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Homing in Medical News

Protein level may serve as predictor of severe osteoarthritis

...usion of VCAM-1 levels in risk prediction models resulted in a more accurate classification of individuals. VCAM-1 promotes leukocyte adhesion and homing to sites of inflammation. In chondrocytes (cartilage cells), VCAM-1 expression is induced by inflammatory cytokines (proteins released by immune syste...

Purdue researchers create prostate cancer 'homing device' for drug delivery

... both papers, compared the targeting molecule to a homing device. "The molecule acts like a homing device for prostate cancer," he said. "PSMA, which... cancer cells and tumor blood vessels, acts as the homing signal that the molecule targets. The molecule and...

Extreme makeover: Stanford scientists explore new way to change cell's identity

...ates that proteins or small RNAs in the cytoplasm of the predominant cell modify the gene expression program of the minority nuclei. In addition to homing in on these regulators, the researchers are repeating the experiment with a variety of different cell types. "This shows that it can be done," said Bl...

Nanoparticles May Help Attack Cancer More Directly

...hard-to-treat cancers, such as breast, pancreatic and liver cancer," senior author Shiladitya Sengupta said in the news release. "The potential to add homing beacons on the surface of the nanoparticles can increase the efficiency of selectively targeting specific tumors and abolish off-target side effects."...

American Cancer Society awards 143 research grants to investigators at 83 institutions nationwide

...e University, is studying the mechanisms by which growth factors induce cancer cells to migrate and metastasize. Unlike many studies that focus on the homing of metastatic cells to distant organs, Dr Santy's interest is in how growth factors initiate the process of cell movement. This work could supply a cr...

Brigham and Women's Hospital Researchers Demonstrate a More Direct Delivery of Cancer Drugs to Tumors

...ancreatic and liver cancer," noted senior study author Shiladitya Sengupta, PhD, of the Department of Medicine at BWH. "The potential to add homing beacons on the surface of the nanoparticles can increase the efficiency of selectively targeting specific tumors and abolish off target side-effects&q...

Scientists discover key factor in controlling the breakdown of bone

...migrate to specific sites in the body in response to chemical mediators in the blood known as chemokines or chemoattractants. These molecules act like homing signals, telling cells that have certain receptors to move toward or away from certain tissues in the body. Previously, Dr. Ishii had discovered t...

University of Ottawa Heart Institute Scientists Successfully Develop Novel Biomaterial to Help Grow New Blood Vessels

...d into damaged muscle, the scaffold attracts special types of cells in the bloodstream called progenitor cells. In turn, the progenitor cells send out homing signals that call other cells to join them in growing new blood vessels. Until now, cell therapy has shown only modest improvement in helping to res...

Bone Marrow-Derived Stem Cells May Offer Novel Therapeutic Option for Skin Disorder

...uman disorders of the extracellular matrix. Efforts are underway to identify the requirements of bone marrow-derived stem cells capable of efficiently homing to wounded skin and producing an array of extracellular matrix proteins. As the principal advantage of systemic therapy is its potential to target not...

Bone marrow-derived stem cells may offer novel therapeutic option for skin disorder

...an disorders of the extracellular matrix. Efforts are underway to identify the requirements of bone marrow-derived stem cells capable of efficiently homing to wounded skin and producing an array of extracellular matrix proteins. As the principal advantage of systemic therapy is its potential to target n...
Homing in Medical Technology

Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support

...ve conditioning therapy. Fate Therapeutics is developing FT1050 to improve the overall efficiency of HSC treatment by enhancing HSC proliferation and homing to the bone marrow. "The mission of Fate Therapeutics is to develop small molecules and biologics that modulate adult stem cells within the body ...

Cardium Reports on Applicability of Corgentin to Stem Cell Therapies: Independent Studies Indicate that Ad5IGF-1 Potentiates Stem Cells to Improve Cardiac Function After Heart Attack

...se of various cytokines and chemokines, including SDF-1 alpha, contributing to massive stem cell mobilization from the bone marrow and their increased homing in the injured heart muscle. The full article can be accessed at www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2640486 . (Logo: http://...

KGI Professor Ian Phillips Awarded Defense Grants for Medical Combat Research

...Hemostat has potential for use in civilian surgery and cases of hemophilia and hemorrhagic stroke. Phillips is also working on ways to add a stem cell homing factor gene to the Hemostat system that would cause stem cells to be drawn to the injury from bone marrow and begin healing the wound even while the i...

