Bellicum Pharmaceuticals Announces Initiation of Phase I/II Clinical Trial of Novel Vaccine for Patients With Advanced Prostate Cancer
...ration of AP1903, a small-molecule dimerizer agent developed by ARIAD Pharmaceuticals, Inc. (Nasdaq: ARIA ). In this way, the immune system's innate homeostasis
is overridden and a potent and durable antigen-specific T cell response may be generated.
The dose-escalation trial will evaluate the safety o...
Study aims to induce recovery from ankylosing spondylitis
... different species of pathogenic bacteria has been implicated in dozens of chronic disease states. ARF has discovered how to restore nuclear receptor homeostasis
so that the body's own immune system can fight these pathogenic bacteria.
The East-West partnership, which will eventually include subjects sufferi...
Six Scientists Receive Awards for Contributions to Alzheimer's Disease Research
...he winner of the 2009 Best Paper in Alzheimer's Disease Neuroimaging Award for his article entitled Ab Plaques Lead to Aberrant Regulation of Calcium homeostasis
In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks. Dr. Backsai will receive $5,000.
Jennifer Whitwell, PhD, of...
6 scientists receive awards for contributions to Alzheimer's disease research
...the winner of the 2009 Best Paper in Alzheimer's Disease Neuroimaging Award for his article entitled Ab Plaques Lead to Aberrant Regulation of Calcium homeostasis
In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks. Dr. Backsai will receive $5,000.
Jennifer Whitwell, PhD, of the Ma...
Arete Therapeutics Presents Positive Clinical and Preclinical Data for AR9281
...vel Inhibitor of Soluble Epoxide Hydrolase, AR9281, Improves
in Diet-Induced Obese Mice" (Wong, K, Zhang, L-N,
Vincelette, J, Che...predisposing obese individuals to diabetes.
-- "Improvement of Glucose homeostasis
by AR9281, a Novel Inhibitor of
Soluble Epoxide Hydrolase, in Diet-I...
Study further expands understanding of leptin's role in brain neurocircuitry
...tion of novel anti-diabetic drug targets."
First identified in 1994 as an appetite and weight-regulation hormone, leptin plays a key role in energy homeostasis
through its effects on the central nervous system. Over the years, investigators have pinpointed a region of the brain's hypothalamus known as the arc...
AGA Institute presents cutting-edge research during DDW
... members. S. Ohashi et al. (8:22 a.m.)
Microbial-innate Immune Interactions at the Epithelial Cell Interface. D. Polk (8:39 a.m.)
Changes in Mucosal homeostasis
Leading to Hypersensitivity to Mucosal Injury in NHE3 Knockout Mice. D. Laubitz et al. (9:04 a.m.)
Colitis-associated variant of TLR2 causes impaired...
Sodium channel blocker shows promise as a potential treatment for cystic fibrosis
...interfering with normal respiration. One of the mechanisms causing airways to not clear mucous correctly in these patients involves the body's natural homeostasis
of sodium which, when absorbed too quickly from the surface of the airway, causes moisture to become absorbed too quickly.
"Cystic fibrosis patients...
Study Results Published in CUTIS Demonstrate Long-Term Safety and Efficacy of Vectical(TM) (calcitriol) Ointment 3 mcg/g in the Management of Mild-to-Moderate Plaque Psoriasis
...values, abnormal urinalysis, skin irritation and psoriasis. Additionally, Vectical(TM) Ointment demonstrated no significant clinical effect on calcium homeostasis
when used continuously over one year by 116 people who were evaluated. Also during the study, patients reported a noticeable improvement in psoriasis...
Beating a Global Killer: HIV/AIDS
... IPF, like other natural autoantibody based fractionated proteins, has an affinity to pathogenic binding and simultaneously produces effects of immune homeostasis
in the presence of replacativly competent HIV. IPF has shown significant antiretroviral activity via immune stimulatory pathways in vitro, notably he...
Homeostasis in Medical Technology
Radius' Investigational Bone Anabolic Agent, BA058, Increased Bone Mineral Density (BMD) at Key Fracture Sites in Phase 2 Clinical Trial in Postmenopausal Osteoporosis
... analogs play a distinct biological role from the PTH (parathyroid hormone) peptide by activating different signaling responses--PTH regulates calcium homeostasis
and bone resorption by acting primarily on target cells in bone and kidney, whereas PTHrP and its analogs regulate cell proliferation and differentiat...
Neuroscience Researcher Has Positive Message for International Alzheimer's Awareness Week, July 6 - 12: 'Even Though World Economy is Declining, Alzheimer's Research is Advancing'
... treat age related memory loss and the diseases of aging. The company's therapeutic products focus on alleviating the consequences of impaired calcium homeostasis
- the imbalance of calcium ions thought to be related to neurodegenerative diseases such as Alzheimer's and Parkinson's.
