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Inhibitors in Medical News

For the Treatment of Rheumatoid Arthritis, Market Share for TNF-alpha Inhibitors Will Decrease Through 2018

Actemra/RoActemra Will Emerge as the Preferred Biological Drug for TNF-Refractory Patients, According to a New Report from Decision Resources WALTHAM, Mass., May 18 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare iss...

SCAI Statement on 'A National Study of the Effect of Individual Proton Pump Inhibitors on Cardiovascular Outcomes in Patients Treated with Clopidogrel Following Coronary Stenting: The Clopidogrel Medco Outcomes Study'

LAS VEGAS, May 6 /PRNewswire/ -- Results of the Clopidogrel Medco Outcomes Study presented today during SCAI's Annual Scientific Sessions found the anti-clotting benefits of clopidogrel (Plavix) may be reduced when taken concurrently with commonly used heartburn medications called proton pump inhi...

Proton pump inhibitors increase risk of heart attacks for patients on common cardiac drug

Patients taking the common cardiac drug clopidogrel following a heart attack are at a significantly higher risk of a recurrence if they are also taking widely used acid-lowering medications called proton pump inhibitors, a new study published online in CMAJ has found ( http://www.cmaj.ca/cgi/rap...

Onyx Pharmaceuticals Acquires Option to License Novel Highly Specific JAK2 Inhibitors From S*BIO

EMERYVILLE, Calif., Jan. 6 /PRNewswire-FirstCall/ -- Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX ) today announced that it has acquired an option to license rights to SB1518, an orally available, potent, and selective inhibitor of Janus Kinase 2 (JAK2), and SB1578, also a JAK2 inhibitor, from S*BIO...

S*BIO Announces Collaboration with Onyx for JAK2 Inhibitors in the North American and European Markets

S*BIO Receives $25 Million Upfront Payment and Equity Investment and Eligible to Receive Additional $525 Million in Option & License Fees and Milestone Payments SINGAPORE, Jan. 6 /PRNewswire/ -- S*BIO Pte Ltd today announced that the company has entered into a Development Collaboration, a...

GlaxoSmithKline and Dynavax Announce Worldwide Strategic Alliance : – Developing First-in-Class Endosomal TLR Inhibitors for Autoimmune and Inflammatory Diseases –

GlaxoSmithKline (LSE:GSK) (NYSE:GSK) and Dynavax Technologies Corporation (NASDAQ:DVAX) today announced a worldwide strategic alliance to discover, develop and commercialize novel inhibitors of endosomal Toll-like Receptors (TLRs) for the treatment of immuno-inflammatory diseases. TLRs are key re...

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Inhibitors in Medical Technology

Debiopharm and EPFL Sign Research Project Agreement to Identify Inhibitors of Signalling Pathways Controlling Cell Fate for Cancer Treatment

LAUSANNE, Switzerland, September 2 /PRNewswire/ -- Debiopharm Group (Debiopharm), a global independent biopharmaceutical development specialist focusing on serious medical conditions and particularly oncology, today announced the signature of a research project with the Ecole Polytechnique Fed...

Poniard Pharmaceuticals Licenses Kinase Inhibitors From The Scripps Research Institute

-Successful Collaboration with Scripps Florida and Scripps Research in La Jolla- SOUTH SAN FRANCISCO, Calif., and LA JOLLA, Calif., May 14 /PRNewswire- FirstCall/ -- Poniard Pharmaceuticals, Inc. (Nasdaq: PARD ), a biopharmaceutical company focused on oncology, ...

Ardea Biosciences Presents Preclinical Data Demonstrating Favorable Resistance Profiles for Non-Nucleoside Reverse Transcriptase Inhibitors for the Treatment of Human Immunodeficiency Virus

BOSTON and CARLSBAD, Calif., Feb. 7 /PRNewswire-FirstCall/ -- Ardea Biosciences, Inc. (Nasdaq: RDEA ) today announced that data was presented demonstrating the potent activity of the Company's non-nucleoside reverse transcriptase inhibitor (NNRTI) family of compounds against the human-immunod...

Potent Hepatitis C Virus Inhibitors Show Efficacy and Potential for Once Daily Dosing in Preclinical Studies

Data Presented at the 2nd Annual International Workshop on Hepatitis C Resistance & New Compounds WATERTOWN, Mass., Nov. 1 /PRNewswire/ -- Researchers from Enanta Pharmaceuticals today presented data on novel Hepatitis C protease inhibitors with potent antiviral activity...

Telik Announces Preclinical Data Demonstrating Anti-Cancer Activity of Dual Inhibitors of Aurora Kinase and VEGFR2

PALO ALTO, Calif., Oct. 25 /PRNewswire-FirstCall/ -- Telik, Inc. (Nasdaq: TELK ) reported positive preclinical data from its ongoing program to develop novel small molecule inhibitors of validated cancer targets including aurora kinases and VEGFR2. The data were presented today at the AACR-NC...

