Worms Reveal More of Longevity's Secrets
...the UW researchers are now trying to determine how hif
protects the worms from aging. In both worms and humans, hif
regulates the activity of several factors that pla..."If we can understand at a very detailed level how hif
is slowing aging, we may be able to use that infor...
JCI online early table of contents: April 6, 2009
..., heart failure. In a new study, Carole Peyssonnaux and her colleagues at Universit Paris Descartes, France, have identified a link between one of the hif
proteins that help cells adapt to low oxygen levels (hypoxia) and iron absorption in the small intestine, which they found was hypoxic. Using transgen...
Bioengineered proteins: Trial confirms new way to tackle cancer
...IF) that helps them carry on growing. Consequently hif
is associated with aggressiveness in some of the m...dicine at the University of Toronto. "The level of hif
is usually very high under conditions of low oxyge... have implications for any type of cancer in which hif
plays a role. "We used kidney cancer as a model be...
Affordable medicine plan goes global
...ch drug companies would have the option to register their products with the hif
and sell the product for no more than the cost of production and distributi...s would only register their products if they expected to earn more from the hif
than from selling their products at high prices.
"The idea is that it's ...
Another way to grow blood vessels
...th lead author Zoltan Arany, MD, PhD, and colleagues, Spiegelman found that hif
was completely left out of the loop when PGC-1alpha accomplished the same f... Were still far from having good drugs to modulate angiogenesis through the hif
pathway, commented Arany. The discovery of a second, alternate pathway, inv...
FOXO factor promotes survival of oxygen-deprived cancer cells
...at enable cells to adapt to the oxygen deficit. This response is primarily mediated by the hypoxia-inducible transcription factors, HIF1 and HIF2.
proteins play a key role in hypoxic tumor development and are often associated with poor patient prognosis. Hypoxic tumor cells exhibit decreased sens...
Combination targets: some drugs may work best when they work together
...llow at the University of Manchester. Furthermore, hif
is associated with protecting tumors from the effe...
It is possible that the effect of AZD6244 on hif
as well as tumor blood vessel growth induced by hif
contributed towards the remarkable effects of the ...
A new recovery for heart attacks
... found to be reliable for increasing the amount of hif
in the cell. Under normal circumstances hif
is constantly made and broken down. However researchers have found that under low-oxygen levels, hif
loses a hydroxyl (oxygen and hydrogen) group from ...