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HTS in Medical Technology

Southern Research Institute Wins $14.7 Million NIH Award to Participate in Molecular Libraries Probe Production Center Network

...he general NIH Program Announcement (PAR-08-035: Solicitation of Assays for hts in the Molecular Libraries Probed Production Centers Network (MLPCN) (NOT-R... a wide range of biological opportunities. Like the MLSCN, the MLPCN offers hts and probe development resources to the community under its Data Sharing and...

ActiveSight and CHDI Leverage Fragment-Based Lead Discovery for Huntington Disease Therapies

... fragments will then be linked or grown into larger, drug-like compounds that are thought to be more efficiently binding than compounds resulting from hts methodologies. Several compounds based on Fragment-based Lead Discovery (FBLD) methodologies are currently in clinical trials, and the technology is ...

Trana Discovery and Southern Research Institute Announce the First RNA-RNA High Throughput Drug Screening Assay Platform for HIV Antivirals

...ion of new compounds for the treatment of HIV. The hts assay was developed in collaboration with Southern...tectors and powerful data processing software, the hts assay that was developed will allow researchers to...en 50,000 compounds per day. "We consider the HIV hts assay as a major breakthrough in the development o...

Avalon Pharmaceuticals Announces Positive Interim Results For AVN944 Phase I Trial

...ing the range of therapeutic targets for drug intervention, including targets and target pathways frequently considered intractable using conventional hts approaches, allows more informed decisions about which compounds to advance towards clinical trials, and facilitates drug development through identifi...

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HTS in Biological Technology

Comparison of Performance between the AlphaQuest - HTS and the Fusion α Multilabel Reader for Detection of cAMP

By Laura Gaidar, Kristin Prasauckas, Kelly Carter-Allen and Loraine Upham PerkinElmer Life Sciences, Inc. Introduction AlphaScreen technology is a highly sensitive, non-isotopic homogenous assay method developed for assay development and h...

Mix-and-Read, Bead- and Cell-Based Immunoassays Using the FMAT 8100 HTS System

Abstract Immunoassays are valuable and widely used tools in the biological sciences. In drug discovery research, immunoassays are used to measure secreted cytokines in the tissue culture supernatants of treated cells. However, scientists often avoid immunoassays in high throu...

A Mix-and-Read Cell-Based Assay for Hybridoma Screening Using the FMAT 8100 HTS System

Abstract The generation of hybrid myeloma cell lines for monoclonal antibody production is a fundamental and well-established technique. However, the tedious methods used to screen for specific antibodies secreted by hybridomas has varied l...

NIST discovers how strain at grain boundaries suppresses high-temperature superconductivity

...arch. One of the main challenges in developing long-length, high-quality hts wires is to mitigate the effect of granularity on wire performance because ... grid reliability. NIST has research programs in both these areas. Improved hts thin-film conductors could also enable more powerful high-field particle ac...

ERT to Showcase Its Clinical Trials Portfolio at DIA's 45th Annual Meeting at Booth #507

...d on Wednesday, June 24, 3.30pm-5.00pm. The presentation entitled "Addressing Suicidality in Clinical Trials" will be chaired by John H. Greist, MD of hts Inc and will discuss FDA safety concerns and regulatory requirements regarding suicidality assessments and the Columbia Suicide Severity Rating Scale ...

RainDance Technologies Signs a Collaboration Agreement with sanofi-aventis and Louis Pasteur University to Launch dScreen Consortium within ALSACE BIOVALLEY cluster

...is project is an excellent opportunity to develop the compartmentalisation of reactions in emulsion droplets for an entirely new field of application: hts for drug discovery," said Andrew Griffiths, head of the Chemical Biology Laboratory at ISIS. "The dScreen Consortium is a great illustration of the ...

Device Computing: The Wave Is Building

...low. Segway said in its recall statement: "Under certain operating conditions, particularly when the batteries are near the end of charge, some Segway hts may not deliver enough power, allowing the rider to fall. This can happen if the rider speeds up abruptly, encounters an obstacle, or continues to rid...

BellBrook Labs gets major research funding

...ment, optimization and validation of a fluorescent hts assay for human sulfotransferases. Sulfotransfe...f Transcreener Kinase Assay, a generic fluorescent hts assay for protein kinases. Kinase malfunction h...a universal kinase assay based on its Transcreener hts Assay platform. The Transcreener Kinase Assay will...

GenTel BioSurfaces launches new assay platform

...or high-throughput quantitative immunoassays. PATH hts was introduced last week at the microarray industr...siness development for GenTel BioSurfaces. "PATH hts was designed to meet the pharmaceutical industry's...ut platform to process more samples, faster," PATH hts uses GenTel's proprietary ultra-thin nitrocellulos...

Promegas Multiplexed Luciferase Reporter and Cell Viability Assays performed on the PHERAstar

... EnduRen Live Cell Substrate, catalog no. E6482* Promega ViviRen Live Cell Substrate, catalog no. E6492* Deerac Fluidics Equator hts low-volume liquid dispenser BMG LABTECH PHERAstar (figure 1) BMG LABTECH PHERAstar luminescence optic module ...

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HTS in Biological Products

Phosphate Colorimetric Assay Kit, PiBlue™ from BioAssay Systems

Description:... assays for phosphatase, lipase, nucleoside triphosphatases (ATPase, GTPase etc). hts and follow up studies for phosphatase inhibitors. Quantitation of phosphate content in protein, lipids, and DNA....
Company:BioAssay Systems

Phosphate Colorimetric Assay Kit from BioAssay Systems

Description:... assays for phosphatase, lipase, nucleoside triphosphatases (ATPase, GTPase etc). hts and follow up studies for phosphatase inhibitors. Quantitation of phosphate content in protein, lipids, and DNA....
Company:BioAssay Systems

luciferase Assay Kit, SuperLight from BioAssay Systems

Description:... 2-min, single-step add-mix-measure assay for luciferase expression and hts in mammalian cells. Linear detection range: 2 fg to 46 ng luciferase....
Company:BioAssay Systems

BD Falcon 96-square well Insert System angled-bottom plate and lid from BD Biosciences - Discovery Labware

Description:... BD Falcon insert hts 96 well, square A-bottom with lid. PET membrane, sterile. (5/ca) Packaging: 5 / pack, 5 / case ...
Company:BD Biosciences - Discovery Labware

INTERFERin from Polyplus Transfection

Description:...o medium changes required). The standard protocol is straightforward. Reverse and batch transfection protocols make INTERFERin the ideal solution for hts applications as well....
Company:Polyplus Transfection

NOVOstar Microplate Reader from BMG LABTECH

Description:...he NOVOstar is an exciting product for cell-based kinetic assays and research development. Previously, cell-based assays required the use of expensive hts equipment, which lead to limited accessibility for scientists in the assay development stage. The NOVOstar offers the right equipment necessary for ce...
Company:BMG LABTECH

Phosphate Colorimetric Assay Kit, 'EnzoLyte from AnaSpec

Description:...e. The kit has the following components: Highly purified Malachite Green reagent Assay buffer A mix and read assay protocol that is compatible with hts liquid handling instruments with Z factors of 0.7 to 0.9. Gurpal S, et al. (2003). Characterization of organic phosphorus in leachate from a grassland...
Company:AnaSpec

Hydrogen Peroxide / Peroxidase Fluorometric (resorufin) Assay Kit, Fluoro H2O2 from BACHEM

Description:... utilized to detect H2O2 release from cells or enzyme coupled reactions, and it allows monitoring of additional parameters. The assay is adaptable for hts format. Application: Fluorescence via microwell plate reader....
Company:BACHEM
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