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Inducible in Medical News

Bellicum Pharmaceuticals Announces Initiation of Phase I/II Clinical Trial of Novel Vaccine for Patients With Advanced Prostate Cancer

...activated at an optimal time and location in the body. It is produced by genetically modifying autologous antigen-loaded dendritic cells to express an inducible costimulatory CD40 (iCD40) receptor. Twenty-four hours after intradermal administration, these genetically modified dendritic cells are activated in d...

Human cells secrete cancer-killing protein, UK study finds

...ctivity. One molecule, known as TRAIL, also exerts cancer-cell-specific effects. However, Rangnekar's most recent study discovered that apoptosis inducible by TRAIL is dependent upon extracellular Par-4 signaling via cell surface GRP78. Thus, the researchers conclude, Par-4 activates a novel pathway invo...

Estrogen linked to lowered immunity in fish

...s iron." The study, Identification of centrarchid hepcidins and evidence that 17β-estradiol disrupts constitutive expression of hepcidin-1 and inducible expression of hepcidin-2 in largemouth bass ( Micropterus salmoides ), was just published in the journal, Fish & Shellfish Immunology . The authors a...

Stem Cell Study Offers Hope for Targeting Tumors

...RAIL effective at killing cancer while sparing healthy cells. "This is the first study to demonstrate a significant reduction in tumor burden with inducible TRAIL-expressing MSCs in a well-controlled and specifically directed therapy," the authors, Dr. Michael Loebinger and Dr. Sam M. Janes of the Centre f...

Recent developments at Burnham Institute for Medical Research, May 2009

...flammation causes harm. One of the key mediators of the inflammatory response is the T-cell. The T-cell is activated by a protein called Interleukin-2 inducible T-cell kinase (ITK). Recently, Dr. Gregory Roth and colleagues, in collaboration with a chemistry group at Boehringer-Ingelheim Pharmaceuticals, Inc.,...

Genetic variants predict recurrence of bladder cancer, patient survival

...e rate is around 50 percent over four years. In this study of 596 patients at M. D. Anderson, 46 percent of those who had a common genotype of the inducible nitric oxide synthase (iNOS) gene experienced a recurrence after receiving maintenance BCG therapy. Only 22 percent of patients with the variant-conta...

Course of West Nile Infection Charted

...ghted in the course of this neurological case that warrant further research for their role in controlling West Nile Virus infection include interferon inducible protein 10 (IP10) and interleukin 13." "The case study also highlights that this strain of the virus, West Nile virus lineage 2, which is endemic ...

Electroacupuncture protects acetylsalicylic acid-induced acute gastritis in rats

...ID-induced ulceration group, and NO levels were also significantly increased in the EA group as compared to the NSAID-induced ulceration group. The inducible expression of COX-1 in the early phase and COX-2 in the late phase suggests that EA pretreatment might up-regulate the mucosal defense mechanism. The ...

LSUHSC research may benefit diabetes by increasing understanding of how to control islet cell growth

...ranscription factor a protein that binds to specific sequences of DNA and controls the target gene expression or action. The researchers developed an inducible system to "turn on" INSM1 in pancreatic cancer cells and found that it resulted in a significant reduction in the cells' growth rate. They showed that...

Inflammation in colon may get doused before fueling cancer development

...rst is a routine protein that the body expresses all the time, she said. But the second Cox has implications in a lot of diseases. "Cox-2 is an inducible protein that is expressed in the body when there is some kind of external stimulous to a cell. We think of high levels of Cox-2 as being a bad thing."...
Inducible in Medical Technology

In Blood Vessel Stents, Innovative Materials Allow Better Control, Delivery of Gene Therapy

...stomize the materials to allow peak release of the vector when it can have the maximum benefit." The adenovirus vector carries genes that code for inducible nitric oxide synthase (iNOS), a protein that controls cell damage in blood vessels. In the current study, the iNOS reduced restenosis by 56 percent in...

