Navigation Links
Inactivation in Medical News

Stress Protein Inactivation Cuts Alzheimer's Peptide in Mice

While previous studies have already revealed that stress boosts the production of a brain peptide critical to Alzheimers disease, a new study on mice has now shown that blocking a different brain peptide slows the stress-induced increases. The study, reported online in the Proceedings of th...

Germgard's New Room-Temperature Surgical Instrument Sterilizer Achieves Total Cycle Time of Three Minutes

.... The tests employ a single, three-minute cycle, including preparation. The inactivation remains at 100% after 7 days of controlled observation, hence is fully comp...f six minutes total time for lumen devices such as endoscopes and for Prion inactivation on neurological tools. Reduced cycle time and room-temperature steri...

Scientists Track Impact of DNA Damage in the Developing Brain

...st the nervous system. St. Jude researchers then developed a mouse that carried an Xrcc1 gene outfitted with biochemical tags targeting the gene for inactivation by the enzyme. The result was a mouse whose nervous system lacked Xrcc1 and so was unable to efficiently repair the single-strand DNA damage. T...

Animal model for schizophrenia identifies a novel approach for treating cognitive impairments

...ew study in Biological Psychiatry , published by Elsevier, by Dr. Kenji Hashimoto and colleagues may represent a "next step," which is to prevent the inactivation of D-serine by the enzyme D-amino acid oxidase (DAAO). The authors found that this approach enhances the efficacy of D-serine in an animal model for ...

NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development

...p maintain allelic exclusion. In this sense homologous pairing of Ig alleles is analogous to pairing of X chromosomes which has an important role in X inactivation in developing female cells. The data suggest that in parallel with X inactivation, homologous pairing of Ig loci contributes to allelic exclusion by e...

Research reveals molecular pathway behind invasive prostate cancers

...hway key to the development of invasive prostate cancers. In a preclinical study led by Maria Diaz-Meco, PhD, the UC team found that simultaneous inactivation of two particular genesknown as PTEN and Par-4caused the rapid development of invasive prostate cancer tumors in mice. "We knew that independent ...

NYU Langone Medical Center's tip sheet to the 45th Annual Meeting of ASCO

...e growth and progression of human melanoma tumors grafted in mice. The researchers observed in the animals a 72 percent reduction in tumor volume, the inactivation of a key protein that normally promotes melanoma survival and a concomitant 81 percent increase in cancer cells that were programmed to die. The resea...

Patient Convenience Focus of New Upgrades to HeliTrax System by CSL Behring

... a 5.0 mL volume diluent. No albumin is used in the formulation or purification of Helixate FS, and its manufacture includes a solvent/detergent viral inactivation step. Known intolerance or allergic reactions to constituents of the preparation is a contraindication to the use of Helixate FS. Known hypersen...

New oncogene gives valuable insight into hepatocellular tumors in humans

...he researchers searched for possible interaction and cooperation of GP130 activation with other pathways altered in hepatocellular adenoma. HNF1α inactivation and gp130 activation were mutually exclusive in HCA (P ...

Scripps Research cancer biology department awarded more than $8 million in new research grants

... bone marrow but is completed in the thymus, and then attack infectious agents as well as cancer cells. Petrie and his colleagues have discovered that inactivation of Notch3 results in an accelerated, age-related decline in the ability of the bone marrow to replenish T lymphocytes; Notch3 has also been implicated...
Inactivation in Medical Technology

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

...rat immunoglobulin M (IgM), an important gene for rat antibody production. inactivation of rat IgM expression is the first step in generating rats that exclusively...an improved understanding of B-cell development and a novel approach to the inactivation of endogenous antibody expression. The antibody platform is available for a...

Bionovo Announces First Quarter 2009 Highlights and Financial Results

...been identified as an active compound of BN108 that is responsible for BN108's selective cytotoxicity. BN108 and TspA3 induce apoptosis through rapid inactivation of AKT and mTOR kinases in breast cancer cells but not in normal cells. Two additional members joined Bionovo's Scientific Advisory Board, Ja...

CSL Behring Receives Orphan-Drug Exclusivity for RiaSTAP(TM), First and Only Approved Treatment of Acute Bleeding Episodes in Patients with Congenital Fibrinogen Deficiency

...ibrinogen levels and confirm a diagnosis, blood coagulation testing is needed. RiaSTAP is a purified fibrinogen concentrate that undergoes virus inactivation and removal for safety assurance. There have been more than 1 million units sold worldwide (marketed outside the U.S. under the trade name Haemocompl...

