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Hypothalamus in Medical News

Study provides documentation that tumor 'stem-like cells' exist in benign tumors

...nt clues about several types of stem cells. The pituitary gland, situated at the base of the brain behind the nose, is stimulated by hormones from the hypothalamus gland to produce a variety of hormones that control other glands throughout the body. About half of all pituitary adenomas which arise from pituitary...

Cancer survivors at greater risk of birth complications; special monitoring needed

...ddition to the deleterious effects of abdominal radiotherapy on reproductive function, radiotherapy to the head can also cause problems by causing the hypothalamus to reduce the production of follicle stimulating hormone and luteinizing hormone, both important in promoting ovulation. "We believe that it is partic...

Making Obese Mice Slim, Without Diet or Exercise

...ce became morbidly obese and diabetic. When researchers added leptin receptors to a particular type of neuron (pro-opiomelanocortin neurons) in the hypothalamus of the mice's brains, their blood glucose levels dropped to normal. The mice, which had previously lain around all day, became more active. They al...

Study further expands understanding of leptin's role in brain neurocircuitry

...ey role in energy homeostasis through its effects on the central nervous system. Over the years, investigators have pinpointed a region of the brain's hypothalamus known as the arcuate nucleus (ARC) as one key area where leptin exerts its influence, and within the ARC, they have identified two types of leptin-res...

Action of ghrelin hormone increases appetite and favors accumulation of abdominal fat

...arra have discovered that, besides stimulating the hypothalamus to generate appetite, ghrelin also acts on the tab...s that intervene in the control of appetite in the hypothalamus and, at the same time, can act on other organs, su...ped should block the action of ghrelin both on the hypothalamus and on the accumulation of abdominal fat. At th...

Jet Lag Upsets Brain's Internal Clocks

...research team found that jet lag upsets two separate, but linked, groups of neurons in a brain structure called the suprachiasmatic nucleus, below the hypothalamus at the base of the brain. One group of neurons (ventral) is synchronized with deep sleep that results from physical fatigue, and the other group of...

Schering-Plough Announces European Submission of Fertility Medicine Corifollitropin Alfa

...sitive) to follitropin beta or any of the other ingredients of PUREGON have a tumour of the ovary, breast, uterus, testis, pituitary gland or hypothalamus are pregnant or breast-feeding have heavy or irregular vaginal bleeding where the cause is not known suffer from primary ovari...

Experimental Weight-Loss Pill Passes Early Test

...em, Behan said. "The challenge was to design a compound that was purely selective for the receptor involved, namely the 2c receptor [located in the hypothalamus region of the brain and involved in weight loss] and avoiding the 2b receptor [located in the heart]," Behan said. The result was lorcaserin, whic...

Scientists identify new gene responsible for puberty disorders

...tions impaired the gene's function," Dr. Layman says. Typically, puberty begins around age 10 in boys and age 8 or 9 in girls. It starts when the hypothalamus in the brain releases more gonadotropin releasing hormone, or GnRH, which stimulates the pituitary gland to make puberty-related hormones. This prompt...

Scientists Create Mice Resistant to Obesity

...d GABA (gamma-aminobutyric acid). They developed transgenic, or mutant, mice that lacked the ability to release GABA in a subset of brain cells in the hypothalamus -- the brain region that controls processes such as hunger, thirst and body temperature. On a normal diet, the normal and mutant mice weighed rough...
Hypothalamus in Medical Technology

VAI Finding Could Lead to New Drugs for Anxiety, Depression

... and we are the first to determine the structural details necessary to develop an ideal drug." CRF is a hormone and neurotransmitter secreted by the hypothalamus area of the brain and is involved in stress response. CRF has been associated with anxiety, depression, and related disorders. The hormone's receptor ...

FASgen Announces New Discovery for Treatment of Stroke

...e area of that research has been for the treatment of metabolic disease disorders, including obesity. As the regulation of appetite is centered in the hypothalamus in the brain, research was undertaken to evaluate the safety of the Company's compounds in the brain. An unexpected and significant discovery resulted...