Exelixis Presents Encouraging Phase 1 Data For XL019, A Novel Selective Inhibitor of JAK2

...continues. About JAK2 and XL019 JAK kinases are activated by cytokines and growth factor receptors and phosphorylate members of the STAT family of inducible transcription factors. JAK2 plays a pivotal role in the cellular response to growth factors that drive blood cell expansion, including erythropoietin ...

AVEO Pharmaceuticals Novel Oncology Research Platform and Clinical Pipeline to Be Featured at AACR

...el" - Poster Session: Mouse Models in Cancer - Section 23, Board 28 -- Monday, April 16, 2007 at 1:00 p.m. to 5:00 p.m. "Directed complementation of inducible tumor models: An approach to generate broad panels of tumors with defined genetic contexts" - Poster Session: Mouse Models of Cancer - Section 22, Boa...

AVEO Presents Preclinical Efficacy Data on AV-412, a Novel Oral Tyrosine Kinase Inhibitor of EGFR/HER2 for EGFR Mutant and Drug-Resistant Lung Cancer

...October." To provide robust models for translational research supporting the development of novel agents for lung cancer, AVEO generated a series of inducible mouse lung cancer models using AVEO's Human Response Prediction(TM) Platform. Using this proprietary platform, AVEO generated several different models...

Phase 2 Results for EntreMed's Panzem NCD Brain Cancer Study Presented at ASCO

...is (programmed cell death), tumor cell cycle inhibition at the G2/M phase of mitosis, and disruption of angiogenesis through the inhibition of hypoxia inducible factor-1 alpha (HIF-1alpha), a protein required for angiogenesis and cell survival under stress. By these mechanisms, Panzem(R) has the potential to a...
Inducible in Medical Definition

Proteopathy

...osure of a host organism to purified prion protein in a disease-causing conformation. [7] [8] There is now evidence that other proteopathies are inducible by a similar mechanism, including AA amyloidosis, apolipoprotein AII amyloidosis, and Aβ amyloidosis. [9] [10] In all of these instances, an a...
Inducible in Biological News

Stem cell research: From molecular physiology to therapeutic applications

... cells to create mouse models for testing HIV and hepatitis C vaccines. Professor Deng has written a summary of recent progress in human embryonic and inducible pluripotent stem cell differentiation into functional pancreatic islet cells and discusses the challenges for future work[3]. Professor Qi Zhou is a...

Protein regulates movement of mitochondria in brain cells

...ted mitochondrial movement regulator (HUMMR), is produced in a state of low oxygen called hypoxia. HUMMR is induced by another protein called hypoxic inducible factor 1 alpha (HIF-1) which is responsible for triggering several processes in the cell that help it function in a low oxygen environment. The p...

A new gene trigger for pregnancy disorder identified

...nterestingly, this enzyme contributes to the breakdown of estrogen into 2ME (2-methoxyestradiol), a metabolite that suppresses the activity of hypoxia inducible factor protein, explains Kalluri. We wondered if, in cases of preeclampsia, COMT was not functioning properly. In support of this hypothesis, we found...

UIC scientists discover how some bacteria survive antibiotics

...sence of the antibiotic in the ribosomal tunnel, and in response, switch on genes that make them resistant to the drug, Mankin said. The phenomenon of inducible antibiotic expression was known decades ago, but the molecular mechanism was unknown. Mankin and his team of researchers -- Nora Vazquez-Laslop, as...

Carnegie Mellon researchers to develop new drug delivery system

...ly engineer them from outside the body and then re-implant them and remotely control their actions in non-invasive ways. By using inducible gene expression, we hope to provide physicians with external control over capsule degradation and the amount of therapeutic enzyme released into the b...

High blood pressure, low energy -- a recipe for heart failure

...y is needed. When a heart cell finds itself short on energy, say because it's being called on to contract harder or faster, its ERR is activated by an inducible co-activator called PGC-1, turning on genes that increase the heart's capacity to burn fats for fuel. In mice that lacked ERR alpha and that were ex...

