Navigation Links
IKK in Medical News

Instead of fighting breast cancer, immune cell promotes its spread

... by activating cells that help break down bone. Along with another protein, ikk alpha, it has been implicated both in tumor formation and metastasis. Th... Tan noted that additional experiments showed that blocking both RANKL and ikk alpha in those breast tumor cells inhibited lung metastases. "More importan...

Oncoproteins double-team and destroy vital tumor-suppressor

...r had an average volume of more than 600 cubic millimeters. ERK, AKT and ikk are three separate cancer-causing kinases - proteins that phosphorylate oth...of human cancers." "Pharmaceutical companies work to target ERK, AKT and ikk separately," Hung notes. "But activating their forkhead target would work a...

Pathway links inflammation, angiogenesis and breast cancer

...a, a protein kinase activated by TNFa," Hung says. ikk inactivates a cancer-suppressing protein complex, ... colleagues works like this: TNFa activates ikk , which as a kinase works by attaching phosphate groups to other proteins. ikk phosphorylates tuberous sclerosis 1 (TSC1) blockin...

Repeated Liver Cell Proliferation, a Cause for Liver Cancer

... colleagues strongly suggest that the control of tissue renewal through the ikk and JNK pathways plays a key role in liver cancer in mouse models. One ... 2005, Karin and his colleagues at UCSD implicated the pathway's activator, ikk , in chemically induced liver cancer. However, the surprising outcome of th...

TNF Helps in the Understanding of the Immune System and Development of Drugs against Various Ills

...NF's warning message travels from the surface of a cell to its nucleus a molecule called Inhibitor of KappaB Kinase (IKK) plays a very important role. ikk carefully controls the level of the immune system's response. Hence by altering this molecule one can develop new medications designed to boost or sup...
IKK in Medical Technology

Nereus Pharmaceuticals to Present Data at the American Association for Cancer Research 2007 Annual Meeting

...nd a new preclinical candidate NPI-1387, a highly selective, small molecule ikk modulator. Nereus will also present preliminary data from its Phase I dose ... has a family of over 400 synthetic small molecule diterpenes that modulate ikk and many downstream cytokines including TNF-alpha, IL-6, IL-8 and others. T...
IKK in Biological News

NCI renewal grant to develop new cancer therapies

...ion as a platform to develop novel combination regimens incorporating histone deacetylase inhibitors and NF-kappa B antagonists such as proteasome and ikk beta inhibitors in the treatment of acute leukemia and other hematologic malignancies." Grant and his team are already leading a multi-institutio...

Cycles of cell death, proliferation key to liver cancer

... colleagues strongly suggest that the control of tissue renewal through the ikk and JNK pathways plays a key role in liver cancer in mouse models. One l... 2005, Karin and his colleagues at UCSD implicated the pathway's activator, ikk , in chemically induced liver cancer. However, the surprising outcome of t...

Protein finding could lead to treatment for inflammatory diseases

...appa Kinase (IKK) complex. The normal function of ikk is to trigger the degradation of a protein that in...bits NF-kB activity. MC160 subsequently causes the ikk complex to fall apart to prevent the phosphorylati...y, than any identified before, by focusing on this ikk complex." Shisler has obtained a patent to purs...

Infection 'alarm' yields clues to immune system behavior

...arefully controls the level of the immune system's response." That makes ikk a very promising target for new medications designed to boost or suppress t...erized by a weak inflammatory response might be helped by a drug that makes ikk even more sensitive to infection messages. The researchers believe their...

Firefly protein lets researchers monitor molecule linked to cancer

...l other disorders. The target molecule, known as ikk (for IKappa kinase), regulates processes that can ...t from the firefly protein, luciferase, to monitor ikk activity in tumor cells and inflamed liver cells i...ear in the August 2005 issue of Nature Methods. ikk stands at a pivot point in the middle of an import...
Other Tags
(Date:8/20/2014)... have discovered that the immune system is defective in people ... why sufferers have ongoing issues with pain. , The research ... could also help to explain why some painkillers may not ... affects up to 10% of the community. There are ... gut pain, which often has the greatest impact on sufferers, ...
(Date:8/20/2014)... Hundreds of Mirena IUD lawsuits ( http://www.themirenalawsuitcenter.com/ ... allegedly injured due to spontaneous migration of the IUD ... Superior Court, Bernstein Liebhard LLP reports. According to a ... Court has established procedures regarding the production of sales ... of the proceeding’s initial disposition pool. (In Re: Mirena ...
(Date:8/20/2014)... News) -- Loss of brain cells that act as ... have trouble falling and staying asleep, a new study ... especially severe and often results in nighttime confusion and ... data from the Rush Memory and Aging Project, which ... and are being followed until death, at which point ...
(Date:8/20/2014)... HealthDay Reporter WEDNESDAY, Aug. 20, 2014 ... been an option, but a new study shows that only ... common reasons women didn,t undergo reconstruction was that they felt ... they were focused on their cancer treatment," said lead researcher ... Kettering Cancer Center, in New York City. Also common ...
(Date:8/20/2014)... and deadliest infectious diseases in the world, killing one ... study tuberculosis have long debated its origins. New research ... to seals and sea lions that brought the disease ... there before Europeans landed on the continent. , The ... of New World Human Tuberculosis," was published in ...
Breaking Medicine News(10 mins):Health News:Pain treatments less effective for those with irritable bowel 2Health News:Mirena Lawsuit News: Case Management Order Issued in New Jersey Mirena Litigation, Bernstein Liebhard LLP Reports 2Health News:Mirena Lawsuit News: Case Management Order Issued in New Jersey Mirena Litigation, Bernstein Liebhard LLP Reports 3Health News:Mirena Lawsuit News: Case Management Order Issued in New Jersey Mirena Litigation, Bernstein Liebhard LLP Reports 4Health News:Seniors' Sleep Woes May Be Linked to Loss of Brain Cells 2Health News:Many Women Who Have Mastectomy Don't Get Breast Reconstruction: Study 2Health News:Many Women Who Have Mastectomy Don't Get Breast Reconstruction: Study 3Health News:New research shows seals and sea lions likely spread tuberculosis to humans 2Health News:New research shows seals and sea lions likely spread tuberculosis to humans 3
(Date:8/20/2014)... could one day be made out of cocoa, rice ... reporting. The novel process they developed and their results, ... and plastic waste problems, appear in the ACS journal ... and colleagues at the Italian Institute of Technology point ... its production reached 288 million tons worldwide, but its ...
(Date:8/20/2014)... When a colony of honeybees grows to about 4,000 ... reproductive cycle: the building of a special type of ... team of experts from the Department of Neurobiology and ... what starts the reproductive cycle of honeybee colonies. The ... The Science of Nature . , Reproduction isn,t ...
(Date:8/20/2014)... and POINT ROBERTS, Washington , August 20, ... Key Role in Addressing Security Concerns in the Payment Industry? ... news source covering leading sectors including biometrics, issues commentary from ... Jason Peaslee , Managing Partner at Thrive Analytics, ... Gino Pereira , CEO of NXT-ID, Inc. (OTCBB: NXTD) ( ...
Breaking Biology News(10 mins):Worker bees 'know' when to invest in their reproductive future 2Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 2Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 3Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 4Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 5Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 6Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 7
Other Contents