Trainor Lab prevents rare birth defect by inactivating p53 gene

Using a mouse model of Treacher Collins Syndrome (TCS), the Stowers Institutes Trainor Lab has demonstrated that it can prevent this rare disorder of craniofacial development either by inactivating a gene implicated in the abnormality or by inhibiting its protein product. The work, which was ...

Effects Of Age-related Vascular Diseases Can Be Reduced By Inactivating TNFa

A new study investigating the potential beneficial effects of TNFa inhibition in vascular aging//, "Vasculoprotective effects of anti-TNFa treatment in aging," appears in the January issue of The American Journal of Pathology. This study shows hope for significantly reducing vascular aging by...

SANYO Donates Systems Effective vs. Flu to United Nations Organization Affiliate - World Association of Former United Nations Internes and Fellows (WAFUNIF)

...lectrolyzed water dripping or running over the purification element in the 'Virus Washer.' Indoor air is then forced to circulate through the element, inactivating airborne viruses which pass through it. SANYO's electrolyzed water technology has been tested and proven effective in suppressing airborne viruse...

Viroblock SA Reports a 99% Boost of Efficacy of Facemasks Against H5N1

...ablish the broad spectrum of action of VCDD Tech against enveloped viruses and the flexibility in its deployment. Our technology is a breakthrough for inactivating enveloped viruses and their strains; I am convinced that we have not yet exploited all its potential. I am pleased to be part of an outstanding team t...

Coalition Says On-Site Infectious Medical Waste Treatment Key To Disease Control and Hospital Sustainability During a Pandemic

...e to an off-site service provider." "The Center for Disease Control staff and other federal health officials have recognized that practice of inactivating amplified cultures and stocks of microorganisms onsite during medical waste treatment is a best practice for emergency preparedness, pandemic response...

Stem cells could halt osteoporosis, promote bone growth

...s could both be stimulated by IFN gamma and produced IFN gamma." The next step was to move to an animal model where IFN gamma effect is blocked by inactivating its receptor, a model called IFN gamma receptor knock-out. Bone density tests, comparable to those used to diagnose people with osteoporosis, were con...

Reduction in antibody gene rearrangement in B cells related to type 1 diabetes, lupus

... assess the level of editing may help direct appropriate therapies. "Right now we have a very crude approach to treating autoimmunity: depleting or inactivating circulating B or T cells wholesale," explains Prak. "Editing errors develop before B cells leave the bone marrow. However, treatments such as B-cell d...

ACS PressPac -- Dec. 10, 2008

...genes involved in producing the enzymes that are responsible for making the toxins produced by the fungus. In lab studies, the researchers showed that inactivating one of the genes, called BcBOT2, blocked the gene cluster's ability to make the botrydial toxin. The finding could help the development of new, more e...

USC researchers identify novel approach for suppressing prostate cancer development

... Los Angeles, Calif. Nov. 24, 2008Researchers at the University of Southern California (USC) have found that inactivating a specific biomarker for aggressive prostate cancer blocks the development of prostate cancer in animal models. Researchers say the upcoming study i...

Glutamate: Too much of a good thing in schizophrenia?

...with new data about the impact of deleting the gene for the glutamate transporter EAAT1. EAAT1, implicated in schizophrenia, plays a critical role in inactivating glutamate by removing it from the synaptic and extracellular spaces. The authors demonstrate that these "knockout" animals show increased responses t...

Inactivating in Medical Technology

Molecular Therapy Succeeds in Preventing Craniofacial Birth Defect in Mice

...towers Institute for Medical Research in Kansas City, Missouri, demonstrated that they could prevent Treacher Collins syndrome (TCS) in mice by either inactivating a gene associated with the disorder or by inhibiting a protein produced by the gene. In TCS, mutations in the TCOF1 gene on chromosome 5 causes a ...

Santaris Pharma Presents Positive Clinical Data on SPC2996 in Chronic Lymphocytic Leukaemia

...beneficial effects in patients are thought to be due to the drug reducing Bcl-2 levels within cancerous CLL lymphocytes by binding specifically to and inactivating the messenger RNA for Bcl-2. High levels of Bcl-2 in CLL cells are associated with resistance to cancer cell death and poor disease outcome. To confir...

Inactivating in Medical Products

Symphony I/C Graft Chambers

Features:...affold for cellular ingrowth and attachment, and a measurable increase in growth factor concentration. LifeNet Quality which enhances safety, reliably inactivating viruses....
Company:DePuy Orthopaedics, Inc.

Inactivating in Medical Definition

Artificial induction of immunity

... a brave piece of rapid medicine development, he probably saved the life of a person who had been bitten by a clearly rabid dog by performing the same inactivating process upon his rabies preparation and then inoculating the patient with it. The patient, who was expected to die, lived, and thus was the first pers...

Inactivating in Biological News

Female human embryos adjust the balance of X chromosomes before implantation

... Amsterdam, The Netherlands: Dutch researchers have found the first evidence that a process of inactivating the X chromosome during embryo development and implantation, which was known to occur in mice but unknown in humans, does, in fact, take place in huma...

Recruitment of reproductive features into other cell types may underlie extended lifespan in animals

...only in germline cells. The mutant worms also were protected from stresses that damaged the DNA of non-mutant worms. The researchers also found that inactivating germline-expressed genes in the mutant worms eliminated the increased lifespan and that longevity-associated mutations in two genes from a different m...

The story of X -- evolution of a sex chromosome

...on." In humans, for example, all genes on the X chromosome are twice as active to account for the lack of genes on the Y. Women accommodate this by inactivating one entire X chromosome so as not to produce too much protein, Bachtrog said. Another change in neo-X that Bachtrog suspects is taking place is the...

