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Humoral in Medical News

NYP/Weill Cornell physician-scientists present at 2009 American Transplant Congress in Boston

...t for Diagnosis of Most Common Kidney Transplant Complications [122] Concurrent Session 17: Immune Monitoring: Chronic Allograft Damage and Chronic humoral Rejection Sunday, May 31, 4:48 p.m.; Room 309 Authors: Thangamani Muthukumar, Ruchuang Ding, Catherine Snopkowski, Aurlie Hummel, Vijay Sharma, Dars...

Stemedica Medical Team Cautions Patients About Stem Cell Therapy & Comments on PLoS Medicine Article

...ve disorder known to have an increased risk of developing cancer. Malignancy and neoplasia are common in A-T secondary to deficient cellular and humoral immunity. This immune deficiency is a contra-indication to stem cell transplant therapy. In addition, the mutations associated with A-T in the A-T m...

Cancer drug effectively treats transplant rejections

...ansplanted kidneys and reversing rejection episodes that did not respond to standard therapies. B-lymphocytes, or B cells, play a large role in the humoral immune response by making immune proteins that attack transplanted organs. "We found a body of literature demonstrating that bortezomib works well ...

Cell-Mediated Immunity and Anti-HLA Antibody Tests Provide Insight to Immune Response in Renal Transplant Patients

...tion and monotherapy.(1) They have also determined humoral sensitization by assessing the circulating anti-HL...t study ("Relationship between immune function and humoral sensitization in renal transplant recipients;" see...ationship between immune function and the level of humoral sensitization in serially matched samples. The I...

Multiple Independent Studies Report on Use of Cylex's Immune Cell Function Assay in Postoperative Monitoring of Kidney, Liver, and Heart Transplant Recipients

...mia. Sunday, June 1, 2008 -- "Effect of induction agent on cellular and humoral responses to renal transplants in sensitized patients" (M. S. Leffell, ...assay in patient monitoring. -- "Relationship between immune function and humoral sensitization in renal transplant recipients" (A. Zeevi, C. Bentlejewsk...

IAVI and VaxDesign partner to develop a clinical trial in a test tube for AIDS vaccines

...lls from volunteers to create simulated human immune responses. The MIMIC models reproduce both innate and adaptive immune responses, and exhibit both humoral and cellular immunity. VaxDesign has the capacity to run thousands of these immune simulations per month. IAVI will first test the technology on lice...

Firefly genes allow testing of new therapy against lymphoma

... In doing so, the researchers developed what they hope will be the first animal model for the disease that includes a severe bone depletion called humoral hypercalcemia of malignancy (HHM), a condition that can affect four out of every five ATLL patients and shorten their lives. The study is publishe...

Mayo Clinic tests novel vaccine for aggressive brain tumors

...stomas are so aggressive. The vaccine uses synthetic versions of EGFRvIII to stimulate both cell-mediated immunity (T cells that attack invaders) and humoral immune responses (B cells that provide ongoing immune surveillance). Participating patients whose tumors exhibit EGFRvIII will be randomized (sele...

A Promising New Vaccination Strategy for Late-Stage Melanoma

... administered alone and together in a prime-boost setting. In a large proportion of the 23 evaluable patients, the vaccine was shown to stimulate both humoral and cellular immune responses consisting of antibodies, CD8+ and CD4+ T cells specific to a broad range of NY-ESO-1 antigenic epitopes. Of nine melano...

Monoclonal antibodies show promise in treatment of blood cancer

...researchers conclude, "In addition, this treatment could greatly aid transplant patients who require multiple organ transplants because they develop a humoral antibody response to their transplanted organs, or they already have preformed antibodies that prevent them from accepting some donor grafts." ...
Humoral in Medical Technology

Oncolytics Biotech Inc. Announces Start of Patient Enrolment in Translational Clinical Trial Investigating REOLYSIN(R) in Patients with Metastatic Colorectal Cancer

...mination of the resected tumour. Secondary objectives include assessing the anti-tumour activity and safety profile of REOLYSIN(R), and monitoring the humoral and cellular immune response to REOLYSIN(R). Eligible patients include those with histologically proven colorectal cancer, planned for potentially c...

GeneThera Announces it is Set to Begin Commercial Testing for Johne's Disease as Soon as January, 2009.