Late-Breaking Data Highlighting Research Advances in Several Blood Disorders to Be Presented At the American Society of Hematology Annual Meeting

...with TET2 mutations, which demonstrated that TET2 defects target hematopoietic stem cells. Moreover, they show that in these five patients TET2 inactivation precedes the JAK2 V617F mutation, suggesting that this new molecular lesion could be an early event in cancer stem cell formation. To furt...

Takeda Submits a New Drug Application in the U.S. for Alogliptin (SYR-322) / ACTOS(R) (pioglitazone HCl) for the Treatment of Type 2 Diabetes

...iego, Inc., and is a member of the DPP-4 inhibitors class, which are newer oral agents for the treatment of type 2 diabetes. DPP-4 inhibitors slow the inactivation of incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). The incretins play a major role in regula...

Medarex Announces Allowance of Investigational New Drug Application for Wholly-Owned Fully Human Anti-PD-L1 Antibody, MDX-1105

...ancer. MDX-1105 is a fully human antibody that targets the PD-L1 pathway to promote enhanced T-cell immune responses against cancer and reverse T-cell inactivation in chronic infectious disease. The open-label, multi-dose, dose-escalation Phase 1 clinical trial is expected to enroll up to 46 patients with selec...

New Lacosamide Data Provides Evidence for Long-Term Efficacy in Diabetic Neuropathic Pain

...ode of action and is the first agent of its kind to be clinically studied for the treatment of diabetic neuropathic pain. It selectively enhances slow inactivation of sodium channels and interacts with the neuroplasticity-relevant target -- collapsin-response mediator protein-2 (CRMP-2). Lacosamide is also being ...

Data Presented at AAN Support Potential for Adjunctive use of Intravenous Lacosamide as Short-Term Replacement for Oral Treatment in Partial Epilepsy

...mide has a dual mode of action and is the first agent of its kind to be clinically studied for the treatment of epilepsy. It selectively enhances slow inactivation of sodium channels and interacts with the neuroplasticity-relevant target-collapsin-response mediator protein-2 (CRMP-2). Lacosamide is also being inv...

Data Presented at AAN Show That Lacosamide Significantly Reduced Pain and was Generally Well Tolerated in Patients With Diabetic Neuropathic Pain

...ode of action and is the first agent of its kind to be clinically studied for the treatment of diabetic neuropathic pain. It selectively enhances slow inactivation of sodium channels and interacts with the collapsin-response mediator protein-2 (CRMP-2). Lacosamide is also being investigated for its potential as a...

FDA Accepts Investigational New Drug Application for ARI-2243 and a First in Man Clinical Trial Set to Begin During the First Half of 2008

... no effect with vildagliptin.(3) In addition to the compelling preclinical efficacy, ARI-2243 is functionally selective through a smart, "soft drug" inactivation process. Specifically, ARI-2243 binds rapidly and tightly to DPP-4 and once bound, the complex dissociates very slowly, thereby preventing the degrada...
Inactivation in Medical Products

UV Sterilizing PCR Workstations

Features:...aratus and reagents within minutes with built-in 30-minute timer Control potential PCR contamination with the built-in high intensity UV tubes for inactivation of DNA between experiments The ultraviolet irradiation can be used as a standard laboratory practice to reduce surface and airborne contaminants i...
Company:UVP, Inc.
Inactivation in Medical Dictionary

Antibiotic Resistance

...anisms leading to antibiotic resistance can vary. ... The evolution of antibiotic resistance of any previously susceptible bacterial ... inactivation of the Antibiotic . Penicillinase. Aminoglycoside Resistance . Appendix ... ...
Inactivation in Biological News

Early stage colon cancer characterized by inactivation of gatekeeper gene

The absence or inactivation of the RUNX3 gatekeeper gene paves the way for the growth and development of colon cancer, Singapore scientists report in the Sept. issue of the journal Cancer Cell . Previous studies have shown that RUNX3 plays a role in gastric, breast, lung and bladder cancers. ...

