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ISOCITRATE in Medical News

Reversing effects of altered enzyme may fight brain tumor growth

... findings in the current issue of the journal Science . According to Guan, researchers have known that a mutation in the gene encoding the enzyme, isocitrate dehydrogenase (IDH1), contributed to certain brain tumors called low grade gliomas and secondary glioblastomas, but no one understood how. Guan, Yue X...

2 gene mutations linked to most common brain cancers -- and longer survival

...y and biologically distinct subgroup of brain cancers that may benefit from targeted therapies in the future," says Parsons. IDH1, which stands for isocitrate dehydrogenase 1, was first spotted last year in results from a genomewide scan of brain cancer mutations led by the Johns Hopkins scientists. At the ...
ISOCITRATE in Biological News

UNC study: Scientists identify chemical compound that may stop deadly brain tumors

...he April 10, 2009 issue of the journal Science . In experiments with tumor cells, the researchers reversed the effects of a mutation in a gene called isocitrate dehydrogenase-1 (IDH1) by replenishing a compound called α-ketoglutarate (α-KG). "When the IDH1 gene is mutated, the level of α-KG i...

Kilogram quantities at last!

...ks to a host of tiny helpers, the yeast Yarrowia lipolytica, which produces isocitrate from refined sunflower oil in previously unachievable yield and in a favorable isocitrate to citrate ratio. After the biomass is filtered out, electrodialysis is use...
ISOCITRATE in Biological Products

Rabbit Anti-ISOCITRATE DEHYDROGENASE Polyclonal Antibody, Unconjugated from AbD Serotec

Description:... RABBIT ANTI isocitrate DEHYDROGENASE...
Company:AbD Serotec
ISOCITRATE in Biological Definition

Citric acid cycle

.... Aconitase Hydration H 2 O III. isocitrate 3. isocitrate dehydrogenase Oxidation NAD + NADH + H + IV. Oxalosuccinate 4. isocitrate dehydrogenase Decarboxylation V...

Citric acid cycle

.... Aconitase Hydration H 2 O III. isocitrate 3. isocitrate dehydrogenase Oxidation NAD + NADH + H + IV. Oxalosuccinate 4. isocitrate dehydrogenase Decarboxylation V...
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