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Inhibited in Medical News

Research Study Shows That Pharmaceutical Field Sales Reps' Productivity Inhibited by Unnecessary Internal Communication

CHAPEL HILL, N.C., May 28 /PRNewswire/ -- Best Practices, LLC launched this research study exclusively for the Pharmaceutical industry to help companies build more effective communication practices in the sales force. The two-pronged research approach, benchmarking surveys with leading pharmac...

Durability of dental fillings improves if the enzyme activity of teeth is inhibited

Composite dental fillings have one problematic feature, in that the bond between the filling and the dental tissue deteriorates over time in fact, sometimes by as much as 50 per cent in one year. As the bond deteriorates, it may allow bacteria to enter and this brings a high risk of further tooth...

Super Chow, Laced With Semi-Synthetic Vitamin E, Inhibited Spread of Cancer

A chemically altered form of vitamin E mixed into mouse chow dramatically reduced spread of aggressive mammary cancer in mice//, suggesting that the compound in pill form could be used to treat human metastatic cancer, according to a report in the October 1 issue of the journal Cancer Research. ...

Men Around the World Seek Cosmetic Surgery

...ne with obesity rates. Some scientists blame high levels of the female hormone oestrogen in food and drink for accentuating the problem. Men feel most inhibited by the condition in summer months, when they would normally remove clothing in hot weather or when swimming. According to the British Associati...

JNCI news brief: Antibody linked to chemotherapy drug inhibits ovarian cancer in lab

... ovarian cancer cell lines, where it bound to cells with high levels of EphA2 but not to those without the protein. In mice, the EphA2 immunoconjugate inhibited tumor growth by 85%󈟎% compared with that in mice treated with a control immunoconjugate, a highly statistically significant difference. In cel...

MEK4, genistein and invasion of human prostate cancer cells

...n had the opposite effect. Computer modeling showed that genistein could bind to the active site of MEK4, and an enzymatic assay showed that genistein inhibited MEK4 kinase activity. The MMP-2 transcript level was statistically significantly higher in normal prostate epithelial cells, which are target cells fo...
Inhibited in Medical Technology

Data Demonstrated ACTEMRA(R) (tocilizumab) Significantly Inhibited Progression of Structural Joint Damage in Rheumatoid Arthritis Patients

- Additional data reinforce long-term efficacy of ACTEMRA across a broad range of rheumatoid arthritis patient populations - NUTLEY, N.J., June 9 /PRNewswire/ -- One-year data from the two-year Phase III LITHE (Toci LI zumab Safety and THE Prevention of Structural Joint Damage) study de...

New Study Demonstrated ACTEMRA(R) (tocilizumab) Inhibited Progression of Joint Damage in Rheumatoid Arthritis Patients

- One-year study results showed improved physical function in patients treated with ACTEMRA - NUTLEY, N.J., Oct. 25 /PRNewswire/ -- One-year data from a two-year Phase III study demonstrated that ACTEMRA(R) (tocilizumab) significantly inhibited the progression of structural joint damage in p...

Cystic Fibrosis - Liposomal Tobramycin Receives Second Orphan Drug Designation Within Weeks

...mes(TM) is released into the bacterial cell. Additionally, our data indicate that bacterial rescue mechanisms that pump tobramycin out of the cell are inhibited by the fusion process. The efficient delivery and maximum release of tobramycin into the bacterial cell together with inhibition of the clearance mech...

Two-Year Data Reinforce Effect of ACTEMRA(R) (tocilizumab) in Inhibiting Progression of Joint Damage and Improving Physical Function in Rheumatoid Arthritis Patients

...meet its primary endpoints in patients with moderately to severely active RA. "The one-year LITHE results demonstrated that ACTEMRA significantly inhibited the progression of structural joint damage, which is a major cause of disability and loss of physical function for RA patients," said Kenneth Bahrt, M...