ALP Life Sciences, LLC Announces Nanoveson(TM) Patent Filing and Whitepaper Availability on Proposed Therapy for Non-Alcoholic Fatty Liver Disease (NAFLD) and Comorbid Diseases
...area of drug metabolism testing.
Research has demonstrated that enterohepatic circulation is the mechanism that maintains quantitative whole body homeostasis
of arachidonic acid. There is extensive research focused on blocking arachidonic acid metabolism along cytochrome P450, leukotriene, prostaglandin, an...
Overweight Siblings of Children With Type 2 Diabetes Likely to Have Abnormal Blood Sugar Levels
... or type 2 diabetes) than other overweight children. However, investigators found no significant differences in insulin resistance, as measured by the homeostasis
Type 2 diabetes is caused by a combination of both genetic and environmental factors. Known risks include obesity, decrease...
Nature Publication Reports on Key Role of Bile Acids in Glucose Metabolism and Insulin Signaling
... role of bile acid
signaling via the nuclear hormone receptor FXR and the G protein-coupled
receptor TGR5. These receptors are key mediators of energy homeostasis
are involved in maintaining integral functions of the liver, intestine and
kidney, organs exposed to bile acid flux. The company's chemocentric
Novel Testosterone Gel Significantly Improves Insulin Sensitivity and Sexual Function in Hypogonadal Men With Type 2 Diabetes and Metabolic Syndrome
...significant improvement in insulin sensitivity in testosterone treated
patients at six and 12 months (p=0.05 and p=0.01, respectively), as
measured by homeostasis
model assessment as an index of insulin resistance
(HOMA-IR). Further, measured by the Index of Erectile Function (IIEF),
patients using the testoster...
Nuvelo Announces Preclinical Data for NU206 Demonstrating Potent Therapeutic Activity in Oral Mucositis Models
...lial cells and accelerated cell repair
by stimulating the Wnt pathway, a signaling pathway that is critical for
cell growth and differentiation during homeostasis
"This study reinforces our belief that NU206 is a potent regenerative
agent," said Dr. Ted W. Love, chairman and chief executive o...
Radius Completes Enrollment of Phase II Clinical Trial of BA058 for Osteoporosis
...-related protein) is a critical peptide for
promoting new bone formation, with a role distinct from PTH (parathyroid
hormone), which regulates calcium homeostasis
and bone resorption. BA058 is
an analog of hPTHrP that is designed to build bone without inducing
hypercalcemia or significant resorption. In preclini...
Arena Pharmaceuticals Announces APD668 Initial Clinical Study Results Suggest Glucose-Dependent Insulinotropic Receptors May Improve Glucose Control in Patients With Type 2 Diabetes
...R agonist into preclinical
"We are encouraged by the clinical study results supporting GDIR
agonists as effective modulators of glucose homeostasis
in patients with
type 2 diabetes, and we look forward to the results of Ortho-McNeil
advancing another of Arena's GDIR compounds into development," st...
Insmed Releases Positive Results from Iplex Phase II HIV-Associated
Adipose Redistribution Syndrome Clinical Study
... which is
IPLEX's ability to improve glucose homeostasis. Competitor products
such as TH9507 and growth hormone reportedly either do not alter
or exacerbate it, respectively. When
considering that up to 40% of this population has impaired glucose
homeostasis, then this property of IPLEX becom...
Homeostasis in Medical Definition
...r example, osmotherapy can be used to treat a patient who has cerebral hemorrhage . This might include the use of mannitol to maintain the brain's homeostasis
| A rather technical, but informative article
Homeostasis in Medical Dictionary
... Calcium metabolism or calcium homeostasis
is the mechanism by which the body maintains adequate calcium levels. Derangements of this mechanism lead to hypercalcemia or hypocalcemia, whic...
... Human iron metabolism is the set of chemical reactions maintaining human homeostasis
of iron. Iron is an essential element for most life on Earth, including human beings. The control of this necessary but potentially toxic... Revie...
...idal abilities" ... B Cell Development and Generation of Lymphocyte Diversity ... ... are the main consequences of perturbed lymphocyte homeostasis
in ALPS Ia: ... Expansion of antigen-specific lymphocyte populations that are not eliminated ... Mouse protein-coding gene Lcp1. Represented b...
...l carcinoma is determined by the size of the primary ... Adrenocortical Carcinoma Key Terms: Biopsy , Carcinoma , Computed tomography , homeostasis
, Hormone , Inferior vena cava , Lymph nodes , Magnetic This site is intended for patients, caregivers, physicians, and researchers whose interest...