New technique allows targeted inactivation of genes in research model

WORCESTER, Mass. Researchers at the University of Massachusetts Medical School (UMMS) report today on a new technique that improves the ability of scientists to target individual genes for inactivationa technique with broad potential implications for both basic science research and human disease. ...

Scientists track impact of DNA damage in the developing brain

...just the nervous system. St. Jude researchers then developed a mouse that carried an Xrcc1 gene outfitted with biochemical tags targeting the gene for inactivation by the enzyme. The result was a mouse whose nervous system lacked Xrcc1 and so was unable to efficiently repair the single-strand DNA damage. The s...

Scientists discover gene mutation responsible for hereditary neuroendocrine tumor

... are unaffected, suggesting an inheritance pattern that is specific to the parent of origin. The researchers also discovered that, as in yeast, the inactivation of hSDH5 dramatically impaired the activity of the SDH complex, which was decreased by approximately 95% in tumors from three patients with PGL2. ...

Building memories with actin

...e question by dosing slices of rat hippocampus with adenosine, a naturally occurring signal that squelches LTP. Adenosine prevents phosphorylation and inactivation of cofilin, an inhibitor of actin filament assembly, the team found. Cofilin's involvement, in turn, implicates signaling cascades headed by GTPases, ...

Female human embryos adjust the balance of X chromosomes before implantation

...ome in every cell a process known as X chromosome inactivation (or XCI). In mice, XCI occurs before embryo im...ans and, in fact, it was thought that this initial inactivation of the X chromosome before implantation did not ha... Furthermore, our research shows that X chromosome inactivation in humans is not very different from other placent...

The battle for CRTC2: How obesity increases the risk for diabetes

...isrupting this alternative pathway," says Montminy. It had been well established that obesity promotes insulin resistance through the inappropriate inactivation of a process called gluconeogenesis, where the liver creates glucose for fuel and which ordinarily occurs only in times of fasting. Yet, not all obese...

Small RNAs can play critical roles in male infertility/contraception

...that most of genes on the X chromosomes are suppressed. This unprecedented observation implies that these small RNAs have critical roles in chromosome inactivation and also in sperm formation. "The sex chromosome silencing in meiotic male germ cells is a well-known phenomenon, which has been termed...

Potential new herpes therapy studied

... genes, partial corruption of the genetic material is sufficient to shut down virus production, as opposed to "early" genes, which would require total inactivation to hinder the process. "What I think is remarkable with the technology is its versatility you can design ribozymes that will be effective against ...

Jefferson scientists discover a key protein regulator of inflammation and cell death

...s, or by tissue damage. AIM2 also appears to be a tumor suppressor, and its inactivation may play a role in the development of cancer, according to Dr. Alnemri. ...ssor, by killing cells with damaged DNA before they transform into cancers. inactivation of AIM2 thus might confer a growth advantage to abnormal cells and lead to ...
Inactivation in Biological Technology

OMT announces a breakthrough in the development of a novel human antibody platform

...d development options. OMT's human antibody technology is the result of an improved understanding of B-cell development and a novel approach to the inactivation of endogenous antibody expression described in the "Science" article. Previously, it took either embryonic stem cells or nuclear transfer cloning -- ...

DOR BioPharma Announces Issuance of European Patent for its LPM(TM) Oral Drug Delivery Technology

...certain dimension to pass through, excluding extremely large molecules, bacteria and viruses. The reverse micelles also structurally prevent the rapid inactivation of peptides by enzymes in the upper gastrointestinal tract. Other sensitive drugs that can be delivered orally with the LPM(TM) system include various...

Tips from the journals of the American Society for Microbiology

...luding norovirus, by food handlers and care providers," say the researchers. (D.R. Macinga, S.A. Sattar, L. Jaykus, J.W. Arbogast. 2008. Improved inactivation of nonenveloped enteric viruses and their surrogates by a novel alcohol-based hand sanitizer. Applied and Environmental Microbiology, 74. 16: 5047-...

Tips from the journals of the American Society for Microbiology

...luding norovirus, by food handlers and care providers," say the researchers. (D.R. Macinga, S.A. Sattar, L. Jaykus, J.W. Arbogast. 2008. Improved inactivation of nonenveloped enteric viruses and their surrogates by a novel alcohol-based hand sanitizer. Applied and Environmental Microbiology, 74. 16: 5047-...

