estrogen, plays an important physiologic role in the initiation and maintenance of mammary gland growth and lactation in humans [1,2]. In addition, prolactin may have effects on cell growth in other tissues and on ...
Company:Diagnostic Systems Laboratories, Inc.

Prolactin IRMA Test

Description:... significant amounts by the anterior pituitary gland and the placenta. Prolactin, in synergy with estrogen, plays an important physiologic role in the initiation and maintenance of mammary gland growth and lactation in humans [1,2]. In addition, prolactin may have effects on cell growth in other tissues and on ...
Company:Diagnostic Systems Laboratories, Inc.

The Impact Walker

Description:... No leg length discrepancy; Heel height is preserved eliminating pelvic tilt during gait. The front section of the walker is slightly flexible making initiation of the swing phase easier and more natural. The strapping system leaves tibialis anterior with maximum space. The yoke shaped strap attachments holdin...
Company:ORTHO-CARE, Inc.

Cutting Balloon Ultra2 Monorail Platform

Description:...cal blades) mounted longitudinally on its outer surface. When the Cutting Balloon Ultra device is inflated, the atherotomes score the plaque, creating initiation sites for plaque propagation. This process, referred to as Atherotomy, allows dilatation of the target lesion with less pressure....
Company:Boston Scientific Corporation

Cutting Balloon Ultra2 Over-the-Wire Platform

Description:...cal blades) mounted longitudinally on its outer surface. When the Cutting Balloon Ultra device is inflated, the atherotomes score the plaque, creating initiation sites for plaque propagation. This process, referred to as Atherotomy, allows dilatation of the target lesion with less pressure....
Company:Boston Scientific Corporation

Initiation in Medical Dictionary

Monocyte

...yte, part of the human body's immune system that protects ... Retrieved from "http://psychology.wikia .com/wiki/ Monocyte " ... A model for LTB4 initiation of monocyte activation and recruitment. LTB4 regulates vascular monocyte chemotactic activity driven by MCP1, through ... Information about ...

Limb

...trieved from "http://en.wiktionary.org /wiki/ limb " ... LIMB DEVELOPMENT. Vertebrate appendages have undergone tremendous. diversification. ... initiation of limb development, but stimulus is. poorly understood. ... The Merck Veterinary Manual (MVM) has served veterinarians and other animal healt...

Dialysis

...st often used for patients who have kidney failure, but it can ... HEMODIALYSIS OVERVIEW Dialysis is a treatment for severe kidney ... for initiation of dialysis in chronic kidney disease ... and maintenance dialysis ... OVERVIEW Peritoneal dialysis (PD) is a procedure that can be us...

CMV retinitis

...is, treatments, tests, and surgical procedures, as well as current news ... There have been reports of CMV retinitis presenting soon after the initiation of ... In Hong Kong, CMV diseases, primarily retinitis , contributed to some 5-6% of the ... CMV retinitis is diagnosed through a standard ...

Initiation in Biological News

Early initiation of Arctic sea-ice formation

Significant sea ice formation occurred in the Arctic earlier than previously thought is the conclusion of a study published this week in Nature . "The results are also especially exciting because they suggest that sea ice formed in the Arctic before it did in Antarctica, which goes against scient...

Impaired energy metabolism linked with initiation of plaques in Alzheimer's brain

Scientists have identified an initiating molecular mechanism in sporadic Alzheimer's disease (AD). The study, published by Cell Press in the December 26th issue of the journal Neuron , provides new information about generation of damaging amyloid β (Aβ) plaques within the AD brain and u...

Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer

Gastric and colorectal cancers account for more than 1 million deaths worldwide every year and several research groups have been working to identify the molecular events that result in the initiation and progression of these tumors. It has been established that interfering with the function of one ...

Drug-proof zebrafish reveal secrets of addiction

...se a major step in the development of addiction is the switch from drug use to drug abuse, we aimed to gain insight into the mechanisms triggering the initiation of addictive behaviour". The team used the mutagenic chemical ENU to generate hundreds of mutant zebrafish. From these, they bred a line that did n...

