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Hepatocytes in Medical News

Critical link in cell death pathway revealed

..." Professor Strasser said. "But in so-called type II cells, which include hepatocytes (liver cells) and pancreatic β-cells (the cells that produce insulin),...ces XIAP is turned off or if the XIAP protein is pharmacologically blocked, hepatocytes or pancreatic β-cells (both type II cells) will die in a type I manner...

Mass. General-based research center will investigate why immune system fails to control hepatitis C

...s of treating hepatitis C and possibly other chronic viral infections." Chung will lead a project to better define the role of the liver cells called hepatocytes in the innate and adaptive immune response to HCV infection. Center co-director Paul Klenerman, PhD, of Oxford University will examine properties ...

Pharmasset Initiates Phase 1b Multiple Ascending Dose Clinical Trial of PSI-7851 in Chronic Hepatitis C Patients

...any mitochondrial or other cellular toxicities that may be associated with some nucleoside analogs. The half-life of the triphosphate in primary human hepatocytes is approximately 38 hours, which suggests the possibility for once-daily dosing. Like R7128, PSI-7851 has demonstrated in vitro activity against all...

Transplanted liver cells function in older animals but do not proliferate as much as in younger ones

...possible mechanism for the failure of transplanted hepatocytes to proliferate in many human patients and the fir...vestigative Pathology. The researchers isolated hepatocytes from both four week old rats (the equivalent age o...originated from the transplant. Repopulation of hepatocytes was 20 percent in young rats, whether the cells ca...

Long-term L-carnitine supplementation prevents development of liver cancer

... the activities of liver enzymes as well as massive degenerative changes and evidence of pre-neoplastic lesions in liver tissues including clusters of hepatocytes with atypia and an increased proliferative rate, diffuse bridging fibrosis and nodule formation, bile ducts with marked reactive atypia showing nuclea...

Stem Cell Innovations' C3A Human Liver Cell Line is Capable of Producing Biosimilar Serum Proteins for Follow-On Biologics

...able to the natural liver cell. We already have the capability for large scale culture of the C3A cell line and expect that our PluriCell(TM) derived hepatocytes will have similar production capabilities. In addition, the C3A line provides an excellent host for the production of recombinant proteins due to the...

Sleep disordered breathing and obesity: Independent effects, causes

...ngly, of the patients whose liver tissue was analyzed, those who were observed to have severe nocturnal hypoxemia also exhibited "ballooning" of their hepatocytes and a pericellular fibrosis of the liver, indicating liver injury. "We demonstrated that the severity of nocturnal oxyhemoglobin desaturation predi...

A rigorous method for liver biopsy

... liver biopsy sections with a machine called "Metriser" which, at a speed of 0.1 mm2/s, automatically measures the residual hepatocyte mass (including hepatocytes vacuolisation), inflammation, fibrosis and the loss of liver tissue tectonics. In the absence of any other means of obtaining correct reproducible ...

Does HBV infection induce acute cellular DNA damage?

...roenterology addresses this question. This research group was leaded by Dr Hui Zhong from Beijing Institute of Biotechnology, China. Using HL7702 hepatocytes with HBV-positive serum as material, they evaluate protein expression levels in HBV infected cells or in non-infected cells; immunofluorescence to sho...

How does insulin influence resistin?

... The result showed resistin induces cellular insulin resistance in H4IIE hepatocytes and L6 rat myoblasts. Serum resistin negatively correlates to insulin sensi...tivity, so insulin is not the major regulator of resistin. Resistin induced hepatocytes insulin resistance takes part in diet induced insulin resistance. ...
Hepatocytes in Medical Technology

Pharmasset Initiates First Time in Human Study of PSI-7851 for the Treatment of Hepatitis C (HCV)

...any mitochondrial or other cellular toxicities that may be associated with some nucleoside analogs. The half-life of the triphosphate in primary human hepatocytes is approximately 38 hours, which suggests the possibility for once-daily dosing. Like R7128, PSI-7851 has demonstrated in vitro activity against all...

