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IKK in Medical News

Instead of fighting breast cancer, immune cell promotes its spread

... by activating cells that help break down bone. Along with another protein, ikk alpha, it has been implicated both in tumor formation and metastasis. Th... Tan noted that additional experiments showed that blocking both RANKL and ikk alpha in those breast tumor cells inhibited lung metastases. "More importan...

Oncoproteins double-team and destroy vital tumor-suppressor

...r had an average volume of more than 600 cubic millimeters. ERK, AKT and ikk are three separate cancer-causing kinases - proteins that phosphorylate oth...of human cancers." "Pharmaceutical companies work to target ERK, AKT and ikk separately," Hung notes. "But activating their forkhead target would work a...

Pathway links inflammation, angiogenesis and breast cancer

...a, a protein kinase activated by TNFa," Hung says. ikk inactivates a cancer-suppressing protein complex, ... colleagues works like this: TNFa activates ikk , which as a kinase works by attaching phosphate groups to other proteins. ikk phosphorylates tuberous sclerosis 1 (TSC1) blockin...

Repeated Liver Cell Proliferation, a Cause for Liver Cancer

... colleagues strongly suggest that the control of tissue renewal through the ikk and JNK pathways plays a key role in liver cancer in mouse models. One ... 2005, Karin and his colleagues at UCSD implicated the pathway's activator, ikk , in chemically induced liver cancer. However, the surprising outcome of th...

TNF Helps in the Understanding of the Immune System and Development of Drugs against Various Ills

...NF's warning message travels from the surface of a cell to its nucleus a molecule called Inhibitor of KappaB Kinase (IKK) plays a very important role. ikk carefully controls the level of the immune system's response. Hence by altering this molecule one can develop new medications designed to boost or sup...
IKK in Medical Technology

Nereus Pharmaceuticals to Present Data at the American Association for Cancer Research 2007 Annual Meeting

...nd a new preclinical candidate NPI-1387, a highly selective, small molecule ikk modulator. Nereus will also present preliminary data from its Phase I dose ... has a family of over 400 synthetic small molecule diterpenes that modulate ikk and many downstream cytokines including TNF-alpha, IL-6, IL-8 and others. T...
IKK in Biological News

NCI renewal grant to develop new cancer therapies

...ion as a platform to develop novel combination regimens incorporating histone deacetylase inhibitors and NF-kappa B antagonists such as proteasome and ikk beta inhibitors in the treatment of acute leukemia and other hematologic malignancies." Grant and his team are already leading a multi-institutio...

Cycles of cell death, proliferation key to liver cancer

... colleagues strongly suggest that the control of tissue renewal through the ikk and JNK pathways plays a key role in liver cancer in mouse models. One l... 2005, Karin and his colleagues at UCSD implicated the pathway's activator, ikk , in chemically induced liver cancer. However, the surprising outcome of t...

Protein finding could lead to treatment for inflammatory diseases

...appa Kinase (IKK) complex. The normal function of ikk is to trigger the degradation of a protein that in...bits NF-kB activity. MC160 subsequently causes the ikk complex to fall apart to prevent the phosphorylati...y, than any identified before, by focusing on this ikk complex." Shisler has obtained a patent to purs...

Infection 'alarm' yields clues to immune system behavior

...arefully controls the level of the immune system's response." That makes ikk a very promising target for new medications designed to boost or suppress t...erized by a weak inflammatory response might be helped by a drug that makes ikk even more sensitive to infection messages. The researchers believe their...

Firefly protein lets researchers monitor molecule linked to cancer

...l other disorders. The target molecule, known as ikk (for IKappa kinase), regulates processes that can ...t from the firefly protein, luciferase, to monitor ikk activity in tumor cells and inflamed liver cells i...ear in the August 2005 issue of Nature Methods. ikk stands at a pivot point in the middle of an import...
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