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Immunohistochemistry in Medical News

Genetic pathway responsible for link between body clock disturbance and worsening arthritis

...arthritis was induced in mice with the CRY gene removed. Expression of the genes responsible for regulation of the human body clock were determined by immunohistochemistry and quantitative Polymerase Chain Reaction. TNF-alpha levels were measured by ELISA, and transactivation of TNF-alpha gene was examined by reporter as...

Prometheus Presents Proprietary Oncology Diagnostic Platform at ASCO Annual Meeting

...sitivity as high as a single cell. Testing of samples from frozen breast cancer tissues demonstrated concordance between reported HER2 status based on immunohistochemistry (IHC), a commonly used biopsy-based method, and the Prometheus diagnostic platform. Further, an analysis of CTCs from metastatic breast cancer patient...

A novel marker of colorectal carcinoma

... RT-PCR. Eighty-eight specimens of human colorectal adenocarcinoma were surgically removed. TSPAN1 protein levels in cancer tissues were determined by immunohistochemistry using a polyclonal antibody against self-prepared TSPAN1. The correlation between TSPAN1 expression and the clinicopathological factors and the overal...

New universal breast cancer marker predicts recurrence and clinical outcome

...ined from the University of Michigan. They used three tissue cores from each patient tumor sample, and analyzed each core for stromal caveolin-1 using immunohistochemistry staining. The absence of stromal caveolin-1 was strongly associated with other predictors of more aggressive disease, such as higher tumor stage a...

NeoGenomics, Inc. Reports First Quarter 2009 Financial Results

...e appended its policies with respect to the reimbursement procedures for a wide variety of laboratory tests including certain FISH, flow cytometry and immunohistochemistry tests in an effort reduce costly payment errors and ensure they are paying for the appropriate services. These changes impacted the lab industry nati...

BioMosaics' Glypican-3 Antibody (clone 1G12) Validated at PhenoPath Laboratories for Immunohistochemical Detection of Liver Cancer

...eference pathology laboratory providing diagnostic immunohistochemistry (IHC), in situ hybridization (ISH), flow cytometry...ded the 1G12 Glypican-3 antibody to its test menu. immunohistochemistry using this antibody provides added specificity to ... paraffin embedded tissue sections used in routine immunohistochemistry tests. For validation, a series of tissues (normal...

Frost & Sullivan: Novel Diagnostics Methods Driving the European Cancer IVD Market Towards Early Detection and Prevention

...sting methods such as immunoassay testing are facing fierce competition from evolving segments such as nucleic acid amplification technology (NAT) and immunohistochemistry testing. The ability to prove the clinical utility and practical use of the test within a laboratory is one of the essential requirements to be succe...

ALS TDI and Asklepios to Develop New Therapeutic Delivery Options for Treating Lou Gehrig's Disease

...ated with other viruses, and have been clinically tested. Samples from animals treated with BNP vectors will be analyzed by a variety of molecular and immunohistochemistry analysis techniques at ALS TDI to determine in which cell types each vector becomes localized in various tissue samples. This project is seen as bols...

Collagen VI may help protect the brain against Alzheimer's disease

...6; assemblies, called oligomers, bind strongly to vulnerable neurons in the brain, but in the presence of collagen VI, this binding was blocked. Using immunohistochemistry and atomic force microscopy, they showed that collagen VI and Aβ form large aggregates with each other that may sequester the smaller, more toxic...

PreMD Files Provisional Patent Application Describing a New Method of Quantifying Cancer Biomarkers

...specimens. "With the news earlier this year of breast cancer patients being incorrectly diagnosed and treated based on erroneous interpretation of immunohistochemistry tests it immediately came to our minds that our existing intellectual property and expertise in colour measurement may be useful in improving this cri...
Immunohistochemistry in Medical Technology

Ipsogen Launches a New Test to Determine Tumor HER2 Status and Guide Herceptin(R) Prescription in Breast Cancer

...cribing unnecessary therapy for others. Testing solution Currently, tumors are tested for HER2 with 2 main complementary technologies: immunohistochemistry (IHC) which identifies HER2 protein expressed in the tumor cells and in situ hybridization (ISH), which quantifies HER2 DNA copy number in the cell ch...

FDA Clears the Pathwork(R) Tissue of Origin Test for Hard-To-Identify Tumors

...ols used to identify tumors of uncertain origin include imaging studies, such as CT scans and MRIs, as well as a thorough pathological evaluation with immunohistochemistry and other techniques," said Federico Monzon, M.D., Director of Molecular Diagnostics of The Methodist Hospital in Houston. "However, for difficult cas...

