What is the relationship between hepatocellular carcinoma and type 2 diabetes mellitus? Hepatocellular
carcinoma (HCC) is the fifth most common malignancy worldwide and the third leading cause of cancer-related deaths. Type 2 diabetes mellitus has been associated with HCC. However, the relationship between type 2 diabetes mellitus and the underlying liver cirrhosis, and the effects o...
Future for radioembolisation in patients with advanced hepatocellular carcinoma
Copenhagen, Denmark, Friday 24 April: Radioembolisation with Yttrium-90 (Y-90) glass microspheres is a safe and effective treatment for patients with advanced HCC portal vein thrombosis, according to new research presented today at EASL 2009, the Annual Meeting of the European Association for the...
New oncogene gives valuable insight into hepatocellular tumors in humans
Copenhagen, Denmark, Thursday 23 April: The first identification of GP130 somatic activating mutations* in human tumours was announced today at EASL 2009, the Annual Meeting of the European Association for the Study of Liver Disease in Copenhagen, Denmark.
Identification of recurrent somatic m...
Liver cell adenoma or hepatocellular carcinoma?
Recently, LCAs with typical backgrounds of the patients are diagnosed by radiological findings without pathological findings due to the progress of diagnostic imaging techniques. A typical LCA shows low density or isodensity on plain computed tomography, presents a homogenous contrasting effect on...
A useful imaging modality for monitoring treatment response to hepatocellular carcinoma
TACE has been widely accepted as a choice of treatment for advanced HCC. CT perfusion is a non-invasive and reproducible technique for assessing perfusion changes due to TACE therapy for locally advanced HCC. However, there are few reports on the application of this technique in evaluating the eff...
How does Fu-Zheng-Jie-Du-Decoction act on PTEN expression in hepatocellular carcinoma?
carcinoma (HCC) patients in China may be treated with Traditional Chinese medicine (TCM). Some say it works, others doubt its effectiveness. These stated that a research group in China had found TCM can down-regulate the expression of PTEN in HCC, which may suppress tumor cell ...
A new chemotherapeutic target for hepatocellular carcinoma Hepatocellular
carcinoma (HCC) is a major health problem worldwide. Currently, the only chance for obtaining a cure in patients with HCC is by either a surgical resection or liver transplantation. However, many HCCs with scattered tumors cannot be operated on. In such patients, effective alternati...
Intra-arterial combination chemotherapy induces long-term survival for hepatocellular carcinoma
Portal venous tumor thrombus (PVTT) is a crucial factor that can worsen the prognosis of patients with hepatocellular
carcinoma (HCC). It often leads to extensive spreading of the tumor throughout the liver, and can increase portal venous blood pressure, resulting in the fatal rupture of esophagea...
A Chinese medicine compound has satisfactory anti-cancer effects on hepatocellular carcinoma
Traditional Chinese medicine is world renowned. It has supernatural effects on some diseases, but the reason is still unknown. One such article was recently reported in the November 7 issue of the World Journal of Gastroenterology dealing with the great significance of a Chinese medicinal compound...
Is RTA a new potential option for the treatment of hydatid cysts?
...laced in an organ tissue into released heat, which then causes tissue necrosis. This technique is currently used for treatment of neoplasms, primarily hepatocellular
The authors wanted to verify whether radiofrequency is able to warm and irreversibly damage hydatid cysts, causing cyst wall necrosis t...
Hepatocellular in Medical Technology
Light Sciences Oncology Completes Patient Enrollment in Phase 3 Clinical Trial of Litx as a Treatment for Hepatocellular Carcinoma
200 Patients Enrolled in Clinical Trial to Assess Survival of Patients Receiving Litx versus Standard of Care Therapies for Unresectable Hepatocellular
BELLEVUE, Wash., Nov. 25 /PRNewswire/ -- Light Sciences Oncology, Inc. (LSO) today announced the completion of enrollment in a ...
