Hepatocyte

Green Tea Component May Slow Prostate Cancer

...surgery. The phase 2 study found "significant" reductions in the men's serum levels of markers predictive of prostate cancer progression, including hepatocyte growth factor, vascular endothelial growth factor and prostate specific antigen. In some men, reductions in levels of these markers were greater than ...

Transplanted liver cells function in older animals but do not proliferate as much as in younger ones

... waste products and worn-out cells from the blood. hepatocyte transplantation has been successful in a number of...an 35 weeks). After six weeks, the amount of hepatocyte proliferation was determined by an assay of CD26 e...eatment would increase the proliferation levels of hepatocyte cells. ...

Cathepsin B increases apoptosis in fulminant hepatic failure

... The traditional view is that hepatocyte necrosis is the main feature of fulminant hepatic ...increasing evidence implicates a dominant role for hepatocyte apoptosis in this pathogenesis. It is not known if cathepsin B-mediated hepatocyte apoptosis is involved in the pathogenesis of fulmi...

A rigorous method for liver biopsy

...titative analysis method of liver biopsy sections with a machine called "Metriser" which, at a speed of 0.1 mm2/s, automatically measures the residual hepatocyte mass (including hepatocytes vacuolisation), inflammation, fibrosis and the loss of liver tissue tectonics. In the absence of any other means of obt...

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

...e Ames bacterial mutagenicity assay, a Chinese hamster ovary (CHO) chromosome aberration assay, an in vitro cytogenetics assay in CHO, an in vitro rat hepatocyte DNA alkaline elution assay, and an in vivo micronucleus assay. rat fertility studies with oral gavage doses of 125, 250, and 1000mg/kg, males w...

A potential approach to treatment of hepatitis B virus infection

...pression by p21 transfection or proteasome inhibition would lead to suppressed HBV replication. They set up a chronic HBV infection model by culturing hepatocyte HL7702 cells with HBV-positive serum without washing off input virus as conventional. HBV DNA titers inside the infected cells represent the final vir...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

...ein NMB; B-lymphocyte stimulator (BLyS); gonadotropin-releasing hormone (GnRH); GnRHr; growth differentiation factor (GDF); hedgehog (Hh); heparanase; hepatocyte growth factor/scatter factor (HGF/SF); highly upregulated in liver cancer (HULC); human chorionic gonadotropin (hCG); hyaluronan (HA); hypoxia inducib...

Noninvasive ways to assess liver disease

...e overestimate the real stage of fibrosis and may erroneously suggest the presence of liver cirrhosis, the authors report. The stiffness may relate to hepatocyte swelling, cholestasis, or infiltrates of inflammatory cells in the inflamed liver, they suggest. FS results need to be interpreted with caution in ...

A promising new approach to cadmium induced hepatoxicity: Cytoprotective effect of midkine

...pment and application of new therapeutic regimens. In research conducted in hepatocyte cell culture, cadmium exposure causes dose and time dependent damage in liv...tion. In this study it was found that exogenous midkine application induces hepatocyte proliferation. Midkine treatment prevented apoptosis, lactate dehydrogenase...

An emerging candidate for protecting patients from liver injury after abdomen surgery

...te chemotactic protein-1 (MCP-1). After careful evaluation, the researchers concluded R1 prevents I/R-induced hepatic microcirculation disturbance and hepatocyte injury by inhibition of leukocyte rolling and adhesion, through depressing the expression of E-selectin in endothelium and CD18 in neutrophils. This r...

Hepatocyte in Medical Technology

Vital Therapies Announces Presentation of ELAD(R) 'Artificial Liver' Data at American Association for the Study of Liver Diseases 2007 Annual Meeting

...ood pumping system at the patient's bedside and enable continuous treatment for up to 12 days. The key to ELAD's(R) performance is a proprietary human hepatocyte cell line that can be grown, stored and shipped worldwide. About Vital Therapies. Inc. Vital Therapies, Inc. is a private San Diego-based liver ther...

Vical Reports Second Quarter 2007 Financial Results, Allowance of Pandemic Influenza IND and Other Advances in Product Development Programs

... Inc. (AnGes), reported positive results following an interim efficacy evaluation in its Japanese Phase 3 angiogenesis trial of its gene-based hepatocyte Growth Factor (HGF) product candidate in patients with advanced peripheral arterial disease (PAD). Based on the recommendation of an Independe...

BioMarin Partner AnGes MG, Inc. Submits BLA to Japanese Ministry of Health

...hers of Osaka University. The company specializes in research, development and practical application of genetic medicine. Current programs include the hepatocyte Growth Factor (HGF) genetic medicine which improves blood circulation by regenerating blood vessels, and an NFkB decoy that controls various types of ...

