Isis Reports Strong Financial Results and Highlights for First Quarter of 2009
...data from a Phase 3 study evaluating mipomersen in homozygous
Familial Hypercholesterolemia (FH) patients and fr...ta from our Phase 3 study evaluating mipomersen in homozygous
Familial Hypercholesterolemia patients. We expect...yme is planning an initial European submission for homozygous
Familial Hypercholesterolemia (FH) with timing exp...
Isis Reports Strong Financial Results and Highlights for Fiscal Year 2008
...data from a Phase 3 study evaluating mipomersen in homozygous
Familial Hypercholesterolemia (FH) patients and fr...ase 3 study evaluating mipomersen in patients with homozygous
FH. Also we and our partners expect to report dat...leting enrollment in a Phase 3 mipomersen study in homozygous
Initiating four additional mi...
Scientists identify new congenital neutropenia syndrome and causative gene mutation
...nd the other is not) in the neutrophil elastase (ELA2) gene. In 2007, Klein's lab identified another causative mutation in a subgroup of SCN patients: homozygous
mutations (where the defect is present in both copies of the gene) in the HAX1 gene.
To conduct the current study, the researchers focused on five ...
IDO2 an active enzyme to target in pancreatic cancer
...der to have an active IDO2 enzyme.
Nineteen percent of the patients were homozygous
wild-type, meaning they had two active alleles, and 42 percent of the patie...heterozygous, meaning they had one active allele. Twenty-five percent were homozygous
for two inactive IDO2 alleles. The remaining 14 percent were difficult to d...
ADHD Gene Doesn't Predict Response to Drugs
"What we found is that the children who have two copies of the Val isoform had an even harder time orienting their goals than children who are homozygous
for Met [that is, have two copies of the Met isoform] or even Val/Met," he said. Each person two copies of the COMT gene, one from each parent.
Isis Reports Financial Results and Highlights for First Quarter of 2008
... Phase 3 program in patients with high cholesterol at high risk for cardiovascular disease including an ongoing Phase 3 study in patients with homozygous
Familial Hypercholesterolemia (FH). o Isis reported updated safety data on mipomersen from an ongoing open-label extension study in 20...
FDA Provides Clarity to Isis Regarding the Development Path for Mipomersen
...DA has indicated that reduction of
LDL-cholesterol is an acceptable surrogate endpoint for accelerated
approval of mipomersen for use in patients with homozygous
hypercholesterolemia (hoFH). The FDA will require data from two ongoing
preclinical studies for carcinogenicity to be included in the hoFH fi...
Isis Reports Financial Results and Highlights for Fiscal year 2007
...ke strong progress with our most important
asset, mipomersen. Earlier in the year, we announced the initiation of the
Phase 3 studies in patients with homozygous
Today we are announcing that we are initiating the rest of the Phase 3
program for mipomersen including studies in pati...
What are simple ways to judge the efficacy of 5-fluorouracil in colonic neoplasm?
.... There are three predominant genotypes of TS: (1) homozygous
with two tandem repeats (2R/2R); (2) homozygous
with three tandem repeats (3R/3R); (3) heterozygou.../3R (n = 22) and 3R/3R (n = 40). Patients who were homozygous
for triple-repeated (3R/3R) sequences showed signi...
Genzyme Delivers Strong Fourth Quarter to Conclude Outstanding Year
...rget cholesterol levels with statins alone or who are intolerant of statins. Mipomersen is currently in phase 3 development for patients with homozygous
familial hypercholesterolemia, and a U.S. marketing application for this indication is anticipated in 2009. The product offers an innovative ...
Homozygous in Medical Technology
Isis Reports Strong Financial Results and Highlights for Second Quarter of 2009
...data from a Phase 3 study evaluating mipomersen in homozygous
Familial Hypercholesterolemia (FH) patients; posit...n the largest, placebo-controlled Phase 3 study in homozygous
FH patients. We reported that the study met its p... file the first NDA for mipomersen in the U.S. for homozygous
FH in the second half of 2010, with a similar fili...
Tufts Medical Center Researchers Create a New Predictive Model for Age-related Macular Degeneration (AMD)
...gh AMD has a strong genetic component, healthy behaviors can modify your genetic susceptibility. For example, among individuals with one genotype, the homozygous
C3 risk genotype, the likelihood of progression to the advanced form of AMD increased from about three-fold for nonsmokers to nearly 10-fold for smoke...
Aegerion Pharmaceuticals, Inc. adds Peter Garrambone to Board of Directors, Secures Additional Capital for Clinical Trials
...gned to explore the efficacy, safety and tolerability of
AEGR 733, Aegerion's lead compound. A Phase III study of AEGR 733 in the
orphan population of homozygous
familial hypercholesterolemic patients is
In addition, Aegerion announced the transition of Jerry Wisler, Co-
Founder, CEO and D...
