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Indoleamine in Medical News

Researchers work to boost effectiveness of the flu vaccine

... attention of the immune system, the body also mounts a counter-regulatory response to make sure the fighting doesn't get out of hand. The enzyme, indoleamine 2,3 dioxygenase, or IDO, is part of that response. MCG researchers, led by Drs. Mellor and David Munn, showed in 1998 that fetuses use IDO to avoid re...

IDO2 an active enzyme to target in pancreatic cancer

...chers from Thomas Jefferson University reported at the 2008 Annual Meeting of the Southern Surgical Association. Previous data show that a protein, indoleamine 2,3-dioxygenase (IDO), is overexpressed in pancreatic ductal adenocarcinomas, according to Jonathan R. Brody, Ph.D., an assistant professor in the Dep...

JCI table of contents: June 20, 2008

... to individuals receiving bone marrow transplants and to those with other immune-mediated diseases. TITLE: Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenasedependent DC functions and regulates experimental graft-versus-host disease in mice AUTHOR CONTACT: Pavan Reddy University of Mich...

New strategies work to put cancer on the firing line

...in Immunogenetics, and Dr. David Munn, pediatric hematologist-oncologist, showed in work published in 1998 in Science that fetuses use the enzyme IDO indoleamine 2,3-dioxygenase to locally disable a pregnant womans immune system and avoid rejection. Subsequent studies demonstrated that tumors also use IDO for ...

Tumors use enzyme to recruit regulatory T-cells and suppress immune response

... Immunotherapy Center and Georgia Research Alliance Eminent Scholar in Immunogenetics. Their work published in Science in 1998 showed fetuses use IDO indoleamine 2,3-dioxygenase to locally disable a pregnant womans immune system and avoid rejection. They showed then that one way IDO suppresses the immune respo...
Indoleamine in Biological News

DNA component can stimulate and suppress the immune response

...of CpG increase inflammation, part of the body's way of eliminating invaders. But high doses block inflammation by increasing expression of the enzyme indoleamine 2,3 dioxygenase, or IDO, an immunosuppressor, the researchers say. "The same therapy can have two different effects," says Rusty Johnson, a fifth-y...

JCI table of contents: Aug. 16, 2007

... cells known as plasmacytoid dendritic cells (pDCs) that produce the enzyme indoleamine 2,3-dioxygenase (IDO) and that are isolated from the lymph nodes that drain...ls from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3,-dioxygenase AUTHOR CONTACT: David H. Munn Medical College of Georgi...
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