Telik Announces Presentation of Preclinical Data on Dual Inhibitors of Aurora Kinases and VEGFR2

PALO ALTO, Calif., Oct. 18 /PRNewswire-FirstCall/ -- Telik, Inc. (Nasdaq: TELK ) announced that preclinical data from its program to develop novel small molecule kinase inhibitors will be presented at the AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics in San Francisco....
Inhibitors in Medical Products

AvantGuard Low Binding Barrier Tips

Description:... through the membrane so the pipettor shaft is protected from carry-over contamination. Tips are certified to be free of RNAse/DNAse and human DNA/PCR inhibitors as well as endotoxins. AvantGard tips are ideal for PCR; preventing carry-over contamination and binding less DNA and Taq to the sides of the tip. Eac...
Company:MIDSCI

AvantGuard Low Binding Barrier Tips, Long Reach

Description:... through the membrane so the pipettor shaft is protected from carry-over contamination. Tips are certified to be free of RNAse/DNAse and human DNA/PCR inhibitors as well as endotoxins. AvantGard tips are ideal for PCR; preventing carry-over contamination and binding less DNA and Taq to the sides of the tip. Eac...
Company:MIDSCI

AvantGuard Low Binding Barrier Tips, Eppendorf

Description:... through the membrane so the pipettor shaft is protected from carry-over contamination. Tips are certified to be free of RNAse/DNAse and human DNA/PCR inhibitors as well as endotoxins. AvantGard tips are ideal for PCR; preventing carry-over contamination and binding less DNA and Taq to the sides of the tip. Eac...
Company:MIDSCI

Angiotensin II

Description:...e determination of Ang II is a helpful tool in monitoring the pharmacological effect and efficiency of a wide variety of angiotensin converting enzyme inhibitors (ACE Inhibitors) or Angiotensin II receptor antagonists as well as for the efficiency of therapeutic approaches in treating congestive heart failure....
Company:Buhlmann Laboratories AG

QIAamp Viral RNA Mini Kit

Features:...ation of high-quality, ready-to-use RNA No organic extraction or alcohol precipitation Consistent, high yields Complete removal of contaminants and inhibitors for reliable downstream applications ...
Company:QIAGEN
Inhibitors in Medical Dictionary

Norepinephrine

... )tetralin ... Learn about taking duloxetine (Cymbalta) to treat fibromyalgia. ... of medications called serotonin and norepinephrine reuptake inhibitors (SNRIs) ... Read more about the prescription drug NOREPINEPHRINE BITARTRATE... norepinephrine bitartrate-injection Index. Glossary. GENERI...

Myelin

...Sclerosis and treatments for the two major causes. ... This bacteria gets inside the myelin sheath. ... Damaged myelin actually has chemical inhibitors that can stop regeneration. At my laboratory, we've been looking at a protein, the myelin -associated glycoprotein ? ... Read about myelin , the...

Lactic acidosis

... ... Lactic acidosis is usually associated with laboratory abnormalities indicating ... Lactic Acidosis . Nucleoside reverse transcriptase inhibitors (NRTIs) ... with hyperlactatemia and lactic acidosis , people taking ... INTRODUCTION A unique form of lactic acidosis can occur in patient...

Histamine

...tors. Mutagenesis studies. Constitutive activity. Future ... Histamine has been shown to have a key physiological role in the control of ... 3.1 inhibitors of histamine release. 3.2 Other agents with antihistaminergic activity ... H2 histamine receptors are found principally in the parietal cells of ....

Hemophilia A

...actor VIII. ... A small percentage of people with hemophilia will develop inhibitors of factor ... Hemophilia A results from a deficiency (lack) of cl...actor VIII. ... A small percentage of people with hemophilia will develop inhibitors of factor ... Hemophilia A - Overview, Hemophilia A is a heredi...

Gastrinoma

...of multiple endocrine neoplasia, a ... Once blood tests diagnose gastrinoma , doctors use several imaging techniques, ... Since proton pump inhibitors came into widespread clinical use, the diagnosis of gastrinoma (Zolling ... of new cases of gastrinoma diagnosed fell by 40 ... ...
Inhibitors in Biological News

New research shows no link between aromatase inhibitors and cardiovascular problems

Berlin, Germany: New evidence has emerged that, contrary to some current fears, aromatase inhibitors (AIs) are not associated with an increased risk of heart problems in women who take them to prevent their breast cancer recurring. In a study presented today (Thursday) at the 6th European Breas...

COX-2 inhibitors significantly reduce risk of cancer

Results from a new, five-year study show that regular use of popular prescription pain relievers may reduce the risk of breast cancer by up to 71 percent and may offer similar benefit in the prevention of prostate, colon and lung cancers. The study findings were released today at the annual meet...