The human brain minimizes energy expenditure and integrates gravity in to the action plan

...he discovery of this biological rule has resulted from the use of a hypothetical-deductive mathematical method which predicted short periods of muscle inactivation and direction-dependent hand kinematics. These predictions have been verified experimentally using human volunteers. Moreover, they have demonstrated ...

Tips from the journals of the American Society for Microbiology

...luding norovirus, by food handlers and care providers," say the researchers. (D.R. Macinga, S.A. Sattar, L. Jaykus, J.W. Arbogast. 2008. Improved inactivation of nonenveloped enteric viruses and their surrogates by a novel alcohol-based hand sanitizer. Applied and Environmental Microbiology, 74. 16: 5047-...

CSL Behring's Innovative HeliTrax(SM) System Helps Physicians Manage Hemophilia A Patients

... 5.0 mL volume diluent. No albumin is used in the formulation or purification of Helixate FS, and its manufacture includes a solvent/detergent viral inactivation step. The most frequently reported adverse event is local injection-site reaction. Known hypersensitivity to mouse or hamster protein may be a contrai...

Bionovo Reports First Quarter 2008 Financial Results

...tochondrial pathway, and induces cell death only in estrogen receptor negative breast cancer cells. BN108 induces cancer cell death by rapid inactivation of both AKT and mTOR pathways in breast cancer cells, but not in normal cells. -- The Company commissioned and reported results from two indepe...

Bionovo to Present Recent Findings of BN107 and BN108, Its Anticancer Agents, at the American Association of Cancer Research

...hrough the mitochondrial pathway. BN107 induces death only in estrogen receptor negative breast cancer cells. BN108 induces cancer cell death by rapid inactivation of both AKT and mTOR pathways in breast cancer cells, but not in normal cells. "BN107 and BN108 mechanisms of action and unique selective properties...

ProMetic to obtain controlling stake in Pathogen Removal and Diagnostic Technologies Inc.

...s, and Bovine Spongiform Encephalopathy ("BSE"), a newly emergent disease that affects both cattle and humans. Dr. Rohwer's studies on the kinetics of inactivation of the TSE agents have provided the scientific foundation for disinfection guidelines in the U.S. and worldwide. Recently Dr. Rohwer and his laborator...
Inactivation in Biological Products

Sterilizing UV PCR Workstation from UVP

Description:... PCR and other samples by reducing the chance of DNA contamination Control potential PCR contamination with the built-in high intensity UV tubes for inactivation of DNA between experiments The ultraviolet irradiation can be used as a standard laboratory practice to reduce surface and airborne contaminants in ...
Company:UVP

EcoR I from USB Corp.

Description:... Source: Escherichia coli RY 13 5'G AATTC3' 3'CTTAA G5' inactivation Conditions: Heat inactivation at 60C for 15 min or ethanol precipitation. Storage Conditions: 10mM Tris-H...
Company:USB Corp.

Bgl I from USB Corp.

Description:... Source: Bacillus globigii 5'GCCNNNN NGGC3' 3'CGGN NNNNCCG5' inactivation Conditions: Heat inactivation at 60C for 15 min or phenol treatment followed by ethanol precipitation. St...
Company:USB Corp.
Inactivation in Biological Definition

Barr body

...father's X chromosome is always deactivated. The inactivation state of chromosomes is passed on to daughter cell...mitosis. Since random chromosomes are selected for inactivation early in embryonic development, this results in di... (Y or W). Mechanism Mammalian X-chromosome inactivation is initiated from the X...

Centromere

...bsequently propagated epigenetically. In rare cases in humans, neocentromeres can form at new sites on the chromosome. This must be coupled with the inactivation of the previous centromere since chromosomes with two functional centromeres (dicentric chromosomes) will result in chromosome breakage during mitosis...

Epigenetics

...related meanings: The study of the processes involved in the unfolding development of an organism. This includes phenomena such as X chromosome inactivation in mammalian females, and gene silencing within an organism. The study of heritable changes in gene function that occur without a change in...

Lyon hypothesis

.... In humans the X chromosome that is inactivated is determined by chance. In marsupials , however, the paternal X chromosome is always inactivated. inactivation is achieved by methylation of the X chromosome DNA, a common way in which the cell silences particular genes. Certain animals have their coloring ...

