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Hematological in Medical News

S*BIO's Oral JAK2 Inhibitor SB1518 Demonstrates Therapeutic Potential for the Treatment of Myeloproliferative and Other Hematological Disorders

Data Presented on Three S*BIO Compounds at The American Society of Hematology 2007 SINGAPORE, Dec. 10 /PRNewswire/ -- S*BIO Pte Ltd today announced the data presentation on its most advanced compounds at The American Society of Hematology 49th Annual Meeting and E...

EntreMed Reports Second Quarter 2009 Financial Results

...icant antitumor activity, including tumor regression, in multiple solid and hematological malignancies. ENMD-2076 has been shown to inhibit a distinct profile of ang..., kinases which have been shown to play important roles in the pathology of hematological cancers. About EntreMed EntreMed, Inc. is a clinical-stage phar...

Boehringer Ingelheim to Commence Phase III Study Investigating the Role of BIBW 2992 as First-Line Treatment for Non-Small Cell Lung Cancer (NSCLC) Patients with EGFR Mutations

...ment is underpinned by using advances in science to develop a range of targeted therapies in areas of medical need, including various solid tumors and hematological cancers. The current focus of research includes compounds in three areas: angiogenesis inhibition, signal transduction inhibition and cell-cycl...

Sysmex Supports Illinois Chapter Leukemia and Lymphoma Society

...want to thank our customers for their generosity in joining us in our efforts to support the Leukemia & Lymphoma Society as they work to eradicate hematological cancers. I trust our joint donation will be especially meaningful to the organization in these challenging economic times. We are all honored to hav...

The Leukemia & Lymphoma Society and FORMA Therapeutics Enter Collaboration to Bring New Therapies to Patients Faster

...s," said John Walter LLS's chief executive officer. "LLS has assembled a promising portfolio of innovative programs to combat a wide range of hematological cancers," says FORMA CEO Steve Tregay, Ph.D. "The team at FORMA is excited to be working with LLS on this bold initiative by providing our unique suit...

Fate Therapeutics to Present Data on Stimulation of Osteogenic Activity Using Small Molecule Modulators of Wnt Pathway

...ogic compounds that guide cell fate for therapeutic purposes. Fate's approach has broad therapeutic potential in areas such as regenerative medicine, hematological diseases, metastatic cancer, traumatic injury and degenerative diseases. The Company is currently conducting a Phase 1b clinical trial of FT1050, a s...

New Report Just Published: World Multiple Myeloma Therapeutics Market Report

...S MARKET REPORT 1. Industry Overview II-1 hematological Cancer Therapies: A Prelude II-1 Treatment Reg...le II-1 Multiple Myeloma: A Second Most Common hematological Cancer II-2 Table 1: hematological Malignancies in the US (2007): Number of Incid...

Fate Therapeutics Granted Exclusive License By The Regents of the University of California to Stem Cell Modulators for Osteo-Regeneration

...ogic compounds that guide cell fate for therapeutic purposes. Fate's approach has broad therapeutic potential in areas such as regenerative medicine, hematological diseases, metastatic cancer, traumatic injury and degenerative diseases. The Company is currently conducting a Phase 1b clinical trial of FT1050, a s...

MDOUTLOOK(R) Quick Polls Report on Clinical Integration of Key Oncology Developments Following ASCO 2009

...overs all major and smaller oncology areas, including lung cancer, breast cancer, gastrointestinal cancer, genitourinary cancer, gynecological cancer, hematological malignancies, and melanoma. MDOUTLOOK is being launched in other complex diseases, such as Rheumatoid Arthritis, Ophthalmology, Parkinson's Disease, a...

5 Spanish centers join a study for a new leukemia and lymphoma treatment technique

...tario La Fe, Valencia: Principal Investigator, Dr. Guillermo Sanz, MD The trial is assessing the safety and efficacy of StemEx as a treatment for hematological malignancies, including leukemia and lymphoma, in a single arm, global, pivotal marketing authorization trial. StemEx is a graft of expanded stem/prog...
Hematological in Medical Technology

S*BIO Initiates U.S. Phase I Clinical Trials of Oral JAK2 Inhibitor SB1518 for the Treatment of Hematological Malignancies

SINGAPORE, Sept. 18 /PRNewswire/ -- S*BIO Pte Ltd today announced the initiation of multi-center Phase I clinical trials of SB1518, a potent and orally-active JAK2 inhibitor, in patients with leukemia and certain types of lymphoma. These first Phase I trials for SB1518 comprise of ascending do...