Molecular Discoveries Shed Light on Liver Cancer -- Hepatocellular Carcinoma (HCC)
Genomics improves our ability to target experimental cancer treatments A promising new drug is in hand, and more are on the way Improved ability to select patients to test particular drugs
MILAN, Italy, April 27 /PRNewswire/ --
At today's sessions of this, the final day of the 4...
Afinitor(R) Phase II Data Show Positive Results for Patients With Multiple Types of Lymphoma, Leading to Phase III Trial
... agencies globally for the treatment of advanced kidney cancer. Afinitor is being studied in multiple cancer types, including NET, breast, gastric and hepatocellular
carcinoma (HCC), as well as tuberous sclerosis complex (TSC) and NHL.
The active ingredient in Afinitor is everolimus, which is available in dif...
Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types
...ase I data (abstract #4587) demonstrated that 61% of patients with advanced hepatocellular
carcinoma (HCC) who received daily treatment with Afinitor(R) (everolimus) ...ic (PK) study of RAD001, an mTOR inhibitor, in patients (pts) with advanced hepatocellular
carcinoma (HCC). Abstract # 4587. American Society of Clinical Oncology 200...
Schering-Plough Highlights Hepatitis C Clinical Data Presentations at the European Association for the Study of the Liver (EASL) Annual Meeting
...g, Child-Pugh class C, grade 2 or higher hepatic encephalopathy, ascites requiring therapeutic paracentesis and/or additional therapy), development of hepatocellular
carcinoma (HCC), liver transplantation or death. All events other than transplantation and death were adjudicated by an independent committee of expe...
Phase 3 Trial of Nexavar in Chemotherapy-Naive Patients with Advanced Melanoma Does Not Meet Primary Endpoint
... intend to build upon the success of Nexavar in our approved indications in hepatocellular
carcinoma (liver cancer) and advanced renal cell carcinoma (kidney cancer)....pproved U.S. package insert for the treatment of patients with unresectable hepatocellular
carcinoma and advanced kidney cancer, hypertension may occur early in the c...
Video: Afinitor(R) Approved in US as First Treatment for Patients With Advanced Kidney Cancer After Failure of Either Sunitinib or Sorafenib
...ision, blood vessel growth and cell metabolism. Afinitor is also being studied in multiple cancer types, including neuroendocrine, breast, gastric and hepatocellular
carcinoma (HCC), as well as tuberous sclerosis complex (TSC) and non-Hodgkin's lymphoma(11).
The active ingredient in Afinitor is everolimus, wh...
MultiCell Technologies Signs Liver Stem Cell R&D Agreement To Develop Products for the Study of Liver Cancer
... process has recently led to a new hypothesis that hepatocellular
carcinoma arises by maturation arrest of liver ste...ximately 18,400 of those cases resulted in death. hepatocellular
carcinoma, resulting from Hepatitis B and Hepatiti...es diagnosed each year. The NCI also reports that hepatocellular
carcinoma is associated with cirrhosis of the live...
Rosetta Genomics Reports First Ever In-Vivo Efficacy Data for a Systemic MicroRNA Therapeutic for Liver Cancer
... of microRNAs in human physiology and disease, the
potential of microRNAs in the diagnosis and treatment of disease, and the
success and timing of the hepatocellular
carcinoma therapeutic program,
constitute forward-looking statements for the purposes of the safe harbor
provisions under The Private Securities Litig...
Jennerex Treats First Patients in Phase 2 JX-594 Trial for Liver Cancer
...reventing tumor progression, as
measured by modified RECIST criteria at eight weeks from initiation of
treatment in patients with unresectable primary hepatocellular
In addition, safety and tolerability, as well as tumor response and
progression-free survival, of JX-594 administered at the two dose level...
Hepatocellular in Medical Definition
Alcoholic liver disease - Cholestasis - Hepatitis - Liver failure - Cirrhosis - NASH - PBC - Budd-Chiari - hepatocellular
Gallbladder / Biliary tree ( Gallstones , Cholecystitis , PSC , Ascending cholangitis ) - Pancreas ( Acu...
