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Homology in Medical News

Apes Love a Good Laugh, Too

... critics have argued that such terminology is anthropomorphic or that human laughing is a unique display in the animal world. But, in fact, there is a homology not just based on the facial expression, which we have suspected since Darwin, but also in the details of the breathing patterns and sounds of the dis...

American Chemical Society's weekly PressPac -- Jan. 23, 2008

...rgey Leikin, John M. Seddon, and Alexei A. Kornyshev and colleagues say the homology recognition between sequences of several hundred nucleotides occurs without...TICLE #1 FOR IMMEDIATE RELEASE DNA Double Helices Recognize Mutual Sequence homology in a Protein Free Environment DOWNLOAD ARTICLE http://dx.doi.org/10.102...

VioQuest to Present Data on Oncology Compounds VQD-002 and Lenocta(TM) at AACR-NCI-EORTC International Meeting

...rved in their RECIST scores. About Lenocta(TM) Lenocta(TM) is an inhibitor of multiple protein tyrosine phosphatases (PTPases), specifically the SRC homology PTPase (SHP-1 & SHP-2) and PTB-1B, based on data from several preclinical studies conducted at the Cleveland Clinic. These intracellular enzymes are i...

Genetic Mutation That Makes Common Cancers Resistant to Drugs Identified

...that confirms AKT1 as an oncogene in breast, colorectal and ovarian cancer. The mutation alters the electrostatics of binding pocket in the pleckstrin homology domain, the portion of the enzyme that docks with phospholipids on the cell membrane," said Dr. Kerry L. Blanchard, Executive Director, Discovery Biol...

'Origin Of Sex' Can Be Revealed By Sperm Proteome

...lutionary underpinnings of sperm characteristics, and may have application to mammalian sperm function. The Drosophila sperm proteins show substantial homology with the axoneme accessory structure of mouse sperm.' Professor Manyuan Long, Professor of Genetics & Evolution at the University of Chicago, said...

Evoprinter, a multigenomic comparative tool for rapid identification of functionally important DNA

...ments are accomplished either by simultaneous or sequential pair wise alignments of input DNAs, with alignment gaps introduced to optimize the overall homology comparisons. Researchers, writing in the October issue of the Proceedings of the National Academy of Sciences have developed a simple, yet effectiv...
Homology in Medical Technology

VioQuest Pharmaceuticals Announces Dosing of First Patient in Phase IIa Solid Tumor Study for Lenocta(TM), a Novel Protein Tyrosine Phosphatase Inhibitor

...ed for the treatment of the parasitic disease leishmaniasis, is an inhibitor of multiple protein tyrosine phosphatases (PTPases), specifically the src homology PTPase (SHP-1 & SHP-2) and PTP1B. Lenocta has also been demonstrated to augment cytokine signaling and responses in hemopoietic cell lines, which can ...

VioQuest Pharmaceuticals Completes Enrollment of Phase I Trial of Lenocta(TM)

...w ready to enroll patients." About Lenocta(TM) Lenocta(TM) is an inhibitor of multiple protein tyrosine phosphatases (PTPases), specifically the SRC homology PTPase (SHP-1 & SHP-2) and PTB-1B, based on data from several preclinical studies conducted at the Cleveland Clinic. These intracellular enzymes are i...

Testing for Human Papillomavirus

...Contributing Editor Human papillomaviruses (HPVs) are small, closed circle, double-stranded DNA viruses, which are classified by nucleic acid sequence homology rather than serologic reactivity. Genital HPVs are the most prevalent sexually transmitted pathogens. Of the approximately 50 anogenital HPVs, there...
Homology in Medical Products

Erythropoietin RIA Test

Description:...culating form of EPO has an estimated molecular mass of ~30.5 kDa. Although EPO itself appears to have a unique structure, the EPO receptor bears some homology to several other growth factor receptors, including those for interleukins 2 and 6, prolactin and growth hormone, suggesting possible functional simil...
Company:Diagnostic Systems Laboratories, Inc.

IGF-1 EIA Endocrine Function 026-AC-27F1 Insulin Growth Factor

Description:...7650 daltons), and is one of a number of related insulin-like growth factors present in the circulation. The molecule shows approximately 50% sequence homology with proinsulin and has a number of biological activities similar to insulin. The peptide is growth hormone (GH) dependent to a high degree, but there...
Company:ALPCO Diagnostics
Homology in Biological News

Protein that promotes cancer cell growth identified

...a cancer cell line that is deficient in Caspase-8 and that EGF signaling can be restored by reconstituting the cells with wildtype Caspase-8. Sequence homology studies helped to identify a RXDLL motif in the protein, a sequence that has been shown in other proteins to function in cell signaling. The researche...

HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection

...d by the administration of the active ingredient of this oil, thymoquinone. Furthermore, it was envisioned that since thymoquinone shares a structural homology with ubiquinone (mitochondrial component) it is likely that it may act as a mitochondrial antioxidant. Indeed pretreatment of pancreatic beta-cells wi...

Biophysical Society announces 2008 International Travel Awards

...ucture of the Unliganded gp120 Based on Structural homology and Molecular Dynamics Symulations. Ariel ...al Model of Epithelial Sodium Channel Based on the homology with Acid-Sensing Ion Channel. Alexandra I. ...ian Council of Medical Research, New Delhi, India, homology Modeling of Signalling Glycoprotein from Camel (SP...

What recognizes what in plant disease resistance?

...gh their leucine-rich repeat domain, the authors show that association is mediated by a completely different region on N's Toll-interleukin-1 receptor homology domain, which is structurally similar to animal innate immunity molecules. These findings provide novel insights into how R proteins recognize pathoge...

Pacific Rim researchers to collaborate on distributed bioinformatics analysis of avian flu

...nalysis Pipeline (iGAP), to analyze avian flu genomes. (The iGAP suite of bioinformatics applications are designed specifically for protein structural homology recognition and functional annotation.) The San Diego-based researchers will also develop a robust production environment for routine computational an...

Common mechanisms for viral DNA replication

...igin of replication. The structure shows that although T-ag and its functionally analogous protein, papilloma virus E1, share no detectable sequence homology in this region, the two domains bind the DNA in similar ways. In both cases, DNA binding is thought to initiate assembly of a complex of the full-leng...

A valuable fly for research into disease

...nto the fundamental principles of biology and genetics. Only in recent years, however, and thanks in large part to the discovery of the high degree of homology between the genetic make-up of flies and vertebrates, has Drosophila emerged as one of the most effective model systems to analyze the function of gen...

Genes involved in biofilms

...uch as: Esp de Enterococcus faecalis , mus20 of Pseudomonas putida , and sty2875 of Salmonella typhi . Thus, taking into account the structural homology between Bap and Esp, it was decided to analyse for a possiblerelationship between the presence of the esp gene and the ability to produce biofilm by E...

Molecular fossils uncover link between viruses and the immune system

... which have permitted detailed comparison of viral structures in atomic detail. Such comparison led to the discovery that viruses without any sequence homology may be related. Earlier approaches to delineate evolutionary history of viruses have failed. Since Charles Darwin evolutionary history of multicell...

Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

...n genome should find those matching sequences. But this didn't work. The homology searches yielded far fewer targets than expected and could not account for ...t scientists were trying to predict the microRNA targets using the sequence homology of the full-length microRNAs. In their Cell article, Han and his colleag...
Homology in Biological Technology

ChemAxon Launches Marvin and JChem Version 5.2; Web Services, native .NET API, Homology Groups, 3D Alignment and Structural Frameworks

BUDAPEST, Hungary, April 15 /PRNewswire/ -- ChemAxon, a software solutions provider for cheminformatics today announced the launch of version 5.2 of their cheminformatics toolkits, Marvin & JChem. The release sees many new functionalities added, new integration options and improvements in ...

Ascenta Therapeutics Announces Results of Preclinical Evaluation of AT-406 in Multiple Cancer Models

...nced that researchers from the University of Pennsylvania presented results at AACR from an independent laboratory study examining the role of Bcl-2 homology (BH) family proteins in the development of chemotherapy resistance in neuroblastoma (Abstract # 3269). Using human-derived neuroblastoma cell lines, ...

FlexiPlate siRNA

...data from RNAi experiments (1). siRNA design is then checked for homology to all other sequences of the genome using an up-to-date, nonredundant sequence database and a proprietary homology analysis tool which incorporates exciting new features (Figure 2...

SNPs Powerful Tools for Association Studies

...dividual at a particular genetic locus Homologous genes or regions Genes or regions found in different species that are very similar. The homology indicates that these genes or regions are evolutionarily conserved, and implicates their functional importance. Intronic SNPs Single nuc...

Cytosolic expression of Green Fluorescent Protein (GFP) and its derivatives in the yeast Saccharomyces cerevisiae: Detection in vivo using the Varian Cary Eclipse

...ly extended by Matz and co-workers 4 , who isolated a red fluorescent protein from the Discosoma coral (DsRed) with 30% sequence homology to Aequoria GFP. This wide variety of spectrally distinct fluorescent proteins provides distinguishable markers for the simultan...

