Ranbaxy Secures Final FDA Approval for Quinapril Hydrochloride + Hydrochlorothiazide Tablets
PRINCETON, N.J., March 5 /PRNewswire/ -- Ranbaxy Pharmaceuticals Inc. (RPI), a wholly owned subsidiary of Ranbaxy Laboratories Limited (RLL), announced today that RLL has received approval from the U.S. Food and Drug Administration to manufacture and market Quinapril Hydrochloride & Hydrochlor...
Video: FDA approves Exforge HCT(R) - the Only High Blood Pressure Treatment to Combine Three Medications in a Single Pill
...maximum dose of Exforge HCT (amlodipine/valsartan/
hydrochlorothiazide 10 mg/320 mg/25 mg) demonstrated significantly gre...ecautions (5.1 )]
Because of the
hydrochlorothiazide component, EXFORGE HCT is contraindicated in patie...required.
Important considerations due to the
hydrochlorothiazide component of EXFORGE HCT: Thiazides have been rep...
One Pill Might Prevent Heart Disease
...ogy annual meeting in Orlando, Fla., and online in The Lancet .
The polypill contains generic versions of the blood pressure medications atenolol,
hydrochlorothiazide and rampiril, as well as simvastatin (Zocor) and aspirin. It is designed to attack three major risk factors of cardiovascular disease -- high blood pr...
Mylan Announces Tentative FDA Approval for Generic Version of Antihypertensive Avalide(R) Tablets
...A) for its Abbreviated New Drug Application (ANDA) for Irbesartan and
Hydrochlorothiazide Tablets, 150 mg/12.5 mg and 300 mg/12.5 mg.
Irbesartan and
hydrochlorothiazide Tablets, indicated for the treatment
of hypertension, are the generic version of Sanofi Aventis' Avalide(R)
Tablets, which had U.S. sales of approxima...
2-drug blood pressure therapy lowers cardiovascular risk
...nts in the study received no more than 40 milligrams of benazepril in each dose; amlodipine doses began at 5 mg and could be increased to 10 mg, while
hydrochlorothiazide doses began at 12.5 mg and could be increased to 25 mg.
Many studies have already shown that reducing blood pressure can reduce the risk of stroke,...
Sanofi-aventis Announces a Good Third Quarter Performance; Increase in 2007 full-year earnings growth guidance
...ittee of the FDA recommended
approval of Avalide(R) as an initial treatment for hypertension. Avalide(R)
is a fixed-dose combination of irbesartan and
hydrochlorothiazide that is
currently approved for the treatment of hypertension in patients with blood
pressure uncontrolled on monotherapy. If approved, the new indicat...
Beta-Blockers Should Not Be First Choice for High Blood Pressure
...than patients who use calcium channel blockers such as Norvasc and Cardizem to manage their blood pressure.
Patients who take diuretics such as
hydrochlorothiazide or a group of drugs called RAS inhibitors (brand names include Altace, Lotensin, and Cozaar) have risks similar to those taking beta-blockers.
D...
King Pharmaceuticals Announces Plan to Present Results from Phase
III Clinical Trial Evaluating ALTACE as Monotherapy and in
Combination with Hydrochlorothiazide at the American Society of
Hypertension Annual Meeting
BRISTOL, Tenn.--(BUSINESS WIRE)--May 8, 2007 - King
Pharmaceuticals, Inc. (NYSE:KG) announced today that the results
from a Phase III clinical trial for its ALTACE(R) (ramipril)
diuretic combination product will be presented at the American
Society of Hypertension's Twenty-Second Annual Scientific ...
King Pharmaceuticals Reports Efficacy of Altace 20mg And Efficacy
of a Combination of Altace 20mg And Hydrochlorothiazide 25mg For
24-hour Blood Pressure Control
BRISTOL, Tenn.--(BUSINESS WIRE)--May 19, 2007 - King
Pharmaceuticals, Inc. (NYSE:KG) reported today that data from its
Phase III clinical trial evaluating Altace (ramipril) 20mg and the
combination of ALTACE 20mg and
hydrochlorothiazide (HCT) 25mg were
presented this weekend at the American Society...
