BioMosaics' Glypican-3 Antibody (clone 1G12) Validated at PhenoPath Laboratories for Immunohistochemical Detection of Liver Cancer

BURLINGTON, Vt. and SEATTLE, March 26 /PRNewswire/ -- BioMosaics Inc., a cancer biomarker development company, announced today that its monoclonal antibody product (clone 1G12) for detection of Glypican-3 (GPC3) has been validated for use as an immunohistochemical test for diagnosis of Hepatocellu...

Hard to Treat Diseases, Inc. (HTDS) Experiments with Hyperbaric Oxygenation (HBO) Traumatic Brain Injury

...'t hyperbaric chambers, HBO treatments were performed at the Hyperbaric Medical Center. These data for the first time showed (all was visualized using immunohistochemical technique and specific antibodies to neuronal markers) that HBO prevent axonal loss and neuronal degeneration, since data concerning brain injury are ...

Stemedica Discovers Significant Breakthrough in the Use of Stem Cells and Stem Cell Factors for the Treatment of Retinal Degeneration

... eye. Healthy non-dystrophic and non-treated (normally dystrophic) animals were also used as independent control groups. Electroretinography (ERG) and immunohistochemical (ICH) analysis was performed on both eyes. "What is very impressive is the immune privileged feature of all three kinds of human stem cells (RPE,...

PLUS Diagnostics First National Laboratory to Offer Highly Specialized Gastrointestinal Tests

...ny Expands Diagnostic Services with K9 Clone DOG-1 immunohistochemical and H. pylori Monoclonal Antibody Tests LAKEW...romal tumor ("GIST"). Known as the K9 clone DOG-1 immunohistochemical assay, the new test is expected to identify up to ...ori is expected to improve the accuracy of today's immunohistochemical tests, so doctors can immediately determine whethe...

Novel gene predicts local recurrence in early onset breast cancer

...1 gene in normal breast epithelial cells, which caused the cells to lose their ability to form proper structures. In addition, the researchers used immunohistochemical staining to examine DEAR1 expression in 14 samples of ductal carcinoma in situ (precancerous abnormalities) with adjacent normal epithelium and in the...

Novel gene predicts local recurrence in early-onset breast cancer

...1 gene in normal breast epithelial cells, which caused the cells to lose their ability to form proper structures. In addition, the researchers used immunohistochemical staining to examine DEAR1 expression in 14 samples of ductal carcinoma in situ (precancerous abnormalities) with adjacent normal epithelium and in the...

CRi's New Vectra(TM) Platform Rapidly Analyzes Tissue Slides and Microarrays in Brightfield and Fluorescence

...tion cellular and tissue images from samples stained with standard H&E, immunohistochemical and immunofluorescence techniques. The Vectra system utilizes CRi's in...ennsylvania , "CRi's Vectra has allowed us to break the boundary of routine immunohistochemical and immunofluorescence studies by supporting multiplexed staining and analy...

Researchers identify potential therapeutic target in osteosarcoma

...ts at the protein level," said co-senior author Wadih Arap, M.D, Ph.D., also Professor of Medicine and Cancer Biology in the David H. Koch Center. immunohistochemical staining analysis of IL-11Ra expression in primary and metastatic human osteosarcoma samples provided further evidence of the potential value of IL-11...

Oetzi's last days

...cted an additional small discoloration of the skin, which was probably caused by a blow from a blunt object. In both cases, the researchers, using new immunohistochemical detection methods, managed to detect very briefly survived, yet unequivocally fatal bleeding. Above the spine are more discolorations that are not ...

How to enhance non-thermal effects of ultrasound

...n enhance non-thermal effects of ultrasound, and the pathological characteristics of the non-thermal damage is different from those of thermal damage. immunohistochemical detection found that PHIFU combined with UCA can promote tumor cell apoptosis and inhibit tumor cell proliferation, which will be reported in another ...