...nes by stimulated T lymphocytes. As the disease progresses from sub clinical to clinical stages, the cell-mediated immune response wanes, and a strong humoral response predominates. About Real Time PCR Traditionally, PCR is performed in a tube and when the reaction is complete the products of...

ImmunoVaccine Technologies' DepoVax(TM) Shows Positive Results for Cancer and Infectious Diseases

... depot effect that significantly enhances vaccine induced cell-mediated and humoral immunity. The efficacy of a single dose of a DepoVax(TM) formulation was ... therapeutic cancer formulations in the clinic this coming year." For the humoral response, a recombinant H5 antigen was used. IVT immunized models once with...

Baxter Initiates Phase III Trial for the Treatment of Alzheimer's Disease

...be posted. About GAMMAGARD LIQUID GAMMAGARD LIQUID is indicated for the treatment of primary immunodeficiency disorders associated with defects in humoral immunity. These include, but are not limited to, congenital X-linked agammaglobulinemia, common variable immunodeficiency, Wiskott-Aldrich syndrome, a...

VIRxSYS to Host a Web Conference to Announce Clinical Trial Update

...he study, VRX1023 delivered antigens that induced long-lasting cellular and humoral immune responses, better than those seen with other viral vectors, a powerf...ive destruction of CD4 T cells that ensues. Activation of both cellular and humoral immunity can also halt the slow destruction of the immune system by the lat...

AlphaVax Continues to Expand the Use of Its Vaccine Platform

...d during the first grant period demonstrated that AlphaVax's smallpox vaccine, which expresses four, highly conserved poxvirus proteins, could provide humoral responses comparable to those obtained with a licensed vaccine. Furthermore, the AlphaVax vaccine protected mice against vaccinia virus challenge and ...

BN ImmunoTherapeutics Starts Clinical Trials With Prostate Cancer Vaccine

...is expected during second half year 2009. The therapeutic vaccine, based on the company's MVA-BN(R) technology, is designed to generate cellular and humoral immune responses to PSA and PAP (prostate specific antigen and prostatic acid phosphatase), which are both well-known prostate cancer tumor targets. ...

University of Miami Team Confirms Value of Monitoring Cell-Mediated Immunity Pre- and Post-Transplant in Management of Kidney Transplant Recipients

...of organ rejection. Several patients showed evidence of cellular (n = 8) or humoral (n = 2) rejection while under monitoring. The patients demonstrating cellul...vel after good immune function was restored. The two patients demonstrating humoral rejections showed no changes in CMI. Finally, of the 23 patients who contra...

New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma

...and resultant data suggest a positive trend for clinical response. These data also demonstrate the induction of a desirable immune response, including humoral and cellular responses. These study results represent a second positive trend for clinical activity for the novel MAGE-A3 cancer immunotherapeutic, fo...

Study Results of GAMMAGARD S/D and GAMMAGARD LIQUID in Patients with Mild-to-Moderate Alzheimer's Disease Announced

... treatment of primary immunodeficiency disorders associated with defects in humoral immunity. These include but are not limited to congenital X-linked agammagl... treatment of primary immunodeficiency disorders associated with defects in humoral immunity. These include but are not limited to congenital X-linked agammagl...
Humoral in Medical Definition

Central tolerance

...D 15156139 . v • d • e Immune system / Immunology Adaptive immune system • Innate immune system • humoral immune system • Cellular immune system Lymphatic system • Inflammation • Complement system ( Classical , Alternative , Lectin , Anap...
Humoral in Medical Dictionary

Immune

...s. 10 The Allergic response. 11 Autoimmune Disorders ... The immune response is a defensive reaction against harmful substances, such as ... The humoral immune system involves proteins called immunoglobulin antibodies ... The immune system is an intricate network of specialized tissues, organ...

Hypersplenism

...larged spleen is one of the symptoms of hypersplenism . ... Splenomegaly and Hypersplenism - The spleen is involved in producing protective humoral antibodies, the production and maturation of B and T cells and plasma cells, ... Hypersplenism from Encyclopedia of Medicine provided by Find ...

Humerus

..... The humerus is the large upper arm bone, and has rounded bony protrusions on ... The shoulder and humerus x-rays demonstrate a proximal humoral fracture that is ... The patient's fractured humerus is placed in a sling and oral analgesics control ... A proximal humerus fracture, als...

