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Iron induces death in tumor cells

Rapid growth of cancer cells and their frequent divisions have their price: Cancer cells need considerably more energy than healthy cells. Their metabolism runs at full speed and requires large amounts of micronutrients, particularly iron. However, high levels of iron in the cell lead to the produ...

Common anesthetic induces Alzheimer's-associated changes in mouse brains

For the first time researchers have shown that a commonly used anesthetic can produce changes associated with Alzheimer's disease in the brains of living mammals, confirming previous laboratory studies. In their Annals of Neurology report, which has received early online release, a team of Mass...

High zinc status in lung cells slows growth and induces DNA damage-induced gene expression

Researchers at the University of Maryland at College Park have discovered that Normal Human Bronchial Epithelial (NHBE) cells cultured in medium with elevated zinc level, at the high end of plasma zinc attainable by oral supplementation, demonstrated inhibition of cell growth, up-regulation of gro...

Intra-arterial combination chemotherapy induces long-term survival for hepatocellular carcinoma

Portal venous tumor thrombus (PVTT) is a crucial factor that can worsen the prognosis of patients with hepatocellular carcinoma (HCC). It often leads to extensive spreading of the tumor throughout the liver, and can increase portal venous blood pressure, resulting in the fatal rupture of esophagea...

Monoclonal Antibody Induces Death in Liver Cancer Cells

Researchers at the University of Pittsburgh School of Medicine have found that a newly available monoclonal antibody has the potential to induce death in liver cancer cells. In a study, the monoclonal antibodies' use demonstrated significantly reduces tumour cell proliferation and surviva...

Cancer Drug Induces HDAC Inhibitor and Enhance Long-term Memory

University of California scientists have found that cancer drug enhances long-term memory and strengthen neural connections in the brain. A protein complex called chromatin causes genomic DNA to compress much like a telephone cord shortens as it coils. When chromatin loosens, genes associa...

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induces in Medical Technology

CIMZIA(R) (certolizumab pegol) Reduces Intestinal Lesions and Induces Endoscopic Improvement in Crohn's Patients

More than 60 percent of moderate to severe patients achieved endoscopic response and more than 40 percent achieved endoscopic remission at Week 10 in data from a 54-week open-label study presented at the American College of Gastroenterology (ACG) Annual Scientific Meeting ORLANDO, Fla., Oct....

Video: Resveratrol-based Nutriceutical (Longevinex(R)) Induces Favorable Changes on Gene Expression in Mouse Heart At Doses 17-320 Times Lower Than Prior Studies

Nutriceutical Shown To Affect 9-Fold More Longevity Genes Than Resveratrol Or A Limited-Calorie Diet Alone - Independent Laboratory Animal Study SAN DIMAS, Calif., July 30 /PRNewswire/ -- Researchers report that a proprietary nutriceutical matrix (Longevinex(R...

Paper in Molecular Cancer Therapeutics Reports that a Novel Combination of Alfacell's ONCONASE(R) and Rosiglitazone Induces a Synergistic Apoptotic Effect in Several Cancer Cell Lines

SOMERSET, N.J., July 21 /PRNewswire-FirstCall/ -- Alfacell Corporation (Nasdaq: ACEL ) today announced that a paper published in Molecular Cancer Therapeutics (2008; 7(7):1871-9) reports that a combination of ONCONASE (ranpirnase) and the thiazolidinedione antidiabetic drug rosiglitazone show...

FAU Receives Patent for Invention Which Induces and Restores Cardiac Muscle Function

Regenerating Damaged Cardiac Tissue Is Significant for the Treatment of Cardiovascular Disease BOCA RATON, Fla., Sept. 21 /PRNewswire-USNewswire/ -- Florida Atlantic University received U.S. patent no. 10/822,496, "Promoting Cardiac Cell Differentiation," based on an invention which induces ...

EntreMed's Aurora Kinase Inhibitor Induces Tumor Regression in Preclinical Models

ROCKVILLE, Md., June 01, 2007 /PRNewswire-FirstCall/ -- EntreMed, Inc. , a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inflammatory diseases, announced the presentation of preclinical results for its Aurora kinase - angiogenesis inhibitor, ENMD-981...

New Review on PROSTVAC(TM) Published by Key Investigators From NCI

...to late stage clinical development that has the potential to extend the lives of people with advanced prostate cancer. Administered subcutaneously, it induces a specific, targeted immune response that attacks prostate cancer cells. Conventional chemotherapy currently used to treat prostate cancer has limited...
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Vasopressin (AVP) RIA Test

Description:...d through activation of cAMP, the effect of AVP is to allow the kidney to reabsorb water and concentrate urine [1]. At high plasma concentrations, AVP induces a generalized vasoconstriction that leads to a rise in arterial blood pressure. A deficiency in AVP secretion or action is a characteristic of polyuri...
Company:Diagnostic Systems Laboratories, Inc.