Enzyme inhibitors block replication of SARS virus

The study was conducted by researchers from Scripps Research; the Genomics Research Center, Academia Sinica, Taiwan; and the National Taiwan University. It is being published today in the journal Chemistry and Biology (Vol. 13, No. 3). Chi-Huey Wong is currently the Ernest W. Hahn Chair in Chemis...

Protease inhibitors reach beyond HIV

The immunodeficiency that arises in HIV may be due to excessive programmed cell death of immune CD4 T cells. HIV protease inhibitors (PI) can block programmed cell death in virus-infected T cells in vitro, but have also been shown to induce programmed cell death at higher concentrations. The mechan...

Anthrax inhibitors identified by Burnham team

A collaborative team of scientists led by The Burnham Institute's Maurizio Pellecchia, Ph.D., has identified inhibitors of the anthrax toxin, termed lethal factor ("LF") that could be developed into an emergency treatment for exposure to inhalation anthrax. These findings will be published by the P...

Breast Cancer May Be 'Uniquely Sensitive' To Inhibitors Of PI3K Pathway

"Because up to 75 percent of breast cancer patients have an abnormality in a specific cell signaling pathway, drugs that target different molecules along that pathway may be especially effective for treating the disease, says a researcher from The University of Texas M. D. Anderson Cancer Center." ...

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Inhibitors in Biological Technology

Global Small Molecule Kinase Inhibitors Market to Reach $16.2 Billion by 2015, According to a New Report by Global Industry Analysts, Inc.

GIA announces the release of a comprehensive global report on Small Molecule Kinase Inhibitors market. World market for small molecule kinase inhibitor drugs is projected to reach $16.2 billion by the year 2015. This is primarily driven by the rising interest over the potential of kinase inhibito...

VIA Pharmaceuticals' DGAT1 Inhibitors Featured in American Diabetes Association Poster Presentation

Preclinical Data Reported by Roche at 69th Scientific Sessions SAN FRANCISCO, June 4 /PRNewswire-FirstCall/ -- VIA Pharmaceuticals, Inc. (Nasdaq: VIAP ), a biotechnology company focused on the development of compounds for the treatment of cardiovascular and metabolic disease, announced toda...

Santaris Pharma Delivers Six LNA-Based RNA Inhibitors to Enzon Pharmaceuticals Ahead of Schedule

COPENHAGEN, April 27 /PRNewswire/ -- As a testimony to the strength of Santaris Pharma's efficient Drug Discovery Engine, the Company announced today the completion of the delivery of six cancer target drug candidates to their collaboration partner Enzon Pharmaceuticals. All six drug candidate...

AngioGenex Presents Data on its Id Targeted Anti-Angiogenesis Inhibitors at Two Scientific Conferences

New York, Feb. 3 /PRNewswire-FirstCall/ -- AngioGenex Inc. (OTC Bulletin Board: AGGX.OB) is a New York-based biotechnology company that is pioneering the targeting of Id genes and proteins for the discovery and development of anti-angiogenic drugs to treat cancer. Today the Company announced that ...

Portola Data on Its Novel Syk Inhibitors and Novel Universal Factor Xa Inhibitor Antidote to be Presented at 2008 American Society of Hematology (ASH) Meeting

SOUTH SAN FRANCISCO, Calif., Dec. 3 /PRNewswire/ -- Portola Pharmaceuticals, a biopharmaceutical company developing innovative drugs that provide significant advances in cardiovascular disease, inflammatory disease and cancer, today announced that data related to the Company's series of novel comp...

GlaxoSmithKline and Mpex Pharmaceuticals Form Alliance to Develop Novel Efflux Pump Inhibitors for Use Against Serious Gram-Negative Infections

- Potential to combine compounds with multiple new and existing antibiotics to create a broad offering of anti-infective medicines with activity against drug-resistant organisms - SAN DIEGO and LONDON, June 16 /PRNewswire/ -- Mpex Pharmaceuticals and GlaxoSmithKline (GSK) toda...
Inhibitors in Biological Products

UltraClean Plant DNA Isolation Kit from Mo Bio Laboratories, Inc.

Description:... Removes polysaccharide and phenolic inhibitors of PCR; yields DNA greater than 50 kb in length...
Company:Mo Bio Laboratories, Inc.

