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HLA in Medical News

StemCyte, Inc. Reaches 1,000th Cord Blood Stem Cell Shipment for Transplant Milestone

...udies are increasing at an incredible pace and this will result in the treatment of some of the most devastating diseases. StemCyte's large library of hla typed product as well as our experience and expertise in this field will position us very well to take advantage of these emerging therapies," explain...

Mayo researchers help discover genetic cause for primary biliary cirrhosis

...ociation which had been identified in previous research. "Although both the hla region and the IL12 pathway are equally involved with susceptibility to primary biliary cirrhosis, hla is very complicated to dissect genetically, with multiple pathways," says D...

Researcher IDs Narcolepsy as Autoimmune Disease

... it needs to eliminate to protect the body. Previous studies had linked the hla variant to narcolepsy, a condition nearly half the study subjects had. ...Mignot, director of Stanford's Center for Narcolepsy, said it's likely that hla and the T-cell variant interact in a way that kills hypocretin cells, altho...

Narcolepsy is an autoimmune disorder, Stanford researcher says

...dreds of thousands of genetic variations of 1,800 people carrying the same hla gene variant. Of the group, 800 had narcolepsy, and the goal was to find wh...ntaining neurons via an autoimmune attack." Mignot said it's likely that hla and this T cell variant interact in a way that kills hypocretin cells. How ...

HIV handicaps itself to escape immune system pressure

...s remarkable resistance comes from an individual's hla genes. Long-term non-progressors tend to have hla genes that help the immune system recognize and fi...ng HIV-infected people with particularly effective hla genes has observed how the virus mutates and evolv...

Genetic risk factors play role in autoantibody-negative rheumatoid arthritis

... of their specificity and predictive value and for hla SE (human leukocyte antigen shared epitope) allele...r both ACPA-positive and ACPA-negative RA. The hla SE alleles contributed 11 percent to the total gen...genetic variance of ACPA-negative RA. In the past, hla genes were estimated to contribute 37 percent to t...

The immune system's role in hepatitis C recurrence after liver transplantation

...lls and the killer cell immunoglobulin-like receptors (KIR) which recognize hla Class I antigens. Researchers, led by Francesca Poli of Italy, examined the role of KIR genotypes and their hla ligands in both HCV disease recurrence and its progression after liver tran...

PGD Technology Offers More Than Designer Babies

...s have been used for chromosomal translocations, common in miscarriages, X-linked genetic illness; gender identification for family balancing; and for hla typing for use in cancer therapy. About Pacific Fertility Center Pacific Fertility Center is a fertility medical practice and egg donor ag...

FDA Clears New Immune Response Claim for the CryoValve(R) SG Pulmonary Human Heart Valve

...a comprehensive review of the scientific literature on allograft heart valves shows that implantation of the CryoValve SG reduces the risk of inducing hla class I and class II alloantibodies, based on Panel Reactive Antibody (PRA) measured at up to one year, compared to the standard- processed pulmonary ...

Even Mismatched Cord Blood Can Help Kids

...t conditions. "In order to match a donor to a recipient, doctors compare hla typing, a test usually performed on a blood sample," Prasad explained. "In every individual, hla typing includes the specific genetic make-up at three locations -- within t...

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HLA in Medical Technology

The Past, Present and Future of HLA Typing

The Human Leukocyte Antigen (HLA) region, located on the short arm of chromosome 6 (6p21.3), is a highly polymorphic region containing about 200 genes. The HLA region is the human equivalent of the Major Histocompatibility Complex (MHC), and as such contains a set of genes that serve as the backb...

Prometheus Announces New Findings Regarding Patients at Risk for Celiac Disease at DDW

... at Digestive Disease Week (DDW) in Chicago, Prometheus reported a statistically significant correlation between antibodies to the flagellin CBir1 and hla haplotypes DQ2.5 and DQ8 in a study of 5,406 patients at risk for celiac disease who are EMA positive. Blood and serum samples were analyzed using PRO...