Ghrelin, Total ELISA Test

Description:...one (1), it also has powerful growth hormone independent effects (2). Administration of Ghrelin peripherally or centrally into the cerebral ventricles induces weight gain in rodents (3) and in humans, Ghrelin levels peak prior to each meal and then fall to lower levels immediately upon feeding. In humans,...
Company:Diagnostic Systems Laboratories, Inc.

Arctic Sun® 2000 Temperature Management System

Description:... The Arctic Sun 2000 represents a new non-invasive approach to therapeutic temperature management. The Arctic Sun System rapidly induces mild hypothermia in those patients who would benefit from therapeutic hypothermia or rapidly reduces temperature in febrile patients. The Arctic...
Company:Medivance

VerifyNow IIb/IIIa Assay

Description:...tion well of the VerifyNow IIb/IIIa assay device contains all of the necessary reagents to perform this analysis. Within the well is an activator that induces the platelet to change the conformation of the GP IIb/IIIa receptor to a form that binds fibrinogen (Iso-TRAP). Additionally, the detection well also ...
Company:Accumetrics

Selecta II Glaucoma Laser System

Description:... fluid output, lowering intraocular pressure. The Selecta II is equipped with a Q-switch that produces a 3-nanosecond high-energy beam of light, which induces the same cell replacement mechanism as traditional argon laser therapy (ALT), but without the burn. The short pulse of the laser does not allow time f...
Company:Lumenis Inc.

Selecta II Glaucoma Laser System

Description:... fluid output, lowering intraocular pressure. The Selecta II is equipped with a Q-switch that produces a 3-nanosecond high-energy beam of light, which induces the same cell replacement mechanism as traditional argon laser therapy (ALT), but without the burn. The short pulse of the laser does not allow time f...
Company:Lumenis Inc.
induces in Medical Definition

Muscle atrophy

...atrophy can be opposed by the signaling pathways which induce muscle hypertrophy, or an increase in muscle size. Therefore one way in which exercise induces an increase in muscle mass is to downregulate the pathways which have the opposite effect. External links MeSH Muscular+atrophy ...
induces in Medical Dictionary

Viral gastroenteritis

.... Up-to-the-minute news coverage of national, regional and international news enhanced with audio and video clips ... of viral gastroenteritis induces vomiting, ... Viral gastroenteritis (VYE-rull gas-tro-en-ter-EYE-tis) is a highly contagious ... Viral gastroenteritis can be caused by ...

Tinea versicolor

...Overview: Tinea versicolor is a common, benign, superficial cutaneous fungal ... In hyperpigmented macules in tinea versicolor , the organism induces an ... tinea versicolor n A fungal infection of the skin caused by Malassezia furfur and characterized by finely desquamating pale tan pa...

Lymphatic obstruction

...ttempted, in some ... In this context, acute cardiac lymphatic obstruction has been found to produce ... Cardiac lymphatic obstruction induces interstitial edema by a mechanism that is ... Cardiac lymphatic obstruction had similar effects on LV function in a group of ... Cardiac ly...

Innate

...ngs is almost innate in us. ... Children do not give up their innate imagination, curiosity, dreaminess easily. ... The TLR5 agonist flagellin induces innate and adaptive immune responses in a ... played distinct roles in the innate response to flagellin, with the ... Defining the Innate ...

Glucose

...ose tolerance tests are one of the tools used to diagnose diabetes. ... This diminished level of blood glucose is recognized by ... Insulin induces the uptake of glucose from the blood into the ... Thus the glucose level of the ... The body has to get rid of this extra glucose and spil...

Granulocyte

...Vancouver, Canada), which stimulates the growth of granulocyte and macrophage colonies. ... AW, Metcalf D. Granulocyte colony-stimulating factor induces ... Ongoing Trials on Basophil granulocyte at Clinical Trials.gov ... US National Guidelines Clearinghouse on Basophil granulocyte ... ......
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Radiation-killed bacteria vaccine induces broad immune response in mice

Vaccines made with bacteria killed by gamma irradiation, rather than by standard methods of heat or chemical inactivation, may be more effective, say researchers supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). Vaccines...

