Researchers from 5 countries to test hygiene hypothesis with EU funding
High living standards and the life style connected to them seem to promote the development of autoimmune diseases and allergic symptoms. This has lead to the assumption that the immune system begins to overreact to the organisms own structures or to exogenous non-infectious proteins, i.e. allergen...
Fox Chase finds that lung cancer patients respond to erlotinib following cetuximab therapy
...mab," Borghaei says. He cautions, however, that these data come from a subset analysis and are retrospective, so they are not conclusive, but are only hypothesis
Although erlotinib is approved for use in patients with non-small cell lung cancer and cetuximab has been studied in this setting for ...
Gloomy Days Dim Cognitive Powers of the Depressed
... see if there was any correlation between days of sunlight and levels of cognitive impairment in people with and without depression.
Their original hypothesis
panned out: Depressed people who soaked up more of the sun's rays over a two-week period had better cognitive function compared with their counterpart...
Small Molecule Might Play Big Part in Lung Cancer
... targeted therapies for specific lung cancers follow this line of scientific thought -- gefitinib (Iressa) and erlotinib (Tarceva).
To test their hypothesis
that miR-21 and EGFR may make attractive targets for therapy, the researchers tested two experimental compounds: an antisense molecule designed to bin...
Is a society with smokers profitable?
As Lpez declared to SINC, "we have not attempted to verify a specific hypothesis
but rather carried out an appraisal of the studies on tobacco consumption f... private costs and the evidence that most smokers want to stop give up, the hypothesis
that taxes and restrictions on consumption increase net welfare gains plaus...
Scientists Reverse Muscular Dystrophy in Mice
...g to one another," continued Thornton. "In theory, if you could make that happen might you might actually make this disease go in reverse."
And the hypothesis
An "antisense morpholino oligonucleotide," a synthetic molecule, succeeded in pulling apart the RNA and the muscleblind proteins.
Hypothesis in Medical Technology
Regular Yoga Practice Is Associated With Mindful Eating
...ut found no association between other types of physical activity, such as walking or running, and mindful eating.
"These findings fit with our hypothesis
that yoga increases mindfulness in eating and leads to less weight gain over time, independent of the physical activity aspect of yoga practice," said...
Radius' Investigational Bone Anabolic Agent, BA058, Increased Bone Mineral Density (BMD) at Key Fracture Sites in Phase 2 Clinical Trial in Postmenopausal Osteoporosis
...tions of osteoporosis and an area in which currently available osteoporosis treatments are weak."
"These data are consistent with the clinical hypothesis
for BA058--greater gains in BMD at the critical anatomic sites with less resorptive effect and less hypercalcemia compared to PTH and its analogs," sa...
Diabetes Gene Raises Odds of Lower Birth Weight
...tal period may cause a baby to be born smaller. Low birth weight is already known to increase the risk of disease later in life, and the fetal insulin hypothesis
proposes that the same gene that causes lower birth weight also increases the risk of developing type 2 diabetes.
"The mechanisms by which CD...
Wyeth Reports Publication of Phase 3 Data for Bazedoxifene/Conjugated Estrogens, an Investigational Compound Being Studied for the Treatment of Menopausal Symptoms
... Sterility , is from the S elective estrogens M enopause A nd R esponse to T herapy (SMART-1) clinical trial. SMART-1 was designed to explore the hypothesis
that bazedoxifene, when paired with conjugated estrogens, may have the potential to eliminate the need for progestin in menopausal therapy in women wi...
MJFF's Rapid Response Innovation Awards Hit Mid-2009 With Over $1 Million Funded in High-Risk/High-Reward Approaches to Parkinson's Disease
...determining whether phenylbutyrate may slow disease progression.
Richard Smeyne, PhD, of Saint Jude Children's Research Hospital will test the hypothesis
that the virulent H5N1 ("bird flu") strain of influenza virus can play a role in inducing parkinsonism. There is significant literature, mostly based ...
Alfacell Provides Shareholder Update
...atment with the drug. Striking decreases in all of these genes in the mesothelioma cell lines were seen after treatment with Onconase validating the hypothesis
that one of the mechanisms of action of Onconase is to decrease resistance to chemotherapy. Moreover, these data in cell lines are complemented by mos...
Hypothesis in Medical Products
Ghrelin, Total ELISA Test
Description:...n acute states of positive energy balance and in chronic obesity, but elevated during fasting and in anorexia nervosa. These data further support the hypothesis
that the secretion of Ghrelin not only has effects opposite to leptin, but is also regulated antipodal to leptin. Whether increased Ghrelin levels in...
Company:Diagnostic Systems Laboratories, Inc.
Hypothesis in Medical Definition
...owever, this principle has very important limits in medical practice. The actual process that occurs when diagnosing a patient is a continuous flow of hypothesis
and testing of that hypothesis, then modifying the hypothesis, and so on. In the context of this method, the principle of Hickam's dictum asserts that...
