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Hydroxyurea in Medical News

Viagra Trial for Sickle Cell Lung Problems Halted

... sickle cell anemia had found a decrease in pulmonary hypertension. But the participants were also aggressively treated with transfusions and the drug hydroxyurea to control crises. In the multicenter trial that was stopped, 134 people were treated with Revatio but without the interventions for crises. "We w...

Studies examine quality of care for hospitalized sickle cell disease patients

...well as a study examining the effects of long-term hydroxyurea use in adult patients with the disease, will also ...ckle cell disease. Prolonged Administration of hydroxyurea Reduces Morbidity and Mortality in Adult Patients ...r study found that the long-term administration of hydroxyurea in adult patients with sickle cell disease is safe...

Turning back the Clock in Inherited Anemias

...ttempts to develop therapies to reactivate HbF directly have been hampered by a lack of understanding of how HbF production is switched off. The drug hydroxyurea often raises HbF in patients, but responses are not uniform and there are potential side effects. Seeking a better approach, researchers Stuart O...

Sickle Cell Drug Underused by Physicians

... Review of data on hydroxyurea shows it works, but long-term effects are unknown ...niversity say their extensive review of studies on hydroxyurea clearly shows its helps people with sickle cell an...e 17 Annals of Internal Medicine , concluded that hydroxyurea is a viable treatment option for now, but more qua...

Effective treatment for sickle cell underused by doctors

...about proper use and possible long-term effects of hydroxyurea in the treatment of sickle cell anemia may be wron...enefit ledger, studies in mice also indicated that hydroxyurea impairs sperm development. The researchers conclud...review could not conclude with any confidence that hydroxyurea increased or decreased the risk of leukemia or oth...

Novel small molecule therapy shows benefit for anemic patients via hydration of red blood cells

...responding increases in hematocrit and RBC count in the patients taking senicapoc when compared to placebo. Notably, the sub-groups of patients taking hydroxyurea achieved similar results. In the low-dose group, the increase in hemoglobin compared to placebo was not statistically significant. Treatment with...

Sickle Cell Disease Pain Can Occur Daily and Is Much More Severe Than Previously Thought

...kidneys, spleen and brain. Because of the potential for damage to organs, people with sickle cell disease have shorter-than-average life expectancy. hydroxyurea is the only FDA-approved treatment specifically for the disease. Other drugs can help symptoms and complications of the disease. Bone marrow transplan...

JCI online early table of contents: Dec. 6, 2007

...mmunomodulatory anticancer drugs, were both shown to be more effective than hydroxyurea at inducing HbF expression by erythrocytes derived in vitro from CD34+ cells from healthy individuals. In addition, the effects of pomalidomide and hydroxyurea on HbF expression were synergistic. As pomalidomide was able to induce HbF ...

Hydroxyurea Treatment For Children With Sickle Cell Disease

...old who had sickle cell anemia were given the drug hydroxyurea orally as a flavored liquid formula. A majority of...all study participants. Patients treated with hydroxyurea also weighed more and were taller than untreated c...e cell disease. "This study demonstrates that hydroxyurea is an efficient and safe treatment option for youn...

Initiation Of New Study To Help Children With Sickle Cell Anaemia

...e study named Stroke With Transfusions Changing to hydroxyurea (SWiTCH ) has been designed to determine if hydroxyurea can replace blood transfusions and if monthly bloo...lood transfusions with outcomes using hydroxyurea. hydroxyurea will not completely eliminate the sickled red cell...
Hydroxyurea in Medical Technology

Studies Examine Quality of Care for Hospitalized Sickle Cell Disease Patients and Effective Methods for Detecting Risk of Stroke in Children With This Disorder

...well as a study examining the effects of long-term hydroxyurea use in adult patients with the disease, will also ...ll disease. Prolonged Administration of hydroxyurea Reduces Morbidity and Mortality in Adult Patients ...r study found that the long-term administration of hydroxyurea in adult patients with sickle cell disease is safe...

Gene Therapy Corrects Sickle Cell Disease in Laboratory Study

...s after birth, does not contain beta-globin, but another form called gamma-globin. St. Jude researchers had found that treating patients with the drug hydroxyurea encourages the formation of fetal hemoglobin and alleviates disease symptoms. "While this is a very useful treatment for the disease, our stu...

BioMarin Announces Positive Results From Phase 2A Clinical Study of 6R-BH4 in Sickle Cell Disease

...ted at 12 U.S. sites. Among other eligibility criteria, to participate in the study, SCD patients were at least 15 years of age and were not receiving hydroxyurea or hypertransfusion therapy. Study patients received 6R-BH4 at 2.5 mg/kg, 5 mg/kg, 10 mg/kg and 20 mg/kg for four weeks each in a 16-week dose-escalat...

Exelixis Presents Clinical Data Supporting the Safety and Initial Clinical Activity of XL228 in Chronic and Acute Leukemia

... 1 or 2 severity and manageable. One Grade 3 event of tumor lysis syndrome in a patient with lymphoid blast crisis receiving concurrent treatment with hydroxyurea was considered a dose-limiting toxicity (DLT) at 7.2 mg/kg. The maximum tolerated dose (MTD) has not been reached, and dose escalation is ongoing. P...

Vion Pharmaceuticals Announces Presentation of Data of Cloretazine(R) (VNP40101M) in Elderly Patients with High-Risk Myelodysplastic Syndromes at the EHA Annual Meeting

...or treatment for their disease. Prior agents used included arsenic trioxide, thalidomide, Ara-C, imatinib mesylate, interferon, amifostine, melphalan, hydroxyurea and 5-azacitiadine. The overall complete response rate was 38% (7 CR and 3 CRp). Three of 10 responders received prior treatment; 8 of the 10 respon...

Novel Small Molecule Therapy Shows Benefit for Anemic Patients Via Hydration of Red Blood Cells

...responding increases in hematocrit and RBC count in the patients taking senicapoc when compared to placebo. Notably, the sub-groups of patients taking hydroxyurea achieved similar results. In the low-dose group, the increase in hemoglobin compared to placebo was not statistically significant. Treatment with ...

Research Identifies Need for Improved Understanding of Sickle Cell Disease in Adulthood

...udy aimed to determine adoption and utilization of hydroxyurea therapy in sickle cell disease among 2,301 Florida...r 16 years of age. It found that the prevalence of hydroxyurea use in this Medicaid population is low. Hydroxyure...s had at least one pharmacy claim for hydroxyurea. hydroxyurea users compared to non-hydroxyurea users were more ...
Hydroxyurea in Medical Dictionary

Hemoglobin

... has anemia. ... Original Article from The New England Journal of Medicine -- Augmentation by Erythropoietin of the Fetal- Hemoglobin Response to hydroxyurea in Sickle Cell Disease Information about hemoglobin in the free online English dictionary and ... Hemoglobin accomplishes oxygen transport b...
Hydroxyurea in Biological News

Gene therapy corrects sickle cell disease in laboratory study

...s after birth, does not contain beta-globin, but another form called gamma-globin. St. Jude researchers had found that treating patients with the drug hydroxyurea encourages the formation of fetal hemoglobin and alleviates disease symptoms. "While this is a very useful treatment for the disease, our studies i...
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