HDAC Fluorometric (Blue) Assay Kit from BioVision

Description:... Contains 100 positive controls for effective screening of HDAC inhibitors by fluorometric method....
Company:BioVision

7.5 M LiCl Precipitation Solution from Ambion

Description:...advantages over other RNA precipitation methods in that it does not precipitate DNA, protein or carbohydrates. It is the method of choice for removing inhibitors of translation or cDNA synthesis from RNA preparations. Note, LiCl precipitation may not remove all DNA contamination from total RNA isolations. If th...
Company:Ambion

LabChip 3000 Drug Discovery System from Caliper Life Sciences

Description:...rations-based, so the quality of results exceeds what is achievable in homogenous, well-based assays. No other screening system identifies weak enzyme inhibitors as reproducibly as the LabChip 3000. Diverse Assay Menu A variety of enzymatic and cell-based assays can be performed on a single LabChip 3000 in...
Company:Caliper Life Sciences

Universal Kinase / Phosphatase Fluorescence superquenching Assay Kit, TruLight™ from Calbiochem

Description:... A sensitive and high speed homogeneous assay for the detection of kinase or phosphatase activity and for screening of inhibitors in a high-throughput screening (HTS) format. This kit is based on a fluorescence superquenching technology that does not require antibodies or radioac...
Company:Calbiochem

FAM FLISP™ Lys-CMK Assay Kit from B-Bridge International

Description:... • B-Bridge's FLISP Kits utilize cell-permeable, fluorescently labeled inhibitors of serine proteases (FLISPs) to measure chymotrypsin-like activity in whole living cells. Select from several cell-permeable serine protease inhibitors labeled with either FAM (carboxyfluorescein) or SR101 (sulforhodamine 101)....
Company:B-Bridge International
Inhibitors in Biological Definition

Cancer

...ther examples of drugs that show promise for chemoprevention include COX-2 inhibitors (which inhibit a cyclooxygenase enzyme involved in the synthesis of proi...tury, radically new therapies are only discovered and introduced gradually. inhibitors of tyrosine kinases ( imatinib and gefitinib ) in the late 1990 were cons...

Competitive inhibitor

... acts on the same active site as the normal enzyme substrate . The substrate molecules cannot enter the active site while the inhibitor is there, and inhibitors cannot enter the site when the substrate is there. Characteristic for this mode of inhibition is that increasing the concentration of substrate reduce...

Enzyme

... enzyme as a substrate. After the catalytic reaction, the product is then passed on to another enzyme. The end product(s) of such a pathway are often inhibitors for one of the first enzymes of the pathway (usually the first irreversible step, called committed step ), thus regulating the amount of end product...

Signal transduction

...fic molecule or " ligand " for which they have affinity, and molecules that are even only slightly different tend to have no effect or else to act as inhibitors . Most extracellular chemical signals have affinity for water and are unable to penetrate the oily barrier posed by the membrane that surrounds cel...

Selective serotonin reuptake inhibitor

... Selective serotonin reuptake inhibitors ( SSRIs ) are a class of antidepressants . They act within the brain to increase the amount of the neurotransmitter , serotonin (5-hydroxytrypta...

Synapse

...rate of vesicles also are subject to regulation, as are many other elements of synaptic transmission. The drugs known as selective serotonin re-uptake inhibitors or SSRIs affect certain synapses by inhibiting the re-uptake of the neurotransmitter serotonin . One important excitatory neurotransmitter, acet...
Inhibitors in Biological Dictionary

Transcriptase

...on of a double helix... Reverse transcriptase inhibitors (RTIs) are a class of antiretroviral drug used t...essays, summaries, ... Get Reverse Transcriptase inhibitors in HIV/AIDS Therapy ... Reverse transcriptase ... - New and used books like Reverse Transcriptase inhibitors in HIV AIDS Therapy Infectious Disease 2nd edition...

Topoisomerase

...erases are divided into two structurally and mechanistically distinct topoisomerases: type IA and type IB Topoisomerase inhibitor Topoisomerase inhibitors are agents designed to interfere with the action of topoisomerase enzymes [ 1 ] ( topoisomerase I and The different roles of DNA topoisomer...

RT-PCR

...AccessQuick™ RT - PCR System saves you four pipetting steps ... cDNA Synthesis Reverse Transcriptases Reverse Transcription Systems RT - PCR RNase inhibitors ... Methods, protocols, techniques, tutorials and other information for biomedical students ... One-tube RT - PCR reaction mixes are supplied by ...

RNase

... Part Two - Total Exposure: Expanded Model for RNase L Fragmentation in CFS Uncovered; The National CFIDS Foundation Announces the Use of Elastase inhibitors as a ... Since this fragment competes with the native RNase L protein for free 2-5A, it ... Interestingly, for this patient, the RNase L rati...

Reverse transcriptase

...so helps in the formation of a double helix... Reverse transcriptase inhibitors (RTIs) are a class of antiretroviral drug used to treat HIV infection, tu...cribe ... reverse transcriptase inhibitor, reverse transcriptase inhibitors ... Reverse transcriptase genes are present in the eukaryotic organisms...

Proton pump

...or other subcellular compartment. Proton pump inhibitors (or "PPI"s) are a group of drugs whose m...gastric acid production. They are the most potent inhibitors of acid secretion available today. The group... Proton pump inhibitors (PPIs) are a group of medications that prevent the...
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