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Hedgehog in Medical News

Penn researchers find key to Sonic hedgehog control of brain development

PHILADELPHIA University of Pennsylvania School of Medicine researchers have discovered how the expression of the Sonic hedgehog gene is regulated during brain development and how mutations that alter this process cause brain malformations. The results appear online this month in Nature Genetics ...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young scientists

... Stanford University, Stanford, California, is studying the function of the hedgehog signaling pathway, in particular, how inappropriate activation of this pathway can lead to the initiation and growth of tumors. Insights into hedgehog signaling may allow for the development of more potent and specific forms o...

Purdue Pharma L.P. Announces a Global Strategic Alliance With Infinity Pharmaceuticals to Advance Discovery and Development Programs in Oncology and Neuropathic Pain

... alliance will focus on supporting Infinity's pipeline of novel, small molecule oncology drug candidates, including IPI-926, a potent inhibitor of the hedgehog pathway, which is being evaluated in a Phase 1 clinical study in patients with advanced solid tumors. IPI-926 has demonstrated significant anti-tumor ...

New Insight Into Most Common Forebrain Malformation

... important piece of molecular machinery, the Sonic hedgehog pathway, a major regulator of fetal brain developm...gger HPE by compromising the function of the Sonic hedgehog pathway. For their first experiments, they turned ... his colleagues found that both Six3 and the Sonic hedgehog pathway were active at the same time and place in ...

New insight into most common forebrain malformation

... important piece of molecular machinery, the Sonic hedgehog pathway, a major regulator of fetal brain developm...gger HPE by compromising the function of the Sonic hedgehog pathway. For their first experiments, they turned ... his colleagues found that both Six3 and the Sonic hedgehog pathway were active at the same time and place in ...

Childhood brain tumor traced to normal stem cells gone bad

...ccurs when a cell-signaling pathway known as Sonic hedgehog (named for a cartoon character) is reactivated by a chance mutation. Sonic hedgehog plays an important role during the embryonic devel...goal was to determine whether activating the Sonic hedgehog cancer pathway in multiple types of brain cells, i...

Certain anti-cancer agents could be harmful to patients with heart disease

... anticancer drugs which go by the strange name of hedgehog antagonists interfere with a biochemical process ...ion in the Journal of Clinical Investigation . hedgehog antagonists are drugs that inhibit the hedgehog signaling pathway, a chain of biochemical signals ...

JCI table of contents: June 20, 2008

...712 VASCULAR BIOLOGY: A prickly problem: hedgehog signaling in the blood vessels of the heart N... signaling pathways that involve the protein sonic hedgehog in maintaining the blood vessels that supply the m...ug development as they suggest that antagonists of hedgehog signaling pathways, such as those being developed ...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

...nsferase (GARFT); glycoprotein NMB; B-lymphocyte stimulator (BLyS); gonadotropin-releasing hormone (GnRH); GnRHr; growth differentiation factor (GDF); hedgehog (Hh); heparanase; hepatocyte growth factor/scatter factor (HGF/SF); highly upregulated in liver cancer (HULC); human chorionic gonadotropin (hCG); hya...

March of Dimes awards $250,000 prize to leaders in understanding embryonic development

...ng work that has expanded our understanding of how hedgehog genes and their protein signals guide the formatio...er and ceremony at the Moana Surfrider here. hedgehog genes have a wide-ranging role in mammalian develo...ision of adult stem cells. The genes are named hedgehog because when mutations that caused the gene to los...
Hedgehog in Medical Technology

Curis Announces Hedgehog and Wnt Antagonist Data Presentation at AACR

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Apr 17, 2007 - Curis, Inc. (NASDAQ:CRIS), a drug development company focused on novel targeted medicines primarily for cancer treatment, today announced that its data was included in two presentations at the 98th Annual Meeting of the American Association for Canc...

Exelixis Announces First Quarter 2008 Financial Results

...ram is initiated by Genentech. -- Bristol-Myers Squibb exercised its option to develop and commercialize our compound XL139, an inhibitor of the hedgehog signaling pathway, for which we received a $20.0 million selection milestone in February 2008. In addition, we exercised our option under the ...

