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Hydroxyl in Medical News

Remote-control closed system invented for inserting radio-active atoms inside fullerenes

...abeled nanomaterial is then further purified by passage through a column that traps the empty-cage fullerenes. The resulting liquid is evaporated and hydroxyl atoms are attached to the molecules so they will be soluble in biofluids. All of the steps of the process are managed remotely and the purified pr...

SANYO Donates Systems Effective vs. Flu to United Nations Organization Affiliate - World Association of Former United Nations Internes and Fellows (WAFUNIF)

...sing tap water and electricity, there are absolutely no harmful chemicals. The electricity works as a catalyst for the salt in the tap water to create hydroxyl radicals and hypochlorous acid to destroy the protein spikes on the surface of the virus. This prevents the virus from attaching to and infecting heal...

A potential drug for ischemia/reperfusion related liver injury

...ated with liver transplantation and major liver surgery. The production of reactive oxygen species (ROS), including superoxide, hydrogen peroxide, and hydroxyl radical, has been demonstrated in reperfusion injury. Resveratrol has been reported to have several biologic effects such as a potent antioxidative ef...

Chinese Red Yeast Rice May Prevent Heart Attack

...eart attack were randomly selected to receive capsules containing XZK or a placebo. The XZK capsules contained a combination of lovastatin, lovastatin hydroxyl acid, ergosterol, and other components, the report said. During five years of follow-up, the researchers found that 10.4 percent of those receivin...

Chemical engineering researchers identify biofilms that cause infections

...you can trick bacteria, but you have to do it well, and another modification does not have any effect on stopping biofilm formation. "By adding that hydroxyl group and making the 7-hydroxyindole, we turn off the bacterium's ability to talk. We short-circuit the bacterium, and it becomes less of a bad actor....

Smog's Origins Get Clearer

...of complex chemical reactions involving the interaction of sunlight with hydrocarbons and nitrogen oxides from vehicle exhaust. Ozone is produced when hydroxyl radicals (OH) are produced from water vapor. It was long believed that most OH radicals involved in urban ozone production were generated by the re...

New Device Developed to Eliminate Superbugs Within Minutes

...shire. They established that in the outdoors, hydroxyl radicals produced through natural reactions betwee...ize of a flower vase that constantly generates the hydroxyl radicals. The device draws in oxygen and expo...s to produce a cold plasma rich in ozone. The hydroxyl radicals are generated by constantly reacting the ...

Super Chow, Laced With Semi-Synthetic Vitamin E, Inhibited Spread of Cancer

...e said. To improve the vitamin, derivatives have been created by swapping a hydroxyl chemical group with an acid. One is alpha-tocopheryl succinate (?-TOS), whi...eryloxyacetic acid (alpha-TEA), which used acetic acid. Replacing the hydroxyl group in vitamin E helps force cancer cells to self destruct, Akporiaye sai...

Elusive Step In DNA Mutation Uncovered By Researchers

...action requires more energy than seems to be available because, formally, it requires that a water molecule (H2O) split apart into a proton (H+) and a hydroxyl anion (OH-). This large energy requirement has puzzled scientists for a long time. Now the research team, led by Landman and Gary Schuster, provost-de...

Computational Model Reveals Working of AZT in Body

...the four naturally occurring deoxynucleosides, the building blocks used to make DNA. However, modified AZT molecules lack a specific chemical group (a hydroxyl group) that would allow DNA replication to continue. This results in premature termination of DNA synthesis. It is thought that the triphosphorylated ...
Hydroxyl in Medical Technology

Boston University Biomedical Engineers Find Chink in Bacteria's Armor

...ree radical production." Free radicals - such as hydroxyl or superoxide radicals - are molecules that carry ...hibit or block the bacterial defense mechanisms to hydroxyl radical damage, you can potentiate or enhance the ...n rapidly stimulates production of toxic levels of hydroxyl radicals. "It's really amazing that despite the ...

Helix Biopharma to Present L-DOS47 Lung Cancer Research Findings at the Fourth International Conference on Tumor Microenvironment in Florence, Italy

...on a naturally occurring enzyme called urease that essentially reverses the urea cycle by breaking down urea into metabolites that include ammonia and hydroxyl ions. By doing so at the site of cancerous tissues in the body, L-DOS47 is believed to modify the microenvironmental conditions of lung cancer cells i...

AGI Dermatics Presents Comparative Data That Indicates OCTN-1 Skin Cells Have the Ability to Recognize, Transport and Utilize L-ergothioneine (EGT) As A Protector Against Oxidative Damage

...d therefore EGT's beneficial role in the treatment of photodamaged skin. Study results show that NHDF treated with EGT had significant lower levels of hydroxyl radicals over a one-hour period than those treated with idebenone, a synthesized form of CoQ10 which has also been thought to exhibit exceptional anti...
Hydroxyl in Medical Dictionary

Pregnanediol

...treatments, and other medical and health issues. ... Pregnanediol has two hydroxyl ... Pregnanediol is an inactive product that forms when the body brea..... Pregnanediol - Substance Summary (SID 7844) ... Pregnanediol has two hydroxyl groups, at 3-alpha and 20-alpha. ... Pregnanediol . Normal Values: mal...