Hepatocellular in Medical Dictionary
Liver function tests
...ems with liver function , a possible side effect of arthritis medications. " Liver function tests " are divided into three categories: 1. hepatocellular
enzymes (AST,ALT) ... Kools AM, Bloomer JR, Abnormal liver function tests . ... ... medical books excerpts online about Abnormal liver fun...
...on the liver disease quickly reverses. ... Liver cancer — Comprehensive overview covers symptoms and treatment of this cancer, including hepatocellular
carcinoma. ... These cancers aren't called liver cancer. ... The liver is a large vertebrate organ positioned in the upper region of the ......
...sease in which malignant (cancer) ... What is hepatocellular
(liver) carcinoma ? hepatocellular
carcinoma is a rare disease ... hepatocellular
carcinoma may occur in multiple sites within the...
... a protein normally produced by the liver and yolk sac ... Original Article from The New England Journal of Medicine -- Early Recognition of hepatocellular
Carcinoma Based on Altered Profiles of Alpha - Fetoprotein Alpha - Fetoprotein (AFP) in Blood, SVCMC; New York NY Bayley Seton, Staten Island,...
Alcoholic liver disease
... disease - Overview, Alcoholic liver disease is damage to the liver and its function due to alcohol abuse.See also: Cirrhosis Causes of hepatocellular
liver disease include alcoholic cirrhosis and viral ... In mixed forms of liver disease , both conditions are present. ... Alcoholic...
...ce used to refer to noncancerous ... A bronchial adenoma is a type of tumor in the windpipe (trachea) or large ... ... adenoma ... Rarely, a hepatocellular
adenoma suddenly ruptures and bleeds ... An adenoma is usually suspected when an imaging test, such as ... The term bronchial adenoma descri...
Hepatocellular in Biological News
Genetically engineered mice yield clues to 'knocking out' cancer
...This indicates that there was a lack of DNA repair in these organs.
During the second year of life, both types of mice also developed pulmonary and hepatocellular
(liver cell) tumors. Double knockout mice had a higher incidence of tumors than the single knockouts.
The researchers state that their results emph...
Society of Interventional Radiology Foundation awards $191,000 in grants
...ative MR Perfusion Parameters With Pathology Following Chemoembolization of hepatocellular
Carcinoma (HCC)," and Brian Jin, "The Correlation of Angiographic Endpoints With Perfusion and Clinical Outcomes During Chemoembolization of hepatocellular
Carcinoma," both at Northwestern University, Chicago, Ill.";
Lydia Kuo, ...
Researchers identify gene linked to aggressive progression of liver cancer
...lating liver cancer progression, a discovery that could one day lead to new targeted therapeutic strategies to fight the highly aggressive disease.
carcinoma, HCC, or liver cancer, is the fifth most common cancer and the third leading cause of cancer deaths in the world. Treatment options for HCC ...
Senescence in liver cells is found by CSHL scientists to help limit acute tissue damage
...xperiments conducted by the same CSHL team last year linking senescence in liver cells with the organ's ability to fight off liver cancer, also called hepatocellular
carcinoma, or HCC.
The new findings are the first to establish a specific role for cellular senescence in a non-cancer pathology, and, the CSHL t...
Gene variation may elevate risk of liver tumor in patients with cirrhosis
... A particular gene variation appears to significantly increase the risk that individuals with cirrhosis of the liver will go on to develop hepatocellular
carcinoma (HCC), a liver tumor that is the third leading cause of cancer death. In the January 2 Journal of the American Medical Association, researc...
Story ideas from Molecular & Cellular Proteomics
...ins that could be used to improve the diagnosis of hepatocellular
carcinoma, the most common type of liver cancer.
carcinoma causes about one million deaths each yea...are either increased or decreased in patients with hepatocellular
carcinoma. Among the many proteins they found, two...
