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Hypothalamic in Medical News

JCI online early table of contents: July 10, 2008

...ulate that the earliest stages of diet-induced insulin resistance might be prevented by inhibition of S6K in the hypothalamus. TITLE: Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats AUTHOR CONTACT: Hiraku Ono Albert Einstein College of Medicine, New York, New ...

Deep brain stimulation may improve memory

...ng this area influences feeding behavior in animals. A new study found that hypothalamic DBS performed in the treatment of a patient with morbid obesity unexpectedl...ring and without stimulation and found that after three weeks of continuous hypothalamic stimulation he showed significant improvements in two learning tests. In a...

Insulin Sensitizer- Energy Conserving Signal to Brain

...s now report evidence in mice that adiponectin receptors are present in the hypothalamic region of the brain and that some forms of the chemical enter the cerebrosp...adiponectin/leptin signals may represent the physiological pathway by which hypothalamic AMPK activity and food intake are stimulated during fasting and suppressed ...

A Fit of Laughter Silenced by an Unusual Surgery

...d very scary. Anastasia's hypothalamus was home to a benign tumor which was causing the seizures. This condition termed in medical parlance as hypothalamic hamartoma, is extremely rare affecting about 30 people worldwide each year. If the condition is left untreated, it could also cause mental retardation...

Clock Gene Plays Role in Weight Gain, Study Finds

...and reduce the risk of developing obesity. Clock genes in the bodys organs operate in conjunction with a central time keeper in the brain, the hypothalamic suprachiasmatic nucleus, but also work somewhat independently, resulting in a complex system of oscillators regulating various functions of the body. ...

A ‘Fit’ of Laughter Silenced by an Unusual Surgey

...ed very scary.” Anastasia's hypothalamus was home to a benign tumor which was causing the seizures. This condition termed in medical parlance as hypothalamic hamartoma, is extremely rare affecting about 30 people worldwide each year. If the condition is left untreated, it could also cause mental retardation...

Link Between Food Cue-related Brain Activity Found

...ucted in the laboratory of Ann E. Kelly showed that expression of a handful of immediate early genes was increased in cortical, striatal, thalamic and hypothalamic brain regions. Food-related cues triggered dramatic changes in the functional connectivity of circuits involved in adaptive behaviour. For example, in...

Biological Basis Behind a Couch Potato

...rther, it suggests a strategy to reduce weight gain and could lead to the development of a drug to stimulate minor activity. The study "Elevated hypothalamic orexin signaling, sensitivity to orexin A and spontaneous physical activity in obesity resistant rats," appears in the online edition of the American ...

Serotonin the Answer for Anti-Obesity Treatment

...mans, is to design specific, safe drugs to fight obesity.’ Dr. Elmquist, who recently left Harvard Medical School, directs the newly formed Center for hypothalamic Research at UT Southwestern. The center, along with the Taskforce for Obesity Research, a National Institutes of Health Interdisciplinary Research Cen...

New Insight To The Role Of Peptide Signals

...ocessing in the brain along with the conventional neurotransmitters. Investigations done by the scientists of University of Edinburgh report that hypothalamic neurons use the chemical signals of 60 types of peptides to communicate. These peptides when are released within the brain, control different forms o...
Hypothalamic in Medical Technology

Orexigen(R) Therapeutics Presents Data on Its Proprietary Formulation of Naltrexone Sustained Release (SR) Used in Contrave(R)

...rave is an investigational weight loss medication with a mechanism of action that works at two sites within the central nervous system. The first is a hypothalamic site that controls the balance of food intake and metabolism. We believe that Contrave is possibly the first treatment for obesity to address a second...

Norditropin(R) Approved for Treatment of Children with Short Stature Associated with Turner Syndrome

...set: Patients who have GHD, either alone or associated with multiple hormone deficiencies (hypopituitarism), as a result of pituitary disease, hypothalamic disease, surgery, radiation therapy, or trauma; or 2) Childhood Onset: Patients who were growth hormone deficient during childhood as a resul...

Norditropin(R) Approved for Treatment of Children with Short Stature Associated with Turner Syndrome

...set: Patients who have GHD, either alone or associated with multiple hormone deficiencies (hypopituitarism), as a result of pituitary disease, hypothalamic disease, surgery, radiation therapy, or trauma; or 2) Childhood Onset: Patients who were growth hormone deficient during childhood as a resul...

Repros' Androxal Shows Highly Statistically Significant Positive Effects in Men with Secondary Hypogonadism

...rmer Medical Officer with the Food and Drug Administration, commented, "This study points out the importance of considering secondary hypogonadism, or hypothalamic dysfunction, when diagnosing hypogonadism in men." Although the syndrome of secondary hypogonadism is characterized by the objective measurements of...

Phase III Clinical Trial with 4-Month Long-Acting Formulation of Triptorelin: Ipsen Decides Not to Perform Further Administration

...rmulation of triptorelin." About triptorelin Triptorelin is a metabolically stabilized analogue of LHRH (Luteinizing Hormone Releasing Hormone) an hypothalamic hormone secreted in a pulsatile fashion. Upon binding to its pituitary receptor LHRH triggers the release of luteinizing hormone, a key factor for the...