Data Presented at AACR Annual Meeting Show Anti-Tumor Activity of Peregrine's Fully Human Anti-PS Antibody in Prostate Cancer Model

...otential of Fully Human Anti-PS Antibodies and Expand the Company's PS-Targeting Platform- -Treatment with Mouse Equivalent to the Human Antibody inhibited Tumor Growth in a Prostate Cancer Model by More than 90%- DENVER and TUSTIN, Calif., April 22 /PRNewswire-FirstCall/ -- Peregrine Pharmaceuticals...

Research Finding Could Revolutionize Asthma Treatment

...r, Dr. Richard Bond, and his colleagues demonstrated the absence of asthma-like symptoms in laboratory mice that do not have the very receptor that is inhibited by beta blockers. This finding was in agreement with earlier studies by Bond and his colleagues showing that low doses of beta blockers improved asth...
Inhibited in Medical Products

ACTH RIA Test

Description:...rs, including catecholamines and cytokines, may also play an important role in ACTH secretion. Both CRF and ACTH production and secretion are directly inhibited by glucocorticoids [1,2]. ACTH stimulates adrenal steroidogenesis, mainly cortisol production, but also aldosterone and adrenal androgen synthesis. De...
Company:Diagnostic Systems Laboratories, Inc.

VerifyNow IIb/IIIa Assay

Description:...tion well. The instrument uses light transmittance to measure the rate at which this clearing occurs. If the GP IIb/IIIa receptors on the platelet are inhibited by abciximab or eptifibatide, there will be minimal binding of the microbeads with activated platelets, since the GP IIb/IIIa receptor sites are block...
Company:Accumetrics
Inhibited in Medical Dictionary

Proliferation

...F) Proliferation Resistance & Physical Protection (PRPP) Working Group ... et al., Approaches to Evaluation of Proliferation ... Nebivolol inhibited accelerated haCSMC proliferation even in the presence of ... This involves proliferation , chemotactic migration into the intimal layers of ... ...

Orgasmic dysfunction

...asm, or has ... Women with orgasmic dysfunction that is not due to another condition often do ... Orgasmic dysfunction . Alternative Names: inhibited sexual excitement; Sex ... Primary orgasmic dysfunction , wherein the woman has never experienced an orgasm, ... The symptom of orgasmic dys...

Melatonin

...tion? ... All about Melatonin . View complete and up to date Melatonin information - part of the Drugs.com trusted ... Melatonin secretion is inhibited by environmental ... Melatonin is used to ease insomnia, combat jet lag, boost the immune system and extend life. ... The use of melatonin i...

Insulin C

... R e c a s t. 2 0 0 8 R E S O U R C E G U I D E. RG12. Insul ... ... uptake of vitamin C (ascorbic acid, ASC) is promoted by insulin and inhibited by ... OF VITAMIN C UPTAKE BY GLUCOSE AND INSULIN . TOP. ABSTRACT ... Insulin not only moves glucose into the cells, but it also escorts Vi...

Hiccups

... (singultus) can be caused by many central and peripheral nervous system ... Additionally, they point out that hiccups and amphibian gulping are inhibited by ... What are hiccups ? Hiccups occur when a spasm contracts the diaphragm, a large ... While very rare, intractable hiccups can cause exh...

Delayed ejaculation

...ed ejaculation ... With some men, delayed ejaculation happens nearly every time ... Delayed ejaculation (DE) Retarded ejaculation (RE) inhibited ... ' delayed ejaculation ? ... cause of retarded or delayed ejaculation is side effects from ... ...
Inhibited in Biological News

La Jolla Institute discovers novel tumor suppressor

...f tumors including lymphomas and some carcinomas." Dr. Kawakami said this surprising occurrence suggested that PLC-beta 3 acted as a safeguard that inhibited the development of a variety of tumors. He and his team set out to investigate further, choosing to focus specifically on myeloproliferative disease ...

Parasites ready to jump

...have evolved. For instance, in the germ cells, which are required for reproduction, the system of so-called piRNAs ensures that transposon activity is inhibited but only if these RNAs are transmitted from the mother. Disruption of this system usually leads to a drastic reduction in the fertility of the progen...