Use of the DCode System to Detect the Food-Borne Bacterial Pathogen Listeria monocytogenes

...togenes has 99.2 % and 98.5% nucleotide homology with the corresponding molecule of the ... fragments from these two species reveals sequence homology where base assignments have been made (...co-migrating fragments possess sequence homology or the same G+C content remains to be d...

Quantitation of DNA for Automated Sequencing Using the VersaFluor Fluorometer

...ne for xHif (Xenopus hypoxia inducible factor) was isolated by a homology screen of a Xenopus muscle genomic library using a 32 P-dCTP la...tratagene) cDNA clone for Xenopus xHif was also isolated using a homology screen of a tadpole library. Rescued plasmid DNA was obtained us...

A Multiple Mutation Model System as a Test Development and Training Tool for Denaturing Gradient Gel Electrophoresis

... The design of DGGE primers follows the general principles of PCR primer design with respect to sequence specificity, lack of internal homology and minimal primer dimer formation. In addition, a GC-rich sequence or clamp is often appended to one of the primers. Such a cla...

RNA Interference and Gene Silencing: History and Overview

...ism related to RNAi and PTGS. Although the rde-2 gene product has not yet been identified, the mut-7 gene encodes a protein with homology to the nuclease domains of RNase D and a protein implicated in Werner syndrome (a rapid aging disease) in humans (1 , ...

Northern Analysis: The Basics

... RNA and oligonucleotides can all be used as hybridization probes. Additionally, sequences with only partial homology (e.g., cDNA from a different species or genomic DNA fragments that might contain an intron) may be used as p...
Homology in Biological Products

Anti-Taste Receptor 2 (TR2) Polyclonal Antibody, Unconjugated from CHEMICON

Description:... Recognizes rat Taste Receptor 2 (TR2). The immunogen shows no significant sequence homology with TR1, gustducin or other pheromone receptors....
Company:CHEMICON

PatternHunter - academic version from Bioinformatics Solutions Inc.

Description:... Superior homology search software - in all the flavours of blast, with increased sensitivity and speed. Free windows version for academic use....
Company:Bioinformatics Solutions Inc.

PatternHunter from Bioinformatics Solutions Inc.

Description:... Superior homology search software - in all the flavours of blast, with increased sensitivity and speed...
Company:Bioinformatics Solutions Inc.

Anti-Potassium Channel, Inward Rectifier Kir4.1 Polyclonal Antibody, Unconjugated from CHEMICON

Description:... Recognizes Kir4.1. The epitope does not share homology with any other known proteins. SPECIES REACTIVITIES: The antibody is also expected to work with mouse and human due to sequence homology. Other spe...
Company:CHEMICON

Anti-K+-Cl- Cotransporter 1 (KCC1) Polyclonal Antibody, Unconjugated from CHEMICON

Description:... Recognizes K+ Cl- Cotransporter-1 (KCC1). The immunogen shows no significant sequence homology with other KCCs or CCC. SPECIES REACTIVITIES: The immunogen sequence is 100% conserved in human, mouse, porcine and rabbit. Reactivity with other sp...
Company:CHEMICON

Rabbit Anti-mTOR Monoclonal Antibody,, Clone ZMD.414 from Invitrogen

Description:...OR protein. On Western blots it identifies the target band at ~235 kDa. Reactivity: Human (positive control: HEK293 cell lysates). Based on sequence homology reactivity with mouse and rat is expected. Applications: Immunoprecipitation Western blotting...
Company:Invitrogen

Rabbit Anti-PKCZeta (C-term) Monoclonal Antibody,, Clone ZMD.330 from Invitrogen

Description:...nd does not cross-react with PKCiota/lambda. Reactivity: Mouse Rat (positive controls: mouse and rat kidney and brain homogenates). Based on sequence homology reactivity with Human and rabbit is expected. Applications: Western blotting Immunofluorescence Immunohistochemistry...
Company:Invitrogen

Rabbit Anti-Human Connexin 36 Monoclonal Antibody,, Clone ZMD.257 from Invitrogen

Description:... Reactivity: Mouse (positive control: mouse Connexin 36-transfected HeLa cell lysates mouse brain retina and pancreas homogenates). Based on sequence homology reactivity with Human rat and zebrafish. Applications: Western blotting ELISA Immunohistochemistry (froz)...
Company:Invitrogen

Anti-PEBP Polyclonal Antibody, unconjugated, Clone ZLK.17 from Invitrogen

Description:... The PhosphatidylEthanolamine-Binding Protein (PEBP) does not share significant homology with other serine protease inhibitors. PEBP is expressed in the central nervous system, spleen, testis, ovary, muscle, and stomach. One important ro...
Company:Invitrogen

Sheep Anti-Human IDO Monoclonal Antibody,, Clone ZMD.420 from Invitrogen

Description:... for the ~44 kDa human IDO protein. Reactivity: Human (positive control: IFN-Gamma-stimmulated Human peripheral blood lymphocytes). Based on sequence homology reactivity with mouse and rat IDO may be observed. Applications: Western blotting ELISA...
Company:Invitrogen
Homology in Biological Definition

Bioinformatics

...ideas in bioinformatics research is the notion of homology . In the genomic branch of bioinformatics, homology is used to predict the function of a gene: if the ...nction. In the structural branch of bioinformatics homology is used to determine which parts of the protein ar...