S*BIO to Develop New JAK-2 Inhibitor for Treatment of Myeloproliferative Disorders and Hematological Malignancies

SINGAPORE, Sept. 11 /PRNewswire/ -- S*BIO Pte Ltd today announced the development of a novel and proprietary orally-administered compound, SB1518, for the treatment of myeloproliferative disorders (MPD) and certain hematological malignancies. MPD is believed to be caused by a specific mutation...

Near-Patient Testing: The Advantages of C-Reactive Protein in Hematological Testing

Professor Jean-Francois Rossi Medical Hematology and Oncology CHU Lapeyronie, Montpellier C-reactive protein (CRP) is an acute-phase protein that has long been recognized as a marker of systemic inflammation. CRP measurement can complement a range of diagnostic markers to monitor infect...

Thiarabine Demonstrates a Reduction of Both Inflammatory and Erosive Disease Parameters in Rheumatoid Arthritis

...cal study which demonstrate a real benefit to the use of thiarabine in RA." "Our current development focus for thiarabine is for the treatment of hematological cancers," stated Jeffrey B. Davis, President & CEO. "But, we believe these new RA data provide compelling evidence that Thiarabine should be devel...

UPCI Joins ExCell Research Study Using Stem Cells for Leukemia and Lymphoma Patients

...g the safety and efficacy of StemEx(R), an investigational product derived from stem cells, as an alternative treatment to bone marrow transplants for hematological malignancies, including leukemia and lymphoma. StemEx is a graft of expanded stem/progenitor cells taken from a single unit of umbilical cord blood an...

Trius Announces Positive Results From Phase 2 Clinical Trial of Torezolid in Patients With Complicated Skin and Skin Structure Infections

...e of 200 mg was as efficacious as the higher doses also provides for a broad safety margin. In our prior 21-day Phase 1 clinical trial, which examined hematological parameters as key markers of oxazolidinone safety, the 200 mg dose of torezolid was comparable to placebo while the labeled dose of linezolid produced...

Micromet's Blinatumomab Achieves Primary Endpoint in Phase 2 Study with Acute Lymphoblastic Leukemia Patients

...dy that activates a patient's T cells to seek out and destroy cancer cells. The patients included in this phase 2 clinical trial were in complete hematological remission following intense chemotherapy regimens, but retained a detectable level of ALL cancer cells in their bone marrow -- so called minimal resid...

Afinitor(R) Phase II Data Show Positive Results for Patients With Multiple Types of Lymphoma, Leading to Phase III Trial

...vasive fungal infections should not receive Afinitor. Oral ulceration is a common side effect with Afinitor. Renal function, blood glucose, lipids and hematological parameters should be evaluated prior to the start of therapy with Afinitor and periodically thereafter. Strong or moderate CYP3A4 or P-glycoprotein in...

Entremed Presents Results of ENMD-2076 Phase 1 Study in Advanced Cancer Patients

...y Expanded Clinical Program Now Includes Solid and hematological Malignancies ROCKVILLE, Md., June 1 /PRNewswi...extend the possible indications for ENMD-2076 into hematological malignancies where preclinical data have been enco... including tumor regression, in multiple solid and hematological malignancies. ENMD-2076 has been shown to inhibit ...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

...vasive fungal infections should not receive Afinitor. Oral ulceration is a common side effect with Afinitor. Renal function, blood glucose, lipids and hematological parameters should be evaluated prior to the start of therapy with Afinitor and periodically thereafter. Strong or moderate CYP3A4 or P-glycoprotein in...
Hematological in Medical Products

Bio-Rad Platelia Aspergillus EIA

Description:...n aid in the diagnosis of Invasive Aspergillosis in immunocompromised patients undergoing hematopoietic stem cell transplantation and in patients with hematological malignancy. Aspergillus infections usually occur following inhalation of Aspergillus spores. Invasive forms constitute the most serious infections....
Company:Bio-Rad Laboratories
Hematological in Medical Definition

Hematopathology

...aphy - Flow cytometry - Blood bank - Microbiological culture - Serology v • d • e Pathology : hematology / hematological malignancy (primarily C81-C96 , D50-D77 ) White blood cells Lymphoid : Lymphoid leukaemia ( ALL , CLL , HCL ) • Lymphoma ( Hodg...