Multiple Studies Presented at San Antonio Breast Cancer Symposium Reinforce Clinical Utility of Oncotype DX(R)

... * A study presented by Kaiser Permanente researchers on Saturday, December 15 found estrogen receptor (ER) expression, as determined by both immunohistochemistry (IHC) and RT-PCR (as measured by Oncotype DX), was prognostic in a group of ER-positive and ER-negative patients. RT-PCR results were more con...

BioMosaics' Glypican-3 Blood & Tissue Tests Receive CE Marking in Europe

...3) ELISA Kit for detecting GPC3 in human serum or plasma, and the GPC3 (Human Glypican-3) Monoclonal Antibody (clone 1G12) to detect GPC3 in tissue by immunohistochemistry (IHC), to be marketed in the European Union. GPC3, an oncofetal antigen, is a member of the glypican family of glycosyl phosphatidylinositol-anchored...

Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy

... therapy for qualified patients. FDA-approved kits use one of three methods to quantify Her-2/neu overexpression in breast tumors. The first is immunohistochemistry (IHC), which involves a semiquantitative, microscopic assessment of antibody reactivity on a fixed tissue sample. Studies have shown that when specim...
Immunohistochemistry in Medical Products

Stains, Immunohistochemistry

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

NexES® IHC

Description:... NexES IHC, the worlds first truly automated immunohistochemistry (IHC) slide staining system introduced a whole new level of staining quality while combining system modularity and ease of operation for improved labo...
Company:Ventana Medical Systems Inc.

Shandon TissueWave

Description:...cessing, decalcification of hard material, routine special stains where heat would accelerate the staining process, and for epitope enhancement during immunohistochemistry staining. Product Detail It is designed for greater flexibility to meet the growing workload demands. This user friendly instrument will free...
Company:ThermoFisher Scientific

GenePaint

Features:...tion studies Assures consistent and reproducible results of excellent quality Saves on the amounts of reagents used Is also applicable to immunohistochemistry applications...
Company:Tecan
Immunohistochemistry in Medical Definition

Hematopathology

...specimen , but also relies on laboratory values , immunohistochemistry , flow cytometry , and molecular diagnostic tes... NK cell lymphomas . The hematopathologist uses immunohistochemistry and flow cytometry , techniques using antibodie...logy Gross examination - Histopathology - immunohistochemistry - Electron microscopy - Immunofluorescence - ...

Pathology

...search techniques, such as electron microscopy , immunohistochemistry , and molecular biology have expanded the means ...al carcinoma of the breast. A pathologist will use immunohistochemistry and fluorescent in-situ hybridization to detect ma...al examination of tissues, with special stains and immunohistochemistry employed to visualize specific proteins and other ...

Medicine

...knowledge and plays a large role in evidence-based medicine . Many modern molecular tests such as flow cytometry, polymerase chain reaction (PCR), immunohistochemistry , cytogenetics , gene rearragements studies and fluorescent in situ hybridization (FISH) fall within the territory of pathology. Radiology ...
Immunohistochemistry in Medical Dictionary

Meninges

...ain and spinal cord of ... Brain and meninges were normal on. gross examination. Tissues were ... meninges , most severely over the cerebellum. immunohistochemistry for WNV was positive. ... ...

Immunofluorescence

...immunofluorescence ) ... only one shown to be antimitochondrial antibody negative by immunofluorescence . ... ... analyzed in excised tumors by immunohistochemistry and double immunofluorescence . ... Immunofluorescence Double Staining for F4/80 and MMP-9 ... By means of immunofluorescence flow cytometry ...

Bovine Spongiform Encephalopathy

...03/15/04) ... Bovine spongiform encephalopathy (BSE) is a slowly ... confirm a diagnosis of bovine . spongiform encephalopathy . Also, immunohistochemistry ... BSE ( Bovine Spongiform Encephalopathy , or Mad Cow Disease) (CDC) BSE Documents (FAS) ... Bovine Spongiform Encephalopathy (BSE) (W...
Immunohistochemistry in Biological News

Astrocytes and synaptic plasticity

...et to the bottom of things, Bergami et al. investigated the fate of both forms after LTP induction in brain slices from the rat cortex. By fluorescent immunohistochemistry they showed that that neurons indeed secrete both mature and pro-BDNF, but that a large amount of the pro-BDNF is immediately taken up by astrocytes. ...

Bee disease a mystery

... find out whether the virus replicates in the mite and if so where this occurs, to understand how the virus is transmitted. They used a process called immunohistochemistry which involves using antibodies which bind to specific surface proteins, enabling the virus particles to be located. There was no evidence of virus re...