Genzyme and Isis Complete Licensing of Mipomersen
...o be completed in a
pivotal study of mipomersen in homozygous
and a new trial in ...out as follows:
-- Total milestones related to homozygous
FH $50 million -- Total milestones...dition to
the mipomersen development program. Like homozygous
FH patients, apheresis-
eligible patients are char...
Karmanos Researchers Study the Impact of Galectin-3 on Breast Cancer Disparity in Caucasian and Asian Women
...e disease-free control
Caucasian women were either homozygous
(12%) or heterozygous (52%) for H64
and the remaining 36% were homozygous
for P64. In contrast, 30% of the
disease-free cont... carried at least one H64 allele, of which
5% were homozygous
and 25% were heterozygous and the remaining 70% we...
Update From Mipomersen Extended Dosing Study Continues to Show That Mipomersen Is Well Tolerated and Maintains Activity in Patients Treated for Up to 16 Months
...nherited from both
parents, or heterozygous (heFH), where the defective gene is inherited from
only one parent so that some function is preserved. The homozygous
a very rare condition estimated to affect approximately one in a million
people. Children with hoFH are at high risk for early coronary events...
Isis Reports Positive Results of Phase 2 Study of ISIS 301012 in Heterozygous FH Patients
...d the most severely affected patients
may need apheresis, an expensive and time-consuming procedure that removes
the "bad" cholesterol from the blood. homozygous
FH is rare, affecting
about one in one million people, but heterozygous FH is much more common
with a prevalence of approximately one in every 500 peo...
Isis Pharmaceuticals Reports Positive Phase 2 Data for ISIS 301012
in Familial Hypercholesterolemia Patients Presented at ACC
... * homozygous
FH patients already being treated with maximally
t...e 2 clinical trial of ISIS 301012 in
patients with homozygous
familial hypercholesterolemia (HoFH),
presented to...kable. Achieving an LDL-C less than 100
mg/dL in a homozygous
FH patient, other than for a few days via
Study Presented at ACC Shows Treatment With ISIS 301012 Added to
Statins for Only 5 Weeks Results in 75% of Patients Achieving LDL-C
Levels Less Than 100 mg/dL and 50% of Patients Achieving LDL-C
Levels of Less Than 70 mg/dL
represented in this study, as well as in homozygous
hypercholesterolemic patients on maximal ...01012
added to maximal lipid lowering therapies in homozygous
hypercholesterolemia (FH) patients were r...en granted orphan drug status for the
treatment of homozygous
FH and Isis plans to begin
Isis Pharmaceuticals Updates Its Positive Phase 2 Data for ISIS
301012 in Familial Hypercholesterolemia Patients
...en granted orphan drug status for the
treatment of homozygous
FH, one of the most severe forms of
for FH in 2007.
ISIS 301012 in homozygous
The data presented...n of ISIS 301012 in the extreme
disease setting of homozygous
FH and in combination with the high
doses of other...
Homozygous in Medical Products
Coatest APC Resistance V Kit
Description:...by prediluting the sample plasma with an excess of V-DEF Plasma bioreagent. The test design makes it possible to discriminate between heterozygous and homozygous
factor V genotypes. It also allows for analysis of plasma from patients on heparin or oral anticoagulant therapy. High discrimination between genotype...
Company:DiaPharma Group, Inc.
Homozygous in Medical Dictionary
Congenital protein C
...deficiency is a condition that runs in families (inherited), which is ... Other congenital thrombophilias include Protein C Deficiency, ... homozygous
Protein C deficiency. ... after birth and require Protein C concentrates or other ... Congenital protein C or S deficiency is a ...
Homozygous in Biological News
February 2009 highlights from Biology of Reproduction
...Now, in a paper on p. 235 of this issue, Sun et al. characterize the phenotype of mice genetically lacking FAAH, fatty acid amide hydrolase. Male mice homozygous
for the Faah knockout have elevated levels of anandamide, an endocannabinoid, in the reproductive system, and their sperm have decreased ability to ...
DNA repair patterns may predict risk of pancreatic cancer
...s or endogenous agents such as reactive oxygen species, there is an increased chance of getting cancer.
Researchers found that the presence of a homozygous
mutant genotype of LIG3 G-39A was associated with a 77 percent reduction in the risk of pancreatic cancer. By contrast, the presence of the gene ATM D...
Fitness in a changing world
... at least one copy of the Eda complete version of the gene (heterozygous or homozygous
for the Eda complete allele). The fish lack the full complement of plates if they are homozygous
for the recessive gene--Eda low. From the laboratory mapping results, and t...
Should embryos with a hereditary disorder be transferred if no unaffected embryos are available?
...y a single gene mutation for which there are no, or limited, treatments, and, in most cases, presenting early in life. An example is an embryo that is homozygous
for cystic fibrosis, where the child will definitely have the disease. In such cases it is inconceivable that doctors would agree to transfer these em...