Pathology

...arch - Paraneoplastic phenomenon - ICD-O - List of oncology-related terms v • d • e Pathology : hematology / hematological malignancy (primarily C81-C96 , D50-D77 ) White blood cells Lymphoid : Lymphoid leukaemia ( ALL , CLL , HCL ) • Lymphoma ( Hodg...
Hematological in Medical Dictionary

Peripheral smear

...ar is a microscope slide made from a drop of blood, that allows the cells to be examined microscopically. Blood films are usually done to investigate hematological problems and,... Briefly explains why and when the blood smear is done ... Help? Blood Smear . Also known as: Peripheral smear ; Manual di...

Neutropenia

... Neutropenia , from Latin prefix neutro- and Greek suffix -πενία (deficiency) is a hematological disorder characterized by an abnormally low number of a type of white blood cell called a neutrophil. Neutrophils usually make up... Increas...

Malignancy

...nancy , pre-cancer or non-invasive tumor: A neoplasm that is not ... hematological malignancies are the types of cancer that ... hematological malignancy /leukemia histology (ICD-O 9590-9989, C81 ... lymphoid mali...
Hematological in Biological News

Combined stem cell-gene therapy approach cures human genetic disease in vitro

...ocus on Fanconi anemia (FA), a genetic disorder responsible for a series of hematological abnormalities that impair the body's ability to fight infection, deliver ox... other cancers. Even after receiving bone marrow transplants to correct the hematological problems, patients remain at high risk of developing cancer and other serio...

Biolex presents Locteron US Phase 2a hepatitis C data at EASL

...patients in the 640 g cohort of Locteron was 30 percent lower than the severity score for the PEG-Intron cohort. Injections site reactions and common hematological parameters among both of the Locteron cohorts and the PEG-Intron cohorts were comparable. Anti-viral effects were comparable among the Locteron and PE...

Phoenix conference highlights TGen's and Scottsdale Healthcare's contributions to molecular oncology

...dale Healthcare scientists scheduled to present include: Dr. Jeffrey Trent, TGen's President and Scientific Director; Dr. Raoul Tibes, Director of the hematological Malignancies Program at TCRS and an Associate Investigator at TGen; Dr. Stephen P. Anthony, Chief Medical Officer of TGen Drug Development Services (T...

Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds

...prostate cancers, no one had tested the extract in hematological cancers nor had the precise mechanism for activity...grape seed extract into prevention or treatment of hematological malignancies and possibly other cancers," said the... is too early to say this is chemo-protective." hematological cancers leukemia, lymphoma and myeloma accounted...

Researchers identify new anti-tumor gene

... Chair in Cancer Research with the VCU Massey Cancer Center. Currently, IFNs are relevant in the clinical treatment of a number of solid tumors and hematological malignancies, such as melanoma, renal cell carcinoma, malignant glioma, lymphomas and leukemias, either as a monotherapy or as an adjuvant to chemothe...

BiovaxID?yields 89 percent survival in patients with aggressive non-Hodgkins

...nt Professor in the Department of Lymphoma at the University of Texas M. D. Anderson Cancer Center. "This paves the way to use vaccines in a number of hematological cancers that are treated by eliminating diseased B-cells." Biovest is now enrolling patients in a pivotal Phase 3 trial to test BiovaxID against f...

Eisai announces Phase II data on E7389, a potential new therapy for the treatment of breast cancer

...ed mild to moderate and included nausea, fatigue, dehydration, arthralgias, dyspnea and neuropathy. None of the patients discontinued the study due to hematological toxicity. "The results from this study with E7389 appear promising, and clinical research on E7389 as a treatment for breast cancer is continuing,...

Genes linked to treatment resistance in children with leukemia

...sis of the high-risk group, the GSTM1 non-null genotype was associated with hematological relapse, a recurrence of the cancer in the blood and bone marrow and the mo... if the child also had a TYMS 3/3 genotype. No genotype was associated with hematological relapse among patients in the lower-risk arm of the study. The researche...

Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells

...thod for identifying cancer cells is it's a very rapid and general method that potentially can be applied to cancer cells from solid tumors as well as hematological malignancies like leukemia." Naviaux looks forward to examining a wider population of cancer cells to validate the method, combining the resources ...
Hematological in Biological Technology

Rib-X Pharmaceuticals Reports Positive Phase 2 Study Results for Radezolid in Community-Acquired Pneumonia

...ratory pathogens . Additionally, radezolid was well tolerated, with the most commonly reported adverse events being mild gastrointestinal upset. No hematological adverse events were reported in this study. "We are extremely encouraged by the positive results we've seen in this Phase 2 trial of radezolid...

Micromet Receives European Orphan Drug Designation for Treatment of Acute Lymphoblastic Leukemia with BiTE Antibody Blinatumomab

...blastic leukemia (ALL) patients with minimal residual disease (MRD)(1). The patients included in this phase 2 clinical trial were in complete hematological remission following intense chemotherapy regimens, but retained a detectable level of ALL cancer cells in their bone marrow - so called minimal residu...

Stemline Therapeutics CEO to Present at IBC's New Frontiers in Cancer Drug Development Conference

...ad compound, SL-401, targets the interleukin-3 receptor present on multiple hematological cancers including leukemia blasts and leukemia cancer stem cells. SL-401 ha...ds directed at multiple high value cancer stem cell targets of a variety of hematological and solid cancers. Stemline has built a robust discovery platform called "S...

Five Cord Blood Transplant Centers in Catalonia and Valencia Join a Study to Test a New Technique to Treat Leukemia and Lymphoma

... Fe, Valencia Principal Investigator, Dr. Guillermo Sanz, MD The trial is assessing the safety and efficacy of StemEx as a treatment for hematological malignancies, including leukemia and lymphoma, in a single arm, global, pivotal marketing authorization trial. StemEx is a graft of expanded stem/prog...

Fate Therapeutics Granted Exclusive License for Stem Cell Modulators by Children's Hospital Boston and Massachusetts General Hospital

...ogic compounds that guide cell fate for therapeutic purposes. Fate's approach has broad therapeutic potential in areas such as regenerative medicine, hematological diseases, metastatic cancer, traumatic injury and degenerative diseases. The Company's first therapeutic candidate is scheduled to enter clinical tri...

EntreMed ENMD-2076 Phase 1 Data to Be Presented at ASCO Annual Meeting

...icant antitumor activity, including tumor regression, in multiple solid and hematological malignancies. ENMD-2076 has been shown to inhibit a distinct profile of ang...nd FGFR3, which have been shown to play important roles in the pathology of hematological cancers. About EntreMed EntreMed, Inc. is a clinical-stage pha...

Nerviano Medical Sciences Receives Approval From the FDA to Enter Phase I Clinical Trials for Their Polo Like Kinase (PLK) Inhibitor

... promising activity in specific patient populations. The clinical development path foresees application of the NMS PLK-1 inhibitor in solid and hematological indications. "I am pleased to see the second IND approval this year and I highly appreciate the consistant delivery of high quality clinical candidate...

The Arcas Group Appoints Executive Vice President

...erica and Europe and covers all major and smaller oncology areas, including lung cancer, breast cancer, gastrointestinal cancer, genitourinary cancer, hematological malignancies and melanoma. MDOUTLOOK will be launched shortly in other complex diseases, such as Ophthalmology, Parkinson's Disease, Alzheimer's. ...

Fate Therapeutics and Stemgent Launch Catalyst: A Unique Industry Program for First Access to the Most Advanced Induced Pluripotent Stem Cell Technology

...eader in developing small molecules and biologics to modulate cell fate for regenerative medicine and therapeutic reprogramming indications, including hematological diseases, metastatic cancer, traumatic injury and degenerative diseases. Stemgent accelerates the translation of stem cell science by providing appli...

Trubion Presents Preclinical Data on Its SCORPION(TM) Multispecific Therapeutics at the 2009 American Association of Cancer Research Annual Meeting

...th potent in vitro activity against B-cell lymphoma B-cell depletion with agents such as Rituxan(R) has proven successful in the treatment of hematological malignancies in the clinic, but patients still relapse and become refractory. Strategies to improve efficacy of B-cell directed therapies include boos...
Hematological in Biological Definition

Cancer

...res with genetic and other endogenous characteristics among susceptible people. Examples include: bladder carcinoma , blood (and bone marrow ) - hematological malignancies , leukemia , lymphoma , Hodgkin's disease , non-Hodgkin's lymphoma , multiple myeloma , brain tumor , breast cancer , cervical ca...
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