Charles Darwin

...He joined Grant in pioneering investigations of the life cycle of marine animals on the shores of the Firth of Forth where Grant found evidence for homology , the radical theory that all animals had similar organs differing only in complexity. In March 1827 Darwin made a presentation to the Plinian socie...

Cladistics

...nomists consider polyphyletic groups to be errors in classification, often occurring because convergence or other homoplasy was misinterpreted as homology . Following Hennig, cladists argue that paraphyly are as harmful as polyphyly. The idea is that monophyletic groups can be defined objectively, in ...

Bioinformatics

...ideas in bioinformatics research is the notion of homology . In the genomic branch of bioinformatics, homology is used to predict the function of a gene: if the ...nction. In the structural branch of bioinformatics homology is used to determine which parts of the protein ar...

Flagellum

... These differences mean that the bacterial and archaeal flagella are a classic case of biological analogy , or convergent evolution, rather than homology . However, in comparison to the decades of well-publicized study of bacterial flagella (e.g. by Berg), archaeal flagella have only recently begun to g...

Gene duplication

...logous genes that code for proteins with similar function but that exists in different species. Orthologs are created from a speciation event. (See homology of sequences in genetics ) It is important (but often hard) to differentiate between paralogs and orthologs in biological research. Experiments on h...
Homology in Biological Dictionary

Homology

In evolutionary biology, homology refers to any similarity between characteristics that is due to their shared ancestry. The word homologous derives from the ancient Greek ομολογειν, 'to agree'. There are examples in... In mathematics, homology is a certain general procedure to ass...

Sequence homology

In evolutionary biology, homology refers to any similarity between characteristics that is due to their shared ancestry. The word homologous derives from the ancient Greek ομολογειν, 'to agree'. There are examples in... In mathematics, particularly algebraic topology and homology t...

UvrA

...they both have ATPase/GTPase activity. The UvrA dimer binds with UvrB and forms a trimer which is able to detect DNA ... ... acid sequence homology with the E. coli UvrA protein comprising 940 residues. ... defined by the mutation in DB7 represents a homolog of the E. coli uvrA gene. ... ...

Synapomorphy

...velopmental approaches attempt to construe ... and phylogeny, which define homology as synapomorphy (Cracraft ... ... event, recognized by possessing the...in the Elongation Factor 1α gene in lineages ... The establishment of homology qua synapomorphy ... qua synapomorphy , i.e. as similarity due to com...

Sequence similarity

... In evolutionary biology, homology refers to any similarity between characteristics that is due to their sh...anPS (EBI) ... ... one example of homology. In evolutionary biology , homology refers to any similarity between ... Sex chromosomes have a shorter re...

Sense strand

... modification of any of the purine ... molecule of claim 1, wherein the sense strand includes a terminal cap moiety at ... ( A) Base pair homology comparison of 736 siRNA sense strand with TNFR1 mRNA. ... 736 SENSE STRAND ACTIVITY IS INHIBITED BY CHEMICAL AND SEQUENCE MODIFICATION ... ...

RecA protein

... long been studied (Ogawa et al. ... When ATP is bound to recA , the protein adopts an active conformation and has a ... The search for DNA homology does not limit stable homologous pairing promoted by RecA protein ... E. coli RecA protein promotes homologous pairing in two ... In vitro...

Molecular evolution

...lecular studies that advance the understanding of phylogeny and evolution . Provides information on the journal and subscriptions. Molecular homology has been acclaimed as the field of study that saved the house of evolution from collapsing by serving as an independent check that confirms ... ...

Leucine zipper

...oth fusion proteins retain the leucine zipper domain of AF10 but not its PHD domain. ... Rather, the leucine zipper is the only region of homology between ... proteins, where the process is referred to as leucine zipper formation. ... induce high-order aggregation of leucine zipper -fl...

Homologous chromosomes

... possibly each have different alleles at those genes. For example, the two chromosomes may have genes encoding eye... In evolutionary biology, homology refers to any similarity between characteristics that is due to their shared ancestry. The word homologous derives from the ancient Greek ομολογε...
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