Clot

... of the blood coagulation step in hemostasis. It is achieved via the aggregation of platelets that form a platelet plug, and the activation of the humoral coagulation system . A... blood clot n. A semisolid gelatinous mass of coagulated blood that consists of red blood cells, white blood cell...
Humoral in Biological News

Dana-Farber oncologists present at ASCO GU -- predict prostate cancer survival using Source MDx test

...ndividual differences in gene transcripts associated with cell-mediated and humoral immunity are associated with survival in CRPC patients. These specific immune system changes were indicative of a decrease in both cell-mediated and humoral immunity in CRPC patients with higher mortality. "The six genes predicti...

NIH hosts event to launch Council of Science Editors' global theme issue

...nterventions towards the poor, published by JAMA and presented by Dr. Majid Ezzati, Harvard School of Public Health (Boston, Mass.) Cellular and humoral responses to in influenza in Gabonese children living in rural and semi-urban areas, published by Journal of Infectious Diseases and presented by Dr. ...

Tips from the Journals of the American Society for Microbiology

...red as a substitute for the Dryvax vaccine. The Wyeth IL-15 vaccine resulted in a 1,000-fold reduction in lethality and highly increased cellular and humoral immune responses. Additionally, mice vaccinated with Wyeth IL-15 fully survived a lethal intranasal challenge ten months after vaccination. The seco...

BiovaxID?yields 89 percent survival in patients with aggressive non-Hodgkins

...s, "it is justifiable to administer vaccines in the setting of B-cell depletion, but vaccine boosts after B-cell recovery may be necessary for optimal humoral responses," concluded the investigators. Lymphocytes are a type of white blood cell. There are two types of lymphocytes: B-cell lymphocytes, which ...

Diabetes researchers pioneer islet cell xenotransplantation in primate studies

.... However, humans and Old World primates have naturally occurring antibodies that are directed against antigens that can cause hyperacute or acute humoral rejection. To combat that, the researchers administered an anti-IL-2 receptor and anti-CD154 (H106) antibody, while maintaining immunosuppression usin...
Humoral in Biological Technology

ImmunoVaccine Technologies Partners with FIT Biotech to advance a therapeutic HIV vaccine

... depot effect that significantly enhances vaccine induced cell-mediated and humoral immunity. This pre-clinical research partnership will combine the complem...will examine the novel vaccine's capabilities of inducing cell-mediated and humoral immunity against HIV virus. "By testing DepoVax(TM) in combination with G...

Medarex Announces Presentations at Annual Meeting of the American Society of Clinical Oncology

...apy Session) O. Hamid - Oral presentation from 1:00 p.m. to 4:15 p.m. local time on Saturday, May 30, 2009. "Increased humoral and cellular immunity in patients (pts) with advanced melanoma treated with ipilimumab" (Abstract #3031, Developmental Therapeutics: Immunotherapy Ses...

Novavax CMO to Present at Phacilitate Vaccine Forum Washington 2009

...g expression and yields. In addition, preclinical and clinical data have shown that VLPs activate multiple arms of the immune system, inducing robust humoral and cell-mediated immunity, which permits vaccine development for a wide range of disease targets. Further, VLPs may be more cost effective to produc...

Phase III Trial Begins for GAMMAGARD LIQUID Plus rHuPH20 in Primary Immunodeficiency Patients

... About GAMMAGARD LIQUID GAMMAGARD LIQUID is indicated for the treatment of primary immunodeficiency disorders associated with defects in humoral immunity. These include but are not limited to congenital X-linked agammaglobulinemia, common variable immunodeficiency, Wiskott-Aldrich syndrome, and...

MedImmune Presents Data Highlighting its Progressive Inflammatory Disease Portfolio at the 72nd Annual Meeting of the American College of Rheumatology

...01 is a phase 1 clinical stage program. -- ICOS - ICOS (Inducible costimulator) is a receptor on activated T-cells that plays a central role in humoral immunity. Elevated levels of ICOS are present in patients with autoimmune diseases and effector cytokines have been shown to correlate with ...

Bavarian Nordic A/S - Interim Report for the Period 1 January to 30 June 2008

...is expected during second half year 2009. The therapeutic vaccine, based on the Company's MVA-BN(R) technology, is designed to generate cellular and humoral immune responses to PSA and PAP (prostate specific antigen and prostatic acid phosphatase), which are both well-known prostate cancer tumor targets. ...

