Critical link in cell death pathway revealed
..." Professor Strasser said.
"But in so-called type II cells, which include hepatocytes
(liver cells) and pancreatic β-cells (the cells that produce insulin),...ces XIAP is turned off or if the XIAP protein is pharmacologically blocked, hepatocytes
or pancreatic β-cells (both type II cells) will die in a type I manner...
Mass. General-based research center will investigate why immune system fails to control hepatitis C
...s of treating hepatitis C and possibly other chronic viral infections." Chung will lead a project to better define the role of the liver cells called hepatocytes
in the innate and adaptive immune response to HCV infection.
Center co-director Paul Klenerman, PhD, of Oxford University will examine properties ...
Pharmasset Initiates Phase 1b Multiple Ascending Dose Clinical Trial of PSI-7851 in Chronic Hepatitis C Patients
...any mitochondrial or other cellular toxicities that may be associated with some nucleoside analogs. The half-life of the triphosphate in primary human hepatocytes
is approximately 38 hours, which suggests the possibility for once-daily dosing. Like R7128, PSI-7851 has demonstrated in vitro activity against all...
Transplanted liver cells function in older animals but do not proliferate as much as in younger ones
...possible mechanism for the failure of transplanted hepatocytes
to proliferate in many human patients and the fir...vestigative Pathology.
The researchers isolated hepatocytes
from both four week old rats (the equivalent age o...originated from the transplant.
Repopulation of hepatocytes
was 20 percent in young rats, whether the cells ca...
Long-term L-carnitine supplementation prevents development of liver cancer
... the activities of liver enzymes as well as massive degenerative changes and evidence of pre-neoplastic lesions in liver tissues including clusters of hepatocytes
with atypia and an increased proliferative rate, diffuse bridging fibrosis and nodule formation, bile ducts with marked reactive atypia showing nuclea...
Stem Cell Innovations' C3A Human Liver Cell Line is Capable of Producing Biosimilar Serum Proteins for Follow-On Biologics
...able to the natural liver cell. We already have the capability for large scale culture of the C3A cell line and expect that our PluriCell(TM) derived hepatocytes
will have similar production capabilities. In addition, the C3A line provides an excellent host for the production of recombinant proteins due to the...
Sleep disordered breathing and obesity: Independent effects, causes
...ngly, of the patients whose liver tissue was analyzed, those who were observed to have severe nocturnal hypoxemia also exhibited "ballooning" of their hepatocytes
and a pericellular fibrosis of the liver, indicating liver injury.
"We demonstrated that the severity of nocturnal oxyhemoglobin desaturation predi...
A rigorous method for liver biopsy
... liver biopsy sections with a machine called "Metriser" which, at a speed of 0.1 mm2/s, automatically measures the residual hepatocyte mass (including hepatocytes
vacuolisation), inflammation, fibrosis and the loss of liver tissue tectonics.
In the absence of any other means of obtaining correct reproducible ...
Does HBV infection induce acute cellular DNA damage?
...roenterology addresses this question. This research group was leaded by Dr Hui Zhong from Beijing Institute of Biotechnology, China.
Using HL7702 hepatocytes
with HBV-positive serum as material, they evaluate protein expression levels in HBV infected cells or in non-infected cells; immunofluorescence to sho...
How does insulin influence resistin?
The result showed resistin induces cellular insulin resistance in H4IIE hepatocytes
and L6 rat myoblasts. Serum resistin negatively correlates to insulin sensi...tivity, so insulin is not the major regulator of resistin. Resistin induced hepatocytes
insulin resistance takes part in diet induced insulin resistance.
Hepatocytes in Medical Technology
Hepatocytes in Medical Products
CRP, Ultra-Sensitive ELISA Test
Description:...processes. CRP is produced by the liver and is normally present at very low levels. Following acute trauma or infection, CRP is rapidly synthesized by hepatocytes
in response to cytokines released into circulation by activated leukocytes. This acute inflammation-dependent response can lead to a 1000-fold or grea...
Company:Diagnostic Systems Laboratories, Inc.