VeroScience Late-Breaking Abstract on Cycloset (A Quick Release Formulation of Bromocriptine Mesylate) Accepted for Poster Presentation at American Diabetes Association 67th Scientific Sessions

...peutics, Inc., that will be held in conjunction with the American Diabetes Association's 67th Scientific Sessions. The symposium, entitled "Evolution, hypothalamic Dopamine Neurochemistry, and Developing New Therapies for Insulin Resistance Syndrome and Type 2 Diabetes," will be held on Sunday, June 24th from 5:3...

Phase IIIb Clinical Data Validate the Overall and Cardiovascular Safety Profile of Cycloset (A Quick Release Formulation of Bromocriptine Mesylate) in Patients with Type 2 Diabetes

...ngle timed (morning) daily dose, Cycloset(TM) is believed to act on circadian neuronal activities within the hypothalamus to reset abnormally elevated hypothalamic drive for increased plasma glucose, triglyceride, and free fatty acid levels in fasting and postprandial states in insulin resistant subjects. Results...
Hypothalamic in Medical Products

ACTH RIA Test

Description:...sis, mainly cortisol production, but also aldosterone and adrenal androgen synthesis. Decreased ACTH secretion can occur in a variety of pituitary and hypothalamic disorders and in certain systemic infections. Elevated plasma levels are observed in patients with ACTH-secreting pituitary (Cushings disease) and non...
Company:Diagnostic Systems Laboratories, Inc.

TSH ELISA Test

Description:...]. TSH secretion is stimulated by thyrotropin-releasing hormone (TRH) which is secreted by the hypothalamus and is regulated at both the pituitary and hypothalamic levels by thyroid hormones. Low levels of thyroid hormones lead to increased TSH secretion and elevated thyroid hormone levels lead to decreased TSH s...
Company:Diagnostic Systems Laboratories, Inc.

TSH IRMA Test

Description:...]. TSH secretion is stimulated by thyrotropin-releasing hormone (TRH) which is secreted by the hypothalamus and is regulated at both the pituitary and hypothalamic levels by thyroid hormones. Low levels of thyroid hormones lead to increased TSH secretion and elevated thyroid hormone levels lead to decreased TSH s...
Company:Diagnostic Systems Laboratories, Inc.

IGFBP-3 IRMA Test

Description:...endent than IGF-I [3]. These aspects of IGFBP-3 physiology allow its measurement to reflect GH activity. Thus, in GH deficiency of either pituitary or hypothalamic origin, IGFBP-3 levels are uniformly low. Blum et al. [3] reported that 128/132 children with GH deficiency had serum IGFBP-3 concentrations below the...
Company:Diagnostic Systems Laboratories, Inc.

IGFBP-3 ELISA Test

Description:...endent than IGF-I [3]. These aspects of IGFBP-3 physiology allow its measurement to reflect GH activity. Thus, in GH deficiency of either pituitary or hypothalamic origin, IGFBP-3 levels are uniformly low. Blum et al. [3] reported that 128/132 children with GH deficiency had serum IGFBP-3 concentrations below the...
Company:Diagnostic Systems Laboratories, Inc.

hGH IRMA Test

Description:...totrophs in the anterior pituitary gland. GH is released from the pituitary into the bloodstream in a pulsatile manner under the regulatory control of hypothalamic somatostatin (SS) and GH-releasing factor (GHRF) [1]. The timing and frequency of GH release appears to be regulated by somatostatin, while the amplit...
Company:Diagnostic Systems Laboratories, Inc.

hGH, Ultra-Sensitive ELISA Test

Description:...totrophs in the anterior pituitary gland. GH is released from the pituitary into the bloodstream in a pulsatile manner under the regulatory control of hypothalamic somatostatin (SS) and GH-releasing factor (GHRF) [1]. The timing and frequency of GH release appears to be regulated by somatostatin, while the amplit...
Company:Diagnostic Systems Laboratories, Inc.

Placental Growth Hormone ELISA Test

Description:...totrophs in the anterior pituitary gland. GH is released from the pituitary into the bloodstream in a pulsatile manner under the regulatory control of hypothalamic somatostatin (SS) and GH-releasing factor (GHRF) [1]. The timing and frequency of GH release appears to be regulated by somatostatin, while the amplit...
Company:Diagnostic Systems Laboratories, Inc.

