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Implicate in Medical News

Amgen and Wyeth Statement on FDA Announcement About Tumor Necrosis Factor (TNF) Blockers

... failure of its products or product candidates. Further, the discovery of significant problems with a product similar to one of Amgen's products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on Amgen's business and results of operations. ...

Amgen Announces KRAS Safety Update to U.S. Prescribing Information for Vectibix(R) (Panitumumab)

...s or failure of our products or product candidates. Further, the discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. ...

Mini-Strokes May Cause Vision Loss

... Hong Kong researchers implicate silent infarcts in glaucoma TUESDAY, July 7 (HealthDay News) -- A study of people who suffer the mini-strokes called silent cerebral infar...

Amgen Highlights Data to Be Presented at ASCO

...ss or failure of our products or product candidates. Further, the discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. ...

A potential new target for treatment of hormone refractory prostate cancer

...hat do not respond to androgen ablation and is required for prostate tumor growth under androgen depleted conditions. Taken together, the findings implicate RNF6 as an important regulator of AR transcriptional activity. "Our work suggests that ubiquitination of AR, and possibly other transcription factors,...

Penn vet researchers identify a critical growth factor that stimulates sperm stem cells to thrive

...s in the interstitial space between seminiferous tubules. Collectively, these results identify Csf1 as an extrinsic stimulator of SSC self-renewal and implicate Leydig and myoid cells as contributors of the testicular stem cell niche. ...

Study Pinpoints New Gene for Cystic Fibrosis

...brosis Foundation, which partially funded the study. Though it's too early to recommend changes in genetic screening or counseling, the findings do implicate IFRD1 in particular, and neutrophil activation in general, as potential targets for drug development. The results were published online Feb. 25 in ...

Drug Reduces Inflammatory Arthritis Symptoms, Lesions

...he study. "Our findings show that ustekinumab is efficacious and safe for treatment of active psoriatic arthritis. Our study is one of the first to implicate the role of interleukin 12/23 P40 cytokines in the pathophysiology of this disorder. Larger and longer term studies are needed to further characterize...

UNC study hints at new approaches to prevent transplant rejection

..., they found that the cells did in fact cause graft-versus-host disease, with the most severe damage to the lung and skin. Not only did these findings implicate TH17 cells in the disease, but they also generated one of the first mouse models to display acute GVHD skin changes consistent with the most common m...

Twin study: Diabetes significantly increases risk for Alzheimer's disease and other dementia

... the sample of older adults. In addition, approximately 30 percent of older adults with diabetes have not been diagnosed. The results of the study implicate adult choices such as exercise, diet and smoking, as well as glycemic control in patients with diabetes, in affecting risk for Alzheimer's disease and...

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Implicate in Medical Technology

Scientists Implicate Gene in Vitiligo and Other Autoimmune Diseases

BETHESDA, Md., April 10, 2007--In a study appearing in the March 22 New England Journal of Medicine, scientists supported by the National Institutes of Healths National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) have discovered a connection between a specific gene and the...

Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer

...s or failure of our products or product candidates. Further, the discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. ...

Amgen Announces Positive Top-Line Results for Denosumab in Trial for Delay of Skeletal Related Events in Bone Metastases Patients Compared to Zometa(R)

...s or failure of our products or product candidates. Further, the discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. ...

Denosumab Demonstrates Superiority Over Zometa(R) in Pivotal Phase 3 Head-to-Head Trial in Breast Cancer Patients With Bone Metastases

...s or failure of our products or product candidates. Further, the discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. ...

Independent Data Monitoring Committee Recommends Resuming Enrollment of Non-Squamous NSCLC Patients in the Motesanib MONET1 Trial

... failure of its products or product candidates. Further, the discovery of significant problems with a product similar to one of Amgen's products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on Amgen's business and results of operations. ...

Nplate(R) Approved in the European Union for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP)

...s or failure of our products or product candidates. Further, the discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. ...

Long-term Follow Up Interim Data Show Nplate(TM) Increased and Sustained Platelet Counts in Adult Chronic ITP Patients

...s or failure of our products or product candidates. Further, the discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. ...

Nplate(TM) (Romiplostim) Receives Positive Opinion for Marketing Authorisation in the European Union

...s or failure of our products or product candidates. Further, the discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. ...

Amgen, Takeda and Millennium Provide Update on Phase 3 Trial of Motesanib in Patients With Non-Small Cell Lung Cancer

...s or failure of our products or product candidates. Further, the discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. ...

Callisto Intends to Move Guanilib into Clinical Trials in Ulcerative Colitis

...ency and removed intestinal blockage in treated animals. "These are important findings and suggest a possible mechanism of action of Guanilib and implicate its therapeutic potential in GI inflammatory diseases such as IBD and IBS," said Dr. Kunwar Shailubhai, Senior Vice President, Discovery Research of C...
Implicate in Medical Dictionary

Labyrinth

...new information, insights ... A detailed overview of the history and spiritual meanings of the labyrinth . ... A labyrinth contains non-verbal, implicate geometric and numerological prompts ... Labyrinths , all about labyrinths , biggest directory of labyrinths , where to find, where to buy, lab...
Implicate in Biological News

Caffeic acid inhibits colitis in a mouse model -- is a drug-metabolizing gene crucial?

...flammatory antioxidant compound widely distributed in foods. The results, which appear in the June 2009 issue of Experimental Biology and Medicine , implicate CYP4B1, a form of cytochrome P450 previously found to be associated with resolution of allergic inflammation in another model. The normalization of C...