Wheat can fatally starve insect predators

..."We're finding compounds like this chitin-binding lectin that don't cost the plant much to produce, unlike producing poisons and stronger walls. Those inducible defenses use a lot of a plant's energy that could be used toward growth and reproduction." The scientists currently are looking for regulatory re...

Mussels evolve quickly to defend against invasive crabs

... crushing their shells. Freeman looked at the inducible defense ?shell thickening ?of blue mussels (Mytliu...reeman describes them as "more worldly" ?expressed inducible shell thickening in the presence of Hemigrapsus. "The mussel's inducible response to H. sanguineus reflects natural selecti...

UCLA scientists uncover mechanism of response to targeted therapy

...Lindau (VHL) were more sensitive to the growth inhibitory effects of CCI-779. One of the main functions of VHL is to regulate a protein called hypoxia inducible factor (HIF). When patients lost VHL, they had high levels of HIF. Thomas said the cancer cells became dependent on HIF to grow, so high levels of the...

Bare metal stents deliver gene therapy to heart vessels with less inflammation in animal studies

...l stents, compared to control animals with conventional, polymer-coated stents. The researchers used a therapeutic gene that encodes for a protein, inducible nitric oxide synthase (iNOS), in the carotid artery studies, because of iNOS's ability to control cell damage in blood vessels. "However, in further s...
Inducible in Biological Technology

Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in Mammalian Cells

complete control system for inducible mammalian expression Denise Wyborski Peter Vaillancourt Stratagene The complete control mammalian expression system allows tight control of gene expression in a wide range of mammalian cell types. ...

Oncothyreon appoints Diana Hausman as Vice President of Clinical Development

...f cancer drug development will be very important as we prepare to move both PX-866, our inhibitor of PI-3 kinase, and PX-478, our inhibitor of hypoxia inducible factor 1-alpha, into Phase 2 trials. We are delighted to have her join our team." "I am very pleased to join Oncothyreon at this particular time in ...

Clontech Laboratories, Inc. Releases the Xfect(TM) and Xfect(TM) Stem Transfection Reagents

...ivery systems and vectors for Tet-On(R) Advanced- and ProteoTuner(TM)-based inducible expression." Researchers recognize that effective, nontoxic DNA trans...y construction kits; the innovative In-Fusion(TM) cloning system; Tet-based inducible gene expression systems; and a range of Macherey-Nagel nucleic acid purific...

MedImmune Presents Data Highlighting its Progressive Inflammatory Disease Portfolio at the 72nd Annual Meeting of the American College of Rheumatology

...ways - Brandon Higgs, Ph.D., Tuesday, October 28 from 9:00 a.m. - 11:00 a.m. in Hall A, Abstract: 1340 -- Memory T lymphocytes expressing the inducible costimulator (icos) are required to maintain the secondary lymphoid tissue architecture in non human primates - Gianluca Carlesso, Ph.D., Tu...

Oncothyreon announces prioritization plan for development programs

...w us to move both programs into Phase 2 development." About PX-478 PX-478 is a novel small molecule compound that inhibits the activity of hypoxia inducible factor (HIF)-1 alpha, a component of the transcription factor HIF-1 that controls the expression of a number of genes important for growth and surviva...

Oncothyreon's PX-478 is effective in preclinical model of human lung cancer

...ter, Houston. Oncothyreon's PX-478 is a small molecule inhibitor of hypoxia inducible factor (HIF)-1 alpha currently in a Phase 1 trial in patients with advanced...78 is a novel small molecule compound that inhibits the activity of hypoxia inducible factor (HIF)-1 alpha, a transcription factor that controls the expression o...

Clontech Laboratories, Inc. Releases the ProteoTuner(TM) Systems

... the ProteoTuner systems to its extensive collection of gene and protein control systems, which include the Tet-On(R) Advanced and Tet-Off(R) Advanced inducible Gene Expression systems for gene expression control and the Knockout(TM) RNAi systems for mRNA knockdown. Each of these three systems has particular, ...