UCSF researchers identify new drug target for Kaposi's sarcoma

...ed a library of 182 compounds that it had specifically and rationally designed to mimic the protease interface. The work identified six molecules that inhibited the Kaposi's sarcoma virus protease activity by at least 50 percent, including one that was highly potent. That discovery potentially opens myriad ...

Noise pollution negatively affects woodland bird communities, says CU-Boulder study

...o be 32 percent more common in the quiet areas, perhaps in part because some of their vocalizations were in the same range as the compressor noise and inhibited communication. Since scrub jays frequently carry, eat and cache pine nuts and disperse them throughout Southwest woodland areas, a decrease in sc...

Study by NTU professors provides important insight into apoptosis or programmed cell death

...dy which removes perhaps a million cells a second. According to Professor Li, they discovered that during apoptosis, the cell's rescue mechanism is inhibited when certain proteins (i.e. 'anti-factors' that are necessary to keep a cell alive) are no longer able to enter the cell's nucleus, thus stopping the ...

GUMC discovery highlights new direction for drug discovery

...nd they called YK-4-279. In this study, they tested YK-4-279 in two different animal models of Ewing's sarcoma and found that the agent significantly inhibited the growth of tumors. There was an 80% reduction in the growth of treated tumors compared to untreated tumors. Toretsky says that while the agent ...
Inhibited in Biological Technology

Prospect Therapeutics, Inc.'s GCS-100 Inhibited Blood Vessel Formation in a Variety of Cancer Models

WELLESLEY HILLS, Mass., May 26 /PRNewswire/ -- Joseph F. Finn, Jr., C.P.A. ("Finn"), announced today that there has been promising initial interest from pharma companies in the intellectual property of Prospect Therapeutics, Inc. ("Prospect"). In preclinical studies, GCS-100 inhibited blood v...

Lethality of H1N1 Influenza Virus Increasing According to Latest Analysis of Virus Peptide Genomic Data

...kin Lethality Gene have been found to act independently in all common influenza strains in human, swine, and bird hosts, both of these genes have been inhibited by the Two-Punch(TM) vaccine system -- designed to be concurrently directed at both genes. The company recently announced that it has made availa...

Telik Reports Preclinical Results at AACR Annual Meeting

...elease an activation byproduct known to be associated with toxicity of other alkylating agents (acrolein). Key findings: TLK58747 inhibited the growth of nine established cell lines of various tumor types and retained its effectiveness against cancer cell lines resistant to standard cancer...

VisEn Launches Next-Generation Fast ('Fluorescence Activatible Sensor Technology') Agent Platform for Expanded Performance in Imaging Disease Biomarkers In Vivo

...iomarker for therapeutic activity, which was closely associated with tumor progression", said Dr. Peterson. Both of the chemotherapeutics in the study inhibited the MMPSense 750 FAST signal in tumors by 88% and 70%, respectively (p=0.0042 and 0.026) only one day after beginning the treatment, at a time whe...

Bionovo Announces Publication of Data on Active Compound and Mechanism of Action for Its Preclinical Cancer Treatment, BN108

...ound from BN108 that is responsible for the selective activity of BN108 towards breast cancer cells. BN108 and TAIII rapidly and selectively inhibited major pro-survival cellular pathways that are often over-active in breast cancer. "Currently available treatments for advanced ...

Novel CU-Boulder technique shrinks size of nanotechnology circuitry

...n added a second ultraviolet laser focused into a halo, or donut, which surrounded the blue light. The special monomer formulation was designed to be inhibited by the UV light, shutting down its transformation from a liquid to a solid, he said. This "halo of inhibition" prevented the edges of the spot or lin...
Inhibited in Biological Products

PPase-2A from Promega

Description:...ynthesis, mitosis and glycogen metabolism. PPase-2A is stimulated in vitro by basic proteins such as protamine, histones and polylysine. The enzyme is inhibited by several environmental toxins and tumor promoters such as okadaic acid and microcystin-LR. The chemically synthesized phosphopeptide, RRA(pT)VA (ava...
Company:Promega