Lactic acid

...es. It was first isolated in 1780 by a Swedish chemist, Carl Wilhelm Scheele, and is a carboxylic acid with a chemical formula of C3H6O3. It has a hydroxyl group... A lactic acid test is a blood test that measures the level of lactic acid produced in the body, mainly by muscle tissue and...
Hydroxyl in Biological News

MIT nanotubes sniff out cancer agents in living cells

...thor of the paper. The sensor can detect DNA-alkylating agents, a class that includes cisplatin, and oxidizing agents such as hydrogen peroxide and hydroxyl radicals. Using the sensors, researchers can monitor living cells over an extended period of time. The sensor can pinpoint the exact location of mo...

Biomedical engineers' detective work reveals antibiotic mechanism

... underlying pathway that caused over-production of hydroxyl radical molecules which contributed to bacterial c...d, some kill bacteria outright, and produce deadly hydroxyl radicals, while other drugs of the class don't trigger hydroxyl radical-production and merely stop bacterial growt...

Methane gas levels begin to increase again

...tle, and the gas and coal industries, and is destroyed by reaction with the hydroxyl free radical (OH), often referred to as the atmosphere's "cleanser." One...ern Hemisphere. At present, however, it is uncertain whether such a drop in hydroxyl free radical concentrations did occur because of the inherent uncertainty i...

Study finds Chinese food good for your heart

...en two-300-milligram XZK capsules or a placebo and tracked over a five-year period. The XZK capsules contained a combination of lovastatin, lovastatin hydroxyl acid, ergosterol and other components. "I think it is surprising that a natural product like XZK would have this great an effect," said Capuzzi. "If...

UF researchers develop improved gene therapy agent

...blame. Tyrosine has as part of its makeup a group of molecules called a hydroxyl group, which attracts phosphates in the cell. When a phosphate binds to the hydroxyl group, it sends a signal to the proteasome the cellular equivalent of taki...

Key molecule discovered in Venus's atmosphere

... Venus Express has detected the molecule hydroxyl on another planet for the first time. This detecti...ding the planets disc. The instrument detected the hydroxyl molecules by measuring the amount of infrared ligh...f. The band of atmosphere in which the glowing hydroxyl molecules are located is very narrow; it is only a...

Flowers' fragrance diminished by air pollution, University of Virginia study indicates

...scents of flowers travel with the wind. The scent molecules produced by flowers are very volatile and they quickly bond with pollutants such as ozone, hydroxyl and nitrate radicals, which destroy the aromas they produce. This means that instead of traveling intact for long distances with the wind, the scents ...

Boston University biomedical engineers find chink in bacteria's armor

...e radical production. Free radicals -- such as hydroxyl or superoxide radicals -- are molecules that carry...hibit or block the bacterial defense mechanisms to hydroxyl radical damage, you can potentiate or enhance the ...n rapidly stimulates production of toxic levels of hydroxyl radicals. Its really amazing that despite the ...

Dopamine used to prompt nerve tissue to regrow

...to promote nerve regeneration. As the nerve tissue reforms, the polymer degrades. Wang's team found that dopamine's structure, which contains two hydroxyl groups, is vital for the material's neuroactivity. Removing even one group caused a complete loss of the biological activity. They also determined tha...

UCI scientists find chlorine may contribute to ozone formation

...ads to ozone formation. The primary cause of urban ozone is the reaction of hydroxyl radical (OH) with hydrocarbons and nitrogen oxides. OH is a highly reactive...s photochemically in air. "For the last 30 years, we've known that the hydroxyl radical is the primary cause of ozone," Saltzman said. "Chlorine plays a si...
Hydroxyl in Biological Technology

Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference

...on a naturally occurring enzyme called urease that essentially reverses the urea cycle by breaking down urea into metabolites that include ammonia and hydroxyl ions. By doing so at the site of cancerous tissues in the body, L-DOS47 is believed to modify the microenvironmental conditions of lung cancer cells i...

SANYO Donates Air Purification Systems Effective Against Flu Viruses to New York Airports and Schools

...Manager in SANYO's Biomedical and Environmental Division. By only using tap water and electricity, there are absolutely no harmful chemicals. The hydroxyl radicals and hypochlorous acid contained in electrolyzed water work together to destroy the protein spikes on the surface of the virus. This prevents ...