ImmunoVaccine Technologies Patents DepoVax(TM) Vaccine Platform

...resident of research and development at IVT. "DepoVax(TM) is superior to conventional vaccine formulations in its ability to raise strong cellular and humoral immune responses to a variety of antigens, a hallmark of IVT's vaccine formulations." DepoVax(TM) has been tested in pandemic influenza and therapeu...

Protherics Licenses its CoVaccine HT Adjuvant to Nobilon for Influenza Vaccine Indications

... response and so helps maximise the production of antibodies. The CoVaccine HT(TM) adjuvant is a sucrose fatty acid sulphate ester that increases both humoral and cell-mediated immune responses to experimental vaccines following intramuscular administration. In nonclinical studies, the adjuvant has been well...

Tips from the Journals of the American Society for Microbiology

...red as a substitute for the Dryvax vaccine. The Wyeth IL-15 vaccine resulted in a 1,000-fold reduction in lethality and highly increased cellular and humoral immune responses. Additionally, mice vaccinated with Wyeth IL-15 fully survived a lethal intranasal challenge ten months after vaccination. The seco...

A Large-Scale Research Project by a Dutch Consortium Addressing a Global Problem

...elopment of Novel Strategies to Induce and Monitor humoral and Cellular Immunity to Protect Hosts From Inf...develop novel strategies to induce and monitor the humoral and cellular immunity that protects the host from ...able us to better understand the roles of both the humoral and the cellular arms of the adaptive immune syste...
Humoral in Biological Definition

Antibody

...4 IgD 3.5 IgE 4 Function 4.1 The humoral immune response 5 Medical applications ...n immune mechanisms respond to antigens. The humoral immune response When a macrophage ingests a p...or bound to cell membranes. They are part of the humoral immune system . Antibodies exist in clonal lines t...

B cell

... B cells are lymphocytes that play a large role in the humoral immune response (as opposed to the cell-mediated immune response ). The a...ickly upon second exposure to the antigen for which they are specific. humoral immunity (the creation of antibodies that circulate in blood plasma and ...

Immune system

... stem cells in the bone marrow . In many species, including mammals , the adaptive immune system can be divided into two major sections: The humoral immune system , which acts against bacteria and viruses in the body liquids (such as blood ). Its primary means of action are proteins called immun...

Immunology

.... The immune system has been divided into innate immune system , and acquired or adaptive immune system , the latter of which is further divided into humoral and cellular components . The mainstay of classical immunology has been the interaction between antibodies and antigens . Without an understand...
Humoral in Biological Dictionary

Lymphocytes

...ance. Most, but not all large granular lymphocytes are more commonly known as the ... B cells are lymphocytes that play a large role in the humoral immune response . The principal functions of B cells are to make antibodies against antigens, perform the role of Antigen Presenting Cells (APCs...

Immune response

...- form the first line of defense in the immune response . ... The primary immune response , which is the response in ... An overview of the humoral immune response will be reviewed here. ... Microbe Evasion of Immune Responses . This module will help you ... The immune response to Re...

Humoral immunity

... The humoral Immune Response (HIR) is the aspect of immunity ...o-stimulation of the B cell can come from... humoral immunity n. The component of the immune system... and circulate as soluble proteins in blood humoral immunity refers to antibody production, and a...

Effector cell

...T cells , ... proposed in which the tissue-homing effector memory T cells , ... B cell activation and effector functions are described in humoral Immunity. ... The T cell is triggered to release effector molecules into the close spaces ... Effector cell mediated cytotoxicity measured ...

Cell-mediated immunity

...e immune system was separated into two branches: humoral immunity ,... Aspects of the topic cell - med.... ... Immunity . Cell - mediated Immunity . humoral ... but sensitized in the thymus and constitute th...oaches to developing an effective HCV vaccine. ... humoral Immunity . Cell - Mediated Immunity . Obstacle...

B lymphocytes

... B cells are lymphocytes that play a large role in the humoral immune response . The principal functions of B cells are to make antib... summaries, ... B cells are lymphocytes that play a large role in the humoral immune response as ... B Lymphocytes : Alterations in the immune s...

B cell

...s are lymphocytes that play a large role in the humoral immune response ... B cell development o...s are lymphocytes that play a large role in the humoral immune response ... B cell n. Any of the ...ifically, B cells play a prominent role in the humoral immune response, as ... B cells are not onl...
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