Elixir Pharmaceuticals Presents Additional Preclinical Data Demonstrating the Potential of Ghrelin Antagonism to Regulate Metabolism, Body Weight and Glycemic Control

... key role in metabolism and energy storage. Ghrelin is a naturally occurring hormone secreted by the stomach, which acts primarily at the level of the hypothalamus in the brain. In the first presentation, Elixir scientists explored whether ghrelin exerts a direct effect on adipocytes (fat cells) and if the effe...

Elixir Pharmaceuticals Presents Preclinical Data Highlighting Its Ghrelin Antagonist Program at the American Diabetes Association's Annual Meeting

...role in metabolism and energy storage. A naturally occurring hormone produced in the stomach, ghrelin is believed to act primarily at the level of the hypothalamus in the brain, which governs metabolism. Elixir scientists have previously demonstrated that, compared to normal (control) mice, ghrelin receptor ...
Hypothalamus in Medical Products

Vasopressin (AVP) RIA Test

Description:... Arginine vasopressin (AVP), also known as Antidiurectic Hormone (ADH), is synthesized in the hypothalamus and is transported via exonal flow to the posterior pituitary for storage and eventual release. AVP secretion is regulated by changes in blood osmolal...
Company:Diagnostic Systems Laboratories, Inc.

Leptin IRMA Test

Description:...e state of these individuals may be related to a leptin resistance and an inability of leptin to enter the cerebral spinal fluid to reach sites in the hypothalamus to regulate appetite. Involvement of a leptin receptor or carrier protein in this kind of regulation has been suggested. Serum leptin levels follow ...
Company:Diagnostic Systems Laboratories, Inc.

Leptin Soluble Receptor ELISA Test

Description:...which signals the brain to counteract weight loss by increasing feed intake and decreasing energy expenditure [3]. Leptin operates at the level of the hypothalamus and acts via specific receptors to control the expression of the appetite stimulator, neuropeptide Y (NPY). This feedback mechanism provided by leptin...
Company:Diagnostic Systems Laboratories, Inc.

Leptin ELISA Test

Description:...e state of these individuals may be related to a leptin resistance and an inability of leptin to enter the cerebral spinal fluid to reach sites in the hypothalamus to regulate appetite. Involvement of a leptin receptor or carrier protein in this kind of regulation has been suggested. Serum leptin levels follow ...
Company:Diagnostic Systems Laboratories, Inc.

ACTH RIA Test

Description:...l circulation, where it has a half-life of approximately 20 minutes [1]. ACTH is secreted in response to corticotropin-releasing factor (CRF) from the hypothalamus [1]. The actions of CRF are augmented by arginine vasopressin. Several other stimulatory and inhibitory factors, including catecholamines and cytokine...
Company:Diagnostic Systems Laboratories, Inc.

TSH ELISA Test

Description:...ine transport and resultant thyroid hormone synthesis [2]. TSH secretion is stimulated by thyrotropin-releasing hormone (TRH) which is secreted by the hypothalamus and is regulated at both the pituitary and hypothalamic levels by thyroid hormones. Low levels of thyroid hormones lead to increased TSH secretion and...
Company:Diagnostic Systems Laboratories, Inc.

TSH IRMA Test

Description:...ine transport and resultant thyroid hormone synthesis [2]. TSH secretion is stimulated by thyrotropin-releasing hormone (TRH) which is secreted by the hypothalamus and is regulated at both the pituitary and hypothalamic levels by thyroid hormones. Low levels of thyroid hormones lead to increased TSH secretion and...
Company:Diagnostic Systems Laboratories, Inc.

FSH ELISA Test

Description:...cles. In the late follicular phase of the menstrual cycle, increased levels of estrogen secreted by the mature follicle exert positive feedback on the hypothalamus and pituitary, resulting in a GnRH surge and a peak of LH and FSH release [2,3]. This surge is followed by rupture of the graafian follicle and ovulat...
Company:Diagnostic Systems Laboratories, Inc.

