FDA Demands Tougher Warnings on Immunosuppressive Drugs
Officials want stronger labeling about fungal infection risk THURSDAY, Sept. 4 (HealthDay News) -- Federal health authorities have asked the manufacturers of four widely used immunosuppressive drugs to bolster safety warnings on the risk of developing opportunistic fungal infections. ...A Newly Identified Immunosuppressive Protein in Rheumatoid Arthritis
A complex autoimmune disease, rheumatoid arthritis (RA) is characterized by chronic inflammation and progressive joint damage. This process begins with hyperplasia//, or excessive increase in size and thickness, of synovial tissue. Along with provoking cartilage and bone destruction, this abnormal ...Immune responses to flu vaccine are diminished in lupus patients
... disease systemic lupus erythematosus (SLE) have an increased risk of infection, due to both disturbances in their immune responses and treatment with immunosuppressive drugs. Because morbidity and mortality related to influenza are increased in immunocompromised patients, it is recommended that patients with SLE get ...Aethlon Medical Announces U.S. Army Agreement
...r(R) is the first-in-class medical device to selectively adsorb viruses and immunosuppressive toxins from the bloodstream. The device has been designed to enhance the be...resents the first-in-class medical device to selectively adsorb viruses and immunosuppressive toxins from the bloodstream. The Hemopurifier(R) seeks to improve Hepatitis...Post-transplant combo can replace toxic immune-suppressing drugs in monkeys
...vent graft rejection, but at the cost of serious side effects. The class of immunosuppressive drugs known as calcineurin inhibitors (examples are cyclosporine and tacrol...linical trials, but current studies use it in combination with conventional immunosuppressive drugs. Alefacept targets memory T cells via a molecule on their surfaces...Peregrine Pharmaceuticals Completes Planned Patient Enrollment in Bavituximab Phase I Cancer Trial
... In addition, a growing body of evidence supports the active role of PS in immune signaling, with recent research showing that exposed PS can have an immunosuppressive effect and dampen the body's normal response to cancer. By binding to and blocking PS, bavituximab is believed to boost the body's ability to combat ...New Drug Promising Against Rheumatoid Arthritis
... Golimumab might help where similar drugs failed, research finds MONDAY, June 29 (HealthDay News) -- The immunosuppressive drug golimumab shows promise in treating rheumatoid arthritis patients who don't respond to other drugs, according to a new study. Golimumab is from t...Living Cell Technologies' Diabetes Clinical Trial Authorized by New Zealand Government
...ls in type 1 diabetes sufferers. DIABECELL(R) comprises encapsulated porcine insulin-producing cells which can be administered without the need to use immunosuppressive drugs. Type 1 diabetes occurs when the body's own immune system destroys the insulin-producing cells of the pancreas (called beta cells). Five to...Predicting fatal fungal infections
...akened immunity, due to HIV infection or other reasons including the use of immunosuppressive drugs after organ transplantation, or for treating autoimmune diseases or c...e think that knowing whether transplant recipients or other patients taking immunosuppressive drugs have low numbers of IgM memory B cells could be useful in deciding wh...ASCO Research Foundation Grant Will Support Study of Peregrine's Bavituximab in Lung Cancer
... In addition, a growing body of evidence supports the active role of PS in immune signaling, with recent research showing that exposed PS can have an immunosuppressive effect and dampen the body's normal response to cancer. By binding to and blocking PS, bavituximab is believed to boost the body's ability to combat ...Aethlon Medical to Present at the 2009 RedChip Small-Cap Investor Conference on June 16, 2009
...ne system proven to capture infectious viruses and immunosuppressive particles from the human circulatory system. Addi...ne system proven to capture infectious viruses and immunosuppressive particles from the human circulatory system. The ...es verify the Hemopurifier(R) effectively captures immunosuppressive exosomes that are secreted by tumors to kill-off i...Emerging Therapies Could Help Ease The Chronic Symptoms of Atopic Dermatitis For Adults and Children
...le systemic therapies for atopic dermatitis pose safety concerns due to their potential side effects, Dr. Eichenfield reported that a few of the newer immunosuppressive agents and newer biologic therapies are being used successfully -- even in children. "Newer immunosuppressives such as mycophenolate mofetil can ...Fifth U.S. Hand Transplant Patient Heads Home to NY
...t him to continue to do so." Hondusky received one dose of Campath, an immunosuppressive medication, during surgery and is on mono-therapy -- one drug for most of t...posed to two or three, reduces the risk of rejection. Risks associated with immunosuppressive drugs include a higher incidence of cancer, infections and other disorders....Scientists Unmask Genetic Markers Associated With Psoriasis
...ween 10 and 30 percent of patients develop psoriatic arthritis, a painful inflammation of the joints. Current treatments, including different types of immunosuppressive agents, aren't always effective, and they can cause serious side effects. Psoriasis has a strong genetic component; a child with two affected pa...The Leukemia & Lymphoma Society and Memgen Announce New Chronic Lymphocytic Leukemia Clinical Trial