Bioheart Reports Promising Results From SDF-1 Modified MyoCell(R) Therapy in Heart Failure Study

...vessels which can provide nutrients to newly engrafted cells) and stem cell homing (attraction of other stem cells to transplantation site for the purpose of ...eased expression of SDF-1 in the damaged myocardium should provide a strong homing signal for endogenous stem cells involved in myocardial repair. -- SDF-1 ...

LigoCyte Pharmaceuticals Announces Collaboration With Biogen Idec to Develop Anti-CD103 Therapies

...ntial respiratory, gastrointestinal, and autoimmune indications. CD103 is the unique alphaE-beta7 integrin that has been implicated in the activation, homing and retention of lymphocytes that mediate inflammatory diseases affecting mucosal regions of the intestine, skin, and lungs. Under terms of the agree...

Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics

...senchymal stem cells from human adipose, or fat, tissue and engineer them into “suicide genes” that seek out and destroy tumors like tiny homing missiles. This gene therapy approach is a novel way to attack small tumor metastases that evade current detection techniques and treatments, the rese...
Homing in Biological News

ORNL, St. Jude track neurons to predict and prevent disease

...e and position of neurons over time. One of Gleason's group members, Ryan Kerekes, already has written software to track the movement of neurons by homing in on each cell's centrosomea key cellular structure. This will enable the software to scour a sequence of video images at high speed, looking for spe...

A budding role for a cellular dynamo

...epends on rapidly producing actin filaments of defined lengths, and we now have an important clue as to how this is regulated," said Goode. "We're now homing in on the precise mechanism by which Bud14 works and extending this analysis to mammalian cells. Once again, yeast has provided the ideal system in wh...

'Smart scaffolds' may help heal broken hearts

...ause they contain a protein that allows progenitor cells to adhere to the damaged tissue and survive long enough to promote healing. These cells emit homing signals that summon other cells to join in the process and give off chemical signals that order cells to grow blood vessels necessary for healing to o...

CSHL scientists discover new way in which ubiquitin modifies transcriptional machinery

...at this class of proteins performs an important job. The CSHL team made another notable discovery. They found that Asr1 has the unique ability of homing in on RNA pol II molecules that are actively turning on genes, while at the same time ignoring otherwise similar enzymes that remain idle. This fact, ...

Stowers Institute's Linheng Li Lab expands understanding of bone marrow stem cell niche

... new technology ex vivo Imaging of Stem Cells, or EVISC to monitor the dynamic behavior of stem cells. This technology enabled the team to track the homing of hematopoietic stem cells after being transplanted in mice. The findings build on the Linheng Li Lab's 2003 discovery of the hematopoietic stem cell...

No place like home: New theory for how salmon, sea turtles find their birthplace

...cientists refer to as natal homing. "What we are proposing is that natal homing can be explained in terms of animals learning the unique magnetic signature...able locations along the way, is not known. Scientists speculate that natal homing evolved because individuals that returned to their home areas to reproduce ...

Simple chemical procedure augments therapeutic potential of stem cells

...nical trials. Karp's procedure might improve their homing abilities. Karp cautions that his lab's discove...c. He's collaborating with another lab to test the homing ability of the SLeX-dotted cells in mice. "We n...at this rolling behavior translates into increased homing and tissue repair," explains Karp. "We may need to...

Seemingly suicidal stunt is normal rite of passage for immune cells

...and his colleagues also found several lymphocyte-specific genes activated by the breaks. "Several of these genes are involved in the migration and homing of lymphocytes," says Sleckman. "Lymphocytes are made in the bone marrow and the thymus, and they have to move to other niches, including the lymph gl...

Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna

...turn to their place of origin but this study is the first to document natal homing for a large, highly migratory fish. "Our study clearly shows that bluefin tuna possess remarkable natal homing abilities that rival those of Pacific salmon and migratory birds. Nearly al...

Atlantic tuna return thousands of miles to birthplace to spawn

...nsustainable at their current levels. In the current study titled, "Natal homing and Connectivity in Atlantic Bluefin Tuna Populations," Rooker and fellow r...in in either the Gulf of Mexico or Mediterranean Sea to spawn. "Rates of homing reported here are extremely high and comparable to Pacific salmon, which ar...
Homing in Biological Technology

Paloma Pharmaceuticals to Present at the American Association for Cancer Research

... endothelial cell, activating it and inducing endothelial signaling events leading to endothelial cell proliferation. Endothelial tubes begin to form, homing in toward the tumor with the formation of capillary loops. Capillaries then undergo a maturation process to stabilize loop structure, but the resultin...