Immunohistochemical in Medical Technology

HistoRx and Radiation Therapy Oncology Group Initiate Brain Tumor Biomarker Research Partnership

...erms of the agreement, HistoRx will provide RTOG researchers access to HistoRx's AQUA(R) technology for biomarker analysis and will develop customized immunohistochemical assays to be used by RTOG in investigating the relationship between specific protein biomarkers and clinical responsiveness in brain tumor patients. H...

Immunohistochemical in Medical Products

Microsatellite Instability/HNPCC by Immunohistochemical Stain

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Immunohistochemical in Medical Definition

Depolarization-induced suppression of inhibition

...tion of LTP in the hippocampus. Nat Neurosci. Aug;5(8):723-4. Cristino L, de Petrocellis L, Pryce G, Baker D, Guglielmotti V, Di Marzo V. (2006) immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain. Neuroscience. Apr 5; In P...

Ocular oncology

.... [ citation needed ] The most common orbital malignancy is orbital lymphoma . This tumor can be diagnosed by biopsy with histopathologic and immunohistochemical analysis. Most patients with orbital lymphoma can be offered chemotherapy or radiation therapy . Orbital dermoid cysts are benign choristomas...

Immunohistochemical in Biological News

Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals

...s of diseases related to this native biological system, but to the development of new agents that will enhance effectiveness in treatment. Previous immunohistochemical and immunoelectron microscope studies have detected OGF and OGFr in both the cytoplasmic and the nuclear compartments. The OGF-OGFr axis is known to ...

Biomarker predicts malignancy potential of HG-PIN lesions in the prostate

...tween 2000 and 2004. Finding that PTOV1 gene expression was elevated in HG-PIN associated with cancer, the investigators used tissue microarray and immunohistochemical analyses to see whether PTOV1 protein levels could discriminate these pre-malignant lesions from HG-PIN that did not develop into prostate cancer. ...

Gene expression test reveals ER and HER-2 status of breast tumors

...maining samples, which showed that the initial results were both reliable and reproducible. The gene expression tests disagreed with traditional immunohistochemical lab analysis of the tumors by 8 percent for ER and 11 percent for HER-2. The researchers note this degree of discrepancy is usual when different diagn...

Infectious disease expert warns of spread of Rocky Mountain spotted fever

...archers took blood and skin tissue samples from 16 patients across Southeastern Arizona suspected of having the infection. Laboratory tests, including immunohistochemical staining, confirmed that 11 had the disease, while the remaining five were still probable cases. When the researchers examined the patients' home e...

Immunohistochemical in Biological Technology

Radiesse(R) Dermal Filler Featured Prominently in Journal of Dermatologic Surgery Special Issue on Fillers

...-- Calcium Hydroxylapatite Filler for Facial Rejuvenation: A Histologic and immunohistochemical Analysis - ALEXANDER L. BERLIN, MD, MUSSARRATT HUSSAIN, MD, AND DAVID J. GO... Calcium Hydroxylapatite Filler for Facial Rejuvenation: A Histologic and immunohistochemical Analysis This study was conducted to characterize the expression of colla...

HistoRx Announces Expanded Access of AQUA(R) Technology to 900+ Researchers at Dana-Farber/Harvard Cancer Center

...gram (HistoRx Academic Research Program), enables the reliable measurement of protein biomarkers in tissue and tissue microarrays based on fluorescent immunohistochemical methods. Assays developed on the system may be used to better understand the origins of diseases as well as to aid in patient selection for clinical t...

HistoRx and Lilly Extend, Expand AQUA(R) Analysis Partnership

...e- based biomarker measurement and analysis to drug development programs, virtually eliminating the subjective interpretation inherent in conventional immunohistochemical methods. In the course of the partnership, HistoRx develops AQUA(R) analysis-based diagnostic assays that are linked to its partners' drugs in develop...

Sigma-Aldrich Announces New Prestige Antibodies(TM) Line for Proteomics and Cell Biology Researchers

...hly characterized and offer significant value to the research community. Each antibody is highly validated for specificity and accompanied by over 500 immunohistochemical images, which are displayed in the publicly accessible Human Protein Atlas. In addition, Prestige Antibodies(TM) are optimized on a single protocol an...