Mayo Researchers Help Discover Genetic Cause for Primary Biliary Cirrhosis

...ociation which had been identified in previous research. "Although both the hla region and the IL12 pathway are equally involved with susceptibility to primary biliary cirrhosis, hla is very complicated to dissect genetically, with multiple pathways," says D...

Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support

...al blood transplant must find a donor that matches at least five of the six hla markers. Finding an unrelated donor match is limited by stringent matching... blood (CB), which extends the donor pool because as few as four of the six hla markers need to match. CB has many other logistical and clinical advantage...

Research Explores the Effects of Stem Cell Source and Patient Age on Stem Cell Transplantation Outcomes

...t, 243 were matched at eight out of eight possible hla loci and 111 were matched at seven hla loci. In those receiving a peripheral blood stem cell transplant, 518 were matched at eight hla loci and 210 at seven...

Northwestern Memorial Transplant Program Initiates New Study

...lls and other cells that play an important part in the body's immune response to foreign substances. These antigens vary from person to person, and an hla compatibility test is performed before organ transplantation to find out if tissues match between a donor and a recipient. The study is limited to...

Pharmexa A/S (DK) - Pharmexa presents data from influenza program

...to us for two reasons. First, we were able to demonstrate protection of the hla transgenic mice from lethal influenza virus challenge using a vaccine desig...ne epitopes as the result of past exposures to influenza virus and that the hla transgenic mice responded in a similar manner." Hørsholm, June 21,...

MaxCyte and Medinet to Present at the 13th Annual Meeting of the International Society for Cellular Therapy (ISCT) in Sydney, Australia

...ed characteristic DC immunophenotype as detected by increased expression of hla class I, hla class II, and co-stimulatory molecules. Compared with current manufacturing...
HLA in Medical Products

Narcolepsy - HLA DNA Panel

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Disease Association HLA Typing

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

OLERUP SSP™ HLA Kits

Description: Complete product line for typing all classical HLA loci including A, B, C DRA, DRB1, DRB3, DRB4, DRB5, DQA, DQB1, DPA1, and DPB1....
Company:QIAGEN

Dynal RELI™ SSO

Description:... The Dynal RELI™ SSO typing technique utilises a generic PCR amplification with biotinylated primers that flank the specific target region of an hla locus. This is followed by hybridisation of the resulting amplicon to an array of Sequence Specific Oligonucleotide probes immobilised on a nylon memb...
Company:Dynal Biotech, LLC

ELPHA / ELPHA DL

Description:... Biotest ELPHA (=Enzyme Linked Probe Hybridization Assay) for class I and class II hla typing shows convincing advantages for your lab routine....
Company:Biotest

Genetic Systems HIV-1 Western Blot

Description:...odies to HIV-1. The solid phase antigens are derived from LAV strain of HIV-1 grown in the CEM cell line. Use of the CEM cell line, which is devoid of hla Class ll antigens, helps reduce cross reactivity to cell related, nonviral bands. In addition, the Genetic Systems HIV-1 Western Blot offers a same-da...
Company:Bio-Rad Laboratories

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HLA in Biological News

New test can detect both genetic and chromosomal abnormalities in embryos

...ame time. "The range of applications is broad and includes single gene defects, abnormal chromosome number, structural chromosome abnormalities and hla [human leukocyte antigen] matching in 'saviour sibling' cases," said Mr Harton. Karyomapping was developed by Professor Alan Handyside of the Londo...

CSHL scientists harness logic of 'Sudoku' math puzzle to vastly enhance genome-sequencing capability

...rchers gain the ability to generate sequences for longer segments of the genome, Hannon envisions wider clinical applications for their method such as hla typing, already an important diagnostic tool for autoimmune diseases, cancer, and for predicting the risk of organ transplantation. ...

Children's Hospital Oakland scientists first to discover new source for harvesting stem cells

...ontain several times more stem cells than umbilical cord blood. "The greater supply of stem cells in placentas will likely increase the chance that an hla (human leukocyte antigen) matched unit of stem cells engrafts, making stem cell transplants available to more people. The more stem cells, the bigger ...