Homeostasis in Biological News
Metal homeostasis research in plants will lead to nutrient-rich food and higher yielding crops
Deficiencies of micronutrients such as Iron and Zinc commonly limit plant growth and crop yields. Dartmouth Professor Mary Lou Guerinot is conducting research to better understand the mechanisms of micronutrient uptake, distribution and regulation.
Guerinot's findings are making it feasible to...
Scripps Research scientists observe human neurodegenerative disorder in fruit flies
...n disease. This suggests that Charcot-Marie-Tooth disease is related to some fundamental and unknown function the protein plays in the development and homeostasis
of the nervous system. Because the unknown function is common to both humans and flies, it probably evolved hundreds of millions of years ago before t...
Drinking 100 percent fruit juice is associated with lower risk of obesity and metabolic syndrome
...to non-consumers, 100% juice consumers had lower mean Body Mass Index (BMI), smaller waist circumference and lower insulin resistance (as estimated by homeostasis
model assessment, HOMA). The researchers noted an inverse association between level of juice intake (oz/day) and these parameters.
Based on the an...
ASBMB Annual Meeting to feature talks on the biochemistry of aging
...roviding evidence that efforts in humans just might work.
The Role of Insulin-like Signaling for the Central and Peripheral Regulation of Nutrient homeostasis
and Life Span
Morris White, Children's Hospital Boston, MA
(Tue, April 21 3:30 PM - 5:50 PM, Room: 356)
White will discuss some of his group's ...
Penn biologists discover how 'silent' mutations influence protein production
...glowing genes, provides an explanation for how a cell "knows" how much of each protein to make, providing just the right amount of protein to maintain homeostasis
yet not too much to cause cell toxicity.
In the study, Penn biologists analyzed how protein levels are governed by synonymous, or silent, mutations...
Iron is involved in prion disease-associated neuronal demise
... Imbalance of iron homeostasis
is a common feature of prion disease-affected huma...n in diseased brains. The imbalance of brain iron homeostasis
worsens with disease progression, and is not an ou...peutic strategies targeted at restoring brain iron homeostasis
in prion disorders.
DREAM: 1 gene regulates pain, learning and memory
...-imbalance rather than the culprit for the disease.
And Calcium regulation is also responsible for tuning the activity of the DREAM-gene. Calcium homeostasis
may thus be the link between pain perception, learning and memory. This is supported by observations of patients suffering from chronic pain: very oft...
Tips from the American Journal of Pathology
... another FPR family member, FPR-2.
The data by Gastardelo et al "provide in vivo evidence that endogenous annexin A1 is an essential mediator for homeostasis
during the inflammatory process." They go on to propose "that these experimental findings may impact the development of novel therapeutics based on th...
Scripps research team sheds light on immune system suppression
...ne, may well be caused by viruses that persist without destroying the differentiated cells they infect, alter their functions, and by this means alter homeostasis
and cause disease," says Oldstone. "Examples would be viruses that persistently infect neurons and cause problems in learning and behavior, viruses th...
From Canada to the Caribbean: Tree leaves control their own temperature, Penn study reveals
...tudy, most likely occurs when leaf temperatures are about 21C, with latitude or average growing-season temperature playing little, if any, role. This homeostasis
of leaf temperature means that in colder climates leaf temperatures are elevated and in warmer climates tree leaves cool to reach optimal conditions f...
Homeostasis in Biological Technology
Scripps Research Institute Highlights Groundbreaking Work of aTyr Pharma Scientific Co-Founder
...s hidden in the synthetases have a role in normal human physiology. Identification of these novel cell signaling proteins that can be used to restore homeostasis
in patients with inflammatory, cardiovascular and metabolic diseases is the discovery engine for aTyr Pharma's product development program and we are ...
Vanda Pharmaceuticals to Present Data on Fanapt(TM) and Tasimelteon at the 162nd American Psychiatric Association Annual Meeting
NR7-009 Common effect of antipsychotics on biosynthesis and
regulation of fatty acids and cholesterol supports a role of lipid
NR1-092 Selective estrogen receptor modulators share the
antipsychotic gene expression profile, suggesting their pote...
New Insights into the Mechanism of Action of Antipsychotic Drugs
... and regulation of fatty acids and cholesterol supports a key role of lipid homeostasis
in schizophrenia" (1).
This publication highlights the discovery of a ... and regulation of fatty acids and cholesterol supports a key role of lipid homeostasis
in schizophrenia." Schizophr Res. 2009 Mar; 108(1-3):134-42.
Nuvelo Announces Positive Results from Phase 1 Clinical Trial of NU206 in Healthy Volunteers
...mbinant, secreted protein that acts as a key
regulator of the Wnt pathway, the critical pathway that stimulates cell growth
and differentiation during homeostasis
and pathogenesis in specific tissues
including the GI epithelium and bone. Preclinical studies suggest it can
promote growth and repair in animal mode...