...lized medicine is not driven, in some instances, on the basis of scientific hypothesis
but through hypothesis
generation sometimes starting with natural history. The key task is to find...
Hypothesis in Medical Dictionary
...easures. A principle value is a foundation upon which... In statistical hypothesis
testing, the p-value is the probability of obtaining a result at least as extreme as the one that was actually observed, assuming that the null hypothesis
is true. The fact that p- values are based on this assumption is crucial t...
...ten a long-term (chronic) condition. ... Overview: Stasis dermatitis is a common inflammatory skin disease that occurs on ... This pooling hypothesis
led to the term stasis dermatitis . ... Information about Venous Stasis Dermatitis and other common conditions of the foot! ... Stasis d...
...ies are a group of progressive conditions that affect the brain and nervous system of many animals, including humans. According to the most widespread hypothesis
they are transmitted by prions, though some other data suggest an... prion diseases ( ′Prī′än di′zēzəz ) ( medicine ) A group of invariably fa...
...betes ... Questions Over Value Of Glucose Monitoring For Non-insulin Using Diabetes ... Abstract and Introduction: The authors investigated the hypothesis
that plasma glucose is associated with a reduction in episodic and/or semantic memory already in ... glucose glossary includes a list of gl...
...sting blood clots . They prevent new clots from forming or existing clots from getting ... Sally Fallon and Mary Enig challenge the lipid hypothesis
of heart disease. ... Yet a heart attack due to a clot can occur even in the absence of arterial blockages. ... Definition of clot from th...
...fession that emphasizes diagnosis, treatment and prevention of mechanical disorders of the musculoskeletal system, especially the spine, under the hypothesis
that these... The ACA is the leading national association representing Doctors of Chiropractic . ... Get the latest chiropractic news delivered...
Hypothesis in Biological News
New hypothesis for origin of life proposed
(Santa Barbara, Calif.) Life may have begun in the protected spaces inside of layers of the mineral mica, in ancient oceans, according to a new hypothesis.
was developed by Helen Hansma, a research scientist with the University of California, Santa Barbara and a program direct...
The pepperoni pizza hypothesis
CHICAGO -- What's the worst that could happen after eating a slice of pepperoni pizza? A little heartburn, for most people.
But for up to a million women in the U.S., enjoying that piece of pizza has painful consequences. They have a chronic bladder condition that causes pelvic pain. Spicy food...
August 2009 Geology and GSA Today media highlights
... and tsunami generation. The presence of trapped, pressurized fluids is one hypothesis
widely invoked to explain these "weak faults," yet it has been notoriously ...ion forcing of tropical systems. Their findings indicate that the long-held hypothesis
that the Inter-Tropical Convergence Zone has migrated southward during the ...
Placenta-derived stem cells may help sufferers of lung diseases
...rs characterized by inflammation and fibrosis is supported in previous studies," says Dr. Ornella Parolini, the study's lead author. "In line with the hypothesis
that cells derived from the amniotic membrane have immunomodulatory properties and have been used as an anti-inflammatory agent, we set out to evaluat...
Penn-Wistar team gains insight into HIV vaccine failure
... and the University of Pennsylvania reports new evidence refuting a popular hypothesis
about the highly publicized failure in 2007 of the Merck STEP HIV vaccine s...d5," says Betts. "This is probably the major factor that disproves the main hypothesis
proposed to explain the STEP trial results."
The team next questioned wh...
Early initiation of Arctic sea-ice formation
...arth to cool. However, the new findings imply that the threshold for sea-ice formation was first crossed in the Arctic, which, say the authors, is "a hypothesis
opposite to that modelled for glacial ice, whereby Antarctica is shown to glaciate much earlier (that is, at higher levels of carbon dioxide) than cir...
Hypothesis in Biological Technology
Researchers enlist DNA to bring carbon nanotubes' promise closer to reality
...u get a variant called the beta-barrel."
While the researchers do not have absolute proof, they say circumstantial evidence strongly supports their hypothesis
that the DNA is forming this well-organized structure and that it recognizes a specific CNT in the same way that biological molecules recognize each o...
ROCK STARS OF SCIENCE: Prana's Co-Founding Scientist, Rudy Tanzi Teams up with Star-Powered Cast in GQ Photoshoot
...ds for Alzheimer's disease research: The Metropolitan Life Foundation Award and The Potamkin Prize.
Dr. Tanzi is also a co-founder of the "Metal hypothesis
of Alzheimer's disease," the premise behind Prana's novel therapeutics for treating the disease.
Also featured in the magazine is Professor Jeffr...
Nile Therapeutics CD-NP Clinical Program for Acute Heart Failure Released From Clinical Hold by FDA
...ardiac pressure and an improvement in renal function. The Company believes that the current preclinical and clinical data supports the pharmacological hypothesis
at doses that have been safely tolerated by patients, and provides CD-NP with the potential for favorable differentiation from other acute heart failu...