July 2008 highlights
primarily in testis, but its functional significance had been
only speculative. In an article on p. 26 Odet et al. report that
male mice homozygous
for a targeted disruption of Ldhc
are severely impaired in fertility, whereas females are fertile.
The fertility defects include impaired sperm mot...
New method developed to identify genetic determinants of Alzheimer's disease
...matography (DHPLC) analysis, which was performed under partially denaturing conditions as determined by profiling the mixture of a tested sample and a homozygous
standard control amplicon at the given ratio. In almost 300 samples detected, the accuracy of the assay reached 100%.
Dr. Tian-Ming Gao, Head of t...
JCI table of contents: Aug. 16, 2007
... tumoral calcinosis and gives clinicians a new candidate gene to consider when attempting to determine the etiology of tumoral calcinosis.
TITLE: A homozygous
missense mutation in human KLOTHO causes severe tumoral calcinosis
Michael J. Econs
Indiana University School of Medicine, Indianap...
Statin treatment improves spatial memory in mouse models of Alzheimer's
...brain nNos levels may play an important role in statin-induced improvement of spatial reference memory.
The transgenic mice used in the study are homozygous
for the gene for beta amyloid protein, making it inevitable that they develop an Alzheimer’s like disease as they age. In fact, they lose their memory...
Novel technology detects human DNA mutations
...s is mutated (i.e., has SNPs). Nanosphere's technology can rapidly, easily, and accurately interrogate both bases in the pair to determine if they are homozygous
(i.e., both are mutant or normal) or heterozygous (i.e., one is mutant, one is normal) ?the most critical step in correlating the SNP with a disease o...
Homozygous in Biological Technology
Polycystic Kidney Disease Assay at Cornell University Uses Transgenomic's Surveyor Nuclease & WAVE Technology
...g it to detect heterozygous changes not readily detected by sequencing. Indeed we were even able to establish that some samples incorrectly scored as homozygous
mutations by DNA sequencing were shown by Surveyor Nuclease to be heterozygous."
ADPKD occurs at a rate of 1/1000 in the US population, affecting...
Discovery of a new retinal gene involved in childhood blindness
...tify significant stretches of homozygosity in SNP markers. SNPs are single nucleotide repeats, which are natural variations in the human genome. These homozygous
regions may contain new genes and are carefully probed based on functional information and then subjected to sequencing. "This method is indeed both v...
Isis Reports Financial Results and Highlights for Third Quarter of 2008
... mipomersen study in heterozygous FH subjects with coronary artery disease -- Completed enrollment of the pivotal Phase 3 mipomersen study in homozygous
FH subjects -- Granted broad patent coverage for the therapeutic use of antisense compounds targeting apolipoprotein B, U.S. Patent No. 7,407,943...
BioTime, Inc. and Embryome Sciences, Inc. Sign Agreement With International Stem Cell Corporation to Provide Unique Human Stem Cell Lines for Research Use
...results in the creation of pluripotent human stem cell lines from unfertilized human eggs. ISCO scientists also have created the first Parthenogenetic homozygous
stem cell line (phSC-Hhom-4) that can be a source of therapeutic cells that will not be immune rejected after transplantation into millions of individ...
Genzyme Reports Strong First-Quarter Growth
...s a well-defined and severely ill patient population. Mipomersen is currently being studied in a Phase 3 clinical trial involving patients with homozygous
familial hypercholesterolemia. This press release contains forward-looking statements regarding
Genzyme's financial outlook and business plans and...
Genzyme and Isis Announce Strategic Alliance Including Exclusive Worldwide License of Mipomersen
...D-related death. Familial hypercholesterolemia can be
present in two forms: homozygous
(hoFH), where the same defective gene is
inherited from both parents, or he...e is inherited from only one parent so that some function is preserved.
form is a very rare condition estimated to affect
approximately one in a mi...
Denaturing HPLC (DHPLC)
...rformed by trial or error. Here injections of the homozygous
sample at temperatures from 52 to 67 °C are m...k for successful PCR amplification by running the homozygous
sample under non denaturing conditions , ie less ...tly different peak pattern than that seen for the homozygous
sample, increase or decrease the column temperatu...
SNPs Powerful Tools for Association Studies
...SNP analysis will result in one of the possible diplotypes. (Figure 2.)
At this SNP locus there are two alleles: T or C. Persons A and C are homozygous
for T and C alleles, respectively; and person B is heterozygous, carrying both the T and C alleles.
1.2. Different kinds of SNPs As previo...
Protein Truncation Tests Using the DCode System
... that no normal product is observed in this lane usually indicates a homozygous
mutation. Sequencing of cDNA indicated a deletion of 174 bp, cor...lack only 58 amino acids. Genomic
sequencing analysis revealed a homozygous
G to A substitution at the last
nucleotide of exon 26 (nt 3576)....