Targeting nerve growth factor may cure liver cancer
...ohistology, these scientists showed that NGF and its receptor trkANGF were expressed in the liver of the patients troubled with liver cirrhosis and/or hepatocellular
carcinoma (HCC) while these two molecules are not detected in the liver of healthy people. For a growth factor to affect a cell, there should be its s...
Liver cancer patients with high serum levels of hepatitis B virus face poorer outcomes
...with a more than 200-fold increase in risk of liver cancer. In areas where HBV is endemic, like China and the Far East, the great majority of cases of hepatocellular
carcinoma (HCC) occur in individuals with the virus. For most patients whose cancer is inoperable, chemotherapy is one of the main treatment options, ...
Mailman School of Public Health researchers report blood DNA can be early predictor of liver cancer
...hepatitis B and C virus infections.
Since most hepatocellular
or liver carcinomas (HCC) are diagnosed at an adva...or on the research. “Having the tools to identify hepatocellular
carcinoma at earlier stages, is truly a breakthrou...ut what this means in terms of early detection for hepatocellular
cancer but optimistic about how it could also be a...
New culture method for hepatitis C virus uses primary hepatocytes and patient serum
... C virus (HCV) infection affects approximately 170,000,000 people worldwide. HCV liver disease, which may induce liver inflammation, cirrhosis, and/or hepatocellular
carcinoma, represents the foremost reason for liver transplantation in much of the U.S.
Study of HCV replication within liver cells, or hepatocyt...
Hepatocellular in Biological Technology
Bayer and Onyx Announce Nexavar Data Presentations at 45th American Society of Clinical Oncology Annual Meeting
... in two cancers - in the treatment of unresectable hepatocellular
carcinoma (HCC), or liver cancer, and in the treat...O."
Nexavar data highlights include:
Effect of Macroscopi...rmance Status on Outcome in Patients with Advanced hepatocellular
Carcinoma Treated with Sorafenib: Analysis of Two ...
Human Genome Sciences Announces Third Quarter 2008 Financial Results and Key Developments
...ial data from this study in 2009. The results of the NSCLC
trial, along with the results of ongoing randomized Phase 2 studies of
HGS-ETR1 in advanced hepatocellular
cancer and advanced multiple myeloma,
will support a decision on whether to advance HGS-ETR1 to Phase 3
development. A sufficiently positive result fr...
Human Genome Sciences Announces Second Quarter 2008 Financial Results and Key Developments
...pletion of Randomization in HGS-ETR1 NSCLC
Trial Expected Shortly; HGS-ETR1 hepatocellular
Cancer Trial and First
Clinical Trial of HGS1029 Initiated
Three randomiz... HGS-ETR1 in combination with Nexavar
(sorafenib) in patients with advanced hepatocellular
cancer (HCC), which
accounts for 80- 90% of all liver cancers. The Company ...
FDA Approves EOVIST(R) to Detect and Characterize Focal Liver Lesions
... is approved for use in patients with
EOVIST is marketed by Bayer Hea...ere characterized as
one of the following choices: hepatocellular
metastasis, focal l...rt for the treatment
of patients with unresectable hepatocellular
carcinoma, hypertension may
occur early in the cou...
Bayer and Onyx Announce Nexavar Data Presentations at 44th American Society of Clinical Oncology Annual Meeting
Nexavar data highlights include:
-- Randomized Phase III trial of soraf...versus placebo in Asian patients with advanced hepatocellular
carcinoma -- Ann Lii-Cheng, MD, PhD, departmen... safety of sorafenib in patients with advanced hepatocellular
carcinoma and vascular invasion or extrahepatic sp...
Human Genome Sciences Announces First Quarter 2008 Financial Results and Key Developments
...rial of HGS-ETR1 by mid-2008 in patients with
hepatocellular cancer, which accounts for 80-90% of all liver cancers.