Team identifies a molecular switch linking infectious disease and depression

...ene deleted were also completely resistant to the depressive-like behavior seen in normal mice exposed to BCG. "This is the first study to directly implicate IDO in depression related to chronic inflammation," Kelley said. The researchers suspect that the metabolites produced when IDO degrades tryptophan...

Plasminogen activator inhibitor type-1 -- a potential link between heart failure and diabetes

...sminogen activator inhibitor type-1 (PAI-1) is profibrotic. The results, which appear in the March 2009 issue of Experimental Biology and Medicine , implicate PAI-1 overexpression, known to accompany insulin resistance and type 2 diabetes, as a factor contributing to the high incidence of heart failure after...

Is there a relationship between sleep-wake rhythm and diabetes?

...e body is high at night and declines in daylight, whereas the insulin level is higher during the day than in the night. Taken together, these new data implicate an association between the sleep-wake rhythm, the so-called circadian rhythm, and fasting glucose levels, which was not known previously. Until now...

AGU journal highlights -- Dec. 31, 2008

...s. No offset in the position of the glacier surface was observed during these events. Instead, modest tsunamis associated with the glacial earthquakes implicate glacier calving as the generator of seismic events, putting to rest the idea that lurching glaciers are responsible for glacial earthquakes at outlet ...

Impaired energy metabolism linked with initiation of plaques in Alzheimer's brain

...e linking impaired energy metabolism, an AD-relevant stress, with BACE1 translation mediated by eIF2? phosphorylation," says Dr. Vassar. "Our findings implicate phosphorylated eIF2? in both the initiation and progression of sporadic AD. Future experiments will determine whether inhibition of eIF2? phosphorylat...

Genes for 9 health indicators

...reviously unknown loci. Five of these associations - HDL with NR1H3 (LXRA), LDL with AR and FADS1/FADS2, glucose with MTNR1B, and insulin with PANK1 - implicate genes with known or postulated roles in metabolism, and are good candidates for further study of the biological role they might play in these conditio...

Yale researchers unravel mystery of brain aneurysms

... disease, providing hope that we may also be able to provide preventive therapy before rupture occurs," Lifton said. For instance, the new findings implicate variations in the gene SOX17, which is known to play a crucial role in the early development and repair of endothelial cells that make up the arterial...

New study points to agriculture in frog sexual abnormalities

...hese two areas of human disturbance, do we see a greater proportion of abnormal animals in one versus another?" Guillette said. Because the results implicate agriculture, future research can narrow the focus to agricultural chemicals, McCoy said. "Because we know what chemicals are used at these agricult...

UC Davis researchers discover how HIV turns food-poisoning into lethal infection

...day bout of diarrhea. Now, UC Davis School of Medicine scientists have discovered how salmonella becomes lethal for AIDS patients. Their findings also implicate a mechanism by which HIV evades the powerful drugs used to treat AIDS. We have found the defect in the immune response that allows Salmonella to cr...

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Implicate in Biological Technology

Amgen to Participate in Reproductive Health Drugs Advisory Committee Meeting in August

...s or failure of our products or product candidates. Further, the discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. ...

Amgen Exercises Option for Exclusive License to Cytokinetics' Cardiac Contractility Program That Includes CK-1827452

... failure of its products or product candidates. Further, the discovery of significant problems with a product similar to one of Amgen's products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on Amgen's business and results of operations. ...

Photos: Amgen and ONSEdge Partner With Cancer Survivor Jan Ping for New Campaign

...ss or failure of our products or product candidates. Further, the discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. ...

Preclinical Data From Amgen's Oncology Pipeline to be Presented at AACR

...s or failure of our products or product candidates. Further, the discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. ...

FDA Accepts Amgen's Submission and Files Biologics License Application for Denosumab

...s or failure of our products or product candidates. Further, the discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. ...

Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting

...s or failure of our products or product candidates. Further, the discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. ...

Amgen Positioned to Deliver Attractive Growth Over Next Five Years

...ss or failure of our products or product candidates. Further, the discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. Th...

Supreme Court limits foreign reach of U.S. patents

...ent law. Thus, Microsoft's activities did not violate United States patent laws. Significance beyond software The Supreme Court's decision may implicate other technology fields where a master sample or piece of information can be easily transported abroad, copied, and combined into a product that would...
Implicate in Biological Dictionary

N Terminus

...the N terminus of dTAF. II. 230 ... The N terminus of G protein-coupled receptors has been implicated in binding to ... Although these data implicate the N terminus of the C5aR in ligand binding, it ... The N terminus affects inhibitory activity and folding ... Together, these data sugges...
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Breaking Medicine News(10 mins):Health News:Industrial Freezers Procurement Category Market Research Report Now Available from IBISWorld 2Health News:Industrial Freezers Procurement Category Market Research Report Now Available from IBISWorld 3Health News:Industrial Freezers Procurement Category Market Research Report Now Available from IBISWorld 4Health News:In Recognition of National Women’s Health and Fitness Day, Cutler Integrative Medicine Details Tips for Living a Healthier and Happier Life 2Health News:Law Offices of D.R. Jones Client Wins 4.7 Million Dollar Verdict, Insurance Company Files Motion for a New Trial 2Health News:Law Offices of D.R. Jones Client Wins 4.7 Million Dollar Verdict, Insurance Company Files Motion for a New Trial 3Health News:Gene Study Finds No Proof Vitamin D Guards Against Type 2 Diabetes 2
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Breaking Biology News(10 mins):NIH taps lab to develop sophisticated electrode array system to monitor brain act 2NIH taps lab to develop sophisticated electrode array system to monitor brain act 3Researchers get $5.25 million to advance nuclear technologies in South Carolina 2NEJM: Crizotinib effective in Phase 1 trial against ROS1 lung cancer 2
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