Anti-Heat Shock Protein 75 (hsp75) (TRAP-1) Ab-2 Monoclonal Antibody, Unconjugated from Lab Vision

Description:...of Hsp90 alpha and beta, Grp94, and Trap-1 (Hsp75). It was found that human TRAP-1 is localized to mitochondria and exhibited ATPase activity that was inhibited by both geldanamycin and radicicol indicating that TRAP-1 has functions that are distinct from those of hsp90. It was also found that TRAP-1 had a bio...
Company:Lab Vision
Inhibited in Biological Definition

Active site

...he structure and chemical properties of the active site allow the recognition and binding of the substrate . The active site in many enzymes can be inhibited or suppressed by the presence of another molecule. There are three primary modes of inhibition. In competitive inhibition , the active site itself is...

Digestion

... the gastric glands to secrete pepsinogen and hydrochloric acid . Secretion of gastrin is stimulated by food arriving in stomach. The secretion is inhibited by low pH . Secretin - is in the duodenum and signals the secretion of sodium bicarbonate in the pancreas and it stimulates the bile secr...

Electron transfer chain

...loosely associated with the inner mitochondrial membrane, and transfers electrons between Complexes III and IV. The electron transfer chain can be inhibited by various poisons . Among them we can cite carbon monoxide , cyanide , azide , antimycin , amytal and rotenone . See also: cytochrome ...

Enzyme

...sting themselves as they become more concentrated unless their activity is inhibited somehow; in a similar vein, purifications of other enzymes that begin with...ll often result in loss of the enzyme being purified unless the protease is inhibited or inactivated. See also List of enzymes References K...

Hormone

...atic regulation of hormones depends, apart from production, on the metabolism and excretion of hormones. Hormone secretion can be stimulated and inhibited by: Other hormones ( stimulating or releasing -hormones) Plasma concentrations of ions or nutrients, as well as binding globulins Neurons an...

Insulin

...s (most prominently glucagon from Islet alpha cells) forces release of glucose into the blood from cellular stores. The release of insulin is strongly inhibited by the stress hormone adrenalin (epinephrine). Signal transduction There are special transport channels in cell membranes through which g...
Inhibited in Biological Dictionary

Sense strand

...terminal cap moiety at ... ( A) Base pair homology comparison of 736 siRNA sense strand with TNFR1 mRNA. ... 736 SENSE STRAND ACTIVITY IS inhibited BY CHEMICAL AND SEQUENCE MODIFICATION ... ...

Pre-mRNA

...me-wide survey of human alternative pre - mRNA splicing with exon junction microarrays. ... snRNAs to the pre - mRNA might be enhanced or inhibited by the presence of short ... an unclassified pre - mRNA sequence by computing the posterior probability that each ... Antisense RNA inhibits...

Polynucleotide Kinase

...10x reaction buffer. Alkaline Phosphatase, shrimp; ... T4 Polynucleotide Kinase is also a 3'-phosphatase. ... · T4 polynucleotide kinase is inhibited by phosphate and ammonium ions. ... T4 Polynucleotide Kinase . BioChain. 500 units. Inquire. Inquire ... Biomolecule Products : Polynucleotide ...

Olfactory nerve

...nerve fiber. ... The transection of the olfactory nerve fibers was confirmed with a ... The olfactory nerve transection also significantly inhibited the accumulation of ... Cranial Nerve I ( Olfactory Nerve ) The primary neuron is the neurosensory cell that is in the olfactory epitheli...

Intergenic region

...are ... The length of the intergenic region increases with the number of 5' ends on the ... Depurination within the intergenic region alone inhibited the binding of the ... Effect of depurination within the intergenic region on replicase binding ... Weak 2 bp periodicity of AT and TA is also ...

DNA ligase

...talyzes the formation of a phosphodiester ... T4 DNA Ligase is strongly inhibited by NaCl ... T4 DNA ligase overnight at 6°C. Less than 2% of ... The ... phosphodiester bond between ... Inhibitors: T4 DNA Ligase is strongly inhibited by NaCl or KCl if the ... What is DNA ligase ? Meaning of DNA liga...
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