AIDS patients face higher risk of HPV-related cancers as immunosuppression grows

Risk of human papillomavirus (HPV)-associated cancers is greater for people living with AIDS and increases with increasing immunosuppression, according to a new study published online July 31 in the Journal of the National Cancer Institute. Although the risk of HPV-associated cancers is known...

Nostrum Pharmaceuticals Obtains Worldwide Licensing Rights From IMTECH for Clinical Development of the Small Molecule Caerulomycin and Its Proprietary Derivatives for Their Novel Indication of Immunosuppression

EDISON, N.J., Feb. 23 /PRNewswire/ -- Nostrum Pharmaceuticals, LLC ("Nostrum"), a privately-held company based in Edison, New Jersey, announced today that it has obtained a worldwide license to develop and commercialize Caerulomycin A, and its proprietary derivatives and analogues ("Caerulomycin")...

Mayo Clinic Study Finds Heart Transplant Patients Benefit from New Approach to Immunosuppression

A new immunosuppression regimen for heart transplant patients can improve kidney function and prevent transplant coronary artery disease//, according to two new Mayo Clinic studies. Mayo researchers will report their findings on April 26 at The International Society for Heart & Lung Transplantation...

More stringent evaluation on the use of generic medications in thoracic transplantation

... Philadelphia, 2 June 2009 A closer look at regulatory and clinical concerns with generic immunosuppression medications in thoracic transplantation is required, according to an educational advisory by the International Society for Heart and Lung Transplantat...

Transplant patients have worse cancer outcomes, analysis shows

...have occurred because this population is not as healthy as the general population or because their cancers may be more aggressive as a result of their immunosuppression treatments. "Some of our data supports this premise, as the extent of the cancers at diagnosis were greater in the transplant recipients," Woodle ...

United Spinal Association Reports Positive Results of Stem Cell Transplantation to Treat Multiple Sclerosis: Study May be Key to Unlocking a Cure

...any MS medications. The results are reported in a National Institutes of Health (NIH)-sponsored study called HALT-MS to confirm whether high-dose immunosuppression followed by autologous stem cell transplantation will prevent MS attacks in patients who are not responding to available treatment options and ultimat...

American Transplant Congress 2009: New Investigator Forum Presents Cutting Edge Research

... Tissue Engineering Organ Allocation Worldwide Current Transplantation Controversies Special Interactive Audience Sessions Biologic immunosuppression Agents NanoMedicine RNA and microRNA biology Cholangiocarcinoma in Liver Transplantation Transplant Tourism Clinical Trials Im...

Pancreatic Islets in Forefront of Diabetes Research

...ificant improvement in quality of life, several obstacles remain, such as limited engraftment [acceptance of the islets within the recipient], chronic immunosuppression and inconsistent supply of human islets," the researchers noted. "These issues must be addressed if the procedure is to be used as a standard of care ...

Study reports success in treating a rare retinal disorder

...tinopathy, 21 individuals showed improvement after receiving treatment with immunosuppression therapy. The study, reported in the April issue of Archives of Ophthalmolog...The patients in the current study were treated with various combinations of immunosuppression medications to counteract the unwanted autoantibodies from the immune syste...

Gleevec(R) substantially reduces risk of cancer returning in patients with life-threatening gastrointestinal stromal tumors (GIST), The Lancet reports

...llowing resolution or improvement of the bullous reaction. Consider potential toxicities - specifically liver, kidney, and cardiac toxicity, and immunosuppression from long-term use. Fetal harm can occur when administered to a pregnant woman; therefore, women of childbearing potential should be advised to ...

Immunosuppression in Medical Technology

Three Independent Studies Include the ImmuKnow(R) Assay to Manage and Optimize Immunosuppression Therapy in Transplant Patients

The results of these studies will be presented during the American Transplant Congress in Boston, MA May 30 - June 3, 2009 COLUMBIA, Md., May 31 /PRNewswire/ -- A study conducted at Westchester Medical Center in Valhalla, NY examined liver transplant recipients to determine whether the use o...