Bioactive hGH ELISA Test

Description:...totrophs in the anterior pituitary gland. GH is released from the pituitary into the bloodstream in a pulsatile manner under the regulatory control of hypothalamic somatostatin (SS) and GH-releasing factor (GHRF) [1]. The timing and frequency of GH release appears to be regulated by somatostatin, while the amplit...
Company:Diagnostic Systems Laboratories, Inc.

hGH ELISA Test

Description:...totrophs in the anterior pituitary gland. GH is released from the pituitary into the bloodstream in a pulsatile manner under the regulatory control of hypothalamic somatostatin (SS) and GH-releasing factor (GHRF) [1]. The timing and frequency of GH release appears to be regulated by somatostatin, while the amplit...
Company:Diagnostic Systems Laboratories, Inc.
Hypothalamic in Medical Dictionary

Hypothalamic

5.4 Other influences upon hypothalamic development. 6 Effects of aging on the hypothalamus ... Hypothalamic -pituitary-adrenal axis (HPA axis) ... Hypothalamic and pituitary development: novel insights into the aetiology". Eur. J. Endocrinol. ... Hypothalamic / pituit...

Optic glioma

...ptic glioma and neurofibromatosis Type 1 (NF1) ... Optic gliomas can affect: ... An optic glioma may also grow in conjunction with a hypothalamic glioma (a mass ... Optic gliomas are rare and the cause is unknown. ... Optic glioma - All Information, Gliomas are tumors that grow ...

Hormone

...out compounded hormone therapies — or, more commonly, Antidiuretic hormone , also known commonly as arginine vasopressin, is a nine ... Within hypothalamic neurons, the hormone is packaged in secretory vesicles with ... Only a small amount of hormone is required to alter cell metabolism. ... ...

Endocrine glands

...ON TO ENDOCRINE GLANDS ... Overview of Individual Endocrine Glands ... endocrine glands and is, in turn, regulated by factors secreted by hypothalamic ... Endocrine Glands : Hormones and Functions. 149. 6.1. 3. The Hypothalamus. 149-152. 6.2, 6.3, 6.4 ... Glands . 153. 6.2. 3. The Pancreas. ...
Hypothalamic in Biological News

How appetite-stimulating brain cells work overtime during fasting

...tein, UCP2, which is present at high levels in the hypothalamic arcuate nucleus--considered to be the key brain si... hypothalamus that fat levels have fallen, leading hypothalamic neurons to activate a program, including hunger, t...o and colleagues] have elegantly demonstrated that hypothalamic responses to food deprivation involve at least thr...

Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice

...ain how Hap1 is linked to feeding-related molecules such as insulin, and to hypothalamic neuronal function," said Xiao-Jiang Li, PhD, professor of human genetics at... "Scientists know that diabetes and obesity are related to abnormalities of hypothalamic function," Li said. "This is a complicated pathway, and Hap1 can help us e...

Study by Einstein researchers could lead to a novel strategy for treating obesity

...oA, a molecule suspected of being one of the critical nutrients influencing hypothalamic regulation of eating behavior. Previous studies had shown that hypothalamic levels of malonyl CoA increase markedly after meals and are suppressed by f...

Slipping past the blood brain barrier: Research shows potential treatment for brain cancer

...r of the research team. The compound - JV-1-36 - is an antagonist of the hypothalamic growth hormone- releasing hormone, which has been found to cause cancerous ...s, such as malignant glioblastomas, to grow. The main known purposes of the hypothalamic growth hormone-releasing hormone usually are to trigger the hormone that ma...

Endocannabinoids ?the brain's cannabis ?demonstrate novel modes of action to stress

...d by the hypothalamus, such as feeding. Di says that the "actions of the endocannabinoids on the synaptic circuits that control the activity of the hypothalamic neurons serve to rapidly inhibit hormone secretion from the pituitary gland, providing a rapid negative feedback mechanism for the regulation of neuro...
Hypothalamic in Biological Technology

FDA Approves Additional Indication for Norditropin(R) for Small for Gestational Age (SGA) in Children

...Adult Onset: Patients who have GHD, either alone or associated with multiple hormone deficiencies (hypopituitarism), as a result of pituitary disease, hypothalamic disease, surgery, radiation therapy, or trauma; or 2) Childhood Onset: Patients who were growth hormone deficient during childhood as a result of co...
Hypothalamic in Biological Products

Rabbit Anti-CRF Polyclonal Antibody, Unconjugated from GeneTex

Description:...dy to CRF The antibody blocks specificially with the ovine CRF sequence that it was raised against. Cells and fibres are found in the paraventricular hypothalamic nucleus of rat brain in colchicine treated 4% FA perfused tissue. Immunogen: CRF: Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-...
Company:GeneTex
Hypothalamic in Biological Definition

Infertility

...gical factors Hypothalamic-pituitary factors: Kallmann syndrome hypothalamic dysfunction Hyperprolactinemia Hypopituitarism Ovarian factor...auses Endocrine problems, i.e. diabetes mellitus , thyroid disorders hypothalamic disorders, i.e. Kallmann syndrome Hyperprolactinemia Hypopituitari...
Hypothalamic in Biological Dictionary

Forebrain

...A basal ganglia- forebrain circuit in the songbird biases motor output to avoid ... GABAergic and cholinergic basal forebrain and preoptic-anterior hypothalamic ... Identify the forebrain , midbrain and hindbrain. ... prosencephalon- (= forebrain ), the most cranial portion of the 3 primary vesicle bra...
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