Research Documents Scalable Production, Survival Following Engraftment and Positive Impact on Cardiac Function in Infarcted Rats for Geron's Human Embryonic Stem Cell-Based Therapeutic for Heart Failure

...identity of spinal cord oligodendroglial progenitors. Moreover, studies showed that GRNOPC1 secretes specific neurotrophic factors, including midkine, hepatocyte growth factor, activin A, transforming growth factor Beta and brain-derived neurotrophic factor. These factors induce growth of neurons and are likely...

Late Breaking Data Released at ADA Showed that the Investigational Use of Januvia and Metformin as Initial Combination Therapy Provided Significant Glucose Lowering Efficacy over 54 Weeks in Patients with Type 2 Diabetes

...Ames bacterial mutagenicity assay, a Chinese hamster ovary (CHO) chromosome aberration assay, an in vitro cytogenetics assay in CHO, an in vitro rat hepatocyte DNA alkaline elution assay, and an in vivo micronucleus assay. In rat fertility studies with oral gavage doses of 125, 250, and 1000 mg/kg, ma...

An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes

...Ames bacterial mutagenicity assay, a Chinese hamster ovary (CHO) chromosome aberration assay, an in vitro cytogenetics assay in CHO, an in vitro rat hepatocyte DNA alkaline elution assay, and an in vivo micronucleus assay. In rat fertility studies with oral gavage doses of 125, 250, and 1000 mg/kg, ma...

Hepatocyte in Medical Products

IGFBP-1, Total IRMA Test

Description:... correlated with growth hormone or glucose levels [12,13]. Subsequently, measurement of IGFBP-1 levels may be useful as a marker of insulin action and hepatocyte function for research investigations. Lee PDK, et al. Proc Soc Exp Biol Med 204:4-29, 1993. Holly JMP. Acta Endocrinol 124 (supp 2): 55-62, 1991...
Company:Diagnostic Systems Laboratories, Inc.

IGFBP-1, Total ELISA Test

Description:... correlated with growth hormone or glucose levels [12,13]. Subsequently, measurement of IGFBP-1 levels may be useful as a marker of insulin action and hepatocyte function for research investigations. Lee PDK, et al. Proc Soc Exp Biol Med 204:4-29, 1993. Holly JMP. Acta Endocrinol 124 (supp 2): 55-62, 1991...
Company:Diagnostic Systems Laboratories, Inc.

Hepatocyte in Medical Dictionary

Granulocyte

... An analysis of neutrophil granulocyte patterns in patients with chronic... Eosinophil Granulocyte . Extraglomerular Mesangial Cell. Gonadotrope. hepatocyte ... Granulocyte . Definition Return to top. Granulocytes are a type of white blood cell ... They are called granulocytes because they hav...

Hepatocyte in Biological News

Green tea may affect prostate cancer progression

...e effects of short-term supplementation with green tea's active compounds on serum biomarkers in patients with prostate cancer. The biomarkers include hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF) and prostate specific antigen (PSA). HGF and VEGF are good prognostic indicators of met...

Model tissue system reveals cellular communication via amino acids

...he extracellular matrix proteins secreted by other cell types in regulating hepatocyte behavior, but to the best of our knowledge, this is the first evidence that...atocytes and used to synthesize new collagen, leading to faster recovery of hepatocyte activity. "Identifying this amino-acid-mediated communication points to...

Blood test may help signal tumor's remission, return in throat cancer patients

...nown as Interleukin (IL)-6 and IL-8, and three growth factors known as growth-related oncogene (GRO)-1, vascular endothelial growth factor (VEGF), and hepatocyte growth factor (HGF). These cytokines and growth factors play an important role in the body’s inflammatory response and in the growth of cells and new ...

New culture method for hepatitis C virus uses primary hepatocytes and patient serum

...dicine has crossed this hurdle using a human fetal hepatocyte culture system that was previously developed in hi...rst experiments, Fausto and colleagues transfected hepatocyte cultures with HCV genomic RNA and found replicatio...ected with different HCV strains were added to the hepatocyte culture system, viral replication occurred and new...

Interaction between lymph and liver cells may affect immune response

...). There were no observable gaps between LSECs and hepatocyte microvilli did not seem to interact with circulati...he authors did not observe any interaction between hepatocyte microvilli and circulating lymphocytes, it is poss...e using electron microscopy. They suggest that the hepatocyte microvilli could function as a rapid screen for ci...

New lead reported in tumor angiogenesis

...world of science, involves a great deal of hard work - and a little luck. Wang said his group began a few years ago studying a secreted protein called hepatocyte growth factor, or HGF, and its role in helping head and neck tumors to turn cancerous. HGF does so, in part, by helping to induce nearby blood vessels...

Embryonic Stem Cells Treated With Growth Factor Reverse Hemophilia In Mice: UNC Researchers

...in the persistent production of factor IX protein that can only come from a hepatocyte (liver cell) and hemophilia reversal," said study lead author Dr. Jeffrey H...ir added. "They went from something that is a very early grandparent of the hepatocyte to becoming hepatocytes. After 115 days, nearly four months after injection...