FSH IRMA Test

Description:...cles. In the late follicular phase of the menstrual cycle, increased levels of estrogen secreted by the mature follicle exert positive feedback on the hypothalamus and pituitary, resulting in a GnRH surge and a peak of LH and FSH release [2,3]. This surge is followed by rupture of the graafian follicle and ovulat...
Company:Diagnostic Systems Laboratories, Inc.

LH ELISA Test

Description:...ich are aromatized to estrogens in the granulosa cells. In the late follicular phase, the increased amounts of estrogen exert positive feedback on the hypothalamus and pituitary resulting in a GnRH surge and a peak of LH and FSH release [1,2]. The LH surge is followed by rupture of the graafian follicle and ovula...
Company:Diagnostic Systems Laboratories, Inc.
Hypothalamus in Medical Definition

Depolarization-induced suppression of inhibition

...pretty ubiquitous phenomenon and has been demonstrated in other areas of the brain such as the basal ganglia , the cortex , the amygdala , and the hypothalamus (Katona et al. 2001, Jo et al. 2005, Bodor et al. 2005, Matyas et al. 2006) DSI mediation by endocannabinoids DSI was thought to ...
Hypothalamus in Medical Dictionary

Hypothalamus

The hypothalamus controls and coordinates physiological events to maintain a ... Pathologic changes in the hypothalamus may lead to many different symptoms, ... Information and resources pertaining to the hypothalamus ... Hypothalamus and Autonomic Nervous System. Back to the Limbic S...

TSH

...... A thyroid - stimulating hormone ( TSH ) blood test is used to detect problems affecting the thyroid gland. ... TSH is produced when the hypothalamus releases a ... Thus an elevated TSH is an indication that someone is hypothyroid. The guidelines for interpreting TSH values have changed o...

Sucrose

... ... separately conditioned to associate a Pavlovian cue with free sucrose pellets. ... Similarly, sucrose ingestion normalizes CRF levels in hypothalamus and amygdala ... ...

Prolactinoma

...ed with a ... The Neuroendocrine Clinical Center offers detailed outpatient evaluation of all disorders affecting the endocrine function of the hypothalamus and pituitary gland, ... Pituitary Disorders Education and Support was established to provide current information and updates on the advances in ...

Polydipsia

...isorders treatment and medications. ... Polydipsia occurs, for example, in ... Polydipsia occurs when the thirst center in the anterior hypothalamus is stimulated. • In most patients, polydipsia occurs as a compensatory response to polyuria to ... Polydipsia is a sign or symptom indicati...

Pituitary dwarfism

...he growth of the individual ... Panhypopituitarism; Dwarfism ; Pituitary dwarfism . Definition Return to top ... MRI of the head can show the hypothalamus and pituitary glands. ... Lifestyle, fitness & health information about Pituitary Dwarfism . ... Many forms of Dwarfism are direct res...

Hypothalamic

...alamic development. 6 Effects of aging on the hypothalamus ... Hypothalamic -pituitary-adrenal axis (HP... Endocrinol. ... Hypothalamic / pituitary axes. hypothalamus ... A hypothalamic tumor is an abnormal growth in the hypothalamus gland, which is ... In children, most hypothalam...

Diabetes insipidus

.... Diabetes insipidus (DI) is an uncommon condition that occurs when the kidneys ... Central diabetes insipidus is caused by damage to the hypothalamus or pituitary ... Cutting Out the Salt, Finding the Flavor of Life( Diabetes Insipidus Foundation) ... Central Diabetes Insipidus (Merck &am...
Hypothalamus in Biological News

Stress puts double whammy on reproductive system, fertility

...levels returned to normal by the next day. Chronically stressed rats, however, were left with longer-term elevations of RFRP levels in the dorsomedial hypothalamus area of the brain, and suppression of activity in the reproductive axis - the hypothalamus-pituitary-gonadal hormone cascade - that is associated with...