Cellectis Sues Precision BioSciences for Infringement of its Patents Concerning Meganuclease Technology

...ay the assignee of cornerstone patents from the late 80's. Finally the team, which discovered meganucleases and published founding works on the I-SceI homing endonucleases leading to the constitution of the Cellectis proprietary patent portfolio, is from Institut Pasteur. A strong scientific background ...

DuPont and Precision BioSciences Collaborate to Accelerate Crop Product Development

...ses to become the world leader in the field of genomic molecular biology. Precision's proprietary DNE technology enables the production of custom-made homing endonucleases that can be used to safely target site-specific DNA breaks for genome modifications. Precision BioSciences is focused on developing its ...
Homing in Biological Definition

Unsolved problems in biology

...erate electrical fields? Why is magnetite in living creatures? How do animals possess long-range navigation and migration abilities? How was the homing ability developed? How can some animals detect earthquake precursors ? What are organism's magnetic senses? What are the effects of natural electric ...
Homing in Biological Dictionary

T lymphocytes

...of Biology ... T lymphocytes also have antigen-specific molecules on their surface which are ... Although the requirements for T lymphocyte homing to lymph nodes (LNs) are well ... and arrest coef´Čücients than naive T lymphocytes in the deep paracortex. ... T lymphocytes play a major ...

Intein

...base presents general information's as well as detailed data for ... The homing endonuclease domain of the HaV intein alleles is mostly deleted. .....rediction: ... An intein -based positive genetic selection system ... homing endonuclease activity can mobilize an intein ... for loss of intein f...
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(Date:4/14/2014)... treat children with uncomplicated acute appendicitis is a reasonable ... fewer missed school days, according to a pilot study. ... Hospital and published online April 12 in the ... the first prospective study on nonoperative management of acute ... , Researchers enrolled 77 patients age 7 to 17 ...
(Date:4/14/2014)... 2014, Perth, Australia. Drug discovery company Proteomics International ... of a companion diagnostic (CDx) test with the ... The research team authenticated the panel of biomarkers ... samples. Seven biomarkers were validated at high stringency ... The mass spectrometry data was then cross-validated using ...
(Date:4/14/2014)... 2014) When it comes to the cost and ... Patients get the best care when they are treated ... extensive experience in their current job, according to a ... and Columbia Business School. The study was published in ... Applied Economics . , The review of more ...
(Date:4/13/2014)... STANFORD, Calif. A low-cost empowerment program for ... and sexual harassment of these girls, who live ... and are frequently attacked, a large new study ... Stanford University School of Medicine, Lucile Packard Children,s ... No Worldwide, validated the program,s effectiveness in combating ...
(Date:4/11/2014)... the processes that control brain cell production could pave ... brain-related disorders. , Scientists have gained new understanding of ... how and when nerve and brain cells are formed ... and keeps it healthy. Their findings could help explain ... which is a fundamental characteristic of many diseases including ...
Breaking Medicine News(10 mins):Health News:Antibiotics alone are a successful treatment for uncomplicated acute appendicitis in kids 2Health News:Antibiotics alone are a successful treatment for uncomplicated acute appendicitis in kids 3Health News:Longer nurse tenure on hospital units leads to higher quality care 2Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 2Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 3Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 4
(Date:4/15/2014)... temperatures in the Congo Basin to increase by ... by greenhouse gases by half, according to a ... Belgium. , Explosive population growth and inefficient agricultural ... in Central Africa. A team of researchers from ... will affect longer-term temperatures in the region. Using ...
(Date:4/15/2014)... systems soon could be powering the forklifts used in ... with faster refueling times than ever before, courtesy of ... Carriers (HHC). , The goal of the project is ... refuel at low pressure four to five times faster ... hydrogen a competitive advantage over batteries for a big ...
(Date:4/14/2014)... study of subarctic forest moths in Finnish Lapland suggests ... change on animals and plants because much of the ... populations of 80 moth species and found that 90 ... the study period, from 1978 to 2009. During that ... 3.5 degrees Fahrenheit, and winter precipitation increased as well. ...
Breaking Biology News(10 mins):Study: Deforestation could intensify climate change in Congo Basin by half 2Low-cost, hydrogen-powered forklifts with rapid refueling, zero emissions coming soon 2Low-cost, hydrogen-powered forklifts with rapid refueling, zero emissions coming soon 3Low-cost, hydrogen-powered forklifts with rapid refueling, zero emissions coming soon 4Moth study suggests hidden climate change impacts 2Moth study suggests hidden climate change impacts 3
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