Neurotransmitter

...rt an effect on the postsynaptic neuron Externally administered, it must mimic the endogenously released substance A biochemical mechanism for inactivation must be present Contents showTocToggle("show","hide") 1 Types of neurotransmitters 2 Mechanism of action 3 Post-synaptic ef...
Inactivation in Biological Dictionary

Ribosomal DNA genes

...NA genes of a limited number of ascomycetes. ... in the nuclear 18s ribosomal RNA gene of deuteromycetes. Curr. ... RPD3 is required for the inactivation of yeast ribosomal DNA genes in stationary phase ... phase, 50% of the ribosomal DNA (rDNA) genes in each cell are ... (16S ribosoma...

Mismatch repair

...bstract DNA mismatch repair (MMR) is an evolutionarily conserved process ... MutS-/L-/H-Dependent Mismatch Repair in Escherichia coli ... inactivation of the human mismatch repair system confers a large increase in ... Mismatch repair provides several genetic stabilization functions; it cor...

Ligation

...procedure. ... DNA ligation is the process of joining together two DNA ... μL ligation buffer to ... Using the NEB Quick Ligation Kit (heat inactivation of PEG in ... NYabortion.com - call us 877-i-matter - birth control ... Am I a good candidate for tubal ligation ? ... I expect on the day of my l...
Other Tags
(Date:10/1/2014)... and Physical Sciences Research Council (EPSRC) will focus ... control systems which run, for example, manufacturing plants, ... network. , The research will help understand ... the systems behind our critical national infrastructure. ... Systems (RITICS), based at Imperial College London, is ...
(Date:10/1/2014)... Marriagelifeinsurance.com has released a new blog post explaining ... , Senior citizens can purchase a joint life insurance ... A joint policy is cheaper, but will only pay ... Life insurance can be used to cover important funeral ... online, as the application process is simple and straightforward. ...
(Date:10/1/2014)... 01, 2014 Phoseon Technology, the pioneer ... to expand the business worldwide. This rapid growth includes ... capacity for manufacturing efforts. The company has experienced average ... years and expects this growth to continue in the ... gains worldwide adoption. , “We are very pleased ...
(Date:10/1/2014)... California (PRWEB) October 01, 2014 Beverly ... Dr. Kathleen Mojas is celebrating 20 years of private ... assisted hundreds of people to achieve greater joy and ... important list of warning signs and suggestions for anyone ... Dr. Mojas explains: “Believe it or not, it’s ...
(Date:10/1/2014)... Anti Aging Clinic (AntiAgingClinic.ca), the Greater ... of choice, is announcing a discounted cost on Botox ... , “We’re doing this because we want to give ... skin clinic in Toronto,” says Dr. Brian Sieber, founder ... Anti Aging Clinic, including laser facials, genesis laser facials, ...
Breaking Medicine News(10 mins):Health News:£2.5 million to recognize and reduce cyber-attack threats to critical infrastructure 2Health News:Elderly Life Insurance - Find Life Insurance for Retired Couples! 2Health News:Phoseon Technology Continues to Drive Growth Worldwide 2Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 2Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 3Health News:Anti Aging Clinic, the GTA’s Premier Provider of Anti Aging Treatments, Announces Deal on Units of Botox 2
(Date:9/30/2014)... September 30, 2014--Sea monkeys have captured the popular attention ... easily observable life cycle -- sold as dehydrated eggs, ... given little more than a tank of salt water. ... pattern: Like other zooplankton, brine shrimp vertically migrate in ... closer to the surface at night and retreating deeper ...
(Date:9/30/2014)... and engineers, led by Clemson University associate professor ... grant from the U.S. Department of Energy,s Experimental ... direct positive impact on South Carolina in the ... contaminants. , "Understanding the scientific and engineering needs ... of nuclear technologies is imperative if South Carolina ...
(Date:9/30/2014)... in almost any aquatic environment on Earth, but when ... are pushed to the limit. The amount of time ... for how different species cope in the future, reveals ... Gothenburg, published in the scientific journal Proceedings of ... apace thanks to increasing levels of greenhouse gases in ...
Breaking Biology News(10 mins):Laser-guided sea monkeys show how zooplankton migrations may affect global ocean currents 2Researchers get $5.25 million to advance nuclear technologies in South Carolina 2Shape up quickly -- applies to fish, too! 2
Other Contents