Sandia researchers construct carbon nanotube device that can detect colors of the rainbow
... chemistry. He and Wong laid the groundwork with their theoretical research, with Wong completing the first-principles calculations that supported the hypothesis
of how the chromophores were arranged on the nanotubes and how the chromophore isomerizations affected electronic properties of the devices.
Chromosome breakpoints contribute to genetic variation
...his was completely counterintuitive. I thought we would have these breakpoints in gene deserts," Lewin said. "We had to rethink the whole evolutionary hypothesis
about what was going on in breakpoints."
In the new study, Denis Larkin, a senior scientist on Lewin's team, compared the chromosomes of nine mamma...
Keryx Biopharmaceuticals Presents Encouraging Preclinical Data at Annual Meeting of the American Association of Cancer Research
...duces synergistic anti-tumor activity in multiple myeloma (AACR Annual Meeting 2008, #4181). The synergy of these combinations confirms Investigators' hypothesis
that rapamycin is active only on mTORC1 and inhibition of mTORC2 by either Erlotinib or Perifosine is necessary to achieve complete shutdown of mTOR s...
Hypothesis in Biological Products
Anti-JIP 1 / 2 (SH3) Polyclonal Antibody, Unconjugated, Clone ZMD.177 from Invitrogen
Description:...c retention of JNK, thereby preventing its nuclear accumulation and the subsequent activation of the JNK pathway. This observation led to the original hypothesis
that JIP1 acts as a cytoplasmic anchor for JNK.JIP1 has been shown to bind selectively to JNK but not to the ERK or p38 MAP kinases; it has also demon...
Hypothesis in Biological Definition
The Chemiosmotic Hypothesis
is the proposal in 1961, by Peter D. Mitchell, that the mitochondrion functioned as a kind of electrochemical capacitor , using the energy of NADH and FADH 2 to create a proton gradient across the mitochondrial membrane and that this energy was used by a...
The Lyon hypothesis
states that in cells with multiple X chromosomes , all but one is inactivated during mammalian embryogenesis . X-inactivation leads to clumped chromatin termed Barr bodies , which are generally considered inert. This formation of Barr bodies is called Lyonization .
...of abiogenesis increased, and it became a tempting hypothesis
that whilst the higher forms of life arose only by...rrently under debate; see, for example, RNA world hypothesis
, proteinoid , Miller experiment .
Scientif...d Leslie_Orgel co-proposed Directed Panspermia hypothesis
for how life started on Earth.
However, it shoul...
Alfred Russel Wallace
...sia ), to collect specimens and study nature. His observations of the marked zoological differences across a narrow zone in the archipelago led to his hypothesis
of the zoogeographical boundary now known as the Wallace line . One of his better known species descriptions during this trip is the gliding tree fr...
...ukaryotes each represent a primary line of descent that diverged early on from an ancestral progenote with poorly developed genetic machinery. This hypothesis
is reflected in the name Archaea, from the Greek archae or ancient. Later he treated these groups formally as domains , each comprising several ki...
... inactive X-chromosome and to bring about its compaction to form the Barr body.
Hypothesis in Biological Dictionary
consists either of a suggested explanation for an observable phenomenon or of a reasoned proposal predicting a possible causal correlation among multiple phenomena. The term derives from the Greek, hypotithenai meaning "to put under" or "to suppose." The... 3.3...
...The Y chromosome and the origin of all of us (men)". Science 268: 1141. ... Y chromosome . Human Y-chromosome DNA haplogroups. Single-origin hypothesis
... But the human Y chromosome , at the same time, plays a central role in human ... Thus, mammalian embryos with a Y chromosome develo...
Wobble base pair
...nous bases, consisting of a purine linked ... bonds, does occur fairly often in RNA (see wobble base pair ) but rarely in DNA. ... wobble hypothesis
Proposed by Francis Crick to observations that the 5′- base of the anticodon was capable of wobble ' in its position during ... Wobble base ...
... ("towards the abdomen") in all vertebrates. ... Lateral, dorsal, and ventral have no meaning in such organisms, ... The Two-Streams hypothesis
is a widely accepted, but still controversial, account of visual processing. As visual information exits the occipital lobe, it follows two main chan...
...he insects, reproduce by physicochemical. THE SPONTANEOUS GENERATION hypothesis
(Copyright CRS Quarterly, 2001) ... conducted his famous scientific disproo...er from the mortal blow ... Spontaneous generation is the incorrect hypothesis
that nonliving things are ... This certainly excluded spontaneous gener...
...many protein ... are in fact the catalytic components of the spliceosome . ... its crucial role, the spliceosome , the ... many to develop the hypothesis
that the spliceosome is ... Mechanical Devices of the Spliceosome : Motors, Clocks, Springs, and Things ... EF-G-like GTPase Snu114p Regulates ...