Navigation Links
Helicase in Medical News

Scientists identify new gene responsible for puberty disorders

...the gene in a large sample of patients diagnosed with delayed puberty but not CHARGE," Dr. Layman says. The identified gene is called chromodomain helicase DNA binding protein 7, or CHD7. In 101 people with IHH and Kallmann syndrome, researchers found seven mutations of CHD7 that weren't present in nearly...

How defects in 1 gene cause 3 distinct and devastating human diseases

...and biochemical activity of an enzyme known as XPD helicase taken from Sulfolobus archaea, microbes distinct f... the repair of damaged DNA. In both instances, the helicase parts the two DNA strands at either the transcript...using mutations in XPD all fall in sites where the helicase binds ATP (the energy currency of the cell) or DNA...

Salk Scientists - Links Between Cancer and Aging

...ied with a functional WRN gene showed decreased DNA damage compared to untreated cells, which was predictable: the WRN gene encodes a protein called a helicase that unwinds tightly coiled DNA strands when cells divide. Loss of WRN protein in individuals with Werner Syndrome is responsible for the disease. Exp...

Heart disease and strokes connected to a motor protein mechanism

...k Chemistry Assistant Professor Charalampos Kalodimos and his coworkers, in the article, "Disorder-order folding transitions underlie catalysis in the helicase motor of SecA." Identifying the way this motor protein works is significant because it may lead to the development of new pharmacological therapies wh...
Helicase in Biological News

GUMC discovery highlights new direction for drug discovery

...olleagues were the first to make a recombinant EWS-FLI1 fusion protein. They used it to discover that the fusion protein stuck to another protein, RNA helicase A (RHA), a molecule that forms protein complexes in order to control gene transcription. "We believe that when RHA binds to EWS-FLI1, the combination ...

DNA template could explain evolutionary shifts

...that each cell that results from the division has the same genetic code. That means it must replicate its DNA. During this process, an enzyme called a helicase separates the two strands, breaking the hydrogen bonds between the A T and G C base pairs. The two separating strands become the replication fork. O...

Leemor Joshua-Tor, PhD, CSHL biologist and WSBS dean, is named an HHMI Investigator

...rand of DNA through its channel and how it utilizes ATP to do this. Additional work is under way in the lab to determine more comprehensively how this helicase complex works. Leemor Joshua-Tor was born in Israel and trained at Tel-Aviv University, where she earned a B.Sc. in chemistry, and at the Weizmann...

Researchers probe a DNA repair enzyme

...y to prevent and repair such damage. Mutations in the human members of this helicase family impede DNA repair and may contribute to breast cancer, Fanconi Anemi... be physiological targets for this helicase. On making these mutations, the helicase no longer behaves like its supposed to, said graduate student Robert Pugh, ...

Copy number variation may stem from replication misstep

...that each cell that results from the division has the same genetic code. That means it must replicate its DNA. During this process, an enzyme called a helicase separates the two strands, breaking the hydrogen bonds between the A T and G C base pairs holding the strands together. The two separating strands b...

Biophysical Society announces winners of 2008 Student Travel Awards

...Using Water-in-Oil Droplet on Hydrogel Bilayers. Christopher P. Toseland, MRC-National Institute for Medical Research, London, United Kingdom, helicase Superfamily 1 and 2 ATPase Mechanisms. Martijn E. van Raaij, University of Twente, Enschede, The Netherlands, Quantitative Atomic Force Microsc...

Scientists discover new regulating mechanism in cells

...ed by retroviruses ?to control the making of certain essential proteins, including some involved in cancer. The mechanism uses an enzyme called RNA helicase A (RHA), which is made by the cell. The study by researchers with The Ohio State University Comprehensive Cancer Center ?Arthur G. James Cancer Ho...

Molecular DNA switch found to be the same for all life

...low others proteins to dock onto the initiator complex," said Berger. "These other proteins can help add layers of complexity, such as assisting with helicase loading or inactivating the initiator after replication has begun. The open rings also probably allow DNA to interact with the interior of the initiat...

Enzyme crystal structure reveals 'unexpected' genome repair functions

... The study is being published in an advance online version of the journal Molecular Cell. The research looked at XPB helicase from an archaea, a single cell organism similar to bacteria. Helicases are enzymes that unwind or separate the strands of the nucleic acid double heli...
Helicase in Biological Technology

Evaluation of FlashPlate in a Helicase Assay

Abstract This study demonstrated the efficacy of the FlashPlate as a high throughput screening (HTS) platform for a helicase functional assay. Helicase activity was measured on a streptavidin coated FlashPlate (SMP103), using two DNA oligos. One of the oligos was biotinylated;...

siRNA screening of the cell cycle with two dynamic GFP sensors (from Discovery Matters Issue 1, July 2005)

...ng the phosphorylation-dependent sub-cellular location domain (PSLD) of DNA helicase B (13). In this cell line a nuclear localization sequence (NLS) within the ... 13. Gu, J. et al. Cell cycle-dependent regulation of a human DNA helicase that localizes in DNA damage foci. Mol. Biol. Cell. 15 (7), 3320–...

RNA Interference and Gene Silencing: History and Overview

...erk RH. (1999). Mut-7 of C. elegans , required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNase D. Cell 99 : 133-141. (
(Date:12/10/2014)... SUNNYVALE, California , December 9, 2014 /PRNewswire/ ... Integrate with ITN,s BCARD Platform ... secure, cloud-based enterprise meeting scheduling solutions for business-to-business ... International, the world leader in mobile near-field communication ... solutions.      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , ...
(Date:12/3/2014)... Calif. , Dec. 2, 2014   ... globally deployed, innovative test solutions for military, aerospace, ... newest version of its successful TS-900 PXI ... performance and features of high-end systems to customers ... outstanding value compared to traditional ATE. ...
Breaking Biology News(10 mins):Wearable Technology Products Demand Highly Accurate Biometric Technology 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3
Other Contents