New study reveals signaling pathways required for expansion of pancreas stem cells

...y and sufficient for proliferation of AR42J progenitor cells, and that this growth is correlated with an increase in Id expression. The group also did immunohistochemistry staining to show that BMP and Id proteins are found in abundance in the embryonic mouse pancreas, which contains proliferating stem cells. A possi...

New genes implicated in rheumatoid arthritis

...y twin, labelled samples with fluorescent dye to distinguish RA cells from disease-free cells, and hybridized each on a 20,000-gene chip. Then, using immunohistochemistry and real-time polymerase chain reaction, they confirmed the expression of the most significantly over-expressed genes in synovial tissues. In addition...

Inflammation and drugs to control this activity studied in a variety of tumors sites

...er follow-up information was available for all of these women. Hartmann and her co-workers determined the amount of COX-2 in these samples by staining immunohistochemistry methods. Forty-one of the 235 women with atypia developed breast cancer over roughly a 15- to 20-year period. The research team found a significant...

3D Atlas Will Help Navigate The Spinal Cord

...oarchitecture). Many pathways in the nervous system contain a particular protein which can be demonstrated in tissue sections using a technique called immunohistochemistry that involves the use of specific antibodies. The often distinct distribution of these chemicals in the rat spinal cord is like a "signature" for one ...
Immunohistochemistry in Biological Technology

Indivumed Supports Roche Diagnostics With Immunohistochemistry Services and Clinical Specimens for Biomarker Discovery and Drug Development

HAMBURG, Germany, Sept. 14 /PRNewswire/ -- Indivumed announces today that a service agreement with Roche Diagnostics GmbH was signed. Within this agreement Indivumed will apply its automated immunohistochemistry service platform for analyzing various biomarkers and drug targets in the area of ...

Sigma-Aldrich and Atlas Antibodies Announce 2,300 New, Highly Validated Prestige Antibodies(RM)

...nce testing steps ensure that Prestige Antibodies are highly specific to their targets. Each Prestige Antibody is also associated with over 500 tissue immunohistochemistry (IHC) images, over 100 cell/line immunocytochemistry (ICC) images, immunofluorescence (IF) and western blotting (WB) data, all publicly accessible via...

NeoGenomics Announces Fourth Quarter and Full Year 2008 Financial Results

...out. During 2009, we expect to bring up another 6-8 molecular tests. During Q4, we also made significant strides in further developing our in-house immunohistochemistry product line. We validated over 100 antibodies and have already grown this business to approximately $100,000/month in revenue. We are also in the p...

Rosetta Genomics Reports Third Quarter 2008 Financial Results; Records First Revenues of $705,000; $7.4 Million Added to Available Cash Due to Repurchase of ARS

...nt study to compare Rosetta Genomics' miRview(TM) squamous, which differentiates squamous from non squamous non small cell lung cancer, with available immunohistochemistry methods. - Initiated a collaboration with the National Institute of Health (NIH) to identify microRNAs involved in the progression of the Huma...

Data Presented at Cancer Molecular Markers Meeting Suggests Clinical Benefit for Integrating New Molecular Tests

..., a molecular diagnostics company focused on oncology, and City of Hope Hospital presented today the results from a meta-analysis examining the use of immunohistochemistry (IHC) to determine the origin of metastatic cancer at the second annual ASCO-NCI-EORTC Meeting on Molecular Markers in Cancer in Hollywood, Fla. In th...

Genomic Health Announces Expansion of Oncotype DX(R) Breast Cancer Test to Include Quantitative Estrogen Receptor (ER) and Progesterone Receptor (PR) Scores

...gy Breast Cancer Symposium in September 2007. It measured ER and PR gene expression in 776 breast cancer patients by both local laboratory and central immunohistochemistry (IHC), and quantitative RT-PCR, as performed by the Oncotype DX assay. Results showed a high degree of agreement between the two methods. In an accomp...

Pathwork(R) Diagnostics Launches Genomics-Based Test For Hard-To-Identify Tumors Through Its CLIA-Certified Laboratory

...itional tools used to identify tumors of uncertain origin include imaging, such as CT scans and MRIs, as well as thorough pathological evaluation with immunohistochemistry and other techniques," said Federico A. Monzon, M.D., pathologist and director of molecular diagnostics at The Methodist Hospital and The Methodist Ho...

ARIUS presents new findings for anti-cancer antibody programs at AACR

...y. Moreover, apoptosis is achieved through inhibition of the AKT pathway, commonly believed to be an important pathway for cancer cell survival. New immunohistochemistry (IHC) studies using this antibody showed that CD9 is expressed in a variety of human tumor samples, resulting in moderate to high levels of staining i...