Pharmasset Nominates PSI-7851 as a Lead Development Candidate for the Treatment of Chronic Hepatitis C

...any mitochondrial or other cellular toxicities that may be associated with some nucleoside analogs. The half-life of the triphosphate in primary human hepatocytes is approximately 38 hours, which suggests the possibility for once-daily dosing. Early animal studies indicate that PSI-7851 can achieve concentration...
Hepatocytes in Medical Products

CRP, Ultra-Sensitive ELISA Test

Description:...processes. CRP is produced by the liver and is normally present at very low levels. Following acute trauma or infection, CRP is rapidly synthesized by hepatocytes in response to cytokines released into circulation by activated leukocytes. This acute inflammation-dependent response can lead to a 1000-fold or grea...
Company:Diagnostic Systems Laboratories, Inc.
Hepatocytes in Medical Dictionary

Alpha-1 antitrypsin

... 1 antitrypsin is made in the liver which releases it into the ... Alpha 1 antitrypsin (AAT) is a glycoprotein synthesized primarily by hepatocytes ... Because alpha 1 antitrypsin is an acute phase reactant, serum levels may be ... ...
Hepatocytes in Biological News

New culture method for hepatitis C virus uses primary hepatocytes and patient serum

Researchers open the way for improved study of hepatitis C virus by devising a novel virus culture system that allows replication of patient-isolated virus in nontransformed hepatocytes, instead of culture-adapted virus strains in transformed cell lines. The related report by Lázaro et al, "Hepati...

Model tissue system reveals cellular communication via amino acids

...cribe the development of a three-dimensional model of liver tissue in which hepatocytes (liver cells) are embedded in a layer of collagen and covered with a layer ...oline was secreted by the endothelial layer of the liver model, taken up by hepatocytes and used to synthesize new collagen, leading to faster recovery of hepatocy...

Studies on imaging and tracking transplanted cells

... useable imaging and tracking data. Bioluminescent imaging of human fetal hepatocytes In a study conducted by Dr. Mark A. Zern and colleagues at the Transplan...se of bioluminescent imaging to track transplanted immortalized human fetal hepatocytes injected into mice was evaluated. According to the researchers, it was esse...

It is important to demonstrate the influence of the microenvironment in the process of metastasis

...argets to combat it. To this end, liver cells - hepatocytes and myofibroblasts - are isolated, and both cultur... produce in each case and compare it with both the hepatocytes and myofibroblasts. More than 44,000 genes T...roup of genes is regulated in the same way by both hepatocytes and myofibroblasts, but there are other groups tha...

New chimeric mouse model for human liver diseases, drug testing

...anded cells is to populate mouse livers with human hepatocytes in the hope of creating a natural environment, whi...simple system that allows them to transplant human hepatocytes into immunodeficient mice, which can now be used t...r in the Laboratory of Genetics, but mouse and rat hepatocytes may function in very different ways when it comes ...

Soft-cell approach cuts animal tests

... using animals. For example, when assessing the toxicity of formaldehyde, which is known to have a toxic effect on the liver, liver type cells such as hepatocytes can be chosen. The in vitro technique is cheap and portable, so scientists can measure immediate toxicity events, rather than waiting for toxici...

Interaction between lymph and liver cells may affect immune response

...s), liver sinusoidal endothelial cells (LSECs) and hepatocytes (liver cells) using electron microscopy. LSECs are...n order to cross the endothelial barrier, and that hepatocytes can function as APCs. In fact, this T cell activat...mphocytes are capable of directly interacting with hepatocytes contradicts the dogma that naïve T cells cannot ga...

Cycles of cell death, proliferation key to liver cancer

...es was the finding that while NF-ƒÛB activation in hepatocytes (liver cells) prevents liver cancer, its activatio...tudied what precedes inflammation ¡V the injury of hepatocytes caused by toxic chemicals, which sets in motion th...Their research showed that the absence of IKKƒÒ in hepatocytes led to increased c-Jun N-terminal kinase (JNK) act...

Evolutionary conservation of a mechanism of longevity from worms to mammals

...in lifespan in three different genetic backgrounds tested. Moreover, when the livers of these mice where analyzed, the authors found that a subset of hepatocytes exhibited loss of heterozygosity (effectively becoming mclk1-/- cells) and had undergone clonal expansion. The authors suggest that these mclk null c...

Gene therapy advance treats hemophilia in mouse models

...ind a way to get these cells to make more of it. In effect, we're using the hepatocytes as a factory to make this protein and secrete it into the bloodstream." To better target the hepatocytes in the mice, the team took the disabled protein coat from the baculovirus A...
Hepatocytes in Biological Technology

Celsis Outlines the Top Five Advantages of Cryo-plateable Hepatocytes

Harness the Dual Benefits of Freshly Isolated Plateability and the Efficiencies of Cryopreservation CHICAGO, June 16 /PRNewswire/ -- In today's competitive environment and economic climate, the financial implications of being the first to file a promising new drug compound or chemical ...

Celsis In Vitro Technologies and Promega to Offer Fast, Reliable Solutions for ADME-Tox Testing With Primary Hepatocytes

BALTIMORE, Feb. 9 /PRNewswire/ -- Celsis In Vitro Technologies (Celsis IVT), a division of Celsis International plc, a Chicago-based life science products and laboratory services company, and Wisconsin-based Promega Corp will take the trial and guesswork out of ADME-Tox testing in primary hepa...