Helix BioPharma to Present L-DOS47 Research Findings at the National Research Council of Canada's Eighth Annual General Meeting of the Genomics and Health Initiative in Saskatoon, Canada

...on a naturally occurring enzyme called urease that essentially reverses the urea cycle by breaking down urea into metabolites that include ammonia and hydroxyl ions. By doing so at the site of cancerous tissues in the body, L-DOS47 is believed to modify the microenvironmental conditions of lung cancer cells i...

AGI Dermatics Clinical Data Identifies L-Ergothioneine as Part of Skin's Natural Antioxidant System

...at EGT and its receptor are active participants in the skin's natural antioxidant system and have a more significant effect than idebenone in reducing hydroxyl radicals. The findings further underscore the value of EGT in topical skincare formulas that provide benefits in treatment of photoaged skin." OCTN-...

Helix BioPharma Corp. contracts KBI Biopharma to develop an L-DOS47 clinical packaging format

...on a naturally occurring enzyme called urease that essentially reverses the urea cycle by breaking down urea into metabolites that include ammonia and hydroxyl ions. By doing so at the site of cancerous tissues in the body, L-DOS47 is believed to modify the microenvironmental conditions of lung cancer cells i...

Stevens researchers provide new information about mass spectrometry

...galle and his colleagues from Stevens. The researchers concluded: For this mechanism to operate, a labile hydrogen atom should be available on the hydroxyl group adjacent to the carbaldehyde functionality. ...

Analysis of a Verapamil Microsomal Incubation using Metabolite ID and Mass FrontierTM

...amine group of verapamil initially produces a previously documented metabolic product at mass 290 which then undergoes demethylation to produce a free hydroxyl group which is the site of glucuronidation in the final step (Figure 3). The results for the mass 453 metabolite should prompt the user to return to t...

Acrylamide Polymerization A Practical Approach

...ich appear to trap air at their surfaces. The remaining unpolymerized monomer can react with alpha amino, sulfhydryl, and phenolic hydroxyl groups of proteins (Allison et al. 1974; Chrambach et al. 1976; Dirksen and Chrambach 1972). For discontinuous systems w...

Decontamination and inhibition of ribonucleases

...activated with chelating agents such as EDTA), ribonucleases (RNases) have virtually no cofactor requirements and advantage of the 2 hydroxyl groups adjacent to the phosphodiester linkages in RNA as a reactive species. Sources for RNase contamination in the Laboratory ...
Hydroxyl in Biological Products

T4 Polynucleotide Kinase Exchange Reaction Buffer from Invitrogen

Description:...eaction T4 Polynucleotide Kinase transfers the 5' phosphate group from DNA to ADP and subsequently transfers the Gamma-phosphate of ATP to the free 5' hydroxyl group to rephosphorylate the DNA....
Company:Invitrogen

Corticosterone EIA Kit from IDS Ltd

Description:...isol, in varying proportions. It is therefore critical to look at relative cross-reactivities of these closely related steroids (differing by only one hydroxyl group at C17) if attempting to differentiate between them by immunoassay. Our assay has a low 0.02% cross-reactivity with cortisol....
Company:IDS Ltd

T4 DNA Ligase from Invitrogen

Description:... T4 DNA Ligase catalyzes the formation of phosphodiester bonds in the presence of ATP between double-stranded DNAs with 3' hydroxyl and 5' phosphate termini. The unique T4 DNA Ligase buffer optimizes ligation which can be performed in 5 minutes (1). Single-stranded nucleic acids ar...
Company:Invitrogen

ARCA (Anti Reverse Cap Analog) from Ambion

Description:... 3 OH group (closer to m7G) is replaced with OCH3. Because of this substitution, the RNA polymerase can only initiate transcription with the remaining hydroxyl group thus forcing ARCA incorporation in the forward orientation. As a result, unlike transcripts synthesized with conventional cap analog, 100% of th...
Company:Ambion

Poly A Polymerase from Invitrogen

Description:... Poly A Polymerase catalyzes the addition of AMP to the 3' hydroxyl terminus of RNA. Poly A Polymerase can add poly(C) and poly(U) to RNA but does so with much-reduced efficiency....
Company:Invitrogen

15(R)-17-phenyl trinor Prostaglandin F2alpha isopropyl ester from Cayman Chemical

Description:...(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2α isopropyl ester is a potential impurity in most commercial preparatio...
Company:Cayman Chemical
Hydroxyl in Biological Definition

Alcohol

...erm, applied to any organic compound in which a hydroxyl group ( - O H ) is bound to a carbon atom, wh... The functional group of an alcohol is a hydroxyl group bonded to an sp 3 hybridized carbon. It c...triacylglycerols) Phenol , an alcohol where the hydroxyl group is bound to a benzene ring Fatty alcoho...