Laser Capture Microdissection of muscle fiber populations and expression analysis by RT-PCR

...nguish muscle fiber types using histochemistry and immunohistochemistry was used to provide criteria for their selective i... multiple neuromuscular junctions 2 . In the past, immunohistochemistry and in situ hybridization were mainly used to stud...d identification of distinct fibers based on their immunohistochemistry and innervation pattern allows us time to process ...

Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions

...9-1) ◊ OCT cryoembedding medium (VWR, Cat. #25608-930) ◊ ColorFrost Plus slides (Fisher Scientific, Cat. #12-550-17) II. immunohistochemistry ◊ Normal goat serum (Vector Laboratories, Cat. #S-1000) ◊ Anti-CD68/Macrosialin antibody (Serotec, Cat. #MCA195...
Immunohistochemistry in Biological Products

ELF® 97 Immunohistochemistry Kit from Molecular Probes (Invitrogen)

Description: ELF® 97 Immunohistochemistry Kit...
Company:Molecular Probes (Invitrogen)

BrdU Immunohistochemistry Assay Kit from Invitrogen

Description: IHC detection kit for BrdU in cells and tissues...
Company:Invitrogen

PCNA Immunohistochemistry Assay Kit from Invitrogen

Description: IHC detection kit for PCNA in cells and tissues...
Company:Invitrogen

Histology, Immunohistochemistry & Tissue Array Services from Dominion Pharmakine S.L.

Description: Our Histology, Immunohistochemistry and tissue arrays services include samples processing, different type of staning, histollogical stains, image analysis, tissue arrays, immunohistochemistry, etc....
Company:Dominion Pharmakine S.L.

UCB Eosinophil Chip-IHC from 3H Biomedical AB

Description:... Umbilical cord blood eosinophils, For immunohistochemistry (IHC)...
Company:3H Biomedical AB

Eosinophil Chip-IHC from 3H Biomedical AB

Description:... Human peripheral blood eosinophils, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Granulocytes...
Company:3H Biomedical AB

UCB MSC Cell Chip-IHC from 3H Biomedical AB

Description:... Umbilical cord blood mesenchymal stem cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Progenitor Cells...
Company:3H Biomedical AB

PBMC Cell Chip-IHC from 3H Biomedical AB

Description:... Human peripheral blood PBMCs, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood PBMC and T Cells...
Company:3H Biomedical AB

UCB MoDC Cell Chip-IHC from 3H Biomedical AB

Description:... Monocyte-derived dendritic cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Dendritic Cells...
Company:3H Biomedical AB

B Cell Chip-IHC from 3H Biomedical AB

Description:... Human peripheral blood CD19+ B cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Monocytes, B Cells, NK Cells and Stem Cells...
Company:3H Biomedical AB
Immunohistochemistry in Biological Definition

Cancer

...s the type of cell that is proliferating, its severity (degree of dysplasia ), its extent and size, and - sometimes with help from cytogenetics and immunohistochemistry - prognostic and therapeutic determinants. Biopsy can be curative if the whole lesion is removed; in this case, the borders of the sample are exami...
Immunohistochemistry in Biological Dictionary

In situ hybridization

...e in situ hybridization (FISH), published by the National Human Genome Research Institute. ... in situ hybridization (FISH) ... List of immunohistochemistry resources on the Internet. Includes a look at immunoenzyme techniques, immunofluorescence, and in situ hybridizations. In situ hybridizati...

Helicase

...f causes ... Mouse monoclonal to RNA Helicase A. RNA Helicase A unwinds double-stranded DNA ... RNA Helicase A antibody (ab54593) used in immunohistochemistry at 3ug/ml on ... "If I were an enzyme I would be DNA helicase so I could unzip Your genes. ... DNA Helicase - Unzip Your Genes. Shopkeeper: N...

Giemsa stain

... a Giemsa stain of a smear prepared from the patient's blood ... ... immunohistochemistry Reagents " Giemsa Stains " Giemsa stain ... Array Processing " immunohistochemistry Reagents " Giemsa Stains " Giemsa stain ... now used in the Wright...

Cytology

...ess invasive than other forms ... AMTS, Inc. is an ISO 9001:2000 registered company that supplies Histology, Pathology, Cytology , Microarray, and immunohistochemistry products to hospitals, Under the Evidence-based Practice Program of the Agency for Healthcare Research and Quality (formerly the Agency for Health ...
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