Stuff of stink bombs investigated for role in pregnancy

...ide has been shown to relax the uterus and it can be produced by the placenta, uterine tissue and the amniotic sac." Dr Carson's interest is in the initiation of term labour, premature labour and pre-eclampsia, which are still poorly understood. He said: "It is possible that research on hydrogen sulphide...

Xie Lab uncovers molecular machinery related to stem cell fate

...ering with the function of the protein translation initiation factor eIF4A. EIF4A and BAM antagonize each other ...ead author on the paper. "Many protein translation initiation factors have been reported to be unregulated in di...our study may help to understand how translational initiation factors participate in stem cell misregulation and...

Initiation in Biological Technology

IIVS Announces Initiation by EPA of a Pilot Program to Evaluate Non-Animal Eye-Irritation Methods

GAITHERSBURG, Md. , July 30 /PRNewswire-USNewswire/ -- The EPA has initiated a new program to evaluate the use of non-animal methods to replace the Draize test for eye irritation labeling for antimicrobial cleaning products. The is the first program of its kind and demonstrates the Ag...

MacroGenics Announces the Initiation of a Phase 2 Clinical Trial to Evaluate the Safety and Efficacy of Monoclonal Antibody MGAWN1 in Subjects with Suspected Central Nervous System Infection Due to West Nile Virus

ROCKVILLE, Md. , July 13 /PRNewswire/ -- MacroGenics, Inc. today announced the initiation of the PARADIGM trial, a Phase 2 clinical study evaluating MGAWN1, a humanized monoclonal antibody, for the treatment of individuals with suspected central nervous system infection due to West Nile Viru...

Oncothyreon announces initiation of Phase 3 trial of Stimuvax in breast cancer

SEATTLE, June 22 /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ONTY ) (TSX:ONY) (the "Company") today announced that Merck KGaA of Darmstadt, Germany, has initiated a global Phase 3 trial of Stimuvax(R) (BLP25 liposome vaccine, L-BLP25) in patients with hormone receptor-positive, locally ad...

Trubion Pharmaceuticals, Inc. Announces Initiation of Phase 1 Study of SBI-087 for the Treatment of Systemic Lupus Erythematosus (SLE)

SEATTLE, March 25 /PRNewswire-FirstCall/ -- Trubion Pharmaceuticals, Inc. (Nasdaq: TRBN ) announced today that its collaboration partner Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE ), has initiated a Phase 1 clinical trial of SBI-087, Trubion's next generation CD20 drug candidate, fo...

Morphotek(R), Inc. Announces Initiation of MORAb-009 Phase II Study in First- Line Treatment of Mesothelioma

EXTON, Pa., March 2 /PRNewswire/ -- Morphotek(R), Inc., a subsidiary of Eisai Corporation of North America, today announced that it has commenced a multi-centered Phase II study of its MORAb-009 monoclonal antibody in mesothelioma. The study will evaluate MORAb-009, plus the chemotherapy drugs...

Human Genome Sciences to Receive $9 Million Milestone Payment Related to GlaxoSmithKline Initiation of Phase 3 Clinical Trial of Syncria(R) in Type 2 Diabetes

ROCKVILLE, Md., Feb. 17 /PRNewswire-FirstCall/ -- Human Genome Sciences, Inc. (Nasdaq: HGSI ) today announced that GlaxoSmithKline (NYSE: GSK ) has initiated a Phase 3 clinical trial program to evaluate the efficacy, safety and tolerability of Syncria (R) (albiglutide) in the long-term treatm...

Initiation in Biological Products

Goat Anti-BRF2 Polyclonal Antibody, Unconjugated from GeneTex

Description:...he multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. BRF2 is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding prot...
Company:GeneTex

m7G(5)ppp(5)G (Cap Analog) from Ambion

Description:...cells. Thus, it is important to cap in vitro transcripts for microinjection experiments. Cap analog is also used as a highly specific inhibitor of the initiation step of protein synthesis....
Company:Ambion

m7G(5)ppp(5)G (Cap Analog) from Ambion

Description:...cells. Thus, it is important to cap in vitro transcripts for microinjection experiments. Cap analog is also used as a highly specific inhibitor of the initiation step of protein synthesis....
Company:Ambion

