Protein level may serve as predictor of severe osteoarthritis
...usion of VCAM-1 levels in risk prediction models resulted in a more accurate classification of individuals.
VCAM-1 promotes leukocyte adhesion and homing
to sites of inflammation. In chondrocytes (cartilage cells), VCAM-1 expression is induced by inflammatory cytokines (proteins released by immune syste...
Purdue researchers create prostate cancer 'homing device' for drug delivery
... both papers, compared the targeting molecule to a homing
"The molecule acts like a homing
device for prostate cancer," he said. "PSMA, which... cancer cells and tumor blood vessels, acts as the homing
signal that the molecule targets. The molecule and...
Extreme makeover: Stanford scientists explore new way to change cell's identity
...ates that proteins or small RNAs in the cytoplasm of the predominant cell modify the gene expression program of the minority nuclei.
In addition to homing
in on these regulators, the researchers are repeating the experiment with a variety of different cell types. "This shows that it can be done," said Bl...
Nanoparticles May Help Attack Cancer More Directly
...hard-to-treat cancers, such as breast, pancreatic and liver cancer," senior author Shiladitya Sengupta said in the news release. "The potential to add homing
beacons on the surface of the nanoparticles can increase the efficiency of selectively targeting specific tumors and abolish off-target side effects."...
American Cancer Society awards 143 research grants to investigators at 83 institutions nationwide
...e University, is studying the mechanisms by which growth factors induce cancer cells to migrate and metastasize. Unlike many studies that focus on the homing
of metastatic cells to distant organs, Dr Santy's interest is in how growth factors initiate the process of cell movement. This work could supply a cr...
Brigham and Women's Hospital Researchers Demonstrate a More Direct Delivery of Cancer Drugs to Tumors
...ancreatic and liver cancer," noted senior study author Shiladitya Sengupta, PhD, of the Department of Medicine at BWH. "The potential to add homing
beacons on the surface of the nanoparticles can increase the efficiency of selectively targeting specific tumors and abolish off target side-effects&q...
Scientists discover key factor in controlling the breakdown of bone
...migrate to specific sites in the body in response to chemical mediators in the blood known as chemokines or chemoattractants. These molecules act like homing
signals, telling cells that have certain receptors to move toward or away from certain tissues in the body.
Previously, Dr. Ishii had discovered t...
University of Ottawa Heart Institute Scientists Successfully Develop Novel Biomaterial to Help Grow New Blood Vessels
...d into damaged muscle, the scaffold attracts special types of cells in the bloodstream called progenitor cells. In turn, the progenitor cells send out homing
signals that call other cells to join them in growing new blood vessels.
Until now, cell therapy has shown only modest improvement in helping to res...
Bone Marrow-Derived Stem Cells May Offer Novel Therapeutic Option for Skin Disorder
...uman disorders of the extracellular matrix. Efforts are underway to identify the requirements of bone marrow-derived stem cells capable of efficiently homing
to wounded skin and producing an array of extracellular matrix proteins. As the principal advantage of systemic therapy is its potential to target not...
Bone marrow-derived stem cells may offer novel therapeutic option for skin disorder
...an disorders of the extracellular matrix. Efforts are underway to identify the requirements of bone marrow-derived stem cells capable of efficiently homing
to wounded skin and producing an array of extracellular matrix proteins. As the principal advantage of systemic therapy is its potential to target n...
Homing in Medical Technology
Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support
...ve conditioning therapy. Fate Therapeutics is developing FT1050 to improve the overall efficiency of HSC treatment by enhancing HSC proliferation and homing
to the bone marrow.
"The mission of Fate Therapeutics is to develop small molecules and biologics that modulate adult stem cells within the body ...
Cardium Reports on Applicability of Corgentin to Stem Cell Therapies: Independent Studies Indicate that Ad5IGF-1 Potentiates Stem Cells to Improve Cardiac Function After Heart Attack
...se of various cytokines and chemokines, including SDF-1 alpha, contributing to massive stem cell mobilization from the bone marrow and their increased homing
in the injured heart muscle. The full article can be accessed at www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2640486 .
KGI Professor Ian Phillips Awarded Defense Grants for Medical Combat Research
...Hemostat has potential for use in
civilian surgery and cases of hemophilia and hemorrhagic stroke. Phillips
is also working on ways to add a stem cell homing
factor gene to the
Hemostat system that would cause stem cells to be drawn to the injury from
bone marrow and begin healing the wound even while the i...
Bioheart Reports Promising Results From SDF-1 Modified MyoCell(R) Therapy in Heart Failure Study
...vessels which can provide nutrients to
newly engrafted cells) and stem cell homing
(attraction of other stem cells
to transplantation site for the purpose of ...eased expression of SDF-1 in the damaged myocardium should
provide a strong homing
signal for endogenous stem cells involved in
-- SDF-1 ...