Owl genomics presents a HEPATOCHIP for diagnosis of non-alcoholic steatohepatitis

...s. Non alcoholic steatohepatitis is a progressive disease of the liver of unknown etiology, characterized histologically by fatty acid accumulation, hepatocyte damage and inflammation resembling alcoholic hepatitis. NASH is a critical stage in the process that spans from hepatic steatosis to cirrhosis and hep...

Hepatocyte in Biological Technology

Celsis Outlines the Top Five Advantages of Cryo-plateable Hepatocytes

...researcher's discretion. Best of Both Worlds. Some cryopreserved hepatocyte preparations retain the fresh hepatocytes' ability to attach to a collagen ...reserved Hepatocytes Comparison of Fresh and Cryo Cynomolgus Monkey hepatocyte CYP P450 Levels 1 Drug Interaction Studies - Study De...

Celsis In Vitro Technologies and Promega to Offer Fast, Reliable Solutions for ADME-Tox Testing With Primary Hepatocytes

...ry in advance, Celsis IVT will help our customers save additional time in their research," he explained. "Together, we are taking the guesswork out of hepatocyte analysis." Determining whether a particular lot of hepatocytes will work for a given application is time-consuming and costly. Much of the effo...

FDA Approves EOVIST(R) to Detect and Characterize Focal Liver Lesions

...ral properties, EOVIST is partially taken up by liver cells, thus enhancing healthy liver tissue (parenchymal enhancement). Lesions with no or minimal hepatocyte function (e.g., cysts, metastases, the majority of hepatocellular carcinomas) will remain unenhanced and will therefore be more readily detected and l...

Ortho Biotech Oncology Research & Development Unites Johnson & Johnson Biopharmaceutical Oncology R&D Assets

...logical role of HGF-MET axis in tumor growth and developmentof metastasis. Fron Biooscie; 2008, 13: 1271-80. (vi) Sattler, M and Salgia R. c-Met and hepatocyte growth factor; potential as novel targets in cancer theray. Curr Oncol Rep; 2007, 9 (2) 102-8. (vii) Boccaccio C, and Comoglio, PM. Invasive growth;...

Naglazyme Approved by Japanese Ministry of Health

...hers of Osaka University. The company specializes in research, development and practical application of genetic medicine. Current programs include the hepatocyte Growth Factor (HGF) genetic medicine which improves blood circulation by regenerating blood vessels, and an NFkB decoy that controls various types of ...

Performance of Ad-A-Gene EGFP-MAPKAP-k2: an adenoviral vector gene delivery system

...e. EMBO J. 11 , 3985–3994 (1992).

10. Dhawan, P. et al . Critical role of p42/44 MAPK activation in anisomycin and hepatocyte growth factor-induced LDL receptor expression: activation of Raf1/MEK-1/p42/44 MAPK cascade alone is sufficient to induce LDL receptor expression. C...

Hepatocyte in Biological Products

BD Hepatocyte Differentiation Environment from BD Biosciences - Discovery Labware

Description: Hepatocyte Differentiation Environment...
Company:BD Biosciences - Discovery Labware

Freedom EVO 150 from Tecan

Description:...te replication Compound stability Automated assays for Absorption, Distribution, Metabolism, Excretion, Toxicity (ADMET) include: Micosome and hepatocyte metabolic stability assays Cell permeability studies Blood brain barrier permeability Skin permeability Eye irritation Compound solubility ...
Company:Tecan

Hepatocyte in Biological Dictionary

Proto-oncogene

...s of genes that when altered have been associated with the ... A proto - oncogene is a gene whose ... The proto - oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post ... The Biology of the Ets1 Pr...

Inducer

...saurus, Word of the Day, and word games. What is inducer ? Meaning of inducer medical term. What does inducer mean? ... gratuitous inducers . hepatocyte growth factor. human T-cell lymphotropic virus type I ... Data indicate that induction with The Inducer ™ has been shown to yield increased .....

Hepatocytes

...d in protein synthesis, protein storage and transformation of carbohydrates, synthesis of cholesterol, bile salts and phospholipids, and... hepatocyte n. A parenchymal cell of the liver. ... Histology at BU 22101ooa - "Ultrastructure of the Cell: hepatocytes and sinusoids" ... Hepatocytes ar...

Granulocyte

...nulocyte colony-stimulating factor levels are not increased in patients ... Eosinophil Granulocyte . Extraglomerular Mesangial Cell. Gonadotrope. hepatocyte ... Granulocyte Colony Stimulating Factor Receptor. Infantile Genetic Agranulocytosis ... ...

G2 phase

... the G2 -synchronized and G2 -arrested cells by the ... BioInfoBank Library :: G2 Phase :: physiology :: [Kinetic features of a white rat hepatocyte population under hormonal disbalance before and after partial ... Unbound MEDLINE | G2 Phase journal articles. Search by keyword, journal, au...