Hyperactivation

Researchers Identify Role Of Protein In Sperm Hyperactivation

Reserachers from the Harvard Medical School have been able to identify a vital component of the mechanism that a sperm uses to speed up its integration with the egg so that fertilization can take place. Reserachers say this study could provide useful pointers when examining the issue of male infert...

Bionovo Presents Positive Results from Phase 1B Trial of Bezielle for Metastatic Breast Cancer

...r energy production. Bezielle induces greater production of reactive oxygen species in cancer cells. This results in high levels of DNA damage and the hyperactivation of PARP. The resulting depletion of NAD and ATP (PARP substrates), results in the inhibition of glycolysis, energetic collapse, and programmed necrosi...

Genetic approach provides new insight into trastuzumab resistance in breast cancer

...stance to trastuzumab-based therapy, and loss of PTEN is known to result in hyperactivation of the PI3K pathway. Abnormal activation of this cell survival signaling pathway has been identified in many primary breast cancers. hyperactivation of the PI3K pathway also can be caused by activating mutations of the PIK3C...

Childhood Abuse Increases the Risk of Alcoholism

...action between MAOA and childhood trauma. They note that previous research showed that people with the low activity variant at the MAOA-LPR locus have hyperactivation of the hippocampus when retrieving negative emotional information. ...

Cataplexy During Status Cataplecticus Resembles REM Sleep

...d right orbitofrontal cortex, the right temporal cortex and the right putamen, which are all activated during normal REM sleep. There was, however, no hyperactivation of the pons, amygdale or occipital cortex, other imaging characteristics of normal REM sleep. "To my knowledge, this report is the first of imag...

Hyperactivation in Medical Technology

Drug-Eluting Stents Outperform Bare Stents in Heart Attack

...ce. As for tirofiban and abciximab, both are in a class of medications known as glycoprotein 2b/3a inhibitors and prevent blood clotting by blocking hyperactivation of platelets. Tirofiban is an attractive alternative for several reasons: It is shorter-acting and is cleared from the body more readily than abcixima...

Hyperactivation in Biological News

Key protein regulating inflammation may prove relevant to controlling sepsis

...rtance of WIP1 as an effective suppressor of inflammation and explained how the body was able to cope with an excess of inflammation brought on by the hyperactivation of the NFκB protein complex, is a signaling molecule that plays a key role in triggering inflammation. "We have shown that WIP1 plays a crit...

Rare cell prevents rampant brain activity

... the study, believes that the mechanism is essential to understanding brain disorders like epilepsy. "A characteristic feature of epilepsy is the hyperactivation of cortical pyramid cells, which is exactly what this mechanism inhibits. It is possible that epilepsy is related to a deficit of Martinotti cells or ...

How sperm crack the whip

...jor component of the calcium ion channel responsible for alkaline-activated hyperactivation and male fertility. According to Clapham, the finding represents the be...any controlling currents inside sperm and also tracing how calcium triggers hyperactivation once it enters the cell. Such studies will enable exploration of sperm mach...

Key brain regulatory gene shows evolution in humans

...atory gene that shows clear evidence of evolution from lower primates to humans. They said the evolution of humans might well have depended in part on hyperactivation of the gene, called prodynorphin (PDYN), that plays critical roles in regulating perception, behavior and memory. They reported that, compared to lo...

New clues to the dark side of a key anti-tumor guardian

...o represents an intriguing paradox when it comes to the broader roles this protein plays in our well being. Past work has shown that in animal models, hyperactivation of the p53 protein is beneficial in terms of bestowing extra protection against tumor formation, but at the same time it has a significant negative ef...