H5N1 avian flu virus vaccine induces immune responses in healthy adults

Results from a clinical trial demonstrate that high doses of an experimental H5N1 avian influenza vaccine can induce immune responses in healthy adults. Approximately half of those volunteers who received an initial and a booster dose of the highest dosage of the vaccine tested in the trial deve...

Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned

Scientists have completed the first human clinical trial of a recombinant vaccine for the deadly toxin ricin ?a potential bioterror threat ?and the results indicate the vaccine is safe and effective in eliciting ricin-neutralizing antibodies, the UT Southwestern Medical Center researchers report. ...

Past experience of pheromones induces dominant courtship behavior in fruit flies

By investigating the interplay between pheromone signaling and behavior in fruit flies, researchers have begun to understand how an adult fly's earlier experience as a young individual can influence its behavior towards other flies as an adult. In particular, the researchers found that pheromone si...

Stress signals link pre-existing sickness with susceptibility to bacterial infection

...metabolic abnormalities that cause these effects also induce a stress signal intended to help the body overcome its energy deficit. The stress-signal induces the production of more mitochondria, the energy generating 'powerplants' of the body, in the hopes that more mitochondria will result in a better powe...

When it comes to brain damage, blankets take the place of drugs

...es or dangerously high fevers are often cooled to reduce their core body temperature to prevent further damage and aid healing. Unfortunately, cooling induces a natural and familiar response - shivering. This shivering counteracts efforts to keep the patient's temperature low, causes physical stress, and is ...
induces in Biological Technology

Novavax Announces Selection of a Respiratory Syncytial Virus Vaccine Candidate for Advanced Preclinical Studies

... the antibody in the body has a limited duration. Therefore, a vaccine that induces long lasting protection against RSV-F would be highly desired by healthcare...st hospitalizations for severe RSV disease, suggesting that a vaccine which induces neutralizing antibody against RSV-F has the potential to be a powerful weap...

PharmAthene's 2nd Generation rPA Anthrax Vaccine, SparVax(TM), Completes FDA Regulatory Strategy Review

...ase II clinical trials involving more than 750 healthy human subjects have been completed and showed that SparVax(TM) appears to be well tolerated and induces an immune response in humans. These studies suggest that three doses of SparVax(TM), administered several weeks apart, should be sufficient to induce...

AEterna Zentaris: New Data Published on its Ghrelin Antagonist Compound, AEZS-123 (JMV2959), Supports its Use in Alcohol Addiction

... About AEterna Zentaris' Ghrelin Antagonist Program Ghrelin is a natural peptide hormone produced by the stomach that increases appetite and induces accumulation of fat tissue. The discovery of ghrelin and its receptors opens up new opportunities for the treatment of obesity and eating disorders th...

PROSTVAC(TM) Data Presented at the ASCO Meeting Demonstrates the Potential for Significant Increases in Life Expectancy in Late-Stage Prostate Cancer

...to late stage clinical development that has the potential to extend the lives of people with advanced prostate cancer. Administered subcutaneously, it induces a specific, targeted immune response that attacks prostate cancer cells. Conventional chemotherapy currently used to treat prostate cancer has limited...

Dendreon Reports First Quarter 2009 Financial Results

...rd therapies. Presented data from the PROTECT (PROvenge Treatment and Early Cancer Treatment) or P-11 Phase 3 study suggesting that PROVENGE induces long-term memory immune responses that are durable and can be maintained following boosting. The results of the study also indicate that CD54 upregul...

First Patient Dosed in Phase I Clinical Trial of Tigris Pharmaceuticals' GGTI-2418

...as started in a Phase I clinical trial of GGTI-2418. GGTI-2418 is a synthetic peptidomimetic inhibitor of geranylgeranyltransferase I (GGTase I) that induces apoptosis by downregulating several pivotal oncogenic and tumor survival pathways. The Phase I study is led by Dr. Peter O'Dwyer, Professor of Me...
induces in Biological Products

Puromycin, Dihydrochloride from Calbiochem

Description:... off-white solid. PROTECT FROM MOISTURE. Protein synthesis inhibitor. Inhibits translation by causing premature release of nascent polypeptide chains. induces DNA fragmentation in thymocytes and in human HL-60 leukemia cells. Purity: ≥98% by TLC. Soluble in H 2 O. RTECS AU7355000, CAS 58-58-2, M.W. 544....
Company:Calbiochem

Rabbit Anti-SKAP55 Polyclonal Antibody, Unconjugated from ABR-Affinity BioReagents

