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Homologous in Medical News

BRIT1 allows DNA repair teams access to damaged sites

... factor at the damage site. The team showed that normal BRIT1 aids repair of double-stranded DNA breaks by allowing access to two repair pathways: homologous recombination (HR) and non-homologous end-joining (NHEC). DNA repair efficiency dropped by between 40 and 60 percent in cells with BRIT1 knocked do...

NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development

... ahead of the June 2009 print issue has found that homologous immunoglobulin (lg) alleles pair up in the nucleus...reak on one lg allele induces repositioning of its homologous partner to pericentromeric heterochromatin (a repr...air machineries. Skok and researchers propose that homologous pairing of alleles undergoing recombination has a ...

Scripps research scientists model 3D structures of proteins that control human clock

...olet light. Photolyases have also been found in bacteria and in some animals, but not in human cells. Humans and mammals, on the other hand, possess a homologous protein known as cryptochrome that modulates the circadian clock. "This is an amazing, and very puzzling, family of proteins, because they do one t...

First Treatment for Muscular Dystrophy in Sight: Scientists Harness Exon-Skipping in Large Animal to Successfully Treat Duchenne Muscular Dystrophy

...logical Association, the Annals of Neurology, treated dogs with naturally occurring canine X-linked muscular dystrophy, a disease which is genetically homologous to the Duchenne muscular dystrophy that strikes 1 of every 3,500 boys born in the United States and worldwide each year. Duchenne muscular dystro...

First treatment for muscular dystrophy in sight: Scientists successfully harness exon-skipping

...gical Association, the Annals of Neurology , treated dogs with naturally occurring canine X-linked muscular dystrophy, a disease which is genetically homologous to the Duchenne muscular dystrophy that strikes 1 of every 3,500 boys born in the United States and worldwide each year. Duchenne muscular dystrop...

Scientists May Isolate Stem Cells From Rats, Other Mammals

... the past two decades, embryonic stem cells have been routinely used to create loss of function (knockout) or gene replacement (knock-in) mutations by homologous recombination in the mouse, providing an invaluable tool for the functional characterization of genes," Ying's group wrote. "Now, the availability of ...
Homologous in Medical Technology

Sunesis Pharmaceuticals to Present Non-Clinical Data at the Annual Meeting of the American Association for Cancer Research

...bit Hall B-F, San Diego Convention Center -- Sensitivity to SNS-595 is related to activation of double strand DNA break repair pathways including homologous recombination Session: Stress Responses Abstract #1859 8:00 a.m. - 12:00 p.m. Exhibit Hall B-F, San Diego Convention Center -- Ex vivo ac...

Pharmacyclics Announces Presentations on Its Novel and Selective HDAC and Bruton's Tyrosine Kinase Inhibitor Compounds

...Chemotherapeutic Agent Resistance Poster Presentation: Novel histone deacetylase (HDAC) inhibitor PCI-24781 disrupts RAD51 foci and inhibits homologous recombination Abstract #1966: 8:00 a.m. -12:00 p.m. Presenter: Shanthi Adimoolam, Ph.D., Pharmacyclics, Inc. Wednesday, April 18, 20...
Homologous in Medical Products

Vysis UroVysion Bladder Cancer Kit

Description:...recurrence in patients previously diagnosed with bladder cancer. The UroVysion Kit consists of a four-color, four-probe mixture of DNA probe sequences homologous to specific regions on chromosomes 3, 7, 9, and 17. The UroVysion probe mixture consists of Chromosome Enumeration Probe (CEP) CEP 3 SpectrumRed, CEP ...
Company:Abbott Diagnostics

LH ELISA Test

Description:...d. Like the FSH, hCG and TSH, the intact LH molecule is a noncovalently-linked dimer containing alpha- and beta-subunits. These glycoproteins all have homologous alpha-subunits, however each hormone has a unique beta-subunit. Both LH and FSH production and secretion are stimulated by gonadotropin-releasing horm...
Company:Diagnostic Systems Laboratories, Inc.

LH IRMA Test

Description:...d. Like the FSH, hCG and TSH, the intact LH molecule is a noncovalently-linked dimer containing alpha- and beta-subunits. These glycoproteins all have homologous alpha-subunits, however each hormone has a unique beta-subunit. Both LH and FSH production and secretion are stimulated by gonadotropin-releasing horm...
Company:Diagnostic Systems Laboratories, Inc.

Solcosept Microfilter Blood Transfusion Sets

Description:...l way to add the safety of microfiltration for a variety of transfusion needs. Whether for intraoperative or postoperative applications, autologous or homologous transfusions, the Solcosept microfilter provides both convenience and versatility in the removal of microaggregates from blood. The two-stage, 40...
Company:Davol, Inc.

Corlok

Description:... Dovetail geometry permitting a precise interlocking fit with adjacent vertebrae. Corlok Allografts are processed from donor vertebral bodies creating homologous spinal allograft implants. Specially designed instruments facilitate the insertion of the Corlok allograft....
Company:Alphatec Spine, Inc.