Genetic study confirms the immune system's role in narcolepsy

...-DQB1*0602. This is one of the genes that encodes hla proteins, which dot the surface of the body's cell...eign proteins. Some researchers theorize that the hla variants found in people with narcolepsy-cataplexy... hypocretins, and helped establish the link to the hla system. ...

HIV pays a price for invisibility

... a cell, a complex of human immune proteins called hla (short for human leukocyte antigen) alert killer T...n attack. Individuals who have certain types of hla proteins control infection better than others. In ...rus multiplies less than in people with some other hla variantslikely because killer T cells in these ind...

HIV adapts to 'escape' immune response

...igen (HLA), a group of molecules that orchestrate immune response. Normally hla molecules present fragments of HIV proteins on the surface of infected cell...s escape mutations that help infected cells avoid destruction, Kaslow said. hla genes themselves vary considerably across populations, most likely due to m...

Oral rinses used for tracking HPV-positive head and neck cancers holds promise for cancer screening

... the data and methodology to further explore the connection between HPV and head and neck cancer formation, as well as the biological factors, such as hla type, that are involved, Gillison said. "The big question in HPV research is centered on biological factors that cause one person to have a medica...

Mate selection more biologically determined in some human populations

...ults. Adding to this debate is the recent study by Raphalle Chaix, Chen Cao and Peter Donnelly. The testing employed genome-wide genotype data and hla types in a sample of African and a sample of European American couples, enabling the researchers to distinguish MHC-specific effects from genome-wide ...

Viral recombination another way HIV fools the immune system

...us PARC/MGH research showed that the effectiveness of the CTL response varies depending on which version or allele of an immune system molecule called hla Class I an individual has inherited. The current study was undertaken to investigate why an HIV-positive research participant known to have a powerfu...

Human embryonic stem cells developed from 4-cell embryo; world first may lessen ethical concerns

...8-cell stage, we might consider to change our PGD policy in cases where we perform human leukocyte antigen (HLA) typing," said Dr. Van de Velde. hla molecules play an important role in the immune system by ensuring that our bodies recognise their own cells as their own. By being able to select an H...
HLA in Biological Technology

ProImmune Launches New MHC-Peptide Binding Assay for Class II HLA Alleles

OXFORD, England, September 24 /PRNewswire/ -- ProImmune Ltd., a leading provider of quality research reagents for monitoring the immune system and services for antigen discovery, has announced the launch of its new MHC-peptide binding assay for Class II HLA alleles, adding to the series of dis...

SmartGene's Services for Faster, More Precise Identification of Bacteria and Fungi to be Used by The Johns Hopkins Hospital

...uence-based diagnostics and improve workflow in the laboratory. Current modules from SmartGene include Bacteria, Fungi, HIV, HCV, MLST, Influenza, and hla typing. Future applications will address human genetics as well as food and environmental pathogens. Discover more at www.smartgene.com . ...

Trubion Presents Preclinical Data on Its SCORPION(TM) Multispecific Therapeutics at the 2009 American Association of Cancer Research Annual Meeting

...o . The CD79BxDR SCORPION can bind to two different targets: CD79B, a lineage-restricted component of the B-cell antigen receptor, and HLA-DR, an hla Class II molecule. Target binding by the SCORPION molecule has an affinity similar to Trubion's Small Modular Immunopharmaceutical (SMIP(TM)) proteins...

SmartGene, Inc. Enters Collaboration with Virco Lab, Inc. to Enhance HIV Genotyping and Resistance Interpretation Services in US

...uence-based diagnostics and improve workflow in the laboratory. Current modules from SmartGene include Bacteria, Fungi, HIV, HCV, MLST, Influenza, and hla typing. Future applications will address human genetics as well as food and environmental pathogens. Discover more at www.smartgene.com . ...

Micromet Adds Sir Walter Bodmer and Bernard Fox to Its Advisory Panel for BiTE Antibody Therapeutics

...aboratory of the Weatherall Institute. Sir Walter Bodmer did seminal work in the area of bacterial genetics, molecular and biochemical analysis of the hla system and its association with disease, differentiation and malignant transformation of colonic epithelial cells, and has profound expertise in immun...