USC researchers present diabetes findings at American Diabetes Association Scientific Sessions

...ortal vein sensors may connect to or signal the brain to respond to hypoglycemia. The symposium will take place on Sunday, June 7 (Session: Beyond the hypothalamus Other Sites Involved in Sensing and Responding to Recurrent Hypoglycemia; Peripheral vs. Central Sensors Importance of Rate of Glucose Drop). Ge...

What happens when we sleep

... the circadian rhythm. With Drs. Oum Hassani and Maan Gee Lee, Dr. Barbara Jones at the MNI were studying a structure in the brain called the lateral hypothalamus (LH) known to be critical for maintaining wakefulness. MCH neurons, co-distributed with Orx neurons, constitute less than 10% of the LH. Previous stud...

Brain background to body mass

...nd use stores of energy, such as fat tissue. A part of the brain called the hypothalamus controls many of our basic functions such as body temperature, hunger and f...ain the status quo. "Very occasionally, mutations in genes active in the hypothalamus have dramatic consequences for weight gain," explains Dr Ruth Loos, a leadi...

Brain enzyme may play key role in controlling appetite and weight gain

...othalamus, an almond-sized structure located deep within the brain that controls body temperature, hunger, and thirst. Specialized nerve cells in the hypothalamus sense whether the body contains adequate amounts of nutrients and stored body fat. The cells then send out signals telling other parts of the brain t...

New master switch found in the brain that regulates appetite and reproduction

...forming the brain of how well fed the body is. The primary hormone that performs that function is leptin, which travels through the bloodstream to the hypothalamus in the brain (the appetite center), keeping the brain aware of the body's nutritional status. "Leptin tells the brain that times are good, your body...

New study shows compounds from soy affect brain and reproductive development

...roduced chemicals that mimic hormones during development. Specifically, the study finds that the compounds alter the sex-specific organization of the hypothalamus a brain region that is essential to the regulation of puberty and ovulation. The study also shows that the phytoestrogens could cause long-term effec...

The epigenetics of increasing weight through the generations

...each generation. Those in the supplemented group, however, did not." "We think DNA methylation may play an important role in the development of the hypothalamus (the region of the brain that regulates appetite)," said Waterland. "Twenty years ago, it was proposed that just as genetic mutations can cause ca...

Scientists learn how food affects the brain

...ch has been shown to reduce memory deficits in animal models of Alzheimer's disease and brain trauma. BDNF is most abundant in the hippocampus and the hypothalamus brain areas associated with cognitive and metabolic regulation. The high consumption of curcumin in India may contribute to the low prevalence ...

U of M researchers discover gene linked to adult-onset obesity

... hypothalamus, a brain region involved in regulating food intake and energy expenditure. Wickman speculated that disruption of normal function in the hypothalamus may underlie the obesity seen in the mutant mice, but he acknowledges that more research is needed to understand where and how this gene works, and co...
Hypothalamus in Biological Technology

Global Biopharmaceutical Leader in Peptide Research Expands Commitment in San Diego/U.S. With New R&D Facility and Ready-To-Market Prostate Cancer Treatment Degarelix

... and Gastroenterology. Since the 1950s, the company has pioneered the research, development and marketing of pharmaceutical products based on natural, hypothalamus and pituitary-based peptide hormones. Headquartered in Switzerland, Ferring has commercial subsidiaries in over 45 countries and its products are...

Laser dissection of depression

...too high activity of the PVN is a pivotal characteristic of depression. The hypothalamus consists of a large number of very small specialized cell groups that all h...gy used. Corticotrophin-releasing factor (CRF) cells in the PVN of human hypothalamus are the central driving force of the stress response and are hyperactive in...

RNArticles: Keeping RNA Intact Prior to RNA Isolation - RNAlater

...n in different regions of rat brain, Dr. Dunn-Meynell collected tissue punches of the arcuate nucleus of the hypothalamus and the ventromedial thalamus. Punches were derived from rat brain tissue that was frozen and cryosectioned ...
Hypothalamus in Biological Products

Porcine Leptin ELISA Kit from Diagnostic Systems Laboratories, Inc.