Preclinical data that support the hepatocellular
cancer study were
presented at the American Association for Cancer Research annual meeting in
Darapladib Advanced by GSK to Phase 3 Developme...
Liver Diseases: A Huge European Health Burden, But Some Trends are Positive
...r, or when damage precludes sufficient liver function, a
liver transplant becomes necessary. Cirrhosis is the major risk factor for
the development of hepatocellular
carcinoma (HCC), a primary cancer of
liver cells, which may also require transplantation.
Estimates suggest 10 million carriers of viral hepatitis i...
Human Genome Sciences Advances Oncology Portfolio
...ion trial of HGS-ETR1 by mid-2008
in patients with hepatocellular
(Logo: http://www.newscom.com/cgi-bin/p...TR1 in combination with Nexavar (sorafenib) in hepatocellular
cancer. The study in hepatocellular
cancer will begin with a safety lead-in to ass...
Accelerated Community Oncology Research Network, Inc. (ACORN), Initiates a Phase 2b Metastatic Breast Cancer Trial in Cooperation With Bayer and Onyx
...afety Considerations For Patients Taking Nexavar
Based on the currently approved U.S. package insert for the treatment
of patients with unresectable hepatocellular
carcinoma, hypertension may
occur early in the course of therapy and blood pressure should be monitored
weekly during the first six weeks of therapy a...
Mersana Therapeutics, Inc. Appoints Chief Scientific Officer, Timothy B. Lowinger, Ph.D.
...otably, he led the team that
discovered and advanced Nexavar(R) (sorafenib), an anti-cancer agent that
is approved for indications including renal and hepatocellular
Phase III studies underway in non-small-cell lung and other cancers. Later,
as the VP and Department Head of Chemistry Research in West H...
Hepatocellular in Biological Products
Hep G2 cell line slides ( human: liver; hepatocellular carcinoma ) from GeneTex
Description: Human Hep G2 cells were cultured in Minimum Essential Medium (Eagle) with 2 mM L-glutamine and harvested at the log phase of growth. In order to keep the antigens in their native forms, cells were fixed in acetone-methanol. The cells are arrayed on a 12-well (5 mm) adhesive coated slide, with eac...
Hepatocellular in Biological Definition
...cervical cancer , colorectal cancer - in the colon , rectum , anus , or appendix , esophageal cancer , endometrial cancer - in the uterus , hepatocellular
carcinoma - in the liver , gastrointestinal stromal tumor (GIST), laryngeal cancer , lung cancer , mesothelioma - in the pleura or pericard...
...al resistance with treatment.
Chronic carriers should be strongly encouraged to avoid consuming alcohol as it increases their risk for cirrhosis and hepatocellular
carcinoma (liver cancer).
Infants born to mothers known to carry Hepatitis B can be treated with antibodies to the hepatitis B virus (Hepatitis B im...
...omatosis , a hereditary disease causing the accumulation of iron in the body, eventually leading to liver damage
Cancer of the liver (primary hepatocellular
carcinoma or cholangiocarcinoma and metastatic cancers, usually from other parts of the gastrointestinal tract )
Wilson's disease , a heredit...
...l tubular adenoma , renal cell carcinoma (Grawitz tumor )
adenoma , hepatocellular
bile ducts epithelium: cholangiocellular adenoma , cholangioc...
Hepatocellular in Biological Dictionary
... determinant of AdoMetDC-induced transformed phenotype and invasiveness. ... Amphiregulin Contributes to the Transformed Phenotype of Human hepatocellular
Carcinoma Cells ... autocrine loop that contributes to the transformed phenotype . ... ISBNDB.COM - Books search engine taking data from hundred...
...loss of heterozygosity (LOH) in various adult tumors. ... Loss of Heterozygosity /genetics* Lung Neoplasms/genetics. Lung Neoplasms ... Results: hepatocellular
carcinoma (HCC) is one of the most prevalent human malignancies in the world. ... Frequent loss of heterozygosity on 6q at the mannose ... We t...