BioMS Medical reports results of exploratory phase II trial of dirucotide in relapsing remitting multiple sclerosis

...mmunomodulation achieved will depend on the relationship among the peptide, hla molecules and T cells. The results of phase II and long-term follow-up tr...progression for five years (versus placebo) in progressive MS patients with hla types DR2 and/or DR4, and generally well tolerated. About BioMS M...

BioMS Medical's lead drug, dirucotide (MBP8298) for the treatment of multiple sclerosis, receives fast track designation from FDA

...mmunomodulation achieved will depend on the relationship among the peptide, hla molecules and T cells. The results of phase II and long-term follow-up tr...progression for five years (versus placebo) in progressive MS patients with hla types DR2 and/or DR4. Thus, dirucotide (MBP8298), if approved, has the pote...

BioMS Medical announces positive interim analysis on phase III trial of dirucotide (MBP8298) for multiple sclerosis

...mmunomodulation achieved will depend on the relationship among the peptide, hla molecules and T cells. The results of phase II and long-term follow-up tr...progression for five years (versus placebo) in progressive MS patients with hla types DR2 and/or DR4. Thus, dirucotide (MBP8298), if approved, has the pote...

BioMS Medical completes patient recruitment in phase III U.S. multiple sclerosis trial

...will depend on the relationship among the peptide, hla molecules and T cells. The results of phase II a...s (versus placebo) in progressive MS patients with hla types DR2 and/or DR4. Thus, MBP8298 (dirucotide) h... genetically determined to express the appropriate hla molecules. About Multiple Sclerosis ----------...

Lilly and BioMS Medical Announce Global Licensing and Development Agreement

...mmunomodulation achieved will depend on the relationship among the peptide, hla molecules and T cells. The results of phase II and long-term follow-up tr...ored therapy for patients genetically determined to express the appropriate hla molecules. MBP8298 is being developed in three late-stage clinical tr...
HLA in Biological Definition

Diabetes mellitus

... to a causative agent). There is a genetic element in the susceptibility of individuals to some of these triggers which has been traced to particular hla genotypes (i.e. genetic "self" identifiers used by the immune system). However, even in those who have inherited the susceptibility, type 1 diabet...

Major histocompatibility complex

... people often use the abbreviation MHC to refer to hla gene products. To disambiguate the usage, some of...literature uses Mhc to refer specifically to the hla protein molecules and reserves MHC for the region ...sistently adhered to. The most intensely studied hla genes are the nine so-called classical Mhc genes...

Paternity testing

...of the three individuals, although older methods have included ABO blood group typing , analysis of various other proteins and enzymes , or using hla antigens . For the most part however, DNA has all but taken over all the other forms of testing. The DNA of an individual is almost exactly the...
HLA in Biological Dictionary

Peptide-binding groove

...n peptide binding groove . A peptide bound in this groove may flank from one or the other side. ... The peptide - binding groove of an hla molecule consists of two parts, a floor and ... In the class I peptide - binding groove , the ends of the helixes of the 1 and 2 ... ... two...
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(Date:7/29/2014)... bacteria and algae, propel themselves using whip-like appendages ... a millimetre long, function like tiny oars, helping ... cilia are found on the surfaces of many ... liquids over the cell. , Flagella and ... expel pathogens from our airways, they establish the ...
(Date:7/28/2014)... by the U.S. Food and Drug Administration (FDA) for ... bacterial pathogens inside human cells, including those that cause ... published in mBio , the online open-access journal ... way of identifying non-antibiotic drugs that could one day ... drugs on the list inhibit the growth of at ...
(Date:7/28/2014)... reached the South Pole in 1911, but new research ... human. , Using data from 16 ice cores collected ... the South Pole, a group led by Joe McConnell ... created the most accurate and precise reconstruction to date ... record, described in an article published today in the ...
Breaking Biology News(10 mins):Microscopic rowing -- without a cox 2Microscopic rowing -- without a cox 3New route to identify drugs that can fight bacterial infections 2Lead pollution beat explorers to South Pole, persists today 2Lead pollution beat explorers to South Pole, persists today 3
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