Description:...e state of these individuals may be related to a leptin resistance and an inability of leptin to enter the cerebral spinal fluid to reach sites in the hypothalamus to regulate appetite. Involvement of a leptin receptor or carrier protein in this kind of regulation has been suggested. Serum leptin levels follow ...
Company:Diagnostic Systems Laboratories, Inc.
Hypothalamus in Biological Definition

Brain

...alon tectum midbrain tegmentum crus cererbri prosencephalon diencephalon epithalamus pineal gland thalamus hypothalamus pituitary gland telencephalon archipallium basal ganglia caudate nucleus substantia nigra striatum amygdalar...

Homeostasis

...ide variety of ions . Most of these organs are controlled by hormones secreted from the pituitary gland , which in turn is directed by the hypothalamus . See also Acclimatization Biological rhythm Metabolism Apoptosis Aging Balance Self-organization Cyber...

Kidney

...ases sodium ion absorption in the convoluted tubule. Any rise or drop in blood osmotic pressure due to a lack or excess of water is detected by the hypothalamus , which notifies the pituitary gland via negative feedback . The pituitary gland secretes antidiuretic hormone, otherwise known as vasopressin (...

Limbic system

...that of a "limb", hence the name) fornicate gyrus archicortex hypothalamus : controls the autonomic nervous system and regulates blood pressure , he...gland and thus regulates the endocrine system. (Not all authors regard the hypothalamus as part of limbic system.) The limbic system is among the oldest parts...

Neurotransmitter

...is generally used as a neurotransmitter in cells involved in emotional regulation. Dopamine acts as the neurotransmitter of choice for cells in the hypothalamus which are effectively the brain's reward system, however it is also involved in the control of movement. Neurotransmitters which have these types o...

Signal transduction

...is the hormone concentration, which is regulated by : Biosynthesis and secretion of hormones in the endocrine tissue . As an example, the hypothalamus receives information, both electrical and chemical. It produces releasing factors that affect the hypophysis and make it produce glandotrope hor...
Hypothalamus in Biological Dictionary

Hypothalamus

The hypothalamus is a portion of the brain that contains a number of small nuclei with a variety of functions. One of the most important functions of the hypothalamus is to link the nervous system to the endocrine system via... hypothalamus n. The part of the brain that lies below the ...

Posterior

...e system. Despite its name, the posterior pituitary gland is not a gland, per se; rather, it is largely a collection of axonal projections from the hypothalamus that... Information about posterior in the free online English dictionary and ... posterior - located at or near or behind a part or near the ...

Pituitary gland

...uitary gland , or hypophysis, is an endocrine gland about the size of a pea and weighing 0.5 g (0.02 oz.). It is a protrusion off the bottom of the hypothalamus at the base of the brain, and rests in a small, bony cavity (sella turcica) covered by a dural fold .... The pituitary is a small, pea-sized ...

Ovulation

... ovulation ( ′ävyə′lāshən ) ( physiology ) Discharge of an ovum or ovule from the ovary. ... The process of ovulation is controlled by the hypothalamus of the ... Brief and Straightforward Guide: What is Ovulation ? ... As a woman begins her period, her body is in the follicular phase of ovulati...

Limbic system

...tructures in the human brain involved in emotion, motivation, and emotional association with memory. ... consists of the cerebrum, thalamus, and hypothalamus (part of the limbic system ) ... Brain Stem: Underneath the limbic system is the brain stem. ... The limbic system is a mid-brain colle...

Infundibulum

...component of the pituitary stalk, containing nerve tracts passing from the hypothalamus to the nervous lobe ... infundibulum ... Information about infundibu...ntrally from between the chiasma and ... The infundibulum connects the hypothalamus to the pituitary gland, or hypophsis. ... ... as to whether the subpulm...

Adrenal glands

...d families Anatomically, the adrenal gland is situated on the ... Endocrine system - Adrenal glands ... Adrenal gland - Corpus luteum - hypothalamus - Ovaries - Pancreas ... The adrenal glands lie on the upper inner surface of each kidney. ... The Adrenal Glands . The Adrenocortex Profile...
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