Luciferase Luminescent Assay Kit, LucLite from PerkinElmer

Description:... containing transfected cells, seal the plate, shake briefly and measure. The signal obtained with luclite has a linear decay characteristic after an initiation phase of approximately one minute. Luclites long-lived luminescent signal produced is cell type dependent, but is generally stable for up to five hour...
Company:PerkinElmer

APO LOGIX - JC-1 Mitochondrial Membrane Potential Detection Kit from BACHEM

Description:... situ detection of apoptosis and mitochondrial membrane potential. The mitochondrial permeability transition event provides an early indication of the initiation of cellular apoptosis. This process is typically defined as a collapse in the electrochemical gradient across the mitochondrial membrane, as measured ...
Company:BACHEM

Initiation in Biological Definition

Apoptosis

...g tissue or from a cell that is part of the immune system . If a cell's capability of apoptosis is damaged (for example, by mutation ), or if the initiation of apoptosis is blocked (by a virus), a damaged cell can continue dividing without restrictions, developing into cancer . For example, as part of the...

Archaea

... - do not show the typical bacterial features, but are extremely similar to those of eukaryotes . For instance, archaean translation uses eukaryotic initiation and elongation factors, and their transcription involves TATA-binding proteins and TFIIB as in eukaryotes. Several other characteristics also set th...

Genetic code

...don AUG both codes for methionine and serves as an initiation site: the first AUG in an mRNA 's coding region i...s first detected. Translation starts with a chain initiation codon (start codon). But unlike stop codons, these are not sufficient to begin the process; nearby initiation sequences are also required to induce transcriptio...

DNA

... one original and one newly synthesized strand. This is called semiconservative replication . The process of replication consists of three steps: initiation , replication and termination . Mechanical properties relevant to biology Strands association and dissociation The hydrogen bonds b...

Enhancer

...hancer sequence and the other with its promoter . An abstract can be found here .) An enhancer does not need to bind close to the transcription initiation site to affect its transcription, as some have been found to bind several hundreds of thousands base pairs upstream or downstream of the start site....

Genetic code

...don AUG both codes for methionine and serves as an initiation site: the first AUG in an mRNA 's coding region i...s first detected. Translation starts with a chain initiation codon (start codon). But unlike stop codons, these are not sufficient to begin the process; nearby initiation sequences are also required to induce transcriptio...

Initiation in Biological Dictionary

Transcription start site

...erase II in eukaryotes recognizes the start site ... TATA box and the transcription start site . This spacing is characteristic ... ... initiation factor interactions and transcription start site selection ... The Role of Human TFIIB in Transcription Start Site Selection in Vitro an...

TATA box

...Mechanisms of TATA Box -Binding Proteins: DNA Kinking is Stabilized by ... The TATA - box binding protein (TBP) is required for the accurate initiation of ... Next: A Variety of TATA - box Binding Proteins ... ...

Structural gene

...tructural unit of inheritance in living organisms. ... Mouse protein-coding gene Eif2s3x. Represented by 612 ESTs from 166 cDNA libraries. ... initiation factor 2, subunit 3, structural gene X-linked. M. musculus ... operon ( ) n. A unit of genetic material that functions in a coordinated manne...

Stem cell

... Editor. ... MicroRNA 92b Controls the G1/S Checkpoint Gene p57 in Human Embryonic Stem Cells ... ... dark side of stem cells . ... leukemia initiation in stem cells does not necessarily ... All archived Cell Stem Cell articles from a year or more ago are ... Publishes reports of novel re...

Start codon

... TAC and AUG denote sequences of DNA and RNA respectively that are the start codon or initiation codon encoding the amino acid methionine (Met) in eukaryotes and a modified Met (fMet) in prokaryotes. The most common start codon is...

SnRNA

...y other academic journal articles, magazine arti... U1 snRNA Regulates initiation of Transcription in Eukaryotes. ... Figure 4: U1 snRNA stimulates TFIIH-dependent abortive initiation by RNA polymerase II: ... ... of a primary small nuclear RNA ( snRNA )...