Hepatocytes in Medical Dictionary
... 1 antitrypsin is made in the liver which releases it into the ... Alpha 1 antitrypsin (AAT) is a glycoprotein synthesized primarily by hepatocytes
... Because alpha 1 antitrypsin is an acute phase reactant, serum levels may be ... ...
Hepatocytes in Biological News
New culture method for hepatitis C virus uses primary hepatocytes and patient serum
Researchers open the way for improved study of hepatitis C virus by devising a novel virus culture system that allows replication of patient-isolated virus in nontransformed hepatocytes, instead of culture-adapted virus strains in transformed cell lines. The related report by Lázaro et al, "Hepati...
Model tissue system reveals cellular communication via amino acids
...cribe the development of a three-dimensional model of liver tissue in which hepatocytes
(liver cells) are embedded in a layer of collagen and covered with a layer ...oline was secreted by the endothelial layer of the liver model, taken up by hepatocytes
and used to synthesize new collagen, leading to faster recovery of hepatocy...
Studies on imaging and tracking transplanted cells
... useable imaging and tracking data.
Bioluminescent imaging of human fetal hepatocytes
In a study conducted by Dr. Mark A. Zern and colleagues at the Transplan...se of bioluminescent imaging to track transplanted immortalized human fetal hepatocytes
injected into mice was evaluated. According to the researchers, it was esse...
It is important to demonstrate the influence of the microenvironment in the process of metastasis
...argets to combat it.
To this end, liver cells - hepatocytes
and myofibroblasts - are isolated, and both cultur... produce in each case and compare it with both the hepatocytes
More than 44,000 genes
T...roup of genes is regulated in the same way by both hepatocytes
and myofibroblasts, but there are other groups tha...
New chimeric mouse model for human liver diseases, drug testing
...anded cells is to populate mouse livers with human hepatocytes
in the hope of creating a natural environment, whi...simple system that allows them to transplant human hepatocytes
into immunodeficient mice, which can now be used t...r in the Laboratory of Genetics, but mouse and rat hepatocytes
may function in very different ways when it comes ...
Soft-cell approach cuts animal tests
... using animals. For example, when assessing the toxicity of formaldehyde, which is known to have a toxic effect on the liver, liver type cells such as hepatocytes
can be chosen.
The in vitro technique is cheap and portable, so scientists can measure immediate toxicity events, rather than waiting for toxici...
Interaction between lymph and liver cells may affect immune response
...s), liver sinusoidal endothelial cells (LSECs) and hepatocytes
(liver cells) using electron microscopy. LSECs are...n order to cross the endothelial barrier, and that hepatocytes
can function as APCs. In fact, this T cell activat...mphocytes are capable of directly interacting with hepatocytes
contradicts the dogma that naïve T cells cannot ga...
Cycles of cell death, proliferation key to liver cancer
...es was the finding that while NF-ƒÛB activation in hepatocytes
(liver cells) prevents liver cancer, its activatio...tudied what precedes inflammation ¡V the injury of hepatocytes
caused by toxic chemicals, which sets in motion th...Their research showed that the absence of IKKƒÒ in hepatocytes
led to increased c-Jun N-terminal kinase (JNK) act...
Evolutionary conservation of a mechanism of longevity from worms to mammals
...in lifespan in three different genetic backgrounds tested. Moreover, when the livers of these mice where analyzed, the authors found that a subset of hepatocytes
exhibited loss of heterozygosity (effectively becoming mclk1-/- cells) and had undergone clonal expansion. The authors suggest that these mclk null c...
Gene therapy advance treats hemophilia in mouse models
...ind a way to get these cells to make more of it. In effect, we're using the hepatocytes
as a factory to make this protein and secrete it into the bloodstream."
To better target the hepatocytes
in the mice, the team took the disabled protein coat from the baculovirus A...
Hepatocytes in Biological Technology
Celsis Outlines the Top Five Advantages of Cryo-plateable Hepatocytes
Harness the Dual Benefits of Freshly Isolated Plateability and the Efficiencies of Cryopreservation
CHICAGO, June 16 /PRNewswire/ -- In today's competitive environment and economic climate, the financial implications of being the first to file a promising new drug compound or chemical ...