Corlok Lumbar Allograft System

Description:... Dovetail geometry permitting a precise interlocking fit with adjacent vertebrae. Corlok Allografts are processed from donor vertebral bodies creating homologous spinal allograft implants. Specially designed instruments facilitate the insertion of the Corlok Allograft....
Company:Alphatec Spine, Inc.
Homologous in Medical Definition

Artificial induction of immunity

...erred have a lifespan of only about 3-6 months. Every placental mammal (including humans) has experienced temporarily-induced immunity by transfer of homologous antibodies from its mother across the placenta , giving it passive immunity to whatever its mother was immune to. This allows some protection for th...
Homologous in Medical Dictionary

Clitoris

...ulva, and vagina. Also has information about female orgasms. clitoris n. A small elongated erectile organ at the anterior part of the vulva, homologous with the penis ... The clitoris is a tiny organ which even the woman ... Category: Clitoris . From Wikimedia Commons, the free media ... Pag...

Chromosomes

... homologous Chromosomes . M-Phase In Detail. Mitosis In Plant Cells. Embryonic Stem Ce...ls, chromosomes 21 and 18 did not have any foci (i.e., were ... In males, homologous chromosomes segregate by an unusual process involving ... Polyploidy:...
Homologous in Biological News

Human RecQ helicases, homologous recombination and genomic instability

Two independent papers in the December 1st issue of G&D detail how human RecQ helicases regulate homologous recombination and protect genome stability. The human RecQ family of helicases consists of 5 members: WRN, BLM, RECQL4, RECQL1 and RECQL5. These enzymes help to unwind DNA so to facilita...

Iowa State University researchers develop process for 'surgical' genetic changes

...e new technique harnesses a natural process called homologous recombination to precisely introduce DNA at a pred...y get the research to the point where you can have homologous recombination. Now, we've done it." Using this p...and allows scientists to take greater advantage of homologous recombination, according to Wright and Townsend. ...

The SIB recognizes the next generation of bioinformaticians

...As the number of sequenced genomes has grown exponentially over the last years, multiple alignments of many protein families now contain more than 100 homologous sequences(and some even several thousand), which makes it possible to investigate the evolutionary constraints that act on particular residues in much...

Stress puts double whammy on reproductive system, fertility

...ablish the critical role played by GnIH in birds, teamed up with Kaufer and Kirby to explore whether stress might affect GnIH levels in the brain. The homologous hormones in mammals have been dubbed RFamide-related peptides, or RFRPs. Kirby showed that acutely stressed rats showed increased RFRP levels for s...

Is this the beginning of the end of plant breeding?

... up and dividing phases. The first lining up is of homologous chromosomesall chromosomes in an adult cell have a...ng from the mother and father of the celland these homologous chromosomes are each made up of two chromatids. The first division divides homologous pairs of chromosomes while the second meiotic divi...

Stowers researchers develop whole genome sequencing approach for mutation discovery

...hanism of EMS mutageneseis and into gene conversion events involving balancer chromosomes genetic tools used to prevent genetic recombination between homologous chromosomes during meiosis. Model organisms like fruit flies are used in research for studying both normal biological processes and human disease...
Homologous in Biological Technology

Cellectis and Regeneron Sign an Agreement Over the use of Homologous Recombination Technology

BIOCITECH, France, July 3 /PRNewswire-FirstCall/ -- Cellectis SA today announced the signature of an agreement with Regeneron Pharmaceuticals, Inc. over the use of Cellectis' patents covering certain uses of homologous recombination for the generation of innovative human therapies, including t...

Generate Adenovirus Vectors in E. coli by Homologous Recombination with the AdEasy Adenoviral Vector System

Efficient gene transfer and high-level protein expression within a variety of cells Tanya Hosfield Lisa Eldridge Stratagene Recombinant adenoviruses provide a versatile means of gene delivery and expression. We describe the AdEasy adenoviral vector system, ###,W ...

J. Craig Venter Institute Researchers Publish Significant Advance in Genome Assembly Technology

...ble to finish creating the synthetic bacterial genome using a method called homologous recombination (a process that cells naturally use to repair chromosome dama...nts were inserted into yeast cells in one step and through the mechanism of homologous recombination were assembled into the synthetic M. genitalium genome. Sev...

Real-time observation of the DNA-repair mechanism

...functioning of the cell and lead to the creation of a cancerous cell. One major DNA-repair mechanism involved in repairing these breaks is known as homologous recombination. This mechanism has been observed for the first time by Delft University of Technology researchers in real time and at the level of a s...

Venter Institute Scientists Create First Synthetic Bacterial Genome

...l years of work perfecting chemical assembly, the team found they could use homologous recombination (a process that cells use to repair damage to their chromosom...lecules well, and that they were able to assemble the fragments together by homologous recombination. This process was used to assemble the last cassettes, from 1...