Oncothyreon highlights corporate and clinical objectives for 2008

... the second half of 2008. PX-478 is a small molecule inhibitor of hypoxia inducible factor-1a (HIF-1a), a component of a transcription factor that is an import...xin (Trx-1), a protein that regulates many other proteins including hypoxia inducible factor (HIF)-1 alpha, vascular endothelial growth factor (VEGF) and activat...

Exelixis Sells 80% Stake in Artemis to Taconic

...atform include knock out and "humanization" platforms and platforms for generating inducible/reversible RNAi knock down models and ASKA models for the inducible and reversible knock down of kinases. These platforms are being continually expanded, most recently with the addition of mouse models humanized for ke...

New Automated Yeast Cell Counter Ends Tedium & Errors of Manual Counting

...e to perform rapid and accurate cell counts. Monitoring the cell count during a fermentation run allows the scientist to activate inducible systems, or harvest at optimal times for the best product yield. The NucleoCounter YC- 100 can provide a fast and accurate DNA-based volumetric cell c...
Inducible in Biological Products

GenoStat Inducible Expression System from Upstate

Description: The GenoStat Inducible Expression System provides tightly regulated control of exogenous gene expression in mammalian cells and is capable of repeated on/off expression kinetics. This degree of control is mediated by the highly specific interaction between the GenoStat Ligand and the chimeric bipar...
Company:Upstate

MaV203 Competent Yeast Cells Library Scale from Invitrogen

Description:...GAL4-based two-hybrid systems. The strain also has leu2 and trp1 mutations for selection of ProQuest bait and prey vectors. MaV203 contains three GAL4 inducible reporter genes, providing four phenotypes, for easier identification of true interactors (Figure 2). The MaV203 competent cells feature: Transfor...
Company:Invitrogen

MaV203 Competent Yeast Cells Subcloning Scale from Invitrogen

Description:...GAL4-based two-hybrid systems. The strain also has leu2 and trp1 mutations for selection of ProQuest bait and prey vectors. MaV203 contains three GAL4 inducible reporter genes, providing four phenotypes, for easier identification of true interactors (Figure 2). The MaV203 competent cells feature: Transfor...
Company:Invitrogen

Mouse Anti-Human HIF-1 beta Monoclonal Antibody, Unconjugated, Clone H1beta234 from Assay Designs/Stressgen Bioreagents

Description:... This antibody detects an ~92 kDa protein corresponding to the apparent molecular mass of the beta subunit of Hypoxia inducible Factor-1 (HIF-1beta) on Western blots....
Company:Assay Designs/Stressgen Bioreagents

IMPACT-CN System from New England Biolabs

Description:... IMPACT (Intein Mediated Purification with an Affinity Chitin-binding Tag) utilizes the inducible self-cleavage activity of engineered protein splicing elements (termed inteins) to purify recombinant proteins by a single affinity column (1-4) (Figu...
Company:New England Biolabs
Inducible in Biological Definition

Molecular biology

...uced. In either case, DNA coding for a protein of interest is now inside a cell, and the protein can now be expressed. A variety of systems, such as inducible promoters and specific cell-signaling factors, are available to help express the protein of interest at high levels. Large quantities of a protein can...
Inducible in Biological Dictionary

Shotgun cloning

...lly for you by GCK3. ... Figure 2.83: Shotgun cloning setup ... Choose Tools > Shotgun Cloning ... General Cloning . General Expression. inducible Protein ... Shotgun Cloning . Sequencing. Shuttle. siRNA (Gene Silencing) Two-Hybrid. Other. Vector Construction ... Shotgun , cloning ,biologi...

Operon

...pedia entries, essays, summaries, research information, and more. ... An operon is a genetic regulatory system found in ... The lac Operon - an inducible system ... This decrease in the complex inactivates the promoter, and the lac operon is turned off. ... The trp Operon - a repressible system. ...

N-terminus

... and the observed N-terminus is shown in parenthesis. ... IMPACT (Intein Mediated Purification with an Affinity Chitin-binding Tag) utilizes the inducible self-cleavage ... C-terminus or N-terminus of the target ... This suggests that the H2B N-terminus might play an inhibitory role in chromatin ...
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