Panacea Pharmaceuticals' Lung Cancer Diagnostic Test, LC Detect(SM), Named One of Time Magazine's Ten Biggest Medical Breakthroughs of 2007

... LC Detect(SM) measures levels of human aspartyl (asparaginyl) beta-hydroxylase (HAAH), a cancer molecular marker, in blood. HAAH has been detected by immunohistochemical staining in a broad range of cancers, including lung cancer, and has been shown to be highly specific and absent in adjacent non-affected tissue as we...

Panacea Pharmaceuticals Announces the Availability of BC Detect(SM), a Serum- Based Diagnostic Test for Breast Cancer

...BC Detect(SM) measures levels of human aspartyl (asparaginyl) beta- hydroxylase (HAAH), a cancer molecular marker, in blood. HAAH has been detected by immunohistochemical staining (IHC) in a broad range of cancers including breast cancer. In addition, HAAH protein levels in serum have been demonstrated to be highly sens...

Laser Capture Microdissection of muscle fiber populations and expression analysis by RT-PCR

...oline esterase stain by Karnowsky and Roots 5 and immunohistochemical staining with a mouse-monoclonal slow myosin heavy...d to 32 minutes by combining the histochemical and immunohistochemical reactions and the direct coupling of the antibody ... fiber type by LCM. The Zenon TM technology based immunohistochemical staining of slow MyHC positive fibers gives a stro...

Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions

...nd mount on positively charged Color Frost Plus slides. B. Immunodetection of CD68+ Macrophages for LCM. Standard immunohistochemical staining protocols usually require prolonged incubation periods in aqueous media, which results in significant degradation of RNA. To overcome this li...

Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C

...sed that the above-mentioned markers are not expressed by all cells in a given tumor, a fact that emphasizes the need to perform immunohistochemical analysis in combination with 2-D PAGE in order to interpret the data. To decide which antibody should be included in the immunoh...

In Situ Cell Death Detection Kit

... This figure shows the detection principle of the TUNEL kits. Labeling with fluorescein may also be followed by immunohistochemical detection using anti-fluorescein-specific antibodies that are conjugated to POD or AP. Typical applications of the TUNEL kits are: ...

Immunohistochemical in Biological Products

Peroxide Block for Image Analysis from ScyTek Laboratories

Description:... This reagent has been developed for use with immunohistochemical (IHC) techniques for the reduction of nonspecific background staining due to endogenous peroxidase. Traditional methods describe blocking peroxidase ...
Company:ScyTek Laboratories

Ready-To-Use IHC Bluing Reagent from Bethyl Laboratories

Description:... Bethyl Laboratories Ready-To-Use IHC Bluing Reagent is used following IHC hematoxylin counterstaining with immunohistochemical procedures. Shelf-Life: 1 year from date of receipt...
Company:Bethyl Laboratories

Clarion mounting medium - DAB NBT TNBT Vega Red and Fuchsin from GeneTex

Description:... Clarin represents the state-of-the-art in permanent mounting media. It is designed for the permanent preservation of immunohistochemical organic insoluble substrates such as diaminobenzidine (DAB), Vega Red, New Fuchsin, and any other organic solvent compatible chromogen substrates on t...
Company:GeneTex

Faramount, Aqueous Mounting Medium, Ready-to-Use from Dako

Description:... This mounting medium is specifically formulated for mounting tissue specimens, cell smears, and cytospins which have been stained with immunohistochemical methods for viewing by light microscopy. It is ideal for use with chromogens, such as AEC, that are alcohol-soluble or incompatible with organic solve...
Company:Dako

Target Retrieval Solution, High pH from Dako

Description:... Target Retrieval Solution, High pH This pH 9.9 solution is intended for heat-induced target retrievel prior to immunohistochemical staining procedures. It is for use on formalin-fixed, paraffin-embedded tissue sections mounted on glass slides. For particular antigens, target retri...
Company:Dako