LigoCyte Pharmaceuticals Announces Collaboration With Biogen Idec to Develop Anti-CD103 Therapies
...ntial respiratory, gastrointestinal,
and autoimmune indications. CD103 is the unique alphaE-beta7 integrin that
has been implicated in the activation, homing
and retention of lymphocytes
that mediate inflammatory diseases affecting mucosal regions of the
intestine, skin, and lungs. Under terms of the agree...
Fat Kills Cancer: Turning Stem Cells from Fat Tissue into
Personalized, Cancer-Targeted Therapeutics
...senchymal stem cells from human adipose, or
fat, tissue and engineer them into “suicide genes” that
seek out and destroy tumors like tiny homing
This gene therapy approach is a novel way to attack small
tumor metastases that evade current detection techniques and
treatments, the rese...
Homing in Biological News
ORNL, St. Jude track neurons to predict and prevent disease
...e and position of neurons over time.
One of Gleason's group members, Ryan Kerekes, already has written software to track the movement of neurons by homing
in on each cell's centrosomea key cellular structure. This will enable the software to scour a sequence of video images at high speed, looking for spe...
A budding role for a cellular dynamo
...epends on rapidly producing actin filaments of defined lengths, and we now have an important clue as to how this is regulated," said Goode. "We're now homing
in on the precise mechanism by which Bud14 works and extending this analysis to mammalian cells. Once again, yeast has provided the ideal system in wh...
'Smart scaffolds' may help heal broken hearts
...ause they contain a protein that allows progenitor cells to adhere to the damaged tissue and survive long enough to promote healing. These cells emit homing
signals that summon other cells to join in the process and give off chemical signals that order cells to grow blood vessels necessary for healing to o...
CSHL scientists discover new way in which ubiquitin modifies transcriptional machinery
...at this class of proteins performs an important job.
The CSHL team made another notable discovery. They found that Asr1 has the unique ability of homing
in on RNA pol II molecules that are actively turning on genes, while at the same time ignoring otherwise similar enzymes that remain idle. This fact, ...
Stowers Institute's Linheng Li Lab expands understanding of bone marrow stem cell niche
... new technology ex vivo Imaging of Stem Cells, or EVISC to monitor the dynamic behavior of stem cells. This technology enabled the team to track the homing
of hematopoietic stem cells after being transplanted in mice. The findings build on the Linheng Li Lab's 2003 discovery of the hematopoietic stem cell...
No place like home: New theory for how salmon, sea turtles find their birthplace
...cientists refer to as natal homing.
"What we are proposing is that natal homing
can be explained in terms of animals learning the unique magnetic signature...able locations along the way, is not known. Scientists speculate that natal homing
evolved because individuals that returned to their home areas to reproduce ...
Simple chemical procedure augments therapeutic potential of stem cells
...nical trials. Karp's procedure might improve their homing
Karp cautions that his lab's discove...c. He's collaborating with another lab to test the homing
ability of the SLeX-dotted cells in mice.
"We n...at this rolling behavior translates into increased homing
and tissue repair," explains Karp. "We may need to...
Seemingly suicidal stunt is normal rite of passage for immune cells
...and his colleagues also found several lymphocyte-specific genes activated by the breaks.
"Several of these genes are involved in the migration and homing
of lymphocytes," says Sleckman. "Lymphocytes are made in the bone marrow and the thymus, and they have to move to other niches, including the lymph gl...
Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
...turn to their place of origin but this study is the first to document natal homing
for a large, highly migratory fish. "Our study clearly shows that bluefin tuna possess remarkable natal homing
abilities that rival those of Pacific salmon and migratory birds. Nearly al...
Atlantic tuna return thousands of miles to birthplace to spawn
...nsustainable at their current levels.
In the current study titled, "Natal homing
and Connectivity in Atlantic Bluefin Tuna Populations," Rooker and fellow r...in in either the Gulf of Mexico or Mediterranean Sea to spawn.
"Rates of homing
reported here are extremely high and comparable to Pacific salmon, which ar...
Homing in Biological Technology
Homing in Biological Definition
Unsolved problems in biology
...erate electrical fields? Why is magnetite in living creatures? How do animals possess long-range navigation and migration abilities? How was the homing
ability developed? How can some animals detect earthquake precursors ? What are organism's magnetic senses? What are the effects of natural electric ...
Homing in Biological Dictionary
...of Biology ... T lymphocytes also have antigen-specific molecules on their surface which are ... Although the requirements for T lymphocyte homing
to lymph nodes (LNs) are well ... and arrest coefﬁcients than naive T lymphocytes in the deep paracortex. ... T lymphocytes play a major ...
...base presents general information's as well as detailed data for ... The homing
endonuclease domain of the HaV intein alleles is mostly deleted. .....rediction: ... An intein -based positive genetic selection system ... homing
endonuclease activity can mobilize an intein ... for loss of intein f...