Argos Therapeutics Presents Immunosuppression Data for Soluble CD83 at the American Society of Transplantation Congress 2007

DURHAM, N.C.--(BUSINESS WIRE)--May 4, 2007 - Argos Therapeutics today announced the presentation of data on the immunosuppressive properties of soluble CD83 at the 7th Joint American Transplant meeting to be held in San Francisco, May 5-9. The presentations will be made in collaboration with scient...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

... following resolution or improvement of the bullous reaction. Consider potential toxicities-specifically liver, kidney, and cardiac toxicity, and immunosuppression from long-term use. Gleevec is metabolized by the CYP3A4 isoenzyme and is an inhibitor of CYP3A4, CYP2D6, and CYP2C9. Dosage of Gleevec should in...

An Independent Study Reports on the Utility of ImmuKnow(R), the Cylex(TM) Immune Cell Function Assay, for Monitoring Heart Transplant Recipients

...gawa, MD, favorably remarked, "These results suggest that ImmuKnow as a non-invasive immune monitoring is indeed a promising means for individualizing immunosuppression in heart transplant recipients." "This study expands our understanding of the applicability of the ImmuKnow immune function assay in effective m...

Pharmacyclics Initiates Phase 1 Clinical Trial of Novel Oral Btk Inhibitor for Refractory B-cell Non-Hodgkin's Lymphoma

...w). Unlike anti-CD20 protein therapies, treatment with PCI-32765 in animal models is not myeloablative, which could result in prolonged and dangerous immunosuppression for the patient. "This is a very selective compound for B-cells, and it could represent an important alternative to rituximab therapy for the t...

Video: Tasigna(R) Demonstrates Rapid Response as Initial Therapy in Life-Threatening Form of Leukemia

...lowing resolution or improvement of the bullous reaction. Consider potential toxicities-specifically liver, kidney, and cardiac toxicity, and immunosuppression from long-term use. Gleevec is metabolized by the CYP3A4 isoenzyme and is an inhibitor of CYP3A4, CYP2D6, and CYP2C9. Dosage of Gleevec shoul...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

...lowing resolution or improvement of the bullous reaction. Consider potential toxicities--specifically liver, kidney and cardiac toxicity, and immunosuppression from long-term use. Gleevec is metabolized by the CYP3A4 isoenzyme and is an inhibitor of CYP3A4, CYP2D6 and CYP2C9. Dosage of Gleevec should...

Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease

...nes following resolution or improvement of the bullous reaction. Consider potential toxicities--specifically liver, kidney and cardiac toxicity, and immunosuppression from long-term use. Gleevec is metabolized by the CYP3A4 isoenzyme and is an inhibitor of CYP3A4, CYP2D6 and CYP2C9. Dosage of Gleevec should increa...

Cylex Announces Plan for Multi-Center Trial of ImmuKnow(R) Assay in South Korea

... Seven Korean medical centers to collaborate on studies of immunosuppression in kidney transplant patients and role of cell-mediated immunity COLUM...e therapy (tacrolimus + mycophenolate mofetil + prednisone) or steroid-free immunosuppression (tacrolimus + mycophenolate mofetil only). The seven institutions that wi...

CellCept(R) and a Reduced Level of CNI Shows Trend Towards Preservation of Kidney Function Versus a Standard-Dose CNI

...oids. Important Safety Information: WARNING: immunosuppression may lead to increased susceptibility to infection ...tion should be given to reducing the amount of immunosuppression in patients who develop PML. In transplant patient...sicians should also consider the risk that reduced immunosuppression represents to the graft. -- CellCept can caus...