New force-fluorescence device measures motion previously undetectable

... other nucleic acid systems and their interaction with proteins and enzymes. The Holliday junction is a four-stranded DNA structure that forms during homologous recombination for example, when damaged DNA is repaired. The junction is named after geneticist Robin Holliday, who proposed the model of DNA-strand ...
Homologous in Biological Products

Sheep NP-SSA (Sheep Serum Albumin), Unconjugated from Biosearch Technologies

Description:... 4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to SSA (Sheep serum albumin) lysine through amide bonds. This product is homologous to NP-BSA....
Company:Biosearch Technologies

Sheep NP-SGG (Sheep Gamma Globulin), Unconjugated from Biosearch Technologies

Description:... 4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to SGG (Sheep gamma globulin) lysine through amide bonds. This product is homologous to NP-BSA....
Company:Biosearch Technologies

Anti-Potassium Channel, Inward Rectifier Kir2.1 Polyclonal Antibody, Unconjugated from CHEMICON

Description:...esent in any other known protein. SPECIES REACTIVITIES: The immunogen sequence is identical in rabbit, bovine, porcine and guinea pig. It is highly homologous in rat and mouse (17/19 residues) and chick (15/19 residues). Other species have not been tested....
Company:CHEMICON

BacMagic™ DNA Kit from Novagen

Description:...ding sequence in a compatible transfer plasmid, such as the pBAC™or pTriEx™ vectors, is cotransfected with BacMagic DNA into insect cells. homologous recombination within the cells restores the function of the virus ORF1629 while the target coding sequence replaces the BAC sequence. Only the recombi...
Company:Novagen

Anti-Cullin-3 (CUL-3) Ab-1 Polyclonal Antibody, Unconjugated from Lab Vision

Description:... CUL-3 is a member of the family of human cullin genes (CUL-1, -2, -3, -4a, -4b, and -5), homologous to the S. cerevisiae cdc53 gene. Cullin-3 is proposed to be a part of E3 protein-ubiqutinnn ligase. It forms a tight complex with cyclin E and targets...
Company:Lab Vision
Homologous in Biological Definition

Allele

... gene. One version might result in red petals, while another might result in white petals. Some organisms are diploid - that is, they have paired homologous chromosomes in their somatic cells , and thus contain two copies of each gene. An organism in which both copies of the gene are identical - that is,...

Apoptosis

...llas), which they called Apaf-1 (apoptotic protease activating factor). The team published their results in an article titled "Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3 [21] . Wang and his team identified and reconstituted the mitoc...

Bioinformatics

...unction of a gene: if the sequence of gene A , whose function is known, is homologous to the sequence of gene B, whose function is unknown, one could infer tha...ation is used to predict the structure of a protein once the structure of a homologous protein is known. This currently remains the only way to predict protein st...

Charles Darwin

...ew into an innovative study of how their beautiful flowers served to control insect pollination and ensure cross fertilisation. As with the barnacles, homologous parts served different functions in different species. Lying on his sickbed, his rooms became filled with experiments on climbing plants. He was visi...

Convergent evolution

...eres ). Structures that are the result of convergent evolution are called analogous structures or homoplasies ; they should be contrasted with homologous structures which have a common origin. Another example is the aerial rootlets found in English ivy ( Hedera helix ) and wintercreeper ( Euonymus...

Bioinformatics

...unction of a gene: if the sequence of gene A , whose function is known, is homologous to the sequence of gene B, whose function is unknown, one could infer tha...ation is used to predict the structure of a protein once the structure of a homologous protein is known. This currently remains the only way to predict protein st...
Homologous in Biological Dictionary

Zygotene

...ctionary with audio pronunciations, thesaurus, Word of the Day, and word games. zygotene ( ) n. The stage in prophase of meiosis during which homologous ... present in Zygotene meiosis I? ... Use of bouquet arrangement in zygotene stage? ... zygotene the second stage of the prophase of me...

Vestigial organ

... Vestigiality describes homologous characters of organisms which have seemingly lost all or most of their original function in a species through evolution. These may take various form...

T7 RNA Polymerase

...on. ... T7 RNA Polymerase is extremely sensitive to salt inhibition. ... Comparison of the T7 RNA polymerase structure with that of the homologous pol I ... The RNA polymerase (RNAP) from bacteriophage T7 has several advantages for use ... ... Structure of T7 RNA Polymerase . 3D S...

Synaptonemal complex

... The synaptonemal complex is a protein structure that forms between two homologous chromosomes during meiosis and that is thought to mediate chromosome ...x " in the Visual Thesaurus. Pronunciation Symbols ... The phenomenon of homologous pairing and crossing-over is being analyzed in ... Later, a synaptonemal ...

Synapsis

... Synapsis is the pairing of two homologous chromosomes that occurs during meiosis. It is a .... Synapsis takes place during prophase I. When homologous chromosomes synapse, they come closer together u...s n. , pl. -ses . The side-by-side association of homologous paternal and maternal chromosomes during the fir...

Site-specific recombination

... Recombination . Site - Specific Recombination . site - specific recombinases: enzymes that recognize. specific sequences and promote ... homologous and Site - Specific Recombination . 19.1 Introduction ... 19.17 Site - Specific Recombination Involves Breakage and Reunion ... ...
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