American Chemical Society Weekly PressPac -- April 8, 2009

... for detecting ricin appear in ACS' Analytical Chemistry , a semi-monthly journal. The scientists note in the new studies that ricin, a ribosomal inactivating protein found in castor beans, is one of the agents most likely to be used in acts of aerosol or food-related bioterrorism. Ricin can be obtained eas...

New potential therapeutic target discovered for genetic disorder -- Barth syndrome

...rmatogenesis causing male sterility. Using this fly model, the study showed that this trait of cardiolipin deficiency can be genetically suppressed by inactivating calcium-independent phospholipase A2, which prevents the degradation of cardiolipin. This method keeps cardiolipin levels normal. Researchers were als...

Researchers isolate protein domain linked to tumor progression

...t out to determine the functions of different parts of an MMP enzyme. These parts, known as domains, usually correlate to a specific protein function. inactivating one domain within a protein can often have significant and unknown consequences. To determine MMP domain function, the researchers used a simple mod...

Common soil mineral degrades the nearly indestructible prion

...ecause it may yield ways to decontaminate soil and other environments where prions reside. "Prions are resistant to many of the conventional means of inactivating pathogens," says Joel Pedersen, a University of Wisconsin-Madison environmental chemist and the senior author of the new study. For example, autoclavi...

Chemist receives NIH funding to unravel tricks of neuronal wiring

...of building complex systems," Maurer said. Traditionally, to elucidate a protein's role in a known pathway, scientists make a "knockout" animal by inactivating the gene that codes for the protein and observing the resulting effect in the animal. However, this technique cannot be used to study proteins involve...

Leptin's long-distance call to the pancreas

...lasts turned out normal amounts of osteocalcin, but much of it was in an inert form. That result suggests leptin affects insulin release by indirectly inactivating osteocalcin. The work boosts researchers' hopes of using osteocalcin to treat diabetesa possibility some drug companies have already started to invest...

Corn researchers discover novel gene shut-off mechanisms

... unusual differences in the natural mechanisms that turn off, or "silence," genes in corn. The discovery, which was made by comparing the impact of inactivating a gene that occurs in both corn and in the much-studied laboratory plant Arabidopsis, provides new insight into how one of the world's most important ...

Inactivating in Biological Technology

SANYO Donates Air Purification Systems Effective Against Flu Viruses to New York Airports and Schools

...articles. Electrolyzed water runs over the air purification element in the 'Virus Washer'. Indoor air is then forced to circulate through the element, inactivating airborne viruses which pass through it. SANYO turned to The Medical Society of the County of Queens to help them identify possible schools that w...

New ActivePure Technology Proven To Reduce Exposure to Methicillin Resistant Staphylococcus Aureus (MRSA)

...d in schools, day cares, nursing homes and restaurants. This technology is also available to consumers. "The use of ActivePure can reduce exposure by inactivating a majority of harmful bacteria, viruses and mold from surfaces in the protected area," said Dr. James Marsden, Regents Distinguished Professor at Kans...

Innovative Fosshield(R) Antimicrobial Technology Shown to Continuously Kill MRSA 'Superbug'

...required for microbes to grow, initiates the release of silver and copper ions from the fibers on demand. These ions disable the microbe's metabolism, inactivating them. The potential for continuous release ensures long lasting antimicrobial performance." "This ability to inactivate microbes in the environment o...

Mechanism for the in-vivo transport of siRNA

...oceeds via HDL and LDL receptors. The researchers proved this assumption by inactivating the receptors, with the result that uptake no longer occurred. Despite the ...abditis elegans. The corresponding gene also has a homologue in mammals. By inactivating it, the scientists showed that it is also necessary in mammals. The overall...

Inactivation of Contaminating Templates in PCR Using High Intensity Ultraviolet Light

...diation, both of the templates have been inactivated. As demonstrated in Figure 1 and 2, UV irradiation is an effective means of inactivating templates, whether the tubes are capped or closed. However, our data suggest that capping the tube and placing it on its side in...

Cells-to-cDNA II Applications

... plate was moved to a heating tile, which brought the samples to 75C for 12 min, simultaneously disrupting the cells and inactivating RNases. The samples were treated with DNase I followed by heat inactivation. Lysate (5 l) was transferred robotically to...

AMPURE PURIFICATION SYSTEM

... average pass rate for the AMPure-purified samples were 701 and 100% respectively. ExoSAP-IT, an alternative approach of inactivating polymerases and degrading unincorporated primers following PCR thermo-cycling, produces samples with lower purity due to...

QIAGEN Multiplex PCR Handbook

...tion of particular genes. Targeted mutations can be introduced that alter the function of the gene locus of interest, for example by inactivating or modifying its function. This allows research on the role of certain genes in complex biological processes. Modified genomic loci ...

HotMasterAn innovative Hot Start/Cold Stop technology for better PCR* results

...of primers can result in mispriming, elongation and the subsequent formation of spurious bands. The Hot Start technique involves inactivating (or leaving out) one critical component of the PCR reaction until the temperature has risen above this optimal annealing temperature. ...

Inactivating in Biological Definition

Anaphase

...ase transition. At this point the Anaphase Promoting Complex (APC) becomes activated. This terminates metaphase (M-phase) activity by cleaving and inactivating the M-phase cyclin required for the function of M-phase cyclin dependent kinases (M-Cdks). It also cleaves securin , a protein that had been inhibi...

Cancer

... of all cancers. Tumor viruses , such as some retroviruses , herpesviruses and papillomaviruses , usually carry some oncogene or tumor suppressor inactivating gene in their genome . It is impossible to tell the initial cause for any specific cancer. However, with molecular biology , it is now possible to...