Description:...d ICAM1, colocalize with F-actin at the T cell-antigen-presenting cell synapse and promotes the clustering of LFA1 and TCR ligation. TCR engagement induces the translocation of SKAP55 to lipid rafts, where the interactions with Fyn take place. CD45 also plays a very important role in SKAP55/TCR-mediated ...
Company:ABR-Affinity BioReagents

Rabbit Anti-BMP2 Polyclonal Antibody, Unconjugated from GeneTex

Description:... Rabbit polyclonal to BMP2 BMP2 belongs to the transforming growth factor beta (TGFB) superfamily. Bone morphogenic protein induces bone formation. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva. Immunogen: Synthet...
Company:GeneTex

15(S)-15-methyl Prostaglandin F2alpha from Cayman Chemical

Description:...ically stable analog of PGF2α. It is a potent uterine stimulant and abortifacient which can be administered intramuscularly to induce labor. It induces luteolysis and reduces serum progesterone concentrations when given as an intramuscular injection in non-pregnant rhesus monkeys....
Company:Cayman Chemical
induces in Biological Definition

Allostery

...ubunits are not connected in such a way that a conformational change in one induces a similar change in the others. Thus all enzyme subunits need not exist in ...te of an adjoining protein subunit . The binding of oxygen to one subunit induces a conformational change in that subunit that interacts with the remaining a...

Allostery

...ubunits are not connected in such a way that a conformational change in one induces a similar change in the others. Thus all enzyme subunits need not exist in ...te of an adjoining protein subunit . The binding of oxygen to one subunit induces a conformational change in that subunit that interacts with the remaining a...

Apoptosis

... are not yet well understood; and both Fas and TNF-R1 trigger events that activate the transcription factor nuclear factor kappa B (NF-κB), which induces the expression of genes that play an important role in diverse biological processes, including cell growth and death, development, and immune response...

Diabetes mellitus

...e , and magnesium . Reduced fluid intake from vomiting combined with amplified urination produce dehydration . As the metabolic acidosis worsens, it induces obvious hyperventilation (termed Kussmaul respiration ). On presentation to hospital, the patient in DKA is typically dehydrated and breathing ...

Immune system

... infectious disease , caused by the HIV virus that destroys CD4 + T cells, is an example of the latter. Immunosuppressive medication intentionally induces an immunodeficiency in order to prevent rejection of transplanted organs . On the other end of the scale, an overactive immune system figures in ...

Long-term potentiation

...responses in spinal cord neurones". Nature 309 (5965), 261-3. PMID 6325946 ^ Rogan MT, Staubli UV, LeDoux JE (1997) "Fear conditioning induces associative long-term potentiation in the amygdala". Nature 390 (6660), 604-7. PMID 9403688 ^ Artola A, Singer W (1987) "Long-term pot...
induces in Biological Dictionary

Untranslated region

...re ... 3'UTR RNA from Alpha-Tropomyosin Gene Suppresses Tumor Activity. ... Tropomyosin-2 cDNA lacking the 3' untranslated region riboregulator induces ... Untranslated , region ,biological ,biology dictionary,biology terminology,biology terms,biology abbreviations ... in the 3' untranslated re...

Transformed phenotype

...sms by which the drug suppresses the transformed phenotype . ... of TM-1 induces a transformed phenotype in immortalized cells (20) , suggesting ... ...nduced cells did not show the transformed phenotype . ... ... parva induces a transformed phenotype with characteristics comparable to leukemic cel...

Retrotransposon

...mpiled from comprehensive ... The Ty5 retrotransposon is used as a genetic model to study the architecture and ... Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells ... Jr, Boeke JD: Human L1 retrotransposon encodes a conserved endonuclease required ... inferre...

Gastrin

...lly decreases. ... Information about gastrin in the free online English dictionary and encyclopedia. ... Aphton's anti- gastrin targeted therapy induces antibodies in patients that bind ... ... the gastrin test is used, when a gastrin test is ordered, and what the results of a gastrin test m...

G2 phase

...rmed that the cells were in G1 or G2 phase (data not shown) ... in G1 was as high as 40% while it was less than 5% in G2 phase . ... HIV-1 induces A NEW, G2 - PHASE FORM OF CELL DEATH IN T-CELLS ... of programmed cell death that kills T-cells in the G2 phase of the cell cycle. ... C....

Electron transport chain

... chain accept and release protons along ... Electron transport chain summary with 15 pages of encyclopedia entries, essays, summaries, ... induces Diaphragm Electron Transport Chain Dysfunction and ... Electron transport chain . • Catalyzes a flow of electrons from NADH. to O. 2 ......
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