Heteroduplex Analysis Using the DCode System
...erozygous compound sample Q493 (C to T) and ΔF508
(-CTT), a homozygous
ΔF508 (-CTT) and a heterozygous ΔI507, three base
dele..., 3 and 5 are resolved from
the homoduplex bands. The ΔF508 homozygous
mutant in lane 4 has no heteroduplex
bands, and the homoduplex b...
Homozygous in Biological Definition
... and thus contain two copies of each gene. An organism in which both copies of the gene are identical - that is, have the same allele - is said to be homozygous
for that gene. An organism which has two different alleles of the gene is said to be heterozygous . Often one allele is "dominant" and the other is ...
...the population will be heterozygous for the allele (i.e. carry one copy of that allele and one copy of another in each somatic cell) and 4% will be homozygous
(carrying two copies of the allele). So all together 36% of diploid individuals would be expected to carry an allele that has a frequency of 20%. Ho...
...ion through a number of mechanisms, including:
Overdominance or heterozygote advantage , where the heterozygote is more fit than either of the homozygous
forms (famously exemplified by human sickle cell anemia conferring resistance to malaria )
Frequency-dependent selection , where the rare varia...
When an organism is referred to as being homozygous
for a specific gene, it means that it carries two...somes (e.g. the genotype is AA or aa ).
dominant genotype occurs when a particular locus ...o alleles for the dominant trait (e.g. AA ).
recessive genotype occurs when a particular locus...
...significant sequence) on a chromosome . A locus can be occupied by any of the alleles of the gene. Diploid or polyploid cells are either homozygous
(have the same allele at a locus) or heterozygous (have different alleles at a locus).
In mathematics , a locus is the set of points sati...
...empt to determine for a finite population what proportion of loci would be homozygous
. This was, in part, motivated by assertions by other geneticists that mor...zygous genotypes would be cancelled out by continual generation of less fit homozygous
These results became important in the formation of the neutral...
Polymerase chain reaction
... on an agarose gel, and the band pattern will tell you if the individual is homozygous
C, or heterzygous T/C. This methodology has several applications, such as ...
Homozygous in Biological Dictionary
Zygosity refers to the similarity of genes for a trait in an organism. If both genes are the same, the organism is homozygous
for the trait. If both genes are different, the organism is heterozygous for that trait. If one gene is missing, it is hemizygous, and if both... An explanation...
...e traits. In a true breeding strain crosses of two individuals from the same strain (or of ... Calling them true - breeding bays or even homozygous
blacks can be confusing ... " True Breeding Bays" aka Non-Chestnut Carriers. Linamix, Wekiva Springs ... ... also result in true - breeding s...
... cells from a ... Find products and compare prices at TheFind.com. Shop online for thousands of great items like the Tissue Culture Dishes. In homozygous
sterile plants, pollen mother cells abort prior to completing meiosis (Figs. ... cells varied significantly between fertile and sterile pla...
... have two copies of each gene in their genome, one inherited from each... recessive gene n. A gene that is phenotypically expressed in the homozygous
state but has its expression masked in the presence of a dominant Open source encyclopedia supplement on Recessive gene ... two alleles at...
... ... was examined in two APRT pseudorevertant cell lines, their two APRT homozygous
... growth medium of the pseudorevertant lines induced adenine salvage to ... The SUX1 pseudorevertant strain was found to carry a single ...
...monohybrid or other sort of genetic cross . ... Monohybrid crosses . 1. In dogs, wire hair (S) is dominant to smooth (s). In a cross of a homozygous
wire-haired dog with a smooth-haired dog, what will ... Turn speakers on ... Monohybrid . Drag genes from the left side of the table into ... ...
...posite kind for mating to occur ... Like normal h90 strains, mat2-102 can mate with strains of either mating type . ... This strain will be homozygous
for the mating type and thus unable to sporulate. ... Heterologous expression of mating - type genes in filamentous fungi. ... Mating t...
...h from Academic Journals, Newspapers, and magazines at HighBeam.com. Free Trial, Credit Card Required. Incomplete Dominance : • Blending of the homozygous
phenotypes. ... Incomplete Dominance . • The alleles for curly hair and straight ... incomplete dominance A type of inheritance in whic...
... gene. ... Homozygote cells are diploid or polyploid and have the same alleles at a locus ... When an organism is referred to as being homozygous
for a specific gene, it ... ... alleles at a genetic locus; a homozygote is an individual having two copies of ... The term homozygote is al...
... for a trait in an organism. If both genes are the same, the organism is homozygous
for the trait. If both genes are different, the organism is heterozygous ...ygous from Biology-Online.org dictionary. ... is it the heterozygous or homozygous
that protects , many ... The other parents and their unaffected son wer...