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Harboring in Medical News

Young Children Might Be Harboring Mental Health Problems

Experts addressing a recent conference at the Institute of Psychiatry in London warned that a tenth of children under five might be harboring a serious psychiatric illness // . In more than 11 % of cases, the children suffered symptoms bad enough to disrupt their daily lives, and failure to ...

Now we know what blocks the effects of a newly developed anticancer therapy

...CEACAM6 mediates its effects and indicated that knocking down expression of CEACAM6 markedly increased the anticancer effects of an adenovirus in mice harboring human tumor cells. The authors therefore suggest that identifying whether or not a tumor expresses CEACAM6 and the downstream proteins required to blo...

JCI online early table of contents: May 1, 2009

...CEACAM6 mediates its effects and indicated that knocking down expression of CEACAM6 markedly increased the anticancer effects of an adenovirus in mice harboring human tumor cells. The authors therefore suggest that identifying whether or not a tumor expresses CEACAM6 and the downstream proteins required to blo...

Hunter-Killed Elk Test Negative for CWD and Other Diseases

...ed. Fortunately, there currently is no evidence of CWD being transmissible to humans or to other non-cervid livestock under normal conditions. Deer harboring CWD may not show any symptoms in the disease's early stages. The incubation period for CWD is from 12 to 18 months, but animals may show clinical sig...

Salmonella Common In U.S. Poultry

...many other pets, including exotic ones. The number of exotic animals in the United States has almost doubled since 2002, with 4.4 million homes now harboring reptiles, and 40,000 households home to hedgehogs, according to a report in the October 2008 issue of Pediatrics . In 2003, a human monkey pox out...

Molecular imaging enables earlier, individualized treatment of thyroid cancer

...ed by surgery, including cancerous cells spreading to other body parts, such as lymph nodes. In addition to emitting electrons that destroy the tissue harboring the radionuclide, radioactive iodine emits photons suitable for imaging. "Normal thyroid tissue as well as residual cancer cells concentrate radioi...

Einstein researchers discover protein that contributes to cancer spread

...cells that did not have Menainv were not." Another finding from the study that has important implications for patient treatment is that tumor cells harboring Menainv are less likely to be responsive to newer breast cancer treatments that inhibit epidermal growth factor receptors (EGFR). Epidermal growth fac...

Key protein molecule linked to diverse human chronic inflammatory diseases

...erosclerosis and insulin resistance. At the molecular level, Li's laboratory discovered that IRAK-1 prefers to phosphorylate transcription factors harboring the Serine-Proline motif including STAT-3 and NFAT. Subsequently, STAT-3 and NFAT are involved in modulating the expression of distinct inflammatory m...

Stomach bug appears to protect kids from asthma, says NYU study

...an antibiotic in the month prior to the survey. The rise in asthma over the past decades, Dr. Blaser says, could stem from the fact that a stomach harboring H. pylori has a different immunological status from one lacking the bug. When H. pylori is present, the stomach is lined with immune cells called ...

Pitt-led research provides insight into development of congenital circulatory defects

...ays a critical and previously unknown role in the formation of the aortic arch vesselsand that mutations in that gene can result in AVMs. In zebrafish harboring the mutation, two aortic arch vessels failed to connect properly to the body's major artery, the dorsal aorta. Instead, dead-end vessels formed then s...
Harboring in Medical Technology

Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer

... Tumor KRAS status was ascertained in more than 90 percent of the 1,183 patients enrolled in the trial. Importantly, in patients with tumors harboring activating KRAS mutations, PFS was significantly inferior in the Vectibix arm. These data confirm previous findings when oxaliplatin-based chemother...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

...eevec(R)(#) (imatinib mesylate) in treating patients with advanced melanoma harboring KIT mutations. A mutation in the protein called KIT, located on the surface...hase II study of Imatinib mesylate (IM) for patients with advanced melanoma harboring somatic alterations of KIT. Abstract # 9001. American Society of Clinical O...

Autism Genes Discovered; Help Shape Connections Among Brain Cells

...0 U.S. children, ASDs are known from family studies to be strongly influenced by genetics. Previous studies have implicated several chromosome regions harboring rare variants in raising the risk of ASDs, but until now, research has not been consistent in identifying and replicating common genetic variants. ...

Micromet Presents Update on BiTE Antibody Pipeline and Reviews Key AACR Presentations at R&D Day

...were highly active against KRAS-and BRAF-mutated human colorectal cancer cell lines. Recent clinical studies have shown that patients with tumor cells harboring mutations in KRAS and BRAF oncogenes do not respond to treatment with Erbitux or Vectibix. These patients make up more than 40% of colorectal cancer p...

Phase 1 Trial of Whole-Parasite Malaria Vaccine to Begin

... potential to confer high levels of protection against malaria comes from previous studies in which volunteers were exposed to the bites of mosquitoes harboring weakened parasites. While the technological challenges associated with translating this approach into an effective and safe vaccine based on live para...