Carbohydrate

...traight-chain aldehydes and ketones with many hydroxyl groups added, usually one on each carbon except t...tose . Further, each carbon atom that supports a hydroxyl group (except for the first and last) is opticall...ke. The aldehyde or ketone group may react with a hydroxyl group on a different carbon atom to form a hemiac...

Glucose

...aldoses . In this ring, each carbon is linked to hydroxyl and hydrogen side groups with the exception of th...L has to do with the isomeric conformation of the hydroxyl on carbon 5. If it is to the right in the Fische...tructurally, they differ in the orientation of the hydroxyl group linked to the first carbon in the ring. The...

Hydrolysis

... that involves breaking an ester link, one hydrolysis product contains a hydroxyl functional group , while the other contains a carboxylic acid functiona.... The fragment that was originally an alkyl group collects the remaining hydroxyl group from the water molecule. Thus the ester is effectively reversed to...

Kidney

...ction of the kidney The kidney regulates the pH, mineral ion concentration and water composition of the blood. By exchanging hydronium ions and hydroxyl ions , the blood plasma is maintained by the kidney at pH 7.4. Urine, on the other hand, becomes either acidic at pH 5 or alkaline at pH 8. Sodium ...

Lipid

...is makes them amphiphilic molecules (having both hydrophobic and hydrophilic portions). In the case of cholesterol , the polar group is a mere -OH ( hydroxyl or alcohol). In the case of phospholipids, the polar groups are considerably larger and more polar, as described below. Phospholipids or, more pr...

Oxidative phosphorylation

...n species Several highly reactive, transient oxygen derivatives can be formed during this process: Hydrogen peroxide Superoxide anion hydroxyl radical ...

Pentose phosphate pathway

...ydrogenation of glucose 6-phosphate into 6-phosphoglucono-δ-lactone . This reaction is catalyzed by glucose 6-phosphate dehydrogenase . The hydroxyl group located on carbon 1 of glucose 6-phosphate is converted into a keto group, and in the process, NADPH is generated. The second step is the ...

Phospholipid

...yl group of each fatty acid is esterified to the hydroxyl groups on carbon-1 and carbon-2. The phosphate gr...are formed from a phosphoester linkage between the hydroxyl of an alcohol ( serine or inositol ) and cytidin...ceramide . Subsequent substitution of the terminal hydroxyl group by phosphatidyl choline forms sphingomyelin....

RNA

...ished from DNA by the presence of an additional hydroxyl group, attached to each pentose ring; as well a...ble from DNA except for the critical presence of a hydroxyl group attached to the pentose ring in the 2' position (DNA has a hydrogen atom rather than a hydroxyl group). This...
Hydroxyl in Biological Dictionary

Self-splicing

...mparable role in the self - splicing reaction, however, and so our unique ... This self - splicing RNA provided the first example of a ... A 3' hydroxyl is the same as the product of self - splicing but opposite to the ... ...

Phosphatase

...e that removes a phosphate group from its substrate by hydrolysing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group . This action is directly opposite to that... Alkaline phosphatase (ALP) (EC 3.1.3.1) is a hydrolase enzyme responsible for removing ph...

Oxidation

...... Oxidation is defined as the interaction between oxygen molecules and all the ... Hydroxyacyl-CoA Dehydrogenase catalyzes oxidation of the hydroxyl in the b ... NADH produced during fatty acid oxidation is reoxidized by transfer of 2e- to ... Oxidation - Definition. The most fundamental rea...

Hydroxyl radical

... hydroxyl in chemistry describes a molecule consisting of...y a covalent bond. The neutral form is known as a hydroxyl radical and the singly-charged hydroxyl anion is called hydroxide.... ...

DNA ligase

...igase . rGka DNA Polymerase. RNA 5' Polyphosphatase ... Catalyzes the formation of a phosphodiester bond between juxtaposed 5' phosphate and 3' hydroxyl termini in duplex DNA or RNA. This enzyme will join blunt end and ... Catalyzes the formation of a phosphodiester bond between juxtaposed 5...

Dideoxy Sequencing

... sugar. Since deoxyribose already lacks a 2'-OH, dideoxyribose lacks hydroxyl groups at both its 2' and 3' carbons. The lack of this hydroxyl group means that, after being added by a DNA polymerase to a growing nuc...

Deoxyribose

...) is a five carbon sugar ... Deoxyribose differs from ribose in lacking a hydroxyl at position 2. ... Deoxyribose (each number on the ring represents a c...gar deoxyribose (a 5 carbon sugar) ... In the case of deoxyribose , a hydroxyl group has been replaced with a single hydrogen atom. Deoxyribose has the ...

Deoxyribonuclease

... DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate terminated polynucleotides with a free hydroxyl group on... deoxyribonuclease n. DNase. ... deoxyribonuclease . Dictionary: de·ox·y·ri·bo·nu·cle ... A deoxyribonuclease (DNase, for short) is...
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