Stem Cell Innovations' PluriCells(TM) to Form the Basis of a Liver Assist Device to Support Patients Waiting for Transplant.

...O of Stem Cell Innovations, Inc. (OTC Pink Sheets: SCLL). This second generation device, based on the PluriCells, "combines the safety of primary hepatocytes (normal liver cells) with the standardization of a cell line," continued Kelly. "We're building on what we learned from our earlier device which util...

GenOdyssee Receives Broad Product Applications Protection in EU for Founding Natural Evolution Technology

...ult to treat, as well as in patients infected with HCV genotype 3 because of the following properties: - Stronger anti-HCV activity in fresh human hepatocytes infected with HCV type 3 (genotype 3a) virus, in which GEA007.1 reduced HCV RNA to levels 3-4 fold lower than IFN alpha 2 drugs. - Stronger anti-H...

The measurement of DNA condensation and mitochondrial changes during apoptosis and necrosis in cell based assays

...s in nuclear and mitochondrial status. Primary rat hepatocytes are exposed to staurosporine or diclofenac for 4- ... Plate out one set of freshly isolated primary rat hepatocytes in growth media containing 0 µM, 50 µM... 2. Plate out a second set of primary rat hepatocytes in 200 ml growth media for 21 h prior to dosing wi...

Detection of antibody-stained cell surface and intracellular protein targets with the Agilent 2100 bioanalyzer

... glucocorticoid receptor (GR) staining of H4 rat hepatocytes were performed. Histogram quality and the percen...ular glucocorticoid receptor (GR) staining of H4 hepatocytes For intracellular detection of GR proteins H4 rat hepatocytes were harvested and washed. The cells were firs...

An Optimal DNA Microarray Substrate for the Identification of Fetal and Somatic Liver Stem Cells of the Rat

.... Goal In our project, fetal hepatocytes of the rat should undergo the most exte...veloped for the identification of fetal hepatocytes will be used. The CreativeChip 3D Slides (Eppendor... methods Cell culture Fetal hepatocytes were cultivated under various conditions. The cult...
Hepatocytes in Biological Products

Matrigel Matrix 100 mm Culture Dishes for Hepatocytes from BD Biosciences - Discovery Labware

Description: BD BioCoat BD MatrigelTM Matrix 100 mm Culture Dishes for hepatocytes, tissue-culture treated polystyrene with a uniform application of MATRIGEL Matrix....
Company:BD Biosciences - Discovery Labware

RH (R780-30) from European Collection of Cell Cultures (ECACC)

Description:... Rat hepatocytes (RH) (>3,000,000 cells)...
Company:European Collection of Cell Cultures (ECACC)
Hepatocytes in Biological Definition

Liver

...l hypertension , the umbilical vein can open up again. Physiology The various functions of the liver are carried out by the liver cells or hepatocytes . The liver produces and excretes bile required for food digestion. Some of the bile drains directly into the duodenum , and some is stored in...
Hepatocytes in Biological Dictionary

Hepatocytes

Hepatocytes make up 70-80% of the cytoplasmic mass of the liver. These cells are involved in protein synthesis, protein storage and transformation of carbohydrates, synthesis of cholesterol, bile salts and phospholipids, and... hepatocyte n. A parenchymal cell of the liver. ... His...

Nucleoli

...t nucleoli may also play a crucial role ... Aquaculture: Image analysis used to measure morphometric characteristics of nuclei and nucleoli of hepatocytes from pejerrey fish U6 snRNA transiently localizes to nucleoli (Lange and Gerbi, 2000) where it ... Nucleoli can be distinguished from other no...

Lobule

...ictionary. Meaning of lobule . ... Branches within the primary lobule give rise to alveolar ducts, ... lobule usage ... Within each lobule , hepatocytes are arranged into hepatic cords separated by ... The Liver Lobule , from Blue Histology (Copyright Lutz Slomianka 1998-2004) ... Comments, Boggs ...

Cotransduction

...ning and complementation. DNA sequence ... Cotransduction frequency may be converted to physical distance by using the ... Cotransduction of hepatocytes by AAV-2 and AAV-5 vectors demonstrates overlap in ... experiment and from the cotransduction experiment outlined above (Fig. 3A ... At the fo...

Bile

... Bile or gall is a bitter yellow, blue and green fluid secreted by hepatocytes from the liver of most vertebrates. In many species, bile is stored in the gallbladder between meals and upon eating is discharged into the... ...
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