Latest Cell Publication Describes the Novel Kinase Regulators Using OriGene's Functional Kinome Collection

...successfully identified novel kinase regulators in hedgehog signaling pathway and in activation of Karposi's S...collection for identification of kinase regulating hedgehog signaling." The uniqueness of the study lies i...creening the collection in a cell-culture model of hedgehog signaling pathway, the authors were able to quickl...

Infinity and MedImmune to Present Preclinical Data From Study of Oral Formulation of IPI-504 At AACR

... 2006, Infinity and MedImmune entered into an agreement to jointly develop and commercialize novel small molecule cancer drugs targeting Hsp90 and the hedgehog cell-signaling pathway. The collaboration is focused on inhibitors of Hsp90, including IPI-504 which is in Phase I/II clinical trials, as well as next...

Infinity and MedImmune Announce Updated Data On Ipi-504 to be Presented At ASCO

... 2006, Infinity and MedImmune entered into an agreement to jointly develop and commercialize novel small molecule cancer drugs targeting Hsp90 and the hedgehog cell-signaling pathway. The collaboration is focused on inhibitors of Hsp90, including IPI-504 which is in Phase I/II clinical trials, as well as next...

Infinity and MedImmune Present Updated Phase I Results of IPI-504 in GIST at ASCO Annual Meeting

... 2006, Infinity and MedImmune entered into an agreement to jointly develop and commercialize novel small molecule cancer drugs targeting Hsp90 and the hedgehog cell-signaling pathway. The collaboration is focused on inhibitors of Hsp90, including IPI-504 which is in Phase I/II clinical trials, as well as next...
Hedgehog in Biological News

UCLA researchers discover new molecular pathway for targeting cancer, disease

...er X receptor (LXR), they were able to inhibit the hedgehog (Hh) signaling pathway, which is involved in the m...vity to inhibit aberrant Hh signaling. "The hedgehog Hh signaling pathway is an important regulator of ...tifies an entirely new and unexpected mechanism of hedgehog pathway modulation," said study author Dr. James A...

Why the thumb of the right hand is on the left hand side

...t fly and in humans alike. One of these molecules hedgehog controls the development of, for example, the ext...the University of Innsbruck. "The concentration of hedgehog makes the thumb of the right hand grow on the left...w on the right hand side." Thus, scientists define hedgehog as a morphogen a signal that is concentration-dep...

Identification of a key molecular pathway required for brain neural circuit formation

... axons (a long extension of a neuron) require attractive and repulsive molecules to lead them to their appropriate targets. One such molecule is Sonic hedgehog (Shh). Five years ago, as a postdoctoral fellow in the laboratory of Dr. Marc Tessier-Lavigne at Stanford University, Frdric Charron discovered that S...

James Briscoe awarded 2008 EMBO Gold Medal

...in his own lab at NIMR since taking up a group leader position in 2000. Specifically, the Briscoe lab studies the central role of the morphogen Sonic hedgehog (Shh) to specify the position and subtype identity of neurons in the ventral spinal cord. "We want to understand how neurons - nerve cells are arr...

Certain anticancer agents could be harmful to patients with heart disease

... anticancer drugs which go by the strange name of hedgehog antagonists interfere with a biochemical process ...ion in the Journal of Clinical Investigation . hedgehog antagonists are drugs that inhibit the hedgehog signaling pathway, a chain of biochemical signals ...

Glypican-3 gene function in regulating body size helps inform novel cancer treatments

...lypican-3 (GPC3), Sunnybrook researchers have discovered how the loss of the GPC3 gene induces overgrowth through certain growth factors such as Sonic hedgehog which stimulate cancer growth. Published today in Developmental Cell, the study examines the molecular mechanism by which lack of functional GPC3 c...

Researchers report the cloning of a key group of human genes, the protein kinases

...dies. They further used the kinome collection in several high-throughput screens, including a screen which identified two novel kinases regulating the hedgehog signaling pathway a key pathway linked to multiple types of human cancer. In addition, together with the group of Dr. Pivi Ojala, University of Helsi...

2 new therapies show promise for cancer patients

...cells sampled from the participants. Among all patients tested to date, there was reduction in this marker, indicating that the drug was affecting the hedgehog pathway. The trial, sponsored by Genentech, also included clinical sites at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Univers...