FDA Approves Tekturna HCT(R) as Initial Treatment in Patients Unlikely to Achieve Their Blood Pressure Goals With a Single Agent
... approved direct renin inhibitor, and the diuretic
hydrochlorothiazide (HCTZ), one of the most commonly-used high blood p...us combinations of Tekturna (75 mg to 300 mg) plus
hydrochlorothiazide (6.25 mg to 25 mg) once daily (without titrating u...pressure response. The combination of Tekturna and
hydrochlorothiazide resulted in additive placebo-adjusted decreases in...
New Data Shows Blood Pressure Reduction Therapy with BENICAR(R) and BENICAR HCT(R) Effectively Reduces Blood Pressure in Elderly Patients to Target Blood Pressure
...ormation for BENICAR HCT also includes the following warnings regarding its
hydrochlorothiazide component:
BENICAR HCT is not recommended in patients with severe renal ...atic coma.
Hypersensitivity Reaction
Hypersensitivity reactions to
hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial ast...
New Study Shows BENICAR(R) (olmesartan medoxomil) Reverses Blood Vessel Damage Independent of Blood Pressure Lowering
...ormation for BENICAR HCT also includes the following
warnings regarding its
hydrochlorothiazide component:
BENICAR HCT is not recommended in patients with severe renal i...e hepatic coma.
Hypersensitivity Reaction
Hypersensitivity reactions to
hydrochlorothiazide may occur in patients
with or without a history of allergy or bronchial ast...
New Data Shows 45 Percent of Patients with Stage 1 Hypertension Reached Normotension with BENICAR(R) and BENICAR HCT(R)
...ormation for BENICAR HCT also includes the following
warnings regarding its
hydrochlorothiazide component:
BENICAR HCT is not recommended in patients with severe renal i...e hepatic coma.
Hypersensitivity Reaction
Hypersensitivity reactions to
hydrochlorothiazide may occur in patients
with or without a history of allergy or bronchial ast...
Lotrel, a Single-Pill Combination for Treating High Blood Pressure, Reduced Cardiovascular Events by 20% in High-Risk Patients
...essure patients treated with Lotrel(R) (amlodipine besylate and
benazepril HCl) had 20% fewer cardiovascular events than those taking a
benazepril and
hydrochlorothiazide (HCTZ) combination. This is the first
cardiovascular outcomes trial in a hypertensive population where all
patients were randomized to receive a singl...
Powerful New Efficacy Data in Moderate and Severe Hypertensive Patients Supports FDA Approval of AVALIDE(R) (Irbesartan-Hydrochlorothiazide) as the First Combination Therapy for Initial Use in Patients Likely to Need Multiple Drugs to Achieve Their Blood
...(n=328), irbesartan 150 mg
monotherapy (n=106), or
hydrochlorothiazide 12.5 mg monotherapy (n=104).
After two weeks, all ...cified adverse events
on AVALIDE vs. irbesartan or
hydrochlorothiazide monotherapy were:
hypotension (0.9% vs. 0% and 0%)...onatal Morbidity and Mortality. -- Because of the
hydrochlorothiazide component, AVALIDE is contraindicated in patie...
New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard
Therapy in Treatment of Hypertension
...with hypertension who do not respond to
first-line
hydrochlorothiazide treatment J Jordan, SW Boye, S Le
Breton, DL Keefe...; Poster 401
* The combination of aliskiren with
hydrochlorothiazide provided
significant additional blood pressure red...eeks of
treatment.
Aliskiren in combination with
hydrochlorothiazide is effective
and well tolerated during long-term t...
Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage
2 Patients Compared With Amlodipine + Benazepril
...ormation for BENICAR HCT also includes the
following warnings regarding its
hydrochlorothiazide component:
BENICAR HCT is not recommended in patients with severe renal
i...e
hepatic coma.
Hypersensitivity Reaction
Hypersensitivity reactions to
hydrochlorothiazide may occur in
patients with or without a history of allergy or bronchial ast...