Target Retrieval Solution, High pH, Concentrated x 10 from Dako

Description:... Target Retrieval Solution, High pH, Concentrated x 10 This pH 9.9 solution is intended for heat-induced target retrievel prior to immunohistochemical staining procedures. It is for use on formalin-fixed, paraffin-embedded tissue sections mounted on glass slides. For particular antigens, target retri...
Company:Dako

Dako Target Retrieval Solution, pH 9 (x 10) from Dako

Description:... Dako Target Retrieval Solution, pH 9 (x 10) This product is a Tris/EDTA buffer, pH 9, intended for heat-induced target retrieval prior to immunohistochemical staining procedures. It is well-suited for use on formalin-fixed, paraffin-embedded tissue sections mounted on glass slides. Compared with 0.01 mol/L ...
Company:Dako

Rat Anti-Vitamin D Receptor Monoclonal Antibody, Unconjugated, Clone 9A7 from ABR-Affinity BioReagents

Description:...detects a 58 kDa and 60 kDa protein representing VDR in avians while the VDRs of mammalian species appear as single bands within the 52-55 kDa range. immunohistochemical staining of VDR in cultured human skin fibroblasts with MA1-710 results in strong nuclear staining. MA1-710 antigen is partially purified chicken...
Company:ABR-Affinity BioReagents

10X Automation Buffer from GeneTex

Description:...nventional horizontal processing techniques. This concentrated buffer is recommended for the rinsing steps when performing most immunoassays including immunohistochemical staining of tissue sections using any of our HistoScan(tm), LymphoScan(tm) or BioStain(tm) Super ABC kits. Seven Step Procedure: 1.After the immunosta...
Company:GeneTex

Human / Mouse / Rat Blood Vessels (CD31 / Von Willebrand Factor (vWF)) IHC staining Kit from CHEMICON

Description:... CHEMICONs Blood Vessel Staining Kit is a very sensitive immunohistochemical tool for the detection of vascular endothelial cells, containing both anti-von Willebrand Factor and anti-CD31 primary antibodies and is applicable to...
Company:CHEMICON

Immunohistochemical in Biological Definition

Immunology

...orescent label, or color-forming enzyme and are used as a "probe" to detect it. Well known applications of this include immunoblotting , ELISA and immunohistochemical staining of microscope slides. The speed, accuracy and simplicity of such tests has led to the development of rapid techniques for the diagnosis of di...

Immunohistochemical in Biological Dictionary

Oviduct

...id not secrete IFN- in response to the TLR2 ... Oviduct -specific expression of two ... Transgene Expression Is Restricted to the Oviduct . ... immunohistochemical detection of miR24 in oviduct sections. ... The mammalian oviduct is anatomically divided into the infundibulum, ampulla, ... The paired ovidu...

Optic lobes

... gotta love life ... Like sheynpunzalan.com or yellowpolkas.com or ishtarpis.com. Whateva! ... BioInfoBank Library :: Optic Lobe :: analysis :: immunohistochemical evidence of methionine enkephalin-like material in the brain of the migratory locust. ... ... pb-no-eb lines and some in Optic lobes . 009Y ... ...

MSH2

...ry nonpolyposis colorectal cancer AND ( msh2 or hnpcc1) (PubMed) ... immunohistochemical staining for the MLH1, MSH2 , and MSH6 proteins was performed ... MLH1 and MSH2 Promoter Mutation Analysis ... immunohistochemical analysis of Msh2 and Fhit protein expression in 62 CRC cases ... Loss...

Fusion Protein

...ess proteins have profound immune stimulatory properties ... Hsp70 fusion proteins elicit antigen-specific CTL responses and protect mice ... immunohistochemical detection of His•Tag fusion proteins in transfected COS-1 cells ... Tag firefly luciferase (Fluc) fusion protein was transiently transfected...