Wisconsin researchers describe how digits grow

...its, also consisting of mesenchymal tissue, which fill the space between the digit rays and eventually regress. Scientists know that the gene Sonic hedgehog (SHH) plays an important role in determining the form and number of digits, and many believe that other secondary signaling centers downstream of SHH ...

GBIF making the search for biodiversity research resources easier

... Copenhagen, 5 December 2007 - If you needed to see a specimen of a hedgehog from Herzegovina or a fish from Fiji, would you know where to look? Finding a natural history collection that has specimens from a particular time or...
Hedgehog in Biological Technology

New properties of skin stem cells

...e cells are able to move depending on their stage of growth. The scientists believe that their growth is governed by previously known mechanism called hedgehog signalling. Mutations in the genes that control this signal system can cause the delayed deactivation of signal transference; the signals thus continu...

March of Dimes Awards $250,000 Prize to Leaders in Understanding Embryonic Development

...ng work that has expanded our understanding of how hedgehog genes and their protein signals guide the formatio...sion of adult stem cells." The genes are named hedgehog because when mutations that caused the gene to los...rch elucidated the processing and structure of the hedgehog protein signal and its attachment to cholesterol, ...

Exelixis Submits XL139 Diligence Report to Bristol-Myers Squibb

...ncer. XL139 is a small molecule inhibitor of the hedgehog signaling pathway. Hedgehog plays a critical role ...omal tissue. In addition, recent data suggest that hedgehog signaling may play a key role in cancer stem cell ...ole in aberrant cell growth and proliferation, the hedgehog pathway is an exciting target for therapeutic inte...

New Scientists Boost Disease-based Research at Boston Biomedical Research Institute

...ding the evolution of proteins involved in neurodegenerative disorders; Dr. Kent Nybakken who is studying the function of a key signaling pathway, the hedgehog pathway, which is important in normal development, stem cell regulation and cancer; and Dr. Sachiko Homma whose studies focus on sarcopenia, which is ...
Hedgehog in Biological Products

Mouse Dopaminergic Neuron Differentiation Kit, 2nd Generation from R&D Systems

Description:...port for cell attachment and spreading. A growth factor panel, consisting of human fibroblast growth factor (FGF) basic, mouse FGF-8b, and mouse sonic hedgehog amino-terminal peptide (Shh-N), is included for effective DA differentiation. The quantity of each component provided in the kit is estimated to be su...
Company:R&D Systems
Hedgehog in Biological Definition

Apoptosis

...th states can be fatal or highly damaging. For instance, misregulation of hedgehog (Hgg) protein signalling (see Development , below) has been implicated in ...rd and the floor plate secrete a gradient of the signaling molecule Sonic hedgehog (Shh), and it is this gradient that directs cells to form patterns in the ...

Morphogenesis

...ailed can make the cell-to-cell signaling protein hedgehog (green in the figure to the left). hedgehog is not free to move very far and activates a thin ...ailed-expressing cells are competent to respond to hedgehog because they express the receptor protein Patched...

Morphogenesis

...ailed can make the cell-to-cell signaling protein hedgehog (green in the figure to the left). hedgehog is not free to move very far and activates a thin ...ailed-expressing cells are competent to respond to hedgehog because they express the receptor protein Patched...
Hedgehog in Biological Dictionary

Spermatogenesis

...ers the topic of spermatogenesis , the production of the male gametes. ... hedgehog homeobox signaling in Spermatogenesis Deletion of Dhh, a hedgehog ... Spermatogenesis summary with 9 pages of encyclopedia entries, essa...

N Terminus

...ity to promote adipocyte ... Swapping the DBD along with the N terminus (DBD-/ and DBD-/) has no additional ... Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity ... that regions near the N terminus of the protein play a ... ...

Endoderm

... , in biology, inner layer of tissue formed in the gastrula stage of the ... 57. The primary germ layer endoderm is derived from : ... Sonic hedgehog signalling from foregut endoderm patterns the avian nasal... Information about endoderm in the free online English dictionary and encyclopedia....
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(Date:8/27/2014)... but deadly disease that exists as five strains, none ... lethal strains is the Sudan ebolavirus (SUDV). Although not ... widespread illness, even as recently as 2012. In a ... Biology , researchers now report a possible therapy that ... John Dye, Sachdev Sidhu, Jonathan Lai and colleagues explain ...
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