Hodgkin

DNA differences may influence risk of Hodgkin disease

A new analysis has found that certain variations in genes that repair DNA can affect a person's risk of developing Hodgkin disease. Published in the April 1, 2009 issue of CANCER , a peer-reviewed journal of the American Cancer Society, the study indicates that differences in these genes should b...

Young Hodgkin Survivors Face Later Risk of Second Cancers

Thyroid, breast, non-Hodgkin lymphoma were the most common types, study says SUNDAY, June 1 (HealthDay News) -- People who survived Hodgkin disease when they were children or adolescents are much more likely than other people to develop certain cancers, says a new study. Hodgkin di...

USC researchers find new clues to risk of Hodgkin lymphoma

A long-term study of twins has led University of Southern California (USC) researchers to find potential links between Hodgkin lymphoma and levels of an immune response protein (interleukin-12). "We found that lower levels of the protein interleukin-12, involved in fighting intracellular infectio...

Researchers Analyzes Risk Between Hodgkin Disease and Heart Attack Mortality

Doctors have long known that patients treated for Hodgkin disease are at an increased risk for heart attacks. Researchers quantify the risk of fatal heart attacks// associated with different types of treatment, and they find that the increased risk persists for at least 25 years after Hodgkin disea...

Millennium Pharmaceuticals Inc./Lymphoma Research Foundation funds lymphoma research

...Associate Professor at the Nebraska Medical Center in Omaha, Nebraska. Lymphoma, the most common type of blood cancer, is broadly categorized into hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). According to a 2008 report from the World Health Organization, there are six types of HL and over 61 ty...

Cell division find prompts overhaul of immune response modeling

...ent of the newly-generated cells die. Professor hodgkin said although there was considerable variation in ...e might be missing something important," Professor hodgkin said. "What if the variation is a design feature o...s programmed from that very first cell," Professor hodgkin said. "We also observed that cell 'siblings' took ...

Research identifies successful new treatment for Hodgkin's lymphoma, reduces long-term risks

...Children's Hospital has identified a new chemotherapy regimen for pediatric hodgkin lymphoma (HL) patients. The new treatment enhances efficacy through dose-de...d (posted in an online first edition). The Children's Oncology Group's hodgkin Lymphoma Committee, led by Schwartz, director of pediatric hematology/oncol...

Hodgkin lymphoma survivors have increased risk of stroke and transient ischemic attack

... Patients treated for hodgkin lymphoma with radiation therapy have a substantial...chemic attack (TIA), or a "mini stroke," following hodgkin lymphoma is limited. In order to quantify the l...performed a retrospective cohort study among 2,201 hodgkin lymphoma survivors. The patients, who had survived...

Cimzia(R) (certolizumab pegol) Now Available for Self-Administration in Adult Patients With Moderate to Severe Crohn's Disease

...udies of CIMZIA for Crohn's disease and other investigational uses, there was one case of lymphoma among 2,657 CIMZIA-treated patients and one case of hodgkin lymphoma among 1,319 placebo-treated patients. In CIMZIA RA clinical trials (placebo-controlled and open label) a total of three cases of lymphoma we...

UCB's CIMZIA(R) (certolizumab pegol) Approved by the U.S. FDA for Adult Patients Suffering From Moderate to Severe Rheumatoid Arthritis

...udies of CIMZIA for Crohn's disease and other investigational uses, there was one case of lymphoma among 2,657 CIMZIA-treated patients and one case of hodgkin lymphoma among 1,319 placebo-treated patients. In CIMZIA RA clinical trials (placebo-controlled and open label) a total of three cases of lymphoma wer...

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Hodgkin in Medical Technology

Pharmion and MethylGene Start Phase 2 Combination Clinical Trial With MGCD0103 and Vidaza(R) in Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma

BOULDER, Colo. and MONTREAL, Jan. 9 /PRNewswire-FirstCall/ -- Pharmion Corporation (Nasdaq: PHRM ) and MethylGene Inc. (TSX: MYG) today announced the enrollment of the first patient in a Phase 2 clinical trial (Trial CL002) evaluating MGCD0103, the Companies' isotype-selective histone deacety...

Video: Partnership Unites UCB with Consumer Product Innovator OXO(R)

...udies of CIMZIA for Crohn's disease and other investigational uses, there was one case of lymphoma among 2,657 CIMZIA-treated patients and one case of hodgkin lymphoma among 1,319 placebo-treated patients. In CIMZIA RA clinical trials (placebo-controlled and open label) a total of three cases of lymphoma wer...

Novel Therapeutic Approaches May Transform Treatment and Improve Patient Outcomes in Several Platelet Disorders

...ed high-dose chemotherapy or autologous stem cell transplant for the treatment of various hematologic cancers (multiple myeloma, non-Hodgkin lymphoma, hodgkin disease, and acute leukemia) were randomized to one of two treatment arms: a traditional arm that received preventive platelet transfusions or an expe...

Pharmion and MethylGene Announce U.S. Orphan Drug Designation Granted for MGCD0103 for the Treatment of Acute Myelogenous Leukemia

...drug designation from the U.S. Food and Drug Administration (FDA) and has been designated an Orphan Medicinal Product by the EMEA for the treatment of hodgkin lymphoma and acute myelogenous leukemia. About Acute Myelogenous Leukemia (AML) Acute myelogenous leukemia (AML) is a cancer of the blood and bone...

Pharmion and MethylGene Announce Orphan Drug Designation Granted by the European Medicines Agency (EMEA) for MGCD0103 for the Treatment of Acute Myelogenous Leukemia

...ation from the U.S. Food and Drug Administration (FDA) for the treatment of hodgkin lymphoma and has been designated an Orphan Medicinal Product by the EMEA for the treatment of hodgkin lymphoma and acute myelogenous leukemia. About Acute Myelogenous Leukemia...

Clinical Data Reported on Vidaza in Hematologic Malignancies and Advanced Solid Tumors

...l Details "A Phase II Study of MGCD0103, a Novel Oral Isotype-Selective Histone Deacetylase (HDAC) Inhibitor in Patients with Relapsed or Refractory hodgkin Lymphoma" (Abstract #8000, Trial 010). Oral, monotherapy treatment with MGCD0103 demonstrated substantial anti-tumor activity in patients with relapse...

Hodgkin in Medical Products

Ferritin IRMA Test

Description:...st for iron deficiency [7]. Elevated serum ferritin levels have been observed in acute and chronic liver disease and lymphoid malignancy (leukemia and hodgkin lymphoma) [1,2]. High serum ferritin levels have also been associated with an elevated risk for myocardial infarction in men [8]. Jacobs A & W...
Company:Diagnostic Systems Laboratories, Inc.

Hodgkin in Biological News

Leemor Joshua-Tor, PhD, CSHL biologist and WSBS dean, is named an HHMI Investigator

...y as an assistant investigator. She was named associate professor at CSHL in 1999 and professor in 2005. She is the recipient of the Dorothy Crowfoot hodgkin Award from the Protein Society and a Beckman Young Investigator Award. A gifted mentor, Dr. Joshua-Tor was named co-director of the undergraduate r...

Why nerve cells work faster than the theory allows

...preads out through the long appendages of the cell with high speed. At the end of the appendages it is transmitted to other cells. In 1952, Alan Lloyd hodgkin and Andrew Fielding Huxley described in a mathematical model how such an action potential originates on the basis of measurements on neurons of the sq...

Emergence of cancer as major cause of childhood death in developing countries is not being adequately addressed

... developing countries in significantly improving the cure rates of leukemia—the most common childhood cancer—as well as Burkitt lymphoma, Wilms tumor, hodgkin disease and other curable malignancies. “We’ve found that recruiting local oncologists to serve as program directors gives the best results,?Ribeir...

Antiretroviral therapy may prevent excess risk of some cancers in people with HIV

...extent, anal cancer, invasive cervical cancer, and hodgkin lymphoma. However, less well understood are the as...a. They also had an increased risk of anal cancer, hodgkin lymphoma, cervical cancer, liver cancer, cancer of.... HAART use was not associated with lower risks of hodgkin lymphoma or other cancers. Although people infecte...

Hodgkin in Biological Technology

Rosetta Genomics and Columbia University Medical Center to Develop MicroRNA-based Diagnostics for Leukemia and Non Hodgkin Lymphoma

-- Target diseases for this collaboration are Diffuse Large Cell Lymphoma, Transformed Follicular Lymphoma, and Chronic Lymphocytic Leukemia -- Collaboration to develop microRNA-based diagnostics test, early detection and prognosis. -- 43,000 people will be diagnosed w...

Cimzia(R) (certolizumab pegol) Provides Long-Term Remission and Response Rates in Infliximab-Refractory Crohn's Patients

...udies of CIMZIA for Crohn's disease and other investigational uses, there was one case of lymphoma among 2,657 CIMZIA-treated patients and one case of hodgkin lymphoma among 1,319 placebo-treated patients. In CIMZIA RA clinical trials (placebo-controlled and open label) a total of three cases of lymphoma we...

New Data Suggest CIMZIA(R) (Certolizumab Pegol) Active in Treating Moderate to Severe Crohn's Patients With Fistulizing Disease

...of CIMZIA(R) for Crohn's disease and other investigational uses, there was one case of lymphoma among 2,657 CIMZIA(R)-treated patients and one case of hodgkin lymphoma among 1,319 placebo-treated patients. The potential role of TNF blocker therapy in the development of malignancies is not known. ...

Hodgkin in Biological Definition

Andrew Huxley

...siology or Medicine for his work with Alan Lloyd hodgkin on the basis of nerve " action potentials ," the ...m to be coordinated by a central nervous system . hodgkin and Huxley shared the prize that year with John C...Eccles , who was cited for research on synapses . hodgkin and Huxley's findings led the pair to hypothesize ...

Axon

... other cell. History Some of the first intracellular recordings in a nervous system were made in the late 1930's by K. Cole and H. Curtis. Alan hodgkin and Andrew Huxley also employed the squid axon (1939) and by 1952 they had obtained a full quantitative description of the ionic basis of the action p...

Biophysics

...physicists Luigi Galvani , discoverer of bioelectricity Hermann von Helmholtz , first to measure the velocity of nerve impulses Alan hodgkin & Andrew Huxley , created modern understanding of nerve impulses Georg von Bksy , research on the human ear Bernard Katz , discovered h...

Insulin

...of which was completely determined. For this he was awarded the Nobel Prize in Chemistry in 1958. In 1967, after decades of work, Dorothy Crowfoot hodgkin determined the spatial conformation of the molecule, by means of X-ray diffraction studies. She also was awarded a Nobel Prize. 1. Preproi...

Ion channel

...y , gene sequence comparison and mutagenesis . History The existence of ion channels was hypothesized by the British biophysicists Alan hodgkin and Andrew Huxley as part of their Nobel Prize -winning theory of the nerve impulse, published in 1952. Channel's existence was confirmed in the ...

Tumor

...ma lymphangioma , lymphangiosarcoma Tumors of blood cells: hematopoietic cells: leukemia lymphoid cells: non-Hodgkin lymphoma , hodgkin lymphoma Tumors of germ cells: Teratoma (mature teratoma, immature teratoma) An epithelial tumor is considered malignant if it ...