Micromet Presents Preclinical Data Showing Activity of Erbitux and Vectibix Based BiTE Antibodies against KRAS- and BRAF-mutated Human Colorectal Cancer Cells

...itumumab(3,4) are not active in colorectal cancer patients with tumor cells harboring mutations in KRAS and BRAF oncogenes. These two populations make up more th...cells against cetuximab/panitumumab-resistant human colorectal cancer cells harboring KRAS and BRAF mutations, resulting in the destruction of these cancer cells...

Romark Announces Presentation of New Data for Nitazoxanide in Chronic Hepatitis C at EASL 2008

...ral presentation by Brent Korba, Ph.D. of, Georgetown University Medical Center, described preclinical studies showing that treatment of cells harboring HCV replicons with nitazoxanide or its primary metabolite, tizoxanide, does not induce viral mutations conferring resistance to nitazoxanide, ...

JAK2 Inhibitor Shows Potent Activity in Cells From MPD Patients

...vo studies, we have seen encouraging preliminary results with Cytopia's compounds including the inhibition of erythroid colony growth from PV patients harboring the JAK2 V617F mutation." Cytopia's Research Director Dr Chris Burns stated: "This data is important validation that our selective JAK2 inhibitors s...

Preclinical Studies Show Potential Progress Toward Identifying Specific Tumor Types With Higher Likelihood of Demonstrating Response to Anti-Cancer Compounds Early in Clinical Development

...Chief Medical Officer of CTI. A new class of thienopyrimidine Src inhibitors demonstrates potent growth suppression of imatinib resistant Ba/F3 cells harboring a wide range of BCR-ABL mutations, including the CML relevant T315I (Abstract #B238) Spyro Mousses, Ph.D., Senior Investigator and Director, Cancer D...

AVEO Presents Preclinical Efficacy Data on AV-412, a Novel Oral Tyrosine Kinase Inhibitor of EGFR/HER2 for EGFR Mutant and Drug-Resistant Lung Cancer

...ical observations from independent groups suggest that lung cancer patients harboring the EGFR L858R mutation (approximately 44 percent of all EGFR mutants) exhi...val after treatment with EGFR kinase inhibitors when compared with patients harboring other EGFR mutations. This suggests the need for inhibitors that are more e...
Harboring in Medical Dictionary

Psychosis

... usually including false ideas about ... Treatment depends on the cause of the psychosis . ... The Merck Manual of ... Psychosis often involves harboring false beliefs (delusions) ... People with psychosis often become unreasonably fearful or ... Psychosis is a generic psychiatric term for a m...
Harboring in Biological News

Urban water ecology at the ESA annual meeting

...hese mosquitoes' success. Larger mosquitoes tend to result from a longer lifespan, which is dangerous because it gives mosquitoes a better chance of harboring pathogens that cause human diseases. Chaves makes the case that cities should separate their sewage overflow from their rain runoff to avoid creating ...

Further gene mutations linked to autism risk

...als from 912 families with multiple autistic children against genetic samples of 1,070 disease-free children. Besides the identification of 27 regions harboring rare variants in children with ASDs, the study also uncovered two novel genes where variations were found, BZRAP1 and MDGA2 thought to be important i...

How mitochondria get their membranes bent

...ure. In the current issue of the the Journal of Cell Biology Rabl, Soubannier et al. report on their quest of slow-growing baker`s yeast mutants harboring deformed mitochondria. Thereby, they discovered the protein Fcj1 ("Formation of criasta junction protein 1"), which is embedded in the inner membrane ...

Study finds multidrug-resistant gram-negative bacteria high in long-term care

...resistance among gram-negative bacteria is becoming an even greater problem in these facilities, with nearly half of long-term care facility residents harboring multidrug-resistant gram-negative bacteria," write the researchers, led by IFAR's Erin'O'Fallon, M.D., M.P.H., in the January issue of the Journal of...

Biofuels boom could fuel rainforest destruction, Stanford researcher warns

...r than the carbon saved from using the current-generation biofuels." Indeed, tropical forests are the world's most efficient storehouses for carbon, harboring more than 340 billion tons, according to Gibbs' research. This is equivalent to more than 40 years worth of global carbon dioxide emissions from burni...

Understanding extinct microbes may influence the state of modern human health

...ch will be of interest to many, including medical professionals and biologists and the public. "We should be thinking of ourselves as "superorganisms" harboring microbes from around the world. This is much more complicated than just the cells that make up the body. We have more than just our body to nurture to...

UT Southwestern researchers identify gene linked to inherited form of fatal lung disease

...isk for developing lung cancer, and Dr. Garcia suspects that mutations in the SFTPA2 gene are associated with both IPF and lung cancer. Another family harboring a different mutation in the SFTPA2 gene also had members that exhibited IPF and lung cancer. Dr. Garcia and her team are now working on molecular ...