Metabolex Announces Positive Results From Phase 1a Clinical Trial of MBX-2982
...ulin secretion. In addition, MBX-2982 stimulates release of the incretin
GLP-1 from the gut. This dual action is unique and may offer improved
over existing diabetes therapies, with potential for
weight loss and improved islet health.
The Phase 1a study was a randomized, placebo-controlled,...
Cytochroma and Mitsubishi Tanabe form partnership for chronic kidney disease therapies in U.S. and Asia
...rmone, nor maintain a state of balance (homeostasis) between calcium and
phosphate in the body. The low levels of active vitamin D hormone and lack
between calcium and phosphate is detected by the parathyroid
gland, which, in turn, continues to secrete PTH, resulting in excessive
levels of PTH in ...
Nuvelo Initiates Phase 1 Clinical Trial of NU206 in Healthy Volunteers
...mbinant, secreted protein that acts as a
key regulator of the Wnt pathway, the critical pathway that stimulates cell
growth and differentiation during homeostasis
and pathogenesis in specific
tissues including the GI epithelium and bone. Preclinical studies suggest
it can promote growth and repair in animal mode...
Lorus Therapeutics presents new findings for the anticancer drugs LOR-253 and LOR-2040
...rst presentation titled, "Preclinical development of LOR-253, a
novel anticancer drug candidate that functions by modulating intracellular
labile zinc homeostasis
leading to cell cycle arrest," will be presented on
April 16, 2008.
In this presentation, Lorus provided data on the preclinical
development of LOR-...
Millennium Over-Delivers on 2007 Goals and Financial Guidance
...eloped to treat ulcerative colitis and Crohn's disease and is on track to enter pivotal trials in late 2008/early 2009. -- Protein homeostasis
oncology program -- MLN4924 (novel Nedd8-activating enzyme inhibitor) -- An investigational new drug (IND) application for MLN4924 was ...
Recombinant Human Renin - Crystallographic Grade
...ombinant human renin and native human renin from human kidney. Human Renin is an important enzyme in the regulation of blood pressure
and electrolyte homeostasis
and therefore is of great clinical importance.
Kinetic and mechanistic functions of human renin are of importance for the
development of hypertension ...
Homeostasis in Biological Definition
or homoeostasis is the property of an open system , especially living organisms, to regulate its internal environment so as to maintain a stable condition, by means of multiple dynamic equilibrium adjustments controlled by interrelated regulation mechanisms.
The term was co...
1.2 Response to stress or DNA damage
1.5 Immune cell regulation ...itochondrion to start the apoptotic process.
In the adult organism, the number of cells with...ell death. This balancing process is part of the homeostasis
required by living organisms to maintain their i...
...e: universality, evolution, diversity, continuity, homeostasis
Universality: biochemistry...omeostasis: adapting to change
Main article: homeostasis
is the property of an open system to regulate ...
...eep its core body temperature at a nearly constant level regardless of the temperature of the surrounding environment (that is, to maintain thermal homeostasis
). This can involve not only the ability to generate heat , but also the ability to cool down if necessary.
Also known as endotherms , warm-blooded ...
...s require both energy and matter in order to continue living.
Living organisms are composed of at least one cell .
Living organisms maintain homeostasis
Species of living organisms will evolve .
All life on Earth is based on the chemistry of carbon compounds. Some assert that this must...
... Osmoregulation is the active regulation of the osmotic pressure of body fluids to maintain the homeostasis
of the body's water content, that is it keeps the body from becoming too dilute or too concentrated. Osmotic pressure is a measure of the tendency...
...ur during elevated physical activity. Within the field of exercise physiology , studies have been conducted that show the effects of dehydration on homeostasis
Important publications in physiology
... organism to keep its body temperature within certain boundaries, even when temperature surrounding is very different.
This process is known as homeostasis
: a dynamic state of stability between an animal's internal environment and its external environment (the study of such processes in zoology has be...
Homeostasis in Biological Dictionary
is the property of a system, either open or closed, that regulates its internal environment and tends to maintain a stable, constant condition. Typically used to refer to a living organism, the concept came from... Human homeostasis
refers to the body's ability to regulate ...
... Osmoregulation is the active regulation of the osmotic pressure of an organism's fluids to maintain the homeostasis
of the organism's water content; that is it keeps the organism's fluids from becoming too dilute or too... Osmoregulation . Osmoregulati...
.... igestive enzymes are responsible for digestion of nutrients as well as their ... Enzymes allow many chemical reactions to occur within the homeostasis
... Enzymes function as organic catalysts. ... Many enzymes function by lowering the ... Digestive enzymes are complex proteins involved i...