Celsis In Vitro Technologies and Promega to Offer Fast, Reliable Solutions for ADME-Tox Testing With Primary Hepatocytes
BALTIMORE, Feb. 9 /PRNewswire/ -- Celsis In Vitro Technologies (Celsis
IVT), a division of Celsis International plc, a Chicago-based life science
products and laboratory services company, and Wisconsin-based Promega Corp
will take the trial and guesswork out of ADME-Tox testing in primary
Stem Cell Innovations' PluriCells(TM) to Form the Basis of a Liver Assist Device to Support Patients Waiting for Transplant.
...O of Stem Cell Innovations, Inc. (OTC Pink Sheets: SCLL).
This second generation device, based on the PluriCells, "combines the safety of primary hepatocytes
(normal liver cells) with the standardization of a cell line," continued Kelly. "We're building on what we learned from our earlier device which util...
GenOdyssee Receives Broad Product Applications Protection in EU for Founding Natural Evolution Technology
to treat, as well as in patients infected with HCV genotype 3 because of
the following properties:
- Stronger anti-HCV activity in fresh human hepatocytes
infected with HCV type 3 (genotype 3a) virus, in which GEA007.1 reduced HCV RNA to levels 3-4 fold lower than IFN alpha 2 drugs.
- Stronger anti-H...
The measurement of DNA condensation and mitochondrial changes during apoptosis and necrosis in cell based assays
...s in nuclear and mitochondrial status. Primary rat hepatocytes
are exposed to staurosporine or diclofenac for 4- ... Plate out one set of freshly isolated primary rat hepatocytes
in growth media containing 0 µM, 50 µM...
2. Plate out a second set of primary rat hepatocytes
in 200 ml growth media for 21 h prior to dosing wi...
Detection of antibody-stained cell
surface and intracellular protein targets
with the Agilent 2100 bioanalyzer
glucocorticoid receptor (GR) staining of H4 rat hepatocytes
performed. Histogram quality and the percen...ular glucocorticoid receptor
(GR) staining of H4 hepatocytes
For intracellular detection of GR
proteins H4 rat hepatocytes
harvested and washed. The cells
An Optimal DNA Microarray Substrate for the Identification of Fetal
and Somatic Liver Stem Cells of the Rat
In our project, fetal hepatocytes
of the rat should undergo the most
exte...veloped for the identification
of fetal hepatocytes
will be used. The CreativeChip 3D Slides (Eppendor... methods
were cultivated under various conditions. The cult...
Hepatocytes in Biological Products
Hepatocytes in Biological Definition
...l hypertension , the umbilical vein can open up again.
The various functions of the liver are carried out by the liver cells or hepatocytes
The liver produces and excretes bile required for food digestion. Some of the bile drains directly into the duodenum , and some is stored in...
Hepatocytes in Biological Dictionary
make up 70-80% of the cytoplasmic mass of the liver. These cells are involved in protein synthesis, protein storage and transformation of carbohydrates, synthesis of cholesterol, bile salts and phospholipids, and... hepatocyte n. A parenchymal cell of the liver. ... His...
...t nucleoli may also play a crucial role ... Aquaculture: Image analysis used to measure morphometric characteristics of nuclei and nucleoli of hepatocytes
from pejerrey fish U6 snRNA transiently localizes to nucleoli (Lange and Gerbi, 2000) where it ... Nucleoli can be distinguished from other no...
...ictionary. Meaning of lobule . ... Branches within the primary lobule give rise to alveolar ducts, ... lobule usage ... Within each lobule , hepatocytes
are arranged into hepatic cords separated by ... The Liver Lobule , from Blue Histology (Copyright Lutz Slomianka 1998-2004) ... Comments, Boggs ...
...ning and complementation. DNA sequence ... Cotransduction frequency may be converted to physical distance by using the ... Cotransduction of hepatocytes
by AAV-2 and AAV-5 vectors demonstrates overlap in ... experiment and from the cotransduction experiment outlined above (Fig. 3A ... At the fo...
... Bile or gall is a bitter yellow, blue and green fluid secreted by hepatocytes
from the liver of most vertebrates. In many species, bile is stored in the gallbladder between meals and upon eating is discharged into the... ...