Powerful online tool for protein analysis provided pro bono by Stanford geneticist

...al activity, than on other, less-critical regions of that protein," Sidow said. If a change interferes with a protein's function, the hapless creature harboring this variant dies out; if not, the creature is fruitful and multiplies, and the variant protein persists in modern species. It's by no means obviou...

Flies may reveal evolutionary step to live birth

...e authors say. Mobile larvae can burrow into the ground to avoid becoming inadvertent hosts to the eggs of parasitic insects or a predator's meal. But harboring offspring for a longer period of time costs the female. The opportunity to take that risk may come with specialization. The Seychelles flies feed o...

Yale researchers unravel mystery of brain aneurysms

... was stricken, his condition was thought to be grave enough that a priest was summoned to confer last rites. The Yale study showed that the risk of harboring an aneurysm increased with the number of risk variants, or alleles. Individuals with the highest number of risk alleles tripled their risk of an aneur...
Harboring in Biological Technology

deCODE Discovers Common Genetic Variations Contributing to Low Bone Mineral Density and Risk of Osteoporosis

...d to low bone mineral density (BMD), the clinical measurement used to diagnose osteoporosis. deCODE had previously identified five sites in the genome harboring SNPs with influence on BMD, and today's study has added four more. They were identified through the correlation of BMD measurements with more than 300...

DuPont Launches Innovative Renewably Sourced Material for Carpet Cushion

...akes it possible to pull spills back to the surface - eliminating damage to the sub-floor, preventing recurring stains and preventing the cushion from harboring permanent odors. "High performance is critical to the successful adoption of bio-based products," said Keith J. Smith , vice presiden...

PTC124 Featured at Third Annual Congress of Myology

...own to cause anywhere from five to 70 percent of the individual cases of most of these inherited diseases. In preclinical models of genetic diseases harboring nonsense mutations, PTC124 was shown to regulate post-transcriptional control processes by restoring full-length, functional proteins. Post-transcript...

DOE JGI plumbs termite guts to yield novel enzymes for better biofuel production

...tmentalized, complex microbial communities required for wood digestion is now coming to light. Like cows, termites have a series of stomachs, each harboring a distinct community of microbes under precisely defined conditions. These bugs within bugs are tasked with particular steps along the conversion pat...

Agendia Acquires Rights to the Discovery of a Major Drug Resistance Mechanism in Breast Cancer Potentially Leading to a Herceptin(R) Sensitivity Test

... interference in cells that are sensitive to a specific cancer drug. If the inactivation of a specific gene confers resistance to a cancer drug, cells harboring the inactivated gene can continue to grow in the presence of the cancer drug and can be readily identified. In the present study deregulation of the p...

Testing Compressed Air Lines for Microbiological Contamination

...rer may use these systems on a continuous basis or on an as-needed basis. The manufacturer may not realize that the compressed air system could be harboring microorganisms. When the air supply system is operating, it may unleash contaminants which could adversely affect the product, including ...

Testing Compressed Air Lines for Microbiological Contamination

...acturer may use these systems on a continuous basis or on an as-needed basis. The manufacturer may not realize that the compressed air system could be harboring microorganisms. When the air supply system is operating, it may unleash contaminants which could adversely affect the product, including op...

Single-Cell Complementation of Barley Mlo Mutants Using a PDS-1000/He Hepta System

...ores susceptibility to Blumeria graminis (Shirasu et al. 1999). This was based on cobombardment experiments involving 2 plasmids harboring either Mlo or GFP (Figure 1). Here we describe a modification of the transformation procedure by using the PDS-1000/He...

Mammalian and Bacterial Expression in One Vector

...ein in BL21(DE3) Cells The hybrid T7/lacO phage promoter was tested by carrying out induction studies using IPTG. BL21(DE3) cells harboring the KPdual-1 construct were grown in LB broth supplemented with 50 m g/ml of kanamycin until the culture reached an OD 600 of ...

High-Titer Retroviral Vectors for Gene Delivery

... has had a tremendous impact on fields for which highly efficient gene delivery is essential. 2 When tissue culture cells are infected with virus harboring a gene of interest, such experiments commonly result in transduction efficiencies of greater than 90%. An additional advantage of retroviral vecto...
Harboring in Biological Definition

Plasmid

...genes or gene-cassettes that confer a selective advantage to the bacterium harboring them, e.g., the ability to build an antibiotic resistance . Every plasmid ...mounts of proteins. In this case you grow the bacteria containing a plasmid harboring the gene of interest. Just as the bacteria produces proteins to confer its ...
Harboring in Biological Dictionary

Peripheral protein

...ms from medicine, science and technology. ... peripheral protein . medical dictionary < protein > ... ... unveiling new signaling cascades harboring peripheral protein drug targets. ... Typically, recruitment of peripheral proteins to the different cellular sites is ... Human Total Prot...
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