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Heriditary dental disorders

Scientists from NIDCR have created an animal model that mimics two human hereditary dental defects-dentinogenesis imperfecta type II and dentin dysplasia. Dr. Ashok Kulkarni and his colleagues genetically// engineered mice that make extra amounts of TGF-b1 (transforming growth factor beta-1) in their teeth. The animals were born with no apparent defects, but at two weeks their teeth became discol...
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