...ancers. Its lead product, ISF35, has demonstrated potent anti-leukemic activity as a single agent and is well-tolerated. ISF35 generates none of the immunosuppressive activities associated with standard cancer treatments. For more information about Memgen, visit www.memgenbio.com . About The Leukemi...Device protects transplanted pancreatic cells from the immune system
... the need for long term immunosuppression, which carries health risks. Transplanting beta cells in a protective device could alleviate the need to use immunosuppressive drugs. ...Research could lead to new non-antibiotic drugs to counter hospital infections
...tinal tract, usually causing no apparent harm. It might even be beneficial to its host. Once the host is weakened by an illness, surgical procedure or immunosuppressive drugs, however, P. aeruginosa can cause infection, inflammation, sepsis and death. Why P. aeruginosa can suddenly turn on its host has eluded ...Gene mutation increases drug toxicity, rejection risk in pediatric kidney transplants
... drug toxicity in children without compromising the drug's protective effects against kidney graft rejection." MMF, or Mycophenolate Mofetil, is an immunosuppressive agent commonly used to prevent rejection in organ transplants, particularly in kidney transplants. After taken orally, the drug is quickly processed b...Scientists discover how deadly fungus protects itself
...nfections occur most commonly in those with compromised immune systems ─ especially AIDS patients and transplant patients who must take lifelong immunosuppressive therapy. The fungus causes an estimated one million deaths each year worldwide, including some 600,000 in sub-Saharan Africa. The lead author of the ...DNA component can stimulate and suppress the immune response
..., Calif. He is working with Drs. Andrew Mellor and David Munn, co-directors of the School of Medicine Immuno Discovery Institute, who discovered IDO's immunosuppressive capabilities more than a decade ago. With the help of Drs. Babak Baban and Phillip Chandler, scientists in MCG's Immunotherapy Center, they've als...Researchers engineer pancreatic cell transplants to evade immune response
...r to prevent rejection of these beta foreign cells. "Ultimately, even with immunosuppressive therapy, most of these individuals end up rejecting the transplanted cells,...d these beta cells to include three adenoviral genes responsible for making immunosuppressive proteins. Diabetic mice that received these engineered foreign beta cells ...High blood sugar's impact on immune system holds clues to improving islet cell transplants
...es, such as type 1 diabetes and lupus, must be done cautiously and selectively to ensure patients are not put at the same risk as those on traditional immunosuppressive therapy. ...Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections
...lead study author and UT Southwestern instructor of pharmacology, commented, "Recent non-affiliated research has further confirmed that exposed PS has immunosuppressive properties and is also clarifying its involvement during viral infection of cells. Our data go a step further, providing compelling evidence that exp...Researcher tricks immune system in diabetic mice
...ing islets. A person who has the transplant procedure must take powerful immunosuppressive drugs to prevent their bodies from rejecting the cells. The drugs, however...ed islets are its own cells. This new technique eliminated the need for the immunosuppressive drugs in mice with chemically-induced diabetes after they had islet transpl...New technique eliminates toxic drugs in islet transplant in diabetic mice
...ing islets. A person who has the transplant procedure must take powerful immunosuppressive drugs to prevent their bodies from rejecting the cells. The drugs, however...ed islets are its own cells. This new technique eliminated the need for the immunosuppressive drugs in mice with chemically-induced diabetes after they had islet transpl...Lycera Closes $36 Million Series A Financing
...apeutic pathways and have the potential for first-in-class oral efficacy without the adverse effects of current standard-of-care antiproliferative and immunosuppressive agents. Visit www.lycera.com for more information. Contact: David Schull or Andreas Marathovouniotis Russo Partners ...Aethlon Medical Announces Data Supported Strategy to Increase Hepatitis-C (HCV) Cure Rates
...e therapeutic filtration of infectious viruses and immunosuppressive proteins. In HCV care, the device inhibits viral ...ne system proven to capture infectious viruses and immunosuppressive particles from the human circulatory system. The ...es verify the Hemopurifier(R) effectively captures immunosuppressive exosomes that are secreted by tumors to kill-off i...Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections
...lead study author and UT Southwestern instructor of pharmacology, commented, "Recent non-affiliated research has further confirmed that exposed PS has immunosuppressive properties and is also clarifying its involvement during viral infection of cells. Our data go a step further, providing compelling evidence that exp...Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections
...lead study author and UT Southwestern instructor of pharmacology, commented, "Recent non-affiliated research has further confirmed that exposed PS has immunosuppressive properties and is also clarifying its involvement during viral infection of cells. Our data go a step further, providing compelling evidence that exp...