Immunosuppression in Biological News

In vitro antibody production enables HIV infection detection in window period -- key to safer blood

...uch as parasitemias and/or nutrition, in different populations may influence and prolong the serological-diagnostic window period of HIV. However, the immunosuppression can be overcome, by in-vitro enhancement of antibody production (termed- Stimmunology). The results, which appear in the August 2009 issue of Experim...

Transplanted fat cells restore function after spinal cord injury

...otion of functional recovery. According to Ohta and colleagues, tests in animal models confirmed that the injected cells survived without the aid of immunosuppression drugs and that the DFAT-grafted animals showed significantly better motor function than controls. "We concluded that DFAT-derived neurotrophic facto...

Breakthrough research identifies how cells from pigs may cure diabetes

...ields a long-term reversal of diabetes in monkeys, opening the path to unprecedented new opportunities for human patients with the disease. To oversee immunosuppression issues, researchers are now working to transplant porcine islets in an engineered pre-vascularized, cytoprotective and immune-privileged implantation ...

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease

...ors, deformation, a worsening of symptoms, or gave rise to inappropriate cells types. Neither cell type was rejected by the immune system. In fact, no immunosuppression was needed at all. Finally, the human embryonic stem cells were grown without mouse feeder layers and in a "defined" culture medium that is compatible...

Transplanted brain cells hold promise for Parkinson's disease

...months to see if the early protection/recovery holds up; he’s already past the three-month mark and to date, recovery is stable. While the rats needed immunosuppression because they received human cells, Dr. Borlongan says humans would not. About a half-million Americans have Parkinson’s disease. Typically the d...

Researchers discover key mechanism by which lethal viruses Ebola and Marburg cause disease

.... There is no cure or approved vaccine for either Marburg or Ebola virus. immunosuppression occurs early after infection and allows the viruses to reproduce rapidly an...logy at Columbia University. "The identification of this new mechanism for immunosuppression is anticipated to lead to new drugs for intervention in filoviral hemorrhag...

Scientist-astronaut sends T-cells into space

...elow 200, he or she is susceptible to the dangerous infections that are the symptoms of acquired immunodeficiency syndrome (AIDS). The problem of immunosuppression in microgravity was first noted during the Apollo moon mission series in the 1960s and 1970s, when 15 out of 29 Apollo astronauts developed infections...

Stem cell transplants improve recovery in animal models for stroke, cerebral palsy

...mmunosuppressive drugs does not appear to be required, in contrast to other types of stem cell treatment. Animals that received MultiStem TM without immunosuppression of any kind did just as well as animals that received MultiStem TM treatment along with daily doses of Cyclosporine A, a drug typically given to tra...

Cyclosporine inhibits hepatitis C virus in vitro

..."Our study suggests that Cyclosporine may play a beneficial role as primary immunosuppression for patients transplanted for HCV infection and may offer an advantage to T...s," the authors conclude, "it will be very important to determine the ideal immunosuppression regimen." ...

Faster immune system testing set to improve poultry quality

...tive tool Reduced immunity is a serious problem for commercial poultry producers worldwide. The major cause is viral infection. All viruses can cause immunosuppression to varying degrees but Marek's disease, infectious bursal disease and chicken anaemia are particular concerns. A simple test to identify flocks that h...

Immunosuppression in Biological Technology

DOR BioPharma Receives FDA Orphan Drug Designation for orBec(R) for the Treatment of Chronic Gastrointestinal GVHD

... to frontline immunosuppression. High-dose systemic corticosteroids are used with some success but carry significant toxicity. The risks of prolonged immunosuppression include local and disseminated infections, Epstein-Barr virus associated lymphoproliferative disease, hypothalamic-pituitary-adrenal (HPA) axis suppre...

Astellas Receives FDA Approval for Use of Prograf(R) (Tacrolimus) in Conjunction With Mycophenolate Mofetil (MMF) in Kidney Transplant Recipients

...plantation, Astellas remains dedicated to the advancement of the science of immunosuppression to enhance the care of transplant patients," said M. Roy First, M.D., Vice ... syndrome (PRES). If PRES is suspected or diagnosed, immediate reduction of immunosuppression is advised. Activation of latent viral infections, including BK virus-asso...

American Transplant Congress 2009

...ric Donor Allocation Policies Tissue Engineering Organ Allocation Worldwide Transplantation Controversies Biologic immunosuppression Agents NanoMedicine ...many more crucial presentations New worldwide research and discoveries will be presented through symp...

University of Minnesota Receives $40 Million for Type 1 Diabetes Research

...t organization that raises medical-grade pigs to supply islets for transplantation. The researchers are currently developing a cell therapy to offset immunosuppression issues related to transplant. Firpo is investigating the reprogramming of adult skin cells into stem cells that can generate islet cells. She...

Gleevec Receives FDA Priority Review as First Therapy to Reduce Recurrence of Gastrointestinal Stromal Tumors After Surgery

...ines following resolution or improvement of the bullous reaction. Consider potential toxicities-specifically liver, kidney and cardiac toxicity, and immunosuppression from long-term use. Gleevec is metabolized by the CYP3A4 isoenzyme and is an inhibitor of CYP3A4, CYP2D6 and CYP2C9. Dosage of Gleevec should increa...

Video: Higher Initial Dose of Gleevec Achieved Better Early Responses than Standard Dose for Patients with Chronic Myeloid Leukemia

...nes following resolution or improvement of the bullous reaction. Consider potential toxicities-specifically liver, kidney, and cardiac toxicity, and immunosuppression from long-term use. Gleevec is metabolized by the CYP3A4 isoenzyme and is an inhibitor of CYP3A4, CYP2D6, and CYP2C9. Dosage of Gleevec should incre...

JCI table of contents: April 22, 2008

... ezio.bonifacio@crt-dresden.de . View the PDF of this article at: https://www.the-jci.org/article.php?id=35197 ACCOMPANYING COMMENTARY TITLE: immunosuppression in islet transplantation AUTHOR CONTACT: Matthias von Herrath La Jolla Institute for Allergy and Immunology, La Jolla, California, USA. Phone: (...

Immune Function in Adult Heart Transplant Patients Reflects Risk for Organ Rejection and Infection

... patient's risk for organ rejection or infection," concluded Dr. Kobashigawa. "We are currently conducting clinical studies using these data to manage immunosuppression in our heart transplant patients, with the goal of limiting risk for rejection and infection." Dr. Kobashigawa's presentation was entitled, "Success...

Novocell Reports Successful Use of Stem Cells to Generate Insulin in Mice

...this has been demonstrated to be an effective therapy, the limited availability of donated pancreatic islets and the adverse side effects of long-term immunosuppression make this replacement therapy unsuitable for the general diabetes population. Together with its stem cell engineering technology for insulin-produci...

New Independent Research Study Indicates That Cylex's ImmuKnow Test May Identify Kidney Transplant Patients at Risk for Early Acute Rejection

...the February 15, 2008 issue of the journal Transplantation. "Based on our immunosuppression protocol, this study is the first to show that high pre-transplant ImmuKnow...t from closer clinical and immunological surveillance to allow for tailored immunosuppression and selective intervention aimed at optimizing both short and long-term gra...

Immunosuppression in Biological Definition

Immune system

...ic determinant / epitope / hapten / memory cell autoimmune disorders CD4 receptor /CD8 receptor / perforin / apoptosis /clonal selection immunosuppression immunosuppressive drug immunotherapy lymphatic system / lymphocyte macrophage major histocompatibility complex / class I MHC ...

Semen

...IV , the virus that causes AIDS . It is also hypothesized that components of semen, such as the spermatozoa as well as the seminal plasma, can cause immunosuppression in the body when introduced to the bloodstream or lymph . Evidence for this dates back to 1898 , when Elie Metchnikoff injected a guinea pig wi...