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Histone in Medical News

Mouse model highlights histone methylation as distinguishing feature for leukemia subtypes

Research using a new mouse model has led to the identification of a potential therapeutic target for a type of leukemia commonly associated with an unfavorable prognosis. The study, published by Cell Press in the November issue of the journal Cancer Cell , also validates examination of histone mo...

Cell pathway, disease linked to histone action

BIRMINGHAM, Ala. University of Alabama at Birmingham (UAB) researchers have discovered a key cell-signaling pathway that regulates cell progression and switches on front-to-back body patterning in tadpoles. Uncovering this signaling pathway will greatly assist scientists in understanding the c...

Scientists discover key event in prostate cancer progression

...sed expression of that gene correlated with progression to the hormone-independent phase. Furthermore, a chemical change an epigenetic change in a histone protein associated with that gene enabled androgen receptors to bind with and activate the gene in hormone-independent prostate cancer. Finally, the...

Michael J. Fox Foundation Awards $3.8 Million To Drive Nine Industry Partnerships For Pre-Clinical Parkinson's Drug Development

...disease Gerard Griffioen, PhD, NV reMYND, Leuven, Belgium Exploring curcumin and curcumin derivatives as putative epigenetic targets of histone deacetylase (HDAC) inhibition in Parkinson's disease Lawrence Helson, MD, Sign Path Pharma, Inc., Quakertown, Pennsylvania Assessment o...

New Report Just Published: World Multiple Myeloma Therapeutics Market Report

...s & Antimetabolites II-35 Bisphosphonates II-36 Alkylating Agents and DNA-Damaging Agents II-36 DNA-Repair Enzyme Inhibitors II-36 histone Deacetylase Inhibitor II-36 Immunomodulators II-36 Proteasome Inhibitor II-36 Tyrosine Kinase Inhibitors II-36 3. Clinical Trials and...

EnVivo to Share Results of its EVP-6124 Phase Ib/IIa Trial at The International Conference on Alzheimer's Disease

...clinical trials for cognition disorders in Alzheimer's disease and Schizophrenia. The company's other programs include an epigenetics program based on histone Deacetylase inhibition (HDACi) with EVP-0334 as the lead molecule for cognition in Alzheimer's disease which is in Phase 1 studies, and several precli...
Histone in Medical Technology

Chipscreen and HUYA Bioscience to Present Clinical Data on Novel HDAC Inhibitor at the 2009 ASCO Annual Meeting

...2, 2009, in Orlando, Florida. Chidamide/HBI-8000 is a novel benzamide class histone deacetylase (HDAC) inhibitor in development by Chipscreen and HUYA for onco...se 1 study of chidamide (CS055/HBI-8000), a novel histone deacetylase inhibitor, in patients with advanced ...

Pharmacyclics announces Global Strategic Alliance with Les Laboratoires Servier

... Pharmacyclics see the website at http://www.pharmacyclics.com ). ABOUT PCI-24781 HDAC inhibitors are a class of compounds that inhibit histone deacetylation, a process that regulates gene expression. PCI-24781 is an oral compound currently in multiple Phase I clinical trials in solid tumors a...

Pharmacyclics, Inc. Announces Closing of a Private Financing With the Principals of Pacific Biopharma Group, Ltd.

...a fruitful relationship." Pharmacyclics currently has four drugs in Phase I to Phase III clinical development for cancer. This includes a leading histone deacetylase inhibitor (PCI-24781) for multiple cancers; an inhibitor of Factor VIIa (PCI-27483) targeting pancreatic, gastric, colon and breast cancer...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

...which interferes with many of the pathophysiological mechanisms involved in cancer. Specifically, panobinostat causes an increased acetylation of both histone and non-histone proteins which are implicated in oncogenesis and thereby modulates their activity. In this way, panobinostat selectively induces the d...

S*BIO Advances JAK2 Inhibitor SB1518 into Phase 1/2 Clinical Trial in Australia for the Treatment of Chronic Idiopathic Myelofibrosis

...S*BIO has a robust proprietary pipeline including SB939, the company's lead histone deacetylase (HDAC) inhibitor, which is currently in Phase 1 trials in Singa...all molecule drugs for the treatment of cancer with leading programs around histone deacetylases (HDAC) and kinases. S*BIO's lead candidate, SB939, entered the...

Chipscreen Biosciences and HUYA Bioscience Int'l Announce Promising Preclincial and Phase I Solid Tumor/Lymphoma Data for Chidamide/HBI-8000, New HDAC Inhibitor for Cancer

...ted activity against T-lymphoma and other tumor types. The compound, known as Chidamide in China and HBI-8000 in the US, is a novel, benzamide class histone deacetylase (HDAC) inhibitor discovered by Chipscreen using a computer-aided rationale design approach. Chidamide/HBI-8000 shows promise for the treat...
Histone in Biological News

Stowers Institute's Workman Lab discovers novel histone demethylase protein complex

The Stowers Institute's Workman Lab has discovered a novel histone demethylase protein complex characterized in work published today in Molecular Cell . The Histone H3 protein is an important component of chromatin, the packing material wrapping up chromosomal DNA and preventing unwanted tra...

Oliguridylation-mediated histone mRNA decay

In the January 1st issue of G&D, Drs. Thomas Mullen and William Marzluff (UNC Chapel Hill) lend new insight into the degradation of mammalian histone mRNA. Histone mRNA is rapidly degraded at the end of S phase, but the mechanism by which this occurs has remained elusive, as metazoan histone mRNA...

Shilatifard Lab sheds light on molecular machinery required for translation of histone crosstalk

The Stowers Institutes Shilatifard Lab has published findings that shed light on the molecular machinery required for the translation of histone crosstalk, or communication between histones. Published in todays issue of Cell, Histone Crosstalk between H2B Monoubiquitination and H3 Methylation...

Linking DNA and histone methylation

In the May 15th issue of G&D, Dr. Michael Carey (UCLA's Jonsson Comprehensive Cancer Center) and colleagues lend new insight into the mechanism of epigenetic silencing of euchromatic genes. Dr. Carey emphasizes that "The study provides a new direction to understand how histone and DNA methyl...

Pushmi-pullyu of B-cell development discovered

...ts showed that these two CRCs influenced the arrangement of DNA on the tiny histone spools inside the cell nucleus and the methylation of the B-cell gene. "W... knew that the two complexes were capable of influencing the arrangement of histone spools and accessibility of different genes, but were pleasantly surprised ...

Universitat Autonoma de Barcelona researchers first to clone mice in Spain

... using standard procedures. Valproic acid is an inhibitor of the enzyme histone deacetylase, located at the cell nucleus where the DNA is found. Research carried out until now has shown that histone deacetylase inhibitors seem to contribute to an increase in levels of gene ...
Histone in Biological Technology

Repligen Reports First Quarter Fiscal Year 2010 Financial Results

...than five million adults worldwide have bipolar disorder. HDAC Inhibitors for Friedreich's Ataxia We are currently developing inhibitors of histone deacetylase enzymes (HDACs) for the treatment of inherited neurodegenerative diseases such as Friedreich's ataxia. Preclinical studies have shown tha...

EnVivo Pharmaceuticals Announces Results and Successful Completion of EVP-6124 Phase Ib/IIa Trial at the International Conference on Alzheimer's Disease

...linical trials for cognition disorders in Alzheimer's disease and Schizophrenia. The company's other programs include an epigenetics program based on histone Deacetylase inhibition (HDACi) with EVP-0334 as the lead molecule for cognition in Alzheimer's disease which is in Phase I studies, and several precli...

EnVivo Pharmaceuticals Announces Reversal of Cognitive Deficits in Alzheimer's Disease Transgenic Mouse Model With Gamma-Secretase Modulator

...clinical trials for cognition disorders in Alzheimer's disease and Schizophrenia. The company's other programs include an epigenetics program based on histone Deacetylase inhibition (HDACi) with EVP-0334 as the lead molecule for cognition in Alzheimer's disease which is in Phase 1 studies, and several precli...

Data Presented at Society of Nuclear Medicine 2009 Annual Meeting Supports Potential of Peregrine's Cotara(R) for the Treatment of Brain Cancer

... Cotara is an experimental treatment for brain cancer that links a radioactive isotope to a targeted monoclonal antibody designed to bind to the DNA histone complex that is exposed by dead and dying cells found at the center of solid tumors. Cotara's targeting mechanism enables it to bind to the dying tum...

New MedPredict Report Reveals Top Alzheimer's Experts' Insights on Diagnostics and Treatments in Development Pipeline

...inhibitors and modulators, beta-secretase inhibitors, Tau phosphorylation inhibitors, cardiovascular agents, anti-amyloids and aggregation inhibitors, histone deacetylases (HDACs), SIRT-1, metal chelators and drugs like Dimebon, specifically designed to enhance mental function," says Berk. "They also update...

Repligen Reports Fourth Quarter and Fiscal Year 2009 Financial Results

...in the U.S. have bipolar disorder. HDAC Inhibitors for Friedreich's Ataxia and Huntington's Disease We are currently developing inhibitors of histone deacetylases (HDACs) for the treatment of inherited neurodegenerative diseases such as Friedreich's ataxia and Huntington's disease. Preclinical stud...
Histone in Biological Products

Rabbit Anti-Human Histone H3, acetyl Polyclonal Antibody, Unconjugated from Lake Placid Biologicals

Description: Antibody specific for histone H3 acetylated at any of the five N-terminal lysine residues. Rabbit polyclonal serum. Antigen: Synthetic peptide derived from histone H3 N-terminal region, mulitpliy acetylated...
Company:Lake Placid Biologicals

Rabbit Anti-Human Histone H3, phospho (Ser10 / Ser28) Polyclonal Antibody, Unconjugated from Lake Placid Biologicals

Description: Antibody specific for phosphorylattion of histone H3 that occurs during mitosis. Rabbit polyclonal serum. Antigen: Synthetic peptides derived from histone H3, phosphorylated at serines 10 or 28...
Company:Lake Placid Biologicals

Mouse Anti-Human Histone H3, trimethyl (Lys27) Monoclonal Antibody, Unconjugated from Lake Placid Biologicals

Description: Antibody specific for trimethyl-Lys27 of histone H3. Mouse monoclonal. Antigen: Synthetic peptide derived from histone H3, trimethylated at lysine 27...
Company:Lake Placid Biologicals

Rabbit Anti-Human acetyl-Histone H3 (Lys 4) Antibody, Unconjugated from Upstate

Description:... 4) Immunogen: KLH-conjugated, synthetic peptide containing the sequence ...RT[ Ac K]Q... in which [ Ac K] corresponds to acetyl lysine 4 of human histone H3 Accession Number: NM_003493 Molecular Weight: Mr ~17kDa Quality Assurance: Routinely evaluated by immunoblot....
Company:Upstate

Rabbit Anti-LSD1 / BHC110 Antibody, Unconjugated from Upstate

Description:...nogen KLH-conjugated, synthetic peptide corresponding to amino acids 47-66 (PAEV-GPGAVGERTPRKKEPP) of human BRAF-HDAC complex protein/Lysine-specific histone demethylase 1 (BHC110/LSD1). Quality Assurance Routinely evaluated by immunoblot. Stability 2 years at -20°C from date of shipment...
Company:Upstate

Rabbit Anti-Histone H2A Polyclonal Antibody, Unconjugated from BioVision

Description:... histone H2A Polyclonal Antibody 100 ug affinity purified rabbit polyclonal antibody. Detects ~14 kDa histone H2A. It does not cross-react with other Histones. Reacts with human/mouse/r...
Company:BioVision

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Histone in Biological Definition

Histone

In biology, histones are the chief proteins of chromatin . They act as spools around which DNA winds and they play a role in gene regulation . Histones are found in the nuclei of eukaryotic cells . Bacteria do not have histones, but histones are found in certain Archaea, namely Euryar...

Barr body

...act state of the Barr body. These changes include histone modifications, such as histone H3 methylation and histone H2A ubiquitylation , as well as direct modificatio...

Centromere

...mitosis. The centromeric DNA is normally in a heterochromatin state, which is probably essential for its function. In this chromatin, the normal histone H3 is replaced with CENP-A, a centromere-specific variant. The presence of CENP-A is believed to be important for the assembly of the kinetochore on...

Chromatin

...rm of double-stranded DNA. The major proteins involved in chromatin are histone proteins . In a eukaryotic cell , nearly all DNA is found compacted i...e form of double-stranded DNA. The major proteins involved in chromatin are histone proteins. In a eukaryotic cell, nearly all DNA is found compacted in chroma...

Gene

...A strands. The DNA strand may also be silenced through DNA methylation or by chemical changes to the protein components of chromosomes (see histone ). This is a permanent form of regulation of the transcription. The RNA is often edited before its translation into a protein. Eukaryotic cell...

Nucleosome

...damental repeating subunit of eukayotic DNA , and is made up of DNA and histone proteins. It is found in the cell nucleus in eukaryotes . All chromati...o exist as a zig-zag structure in vivo) with a packing ratio of ~40. The H1 histone stabilizes this structure. Beyond 30 nm fiber the structure of chromatin is...
Histone in Biological Dictionary

Histone

Nonpolar interactions between the histone and deoxyribose sugars on DNA ... For an example of histone modifications in transcription regulation see RNA ... histone ( ) n. Any of several small, basic proteins most commonly found in association with the DNA ... between the histone...

Untranslated region

... untranslated region of SPR of. patient's DNA. ... Key role of the 3' untranslated region in the cell cycle regulated expression of ... histone H2A genes: minor synergistic effect of the 5' untranslated region ... ... based predictions of secondary structure of the 3' untranslated ...

Ribosomal DNA genes

... gene on this clone contains repetitive DNA . ... SFL ORG. NEWS CENTER. Covering SPACE, SCIENCE, AVIATION, and TECHNOLOGY ... player in both histone deacetylation and DNA methylation of ribosomal RNA genes . ... ... Instability in the Ribosomal DNA Gene Cluster of Saccharomyces cer...

Phosphorylation

...p; Nuclear Signaling abwire — the ... phosphorylation , has led to the histone code hypothesis', in ... example, histone H3 phosphorylation levels are increased in ... A phosphorylation might...

Nucleosome

...:0034728 : nucleosome organization [273 gene products] ... A second histone (H1 in the illustration) fastens the DNA to the nucleosome core. ... Nucleosomes are usually packed together, with the aid of a histone (H1,) to form ... Nucleosome summary with 9 pages of encyclopedia ent...

Nuclein

...s the man who discovered DNA, in 1869. ... He referred to it as ' nuclein ' because it had come from the nucleus. ... see a biologist a. RNA b. histone c. nuclein d. lipid Nuclein - Definition of Nuclein at Dictionary.com a free online dictionary with ... nuclein nu·